Recent research and development of PLGA/PLA microspheres/nanoparticles: A review in scientific and industrial aspects View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2019-03

AUTHORS

Feng Qi, Jie Wu, Hao Li, Guanghui Ma

ABSTRACT

Poly(D,L-lactic-co-glycolic acid) (PLGA)/poly (lactic acid) (PLA) microspheres/nanoparticles are one of the most successful drug delivery systems (DDS) in lab and clinic. Because of good biocompatibility and biodegradability, they can be used in various areas, such as long-term release system, vaccine adjuvant, tissue engineering, etc. There have been 15 products available on the US market, but the system still has many problems during development and manufacturing, such as wide size distribution, drug stability issues, and so on. Recently, many new and modified methods have been developed to overcome the above problems. Some of the methods are easy to scale up, and have been available on the market to achieve pilot scale or even industrial production scale. Furthermore, the relevant FDA guidance on the DDS is still incomplete, especially for abbreviated new drug application. In this review, we present some recent achievement of the PLGA/PLA microspheres/nanoparticles, and discuss some promising manufacturing methods. Finally, we focus on the current FDA guidance on the DDS. The review provides an overview on the development of the system in pharmaceutical industry. More... »

PAGES

14-27

References to SciGraph publications

  • 2002-02. Peptide Acylation by Poly(α-Hydroxy Esters) in PHARMACEUTICAL RESEARCH
  • 2018-02. Exploiting the pliability and lateral mobility of Pickering emulsion for enhanced vaccination in NATURE MATERIALS
  • 2017-05. Scientific and Regulatory Considerations for Generic Complex Drug Products Containing Nanomaterials in THE AAPS JOURNAL
  • 2009-11. Pharmacokinetics and Efficacy of a Biweekly Dosage Formulation of Exenatide in Zucker Diabetic Fatty (ZDF) Rats in PHARMACEUTICAL RESEARCH
  • 2011-01. Microneedle-Based Intradermal Delivery Enables Rapid Lymphatic Uptake and Distribution of Protein Drugs in PHARMACEUTICAL RESEARCH
  • 2013-10. Encapsulation of titanium dioxide nanoparticles in PLA microspheres using supercritical emulsion extraction to produce bactericidal nanocomposites in JOURNAL OF NANOPARTICLE RESEARCH
  • 2015-07. Microcosmic Mechanism of Dication for Inhibiting Acylation of Acidic Peptide in PHARMACEUTICAL RESEARCH
  • 2000-03. Stabilization of Proteins Encapsulated in Cylindrical Poly(lactide-co-glycolide) Implants: Mechanism of Stabilization by Basic Additives in PHARMACEUTICAL RESEARCH
  • 2016-10. A Novel Method for Preparing Surface-Modified Fluocinolone Acetonide Loaded PLGA Nanoparticles for Ocular Use: In Vitro and In Vivo Evaluations in AAPS PHARMSCITECH
  • 2017-10. Injectable Sustained-Release Depots of PLGA Microspheres for Insoluble Drugs Prepared by hot-Melt Extrusion in PHARMACEUTICAL RESEARCH
  • 2015-09. Immunopotentiator-Loaded Polymeric Microparticles as Robust Adjuvant to Improve Vaccine Efficacy in PHARMACEUTICAL RESEARCH
  • 2010-03. Points to Consider when Establishing Drug Product Specifications for Parenteral Microspheres in THE AAPS JOURNAL
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1007/s11705-018-1729-4

    DOI

    http://dx.doi.org/10.1007/s11705-018-1729-4

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1104476454


    Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
    Incoming Citations Browse incoming citations for this publication using opencitations.net

    JSON-LD is the canonical representation for SciGraph data.

    TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

    [
      {
        "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
        "about": [
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/0903", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Biomedical Engineering", 
            "type": "DefinedTerm"
          }, 
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/09", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Engineering", 
            "type": "DefinedTerm"
          }
        ], 
        "author": [
          {
            "affiliation": {
              "alternateName": "University of Missouri", 
              "id": "https://www.grid.ac/institutes/grid.134936.a", 
              "name": [
                "Beijing Nuokangda Pharmaceutical Technology Co., Ltd, 100176, Beijing, China", 
                "Department of Mechanical and Aerospace Engineering, University of Missouri, 65211, Columbia, MO, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Qi", 
            "givenName": "Feng", 
            "id": "sg:person.01335170005.75", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01335170005.75"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Institute of Process Engineering", 
              "id": "https://www.grid.ac/institutes/grid.458442.b", 
              "name": [
                "National Key Laboratory of Biochemical Engineering, Key Laboratory of Biopharmaceutical Production and Formulation Engineering, PLA, Institute of Process Engineering, Chinese Academy of Sciences, 100190, Beijing, China"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Wu", 
            "givenName": "Jie", 
            "id": "sg:person.01243572134.82", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01243572134.82"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "University of Missouri", 
              "id": "https://www.grid.ac/institutes/grid.134936.a", 
              "name": [
                "Department of Mechanical and Aerospace Engineering, University of Missouri, 65211, Columbia, MO, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Li", 
            "givenName": "Hao", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Institute of Process Engineering", 
              "id": "https://www.grid.ac/institutes/grid.458442.b", 
              "name": [
                "National Key Laboratory of Biochemical Engineering, Key Laboratory of Biopharmaceutical Production and Formulation Engineering, PLA, Institute of Process Engineering, Chinese Academy of Sciences, 100190, Beijing, China"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Ma", 
            "givenName": "Guanghui", 
            "id": "sg:person.01303101171.55", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01303101171.55"
            ], 
            "type": "Person"
          }
        ], 
        "citation": [
          {
            "id": "https://doi.org/10.1016/j.ijpharm.2016.03.048", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1001573467"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1039/c4tb01165a", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1002987698"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.biomaterials.2008.12.044", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1003077604"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.jconrel.2014.09.003", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1004814038"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.colsurfa.2014.05.017", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1004891858"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.3390/ijms15033640", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1005014557"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.jconrel.2009.03.014", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1005725450"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.ophtha.2013.02.018", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1007323925"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1039/c002866e", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1008048995"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1039/c002866e", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1008048995"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0168-3659(99)00023-1", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1010619168"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.colsurfb.2011.05.051", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1010855871"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.ijpharm.2011.02.057", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1011821599"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0168-3659(01)00289-9", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1012371351"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.ejps.2016.03.012", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1012717594"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1155/2011/290602", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1012872486"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s11095-015-1622-5", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1013350546", 
              "https://doi.org/10.1007/s11095-015-1622-5"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1023/a:1007513425337", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1013387808", 
              "https://doi.org/10.1023/a:1007513425337"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.ejpb.2014.09.012", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1014599629"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/j.1524-4725.2008.01042.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1014843305"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/j.1524-4725.2008.01042.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1014843305"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.ijpharm.2012.12.037", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1015511185"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/j.1468-1293.2004.00190.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1015943693"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.jconrel.2004.11.025", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1016537837"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.xphs.2016.05.002", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1016819208"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.biomaterials.2016.11.037", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1016946357"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.biomaterials.2016.11.037", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1016946357"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.biomaterials.2016.11.037", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1016946357"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1039/c3tb21099e", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1018011169"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.actbio.2014.06.018", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1022418254"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.supflu.2013.01.009", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1025646137"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.jconrel.2009.03.006", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1025785832"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0169-409x(97)00050-1", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1025791313"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.colsurfa.2014.03.085", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1026563093"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0304-4165(02)00153-8", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1026788288"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1208/s12248-009-9156-6", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1028111429", 
              "https://doi.org/10.1208/s12248-009-9156-6"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.colsurfb.2013.08.048", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1028535310"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s11095-009-9966-3", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1030131417", 
              "https://doi.org/10.1007/s11095-009-9966-3"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s11095-009-9966-3", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1030131417", 
              "https://doi.org/10.1007/s11095-009-9966-3"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0168-3659(01)00258-9", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1030782737"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.2147/ijn.s45186", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1030813137"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.progpolymsci.2007.05.017", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1030848231"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s11051-013-1987-5", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1031160634", 
              "https://doi.org/10.1007/s11051-013-1987-5"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.biomaterials.2014.04.022", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1032503604"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.ejps.2016.08.024", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1033000871"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/00002030-200311210-00009", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1035570570"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/00002030-200311210-00009", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1035570570"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.jconrel.2012.04.022", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1036270249"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.colsurfb.2016.05.085", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1036556788"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.powtec.2007.01.035", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1037694894"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/01.prs.0000234612.20611.5a", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1037951542"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/01.prs.0000234612.20611.5a", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1037951542"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0939-6411(96)00017-3", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1039149136"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s11095-010-0123-9", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1039248658", 
              "https://doi.org/10.1007/s11095-010-0123-9"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s11095-010-0123-9", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1039248658", 
              "https://doi.org/10.1007/s11095-010-0123-9"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/jbm.a.35354", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1039368042"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1080/03639040701498759", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1040393806"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.ijpharm.2012.10.039", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1041877559"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.ejps.2016.03.024", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1042869764"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.colsurfb.2005.08.004", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1043864623"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1023/a:1014272816454", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1044168894", 
              "https://doi.org/10.1023/a:1014272816454"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0168-3659(00)00352-7", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1045324266"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.2217/nnm.14.156", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1045704532"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1208/s12249-015-0448-0", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1045801870", 
              "https://doi.org/10.1208/s12249-015-0448-0"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1517/17425247.2016.1134484", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1047500455"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.3389/fphar.2016.00185", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1047581941"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.memsci.2014.04.035", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1047980805"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s11095-015-1666-6", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1048915686", 
              "https://doi.org/10.1007/s11095-015-1666-6"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.ijpharm.2011.08.035", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1048986230"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1080/09205063.2013.807457", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1050658114"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.colsurfb.2006.05.014", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1050774843"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1126/sciadv.1600519", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1051004793"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.ejps.2014.05.027", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1051732265"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.addr.2007.11.008", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1052072756"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/jbm.820270904", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1052230523"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/jbm.820270904", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1052230523"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.jconrel.2006.02.015", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1052382663"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.jconrel.2010.05.011", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1052757501"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1021/la3017112", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1056156327"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1021/mp800027f", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1056213923"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1021/mp800027f", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1056213923"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1021/mp800087t", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1056213950"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1021/mp800087t", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1056213950"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1021/nn5066793", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1056226521"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1089/jop.2011.0184", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1059285084"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1089/ten.tea.2013.0075", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1059316338"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1142/s021963521650031x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1063002981"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1208/s12248-017-0044-1", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1074186411", 
              "https://doi.org/10.1208/s12248-017-0044-1"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1208/s12248-017-0044-1", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1074186411", 
              "https://doi.org/10.1208/s12248-017-0044-1"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1142/s0219635216500321", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1079395263"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1021/acsami.6b13566", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1084124331"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1146/annurev-bioeng-071516-044712", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1086104749"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s11095-017-2228-x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1090880912", 
              "https://doi.org/10.1007/s11095-017-2228-x"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s11095-017-2228-x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1090880912", 
              "https://doi.org/10.1007/s11095-017-2228-x"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1080/09205063.2017.1390381", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1092130904"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1021/acsami.7b14330", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1092595205"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1021/acsami.7b14330", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1092595205"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nmat5057", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1100163826", 
              "https://doi.org/10.1038/nmat5057"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nmat5057", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1100163826", 
              "https://doi.org/10.1038/nmat5057"
            ], 
            "type": "CreativeWork"
          }
        ], 
        "datePublished": "2019-03", 
        "datePublishedReg": "2019-03-01", 
        "description": "Poly(D,L-lactic-co-glycolic acid) (PLGA)/poly (lactic acid) (PLA) microspheres/nanoparticles are one of the most successful drug delivery systems (DDS) in lab and clinic. Because of good biocompatibility and biodegradability, they can be used in various areas, such as long-term release system, vaccine adjuvant, tissue engineering, etc. There have been 15 products available on the US market, but the system still has many problems during development and manufacturing, such as wide size distribution, drug stability issues, and so on. Recently, many new and modified methods have been developed to overcome the above problems. Some of the methods are easy to scale up, and have been available on the market to achieve pilot scale or even industrial production scale. Furthermore, the relevant FDA guidance on the DDS is still incomplete, especially for abbreviated new drug application. In this review, we present some recent achievement of the PLGA/PLA microspheres/nanoparticles, and discuss some promising manufacturing methods. Finally, we focus on the current FDA guidance on the DDS. The review provides an overview on the development of the system in pharmaceutical industry.", 
        "genre": "research_article", 
        "id": "sg:pub.10.1007/s11705-018-1729-4", 
        "inLanguage": [
          "en"
        ], 
        "isAccessibleForFree": false, 
        "isPartOf": [
          {
            "id": "sg:journal.1135946", 
            "issn": [
              "2095-0179", 
              "2095-0187"
            ], 
            "name": "Frontiers of Chemical Science and Engineering", 
            "type": "Periodical"
          }, 
          {
            "issueNumber": "1", 
            "type": "PublicationIssue"
          }, 
          {
            "type": "PublicationVolume", 
            "volumeNumber": "13"
          }
        ], 
        "name": "Recent research and development of PLGA/PLA microspheres/nanoparticles: A review in scientific and industrial aspects", 
        "pagination": "14-27", 
        "productId": [
          {
            "name": "readcube_id", 
            "type": "PropertyValue", 
            "value": [
              "6dd27c0356a60051025bb3366c34b541f41e1b302baa37eda2781d1a8eccf01a"
            ]
          }, 
          {
            "name": "doi", 
            "type": "PropertyValue", 
            "value": [
              "10.1007/s11705-018-1729-4"
            ]
          }, 
          {
            "name": "dimensions_id", 
            "type": "PropertyValue", 
            "value": [
              "pub.1104476454"
            ]
          }
        ], 
        "sameAs": [
          "https://doi.org/10.1007/s11705-018-1729-4", 
          "https://app.dimensions.ai/details/publication/pub.1104476454"
        ], 
        "sdDataset": "articles", 
        "sdDatePublished": "2019-04-11T10:20", 
        "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
        "sdPublisher": {
          "name": "Springer Nature - SN SciGraph project", 
          "type": "Organization"
        }, 
        "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000348_0000000348/records_54328_00000001.jsonl", 
        "type": "ScholarlyArticle", 
        "url": "https://link.springer.com/10.1007%2Fs11705-018-1729-4"
      }
    ]
     

    Download the RDF metadata as:  json-ld nt turtle xml License info

    HOW TO GET THIS DATA PROGRAMMATICALLY:

    JSON-LD is a popular format for linked data which is fully compatible with JSON.

    curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s11705-018-1729-4'

    N-Triples is a line-based linked data format ideal for batch operations.

    curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s11705-018-1729-4'

    Turtle is a human-readable linked data format.

    curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s11705-018-1729-4'

    RDF/XML is a standard XML format for linked data.

    curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s11705-018-1729-4'


     

    This table displays all metadata directly associated to this object as RDF triples.

    349 TRIPLES      21 PREDICATES      111 URIs      19 LITERALS      7 BLANK NODES

    Subject Predicate Object
    1 sg:pub.10.1007/s11705-018-1729-4 schema:about anzsrc-for:09
    2 anzsrc-for:0903
    3 schema:author Nc2dde1d9716a448ea143938a5963fdae
    4 schema:citation sg:pub.10.1007/s11051-013-1987-5
    5 sg:pub.10.1007/s11095-009-9966-3
    6 sg:pub.10.1007/s11095-010-0123-9
    7 sg:pub.10.1007/s11095-015-1622-5
    8 sg:pub.10.1007/s11095-015-1666-6
    9 sg:pub.10.1007/s11095-017-2228-x
    10 sg:pub.10.1023/a:1007513425337
    11 sg:pub.10.1023/a:1014272816454
    12 sg:pub.10.1038/nmat5057
    13 sg:pub.10.1208/s12248-009-9156-6
    14 sg:pub.10.1208/s12248-017-0044-1
    15 sg:pub.10.1208/s12249-015-0448-0
    16 https://doi.org/10.1002/jbm.820270904
    17 https://doi.org/10.1002/jbm.a.35354
    18 https://doi.org/10.1016/j.actbio.2014.06.018
    19 https://doi.org/10.1016/j.addr.2007.11.008
    20 https://doi.org/10.1016/j.biomaterials.2008.12.044
    21 https://doi.org/10.1016/j.biomaterials.2014.04.022
    22 https://doi.org/10.1016/j.biomaterials.2016.11.037
    23 https://doi.org/10.1016/j.colsurfa.2014.03.085
    24 https://doi.org/10.1016/j.colsurfa.2014.05.017
    25 https://doi.org/10.1016/j.colsurfb.2005.08.004
    26 https://doi.org/10.1016/j.colsurfb.2006.05.014
    27 https://doi.org/10.1016/j.colsurfb.2011.05.051
    28 https://doi.org/10.1016/j.colsurfb.2013.08.048
    29 https://doi.org/10.1016/j.colsurfb.2016.05.085
    30 https://doi.org/10.1016/j.ejpb.2014.09.012
    31 https://doi.org/10.1016/j.ejps.2014.05.027
    32 https://doi.org/10.1016/j.ejps.2016.03.012
    33 https://doi.org/10.1016/j.ejps.2016.03.024
    34 https://doi.org/10.1016/j.ejps.2016.08.024
    35 https://doi.org/10.1016/j.ijpharm.2011.02.057
    36 https://doi.org/10.1016/j.ijpharm.2011.08.035
    37 https://doi.org/10.1016/j.ijpharm.2012.10.039
    38 https://doi.org/10.1016/j.ijpharm.2012.12.037
    39 https://doi.org/10.1016/j.ijpharm.2016.03.048
    40 https://doi.org/10.1016/j.jconrel.2004.11.025
    41 https://doi.org/10.1016/j.jconrel.2006.02.015
    42 https://doi.org/10.1016/j.jconrel.2009.03.006
    43 https://doi.org/10.1016/j.jconrel.2009.03.014
    44 https://doi.org/10.1016/j.jconrel.2010.05.011
    45 https://doi.org/10.1016/j.jconrel.2012.04.022
    46 https://doi.org/10.1016/j.jconrel.2014.09.003
    47 https://doi.org/10.1016/j.memsci.2014.04.035
    48 https://doi.org/10.1016/j.ophtha.2013.02.018
    49 https://doi.org/10.1016/j.powtec.2007.01.035
    50 https://doi.org/10.1016/j.progpolymsci.2007.05.017
    51 https://doi.org/10.1016/j.supflu.2013.01.009
    52 https://doi.org/10.1016/j.xphs.2016.05.002
    53 https://doi.org/10.1016/s0168-3659(00)00352-7
    54 https://doi.org/10.1016/s0168-3659(01)00258-9
    55 https://doi.org/10.1016/s0168-3659(01)00289-9
    56 https://doi.org/10.1016/s0168-3659(99)00023-1
    57 https://doi.org/10.1016/s0169-409x(97)00050-1
    58 https://doi.org/10.1016/s0304-4165(02)00153-8
    59 https://doi.org/10.1016/s0939-6411(96)00017-3
    60 https://doi.org/10.1021/acsami.6b13566
    61 https://doi.org/10.1021/acsami.7b14330
    62 https://doi.org/10.1021/la3017112
    63 https://doi.org/10.1021/mp800027f
    64 https://doi.org/10.1021/mp800087t
    65 https://doi.org/10.1021/nn5066793
    66 https://doi.org/10.1039/c002866e
    67 https://doi.org/10.1039/c3tb21099e
    68 https://doi.org/10.1039/c4tb01165a
    69 https://doi.org/10.1080/03639040701498759
    70 https://doi.org/10.1080/09205063.2013.807457
    71 https://doi.org/10.1080/09205063.2017.1390381
    72 https://doi.org/10.1089/jop.2011.0184
    73 https://doi.org/10.1089/ten.tea.2013.0075
    74 https://doi.org/10.1097/00002030-200311210-00009
    75 https://doi.org/10.1097/01.prs.0000234612.20611.5a
    76 https://doi.org/10.1111/j.1468-1293.2004.00190.x
    77 https://doi.org/10.1111/j.1524-4725.2008.01042.x
    78 https://doi.org/10.1126/sciadv.1600519
    79 https://doi.org/10.1142/s021963521650031x
    80 https://doi.org/10.1142/s0219635216500321
    81 https://doi.org/10.1146/annurev-bioeng-071516-044712
    82 https://doi.org/10.1155/2011/290602
    83 https://doi.org/10.1517/17425247.2016.1134484
    84 https://doi.org/10.2147/ijn.s45186
    85 https://doi.org/10.2217/nnm.14.156
    86 https://doi.org/10.3389/fphar.2016.00185
    87 https://doi.org/10.3390/ijms15033640
    88 schema:datePublished 2019-03
    89 schema:datePublishedReg 2019-03-01
    90 schema:description Poly(D,L-lactic-co-glycolic acid) (PLGA)/poly (lactic acid) (PLA) microspheres/nanoparticles are one of the most successful drug delivery systems (DDS) in lab and clinic. Because of good biocompatibility and biodegradability, they can be used in various areas, such as long-term release system, vaccine adjuvant, tissue engineering, etc. There have been 15 products available on the US market, but the system still has many problems during development and manufacturing, such as wide size distribution, drug stability issues, and so on. Recently, many new and modified methods have been developed to overcome the above problems. Some of the methods are easy to scale up, and have been available on the market to achieve pilot scale or even industrial production scale. Furthermore, the relevant FDA guidance on the DDS is still incomplete, especially for abbreviated new drug application. In this review, we present some recent achievement of the PLGA/PLA microspheres/nanoparticles, and discuss some promising manufacturing methods. Finally, we focus on the current FDA guidance on the DDS. The review provides an overview on the development of the system in pharmaceutical industry.
    91 schema:genre research_article
    92 schema:inLanguage en
    93 schema:isAccessibleForFree false
    94 schema:isPartOf Na5ad1e874d4946318c59164369ab2ffa
    95 Nb1967e027a95471a8011786b2549ba10
    96 sg:journal.1135946
    97 schema:name Recent research and development of PLGA/PLA microspheres/nanoparticles: A review in scientific and industrial aspects
    98 schema:pagination 14-27
    99 schema:productId N4ef72b6b33034b439d55fc7f5aac7fa1
    100 Nb9ca757fd90d45df9bcb6d4fbb52b985
    101 Nef022d6c03fa40ff94597899284ea102
    102 schema:sameAs https://app.dimensions.ai/details/publication/pub.1104476454
    103 https://doi.org/10.1007/s11705-018-1729-4
    104 schema:sdDatePublished 2019-04-11T10:20
    105 schema:sdLicense https://scigraph.springernature.com/explorer/license/
    106 schema:sdPublisher Naf2cfc3f2c324a36acb025c02ee685bf
    107 schema:url https://link.springer.com/10.1007%2Fs11705-018-1729-4
    108 sgo:license sg:explorer/license/
    109 sgo:sdDataset articles
    110 rdf:type schema:ScholarlyArticle
    111 N1a892970dad240aea30217a868c8bb9b rdf:first sg:person.01303101171.55
    112 rdf:rest rdf:nil
    113 N25dac8f032c84de8aafcf39ff32c392f schema:affiliation https://www.grid.ac/institutes/grid.134936.a
    114 schema:familyName Li
    115 schema:givenName Hao
    116 rdf:type schema:Person
    117 N4ef72b6b33034b439d55fc7f5aac7fa1 schema:name doi
    118 schema:value 10.1007/s11705-018-1729-4
    119 rdf:type schema:PropertyValue
    120 Na5ad1e874d4946318c59164369ab2ffa schema:volumeNumber 13
    121 rdf:type schema:PublicationVolume
    122 Naf2cfc3f2c324a36acb025c02ee685bf schema:name Springer Nature - SN SciGraph project
    123 rdf:type schema:Organization
    124 Nb04e4db60a374c449d9b0740970ca80e rdf:first sg:person.01243572134.82
    125 rdf:rest Neb959e6bf8ac4dd39c4eafca327dc4fa
    126 Nb1967e027a95471a8011786b2549ba10 schema:issueNumber 1
    127 rdf:type schema:PublicationIssue
    128 Nb9ca757fd90d45df9bcb6d4fbb52b985 schema:name dimensions_id
    129 schema:value pub.1104476454
    130 rdf:type schema:PropertyValue
    131 Nc2dde1d9716a448ea143938a5963fdae rdf:first sg:person.01335170005.75
    132 rdf:rest Nb04e4db60a374c449d9b0740970ca80e
    133 Neb959e6bf8ac4dd39c4eafca327dc4fa rdf:first N25dac8f032c84de8aafcf39ff32c392f
    134 rdf:rest N1a892970dad240aea30217a868c8bb9b
    135 Nef022d6c03fa40ff94597899284ea102 schema:name readcube_id
    136 schema:value 6dd27c0356a60051025bb3366c34b541f41e1b302baa37eda2781d1a8eccf01a
    137 rdf:type schema:PropertyValue
    138 anzsrc-for:09 schema:inDefinedTermSet anzsrc-for:
    139 schema:name Engineering
    140 rdf:type schema:DefinedTerm
    141 anzsrc-for:0903 schema:inDefinedTermSet anzsrc-for:
    142 schema:name Biomedical Engineering
    143 rdf:type schema:DefinedTerm
    144 sg:journal.1135946 schema:issn 2095-0179
    145 2095-0187
    146 schema:name Frontiers of Chemical Science and Engineering
    147 rdf:type schema:Periodical
    148 sg:person.01243572134.82 schema:affiliation https://www.grid.ac/institutes/grid.458442.b
    149 schema:familyName Wu
    150 schema:givenName Jie
    151 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01243572134.82
    152 rdf:type schema:Person
    153 sg:person.01303101171.55 schema:affiliation https://www.grid.ac/institutes/grid.458442.b
    154 schema:familyName Ma
    155 schema:givenName Guanghui
    156 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01303101171.55
    157 rdf:type schema:Person
    158 sg:person.01335170005.75 schema:affiliation https://www.grid.ac/institutes/grid.134936.a
    159 schema:familyName Qi
    160 schema:givenName Feng
    161 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01335170005.75
    162 rdf:type schema:Person
    163 sg:pub.10.1007/s11051-013-1987-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031160634
    164 https://doi.org/10.1007/s11051-013-1987-5
    165 rdf:type schema:CreativeWork
    166 sg:pub.10.1007/s11095-009-9966-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030131417
    167 https://doi.org/10.1007/s11095-009-9966-3
    168 rdf:type schema:CreativeWork
    169 sg:pub.10.1007/s11095-010-0123-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039248658
    170 https://doi.org/10.1007/s11095-010-0123-9
    171 rdf:type schema:CreativeWork
    172 sg:pub.10.1007/s11095-015-1622-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013350546
    173 https://doi.org/10.1007/s11095-015-1622-5
    174 rdf:type schema:CreativeWork
    175 sg:pub.10.1007/s11095-015-1666-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048915686
    176 https://doi.org/10.1007/s11095-015-1666-6
    177 rdf:type schema:CreativeWork
    178 sg:pub.10.1007/s11095-017-2228-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1090880912
    179 https://doi.org/10.1007/s11095-017-2228-x
    180 rdf:type schema:CreativeWork
    181 sg:pub.10.1023/a:1007513425337 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013387808
    182 https://doi.org/10.1023/a:1007513425337
    183 rdf:type schema:CreativeWork
    184 sg:pub.10.1023/a:1014272816454 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044168894
    185 https://doi.org/10.1023/a:1014272816454
    186 rdf:type schema:CreativeWork
    187 sg:pub.10.1038/nmat5057 schema:sameAs https://app.dimensions.ai/details/publication/pub.1100163826
    188 https://doi.org/10.1038/nmat5057
    189 rdf:type schema:CreativeWork
    190 sg:pub.10.1208/s12248-009-9156-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028111429
    191 https://doi.org/10.1208/s12248-009-9156-6
    192 rdf:type schema:CreativeWork
    193 sg:pub.10.1208/s12248-017-0044-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1074186411
    194 https://doi.org/10.1208/s12248-017-0044-1
    195 rdf:type schema:CreativeWork
    196 sg:pub.10.1208/s12249-015-0448-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045801870
    197 https://doi.org/10.1208/s12249-015-0448-0
    198 rdf:type schema:CreativeWork
    199 https://doi.org/10.1002/jbm.820270904 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052230523
    200 rdf:type schema:CreativeWork
    201 https://doi.org/10.1002/jbm.a.35354 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039368042
    202 rdf:type schema:CreativeWork
    203 https://doi.org/10.1016/j.actbio.2014.06.018 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022418254
    204 rdf:type schema:CreativeWork
    205 https://doi.org/10.1016/j.addr.2007.11.008 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052072756
    206 rdf:type schema:CreativeWork
    207 https://doi.org/10.1016/j.biomaterials.2008.12.044 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003077604
    208 rdf:type schema:CreativeWork
    209 https://doi.org/10.1016/j.biomaterials.2014.04.022 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032503604
    210 rdf:type schema:CreativeWork
    211 https://doi.org/10.1016/j.biomaterials.2016.11.037 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016946357
    212 rdf:type schema:CreativeWork
    213 https://doi.org/10.1016/j.colsurfa.2014.03.085 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026563093
    214 rdf:type schema:CreativeWork
    215 https://doi.org/10.1016/j.colsurfa.2014.05.017 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004891858
    216 rdf:type schema:CreativeWork
    217 https://doi.org/10.1016/j.colsurfb.2005.08.004 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043864623
    218 rdf:type schema:CreativeWork
    219 https://doi.org/10.1016/j.colsurfb.2006.05.014 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050774843
    220 rdf:type schema:CreativeWork
    221 https://doi.org/10.1016/j.colsurfb.2011.05.051 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010855871
    222 rdf:type schema:CreativeWork
    223 https://doi.org/10.1016/j.colsurfb.2013.08.048 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028535310
    224 rdf:type schema:CreativeWork
    225 https://doi.org/10.1016/j.colsurfb.2016.05.085 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036556788
    226 rdf:type schema:CreativeWork
    227 https://doi.org/10.1016/j.ejpb.2014.09.012 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014599629
    228 rdf:type schema:CreativeWork
    229 https://doi.org/10.1016/j.ejps.2014.05.027 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051732265
    230 rdf:type schema:CreativeWork
    231 https://doi.org/10.1016/j.ejps.2016.03.012 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012717594
    232 rdf:type schema:CreativeWork
    233 https://doi.org/10.1016/j.ejps.2016.03.024 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042869764
    234 rdf:type schema:CreativeWork
    235 https://doi.org/10.1016/j.ejps.2016.08.024 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033000871
    236 rdf:type schema:CreativeWork
    237 https://doi.org/10.1016/j.ijpharm.2011.02.057 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011821599
    238 rdf:type schema:CreativeWork
    239 https://doi.org/10.1016/j.ijpharm.2011.08.035 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048986230
    240 rdf:type schema:CreativeWork
    241 https://doi.org/10.1016/j.ijpharm.2012.10.039 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041877559
    242 rdf:type schema:CreativeWork
    243 https://doi.org/10.1016/j.ijpharm.2012.12.037 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015511185
    244 rdf:type schema:CreativeWork
    245 https://doi.org/10.1016/j.ijpharm.2016.03.048 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001573467
    246 rdf:type schema:CreativeWork
    247 https://doi.org/10.1016/j.jconrel.2004.11.025 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016537837
    248 rdf:type schema:CreativeWork
    249 https://doi.org/10.1016/j.jconrel.2006.02.015 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052382663
    250 rdf:type schema:CreativeWork
    251 https://doi.org/10.1016/j.jconrel.2009.03.006 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025785832
    252 rdf:type schema:CreativeWork
    253 https://doi.org/10.1016/j.jconrel.2009.03.014 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005725450
    254 rdf:type schema:CreativeWork
    255 https://doi.org/10.1016/j.jconrel.2010.05.011 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052757501
    256 rdf:type schema:CreativeWork
    257 https://doi.org/10.1016/j.jconrel.2012.04.022 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036270249
    258 rdf:type schema:CreativeWork
    259 https://doi.org/10.1016/j.jconrel.2014.09.003 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004814038
    260 rdf:type schema:CreativeWork
    261 https://doi.org/10.1016/j.memsci.2014.04.035 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047980805
    262 rdf:type schema:CreativeWork
    263 https://doi.org/10.1016/j.ophtha.2013.02.018 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007323925
    264 rdf:type schema:CreativeWork
    265 https://doi.org/10.1016/j.powtec.2007.01.035 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037694894
    266 rdf:type schema:CreativeWork
    267 https://doi.org/10.1016/j.progpolymsci.2007.05.017 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030848231
    268 rdf:type schema:CreativeWork
    269 https://doi.org/10.1016/j.supflu.2013.01.009 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025646137
    270 rdf:type schema:CreativeWork
    271 https://doi.org/10.1016/j.xphs.2016.05.002 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016819208
    272 rdf:type schema:CreativeWork
    273 https://doi.org/10.1016/s0168-3659(00)00352-7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045324266
    274 rdf:type schema:CreativeWork
    275 https://doi.org/10.1016/s0168-3659(01)00258-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030782737
    276 rdf:type schema:CreativeWork
    277 https://doi.org/10.1016/s0168-3659(01)00289-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012371351
    278 rdf:type schema:CreativeWork
    279 https://doi.org/10.1016/s0168-3659(99)00023-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010619168
    280 rdf:type schema:CreativeWork
    281 https://doi.org/10.1016/s0169-409x(97)00050-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025791313
    282 rdf:type schema:CreativeWork
    283 https://doi.org/10.1016/s0304-4165(02)00153-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026788288
    284 rdf:type schema:CreativeWork
    285 https://doi.org/10.1016/s0939-6411(96)00017-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039149136
    286 rdf:type schema:CreativeWork
    287 https://doi.org/10.1021/acsami.6b13566 schema:sameAs https://app.dimensions.ai/details/publication/pub.1084124331
    288 rdf:type schema:CreativeWork
    289 https://doi.org/10.1021/acsami.7b14330 schema:sameAs https://app.dimensions.ai/details/publication/pub.1092595205
    290 rdf:type schema:CreativeWork
    291 https://doi.org/10.1021/la3017112 schema:sameAs https://app.dimensions.ai/details/publication/pub.1056156327
    292 rdf:type schema:CreativeWork
    293 https://doi.org/10.1021/mp800027f schema:sameAs https://app.dimensions.ai/details/publication/pub.1056213923
    294 rdf:type schema:CreativeWork
    295 https://doi.org/10.1021/mp800087t schema:sameAs https://app.dimensions.ai/details/publication/pub.1056213950
    296 rdf:type schema:CreativeWork
    297 https://doi.org/10.1021/nn5066793 schema:sameAs https://app.dimensions.ai/details/publication/pub.1056226521
    298 rdf:type schema:CreativeWork
    299 https://doi.org/10.1039/c002866e schema:sameAs https://app.dimensions.ai/details/publication/pub.1008048995
    300 rdf:type schema:CreativeWork
    301 https://doi.org/10.1039/c3tb21099e schema:sameAs https://app.dimensions.ai/details/publication/pub.1018011169
    302 rdf:type schema:CreativeWork
    303 https://doi.org/10.1039/c4tb01165a schema:sameAs https://app.dimensions.ai/details/publication/pub.1002987698
    304 rdf:type schema:CreativeWork
    305 https://doi.org/10.1080/03639040701498759 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040393806
    306 rdf:type schema:CreativeWork
    307 https://doi.org/10.1080/09205063.2013.807457 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050658114
    308 rdf:type schema:CreativeWork
    309 https://doi.org/10.1080/09205063.2017.1390381 schema:sameAs https://app.dimensions.ai/details/publication/pub.1092130904
    310 rdf:type schema:CreativeWork
    311 https://doi.org/10.1089/jop.2011.0184 schema:sameAs https://app.dimensions.ai/details/publication/pub.1059285084
    312 rdf:type schema:CreativeWork
    313 https://doi.org/10.1089/ten.tea.2013.0075 schema:sameAs https://app.dimensions.ai/details/publication/pub.1059316338
    314 rdf:type schema:CreativeWork
    315 https://doi.org/10.1097/00002030-200311210-00009 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035570570
    316 rdf:type schema:CreativeWork
    317 https://doi.org/10.1097/01.prs.0000234612.20611.5a schema:sameAs https://app.dimensions.ai/details/publication/pub.1037951542
    318 rdf:type schema:CreativeWork
    319 https://doi.org/10.1111/j.1468-1293.2004.00190.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1015943693
    320 rdf:type schema:CreativeWork
    321 https://doi.org/10.1111/j.1524-4725.2008.01042.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1014843305
    322 rdf:type schema:CreativeWork
    323 https://doi.org/10.1126/sciadv.1600519 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051004793
    324 rdf:type schema:CreativeWork
    325 https://doi.org/10.1142/s021963521650031x schema:sameAs https://app.dimensions.ai/details/publication/pub.1063002981
    326 rdf:type schema:CreativeWork
    327 https://doi.org/10.1142/s0219635216500321 schema:sameAs https://app.dimensions.ai/details/publication/pub.1079395263
    328 rdf:type schema:CreativeWork
    329 https://doi.org/10.1146/annurev-bioeng-071516-044712 schema:sameAs https://app.dimensions.ai/details/publication/pub.1086104749
    330 rdf:type schema:CreativeWork
    331 https://doi.org/10.1155/2011/290602 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012872486
    332 rdf:type schema:CreativeWork
    333 https://doi.org/10.1517/17425247.2016.1134484 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047500455
    334 rdf:type schema:CreativeWork
    335 https://doi.org/10.2147/ijn.s45186 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030813137
    336 rdf:type schema:CreativeWork
    337 https://doi.org/10.2217/nnm.14.156 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045704532
    338 rdf:type schema:CreativeWork
    339 https://doi.org/10.3389/fphar.2016.00185 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047581941
    340 rdf:type schema:CreativeWork
    341 https://doi.org/10.3390/ijms15033640 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005014557
    342 rdf:type schema:CreativeWork
    343 https://www.grid.ac/institutes/grid.134936.a schema:alternateName University of Missouri
    344 schema:name Beijing Nuokangda Pharmaceutical Technology Co., Ltd, 100176, Beijing, China
    345 Department of Mechanical and Aerospace Engineering, University of Missouri, 65211, Columbia, MO, USA
    346 rdf:type schema:Organization
    347 https://www.grid.ac/institutes/grid.458442.b schema:alternateName Institute of Process Engineering
    348 schema:name National Key Laboratory of Biochemical Engineering, Key Laboratory of Biopharmaceutical Production and Formulation Engineering, PLA, Institute of Process Engineering, Chinese Academy of Sciences, 100190, Beijing, China
    349 rdf:type schema:Organization
     




    Preview window. Press ESC to close (or click here)


    ...