Efficacité et tolérance des capsaïcinoïdes topiques dans le traitement de la douleur neuropathique. Une revue systématique et méta-analyse des essais ... View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2017-12

AUTHORS

A. U. Trillig, R. Deumens, A. Mouraux, F. Bauchy, P. Forget

ABSTRACT

La douleur neuropathique est fréquente, et sa prise en charge peut être difficile en cas d’inefficacité des traitements et de survenue d’effets secondaires. Une alternative aux traitements systémiques est l’application topique de capsaïcinoïdes. L’objectif du travail est d’évaluer l’efficacité d’un traitement topique à base de capsaïcinoïdes dans le traitement de la douleur neuropathique. En accord avec les recommandations PRISMA, une recherche systématique des essais cliniques publiés entre le 1er janvier 1990 et le 31 août 2014, en langue anglaise et française, a été réalisée dans PubMed/Central et la Cochrane Database. Les indications, les modalités de traitement et les résultats thérapeutiques ont été collectés. Des analyses qualitative et quantitative (méta-analyses) des données ont été réalisées. Dix-sept études ont été incluses à partir de 153 études identifiées. Les données rassemblées permettent de conclure à l’efficacité de la capsaïcine pour traiter les douleurs neuropathiques postherpétiques et la polyneuropathie sensorielle distale associée au VIH. Les indications pourraient être élargies, mais les données sont insuffisantes pour tirer des conclusions. La capsaïcine topique est efficace pour les douleurs neuropathiques postherpétiques et dans la neuropathie associée au VIH. Des recherches complémentaires sont nécessaires dans d’autres indications, ainsi que pour évaluer l’éventuelle place d’autres capsaïcinoïdes. More... »

PAGES

239-249

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s11724-017-0518-z

DOI

http://dx.doi.org/10.1007/s11724-017-0518-z

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