Enzymic synthesis, physicochemical, and cell activity of glucosyl ester derivatives based on N-fatty acyl amino acid View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2019-03

AUTHORS

Dong An, Dexin Feng

ABSTRACT

Series of glucosyl esters derivatives were synthesized by enzymatic acylation and some surface properties, and cell activity were calculated and tested. The antitumor activity in vitro against three cancer cells, human colon carcinoma (K562), human hepatoma (HepG2), and human breast adenocarcinoma (MCF-7) of compounds, were evaluated using MTT methods. The glucosyl esters could significantly displayed high anticancer activity. Thereinto, compounds 12 and 12′ showed higher inhibition effect to cancer cells than others. Several compounds were more active than control drug 5-FU. The structure–activity relationship analysis revealed that lipophilic properties might be essential parameter for their activity. More... »

PAGES

653-662

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s11696-018-0614-4

DOI

http://dx.doi.org/10.1007/s11696-018-0614-4

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1107608998


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