Low-Purine Diet Is More Effective Than Normal-Purine Diet in Reducing the Risk of Gouty Attacks After Sleeve Gastrectomy in Patients ... View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2018-05

AUTHORS

Luigi Schiavo, Guillaume Favrè, Vincenzo Pilone, Gianluca Rossetti, Gabriele De Sena, Antonio Iannelli, Alfonso Barbarisi

ABSTRACT

BACKGROUND: Obese patients with preoperative gout often suffer of gouty attacks after bariatric surgery (BS), probably due to the lack of an adequate postoperative diet. OBJECTIVES: The objectives of the study are to assess whether sleeve gastrectomy (SG) is effective in reducing the frequency of gouty attacks and also whether a postoperative low-purine diet (LPD) may further reduce these attacks as compared to a normal-purine diet (NPD) in a series of patients suffering of gout before SG. METHODS: In this retrospective study, we measured and compared total body weight (TBW), body mass index (BMI), uric acid levels (UAL), anti-gout medication (allopurinol) requirements, and frequency in gouty attacks in 40 patients that underwent SG and who received either a LPD (n = 24) or NPD (n = 16). Compliance in following the prescribed diet was assessed in both groups study. RESULTS: Before surgery, LPD and NPD patients had hyperuricemia and were receiving allopurinol. One year after SG, LPD and NPD groups showed a significant decrease in serum UAL (p < 0.001 and p = 0.00175, respectively). However, serum UAL decreased more significantly with the LPD compared to the NPD (p < 0.001). Furthermore, while NPD group showed a significant decrease in allopurinol requirements (p = 0.00130) and on the frequency in gouty attacks (p < 0.001), LPD group were off allopurinol therapy and had no gouty attacks 12 months after SG. Both groups showed high compliance in following the prescribed diets. CONCLUSION: LPD is more effective in reducing the frequency of gouty attacks after SG compared with NPD in patients suffering of gout before surgery. More... »

PAGES

1263-1270

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s11695-017-2984-z

DOI

http://dx.doi.org/10.1007/s11695-017-2984-z

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1092336180

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/29058239


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    "description": "BACKGROUND: Obese patients with preoperative gout often suffer of gouty attacks after bariatric surgery (BS), probably due to the lack of an adequate postoperative diet.\nOBJECTIVES: The objectives of the study are to assess whether sleeve gastrectomy (SG) is effective in reducing the frequency of gouty attacks and also whether a postoperative low-purine diet (LPD) may further reduce these attacks as compared to a normal-purine diet (NPD) in a series of patients suffering of gout before SG.\nMETHODS: In this retrospective study, we measured and compared total body weight (TBW), body mass index (BMI), uric acid levels (UAL), anti-gout medication (allopurinol) requirements, and frequency in gouty attacks in 40 patients that underwent SG and who received either a LPD (n\u00a0=\u00a024) or NPD (n\u00a0=\u00a016). Compliance in following the prescribed diet was assessed in both groups study.\nRESULTS: Before surgery, LPD and NPD patients had hyperuricemia and were receiving allopurinol. One year after SG, LPD and NPD groups showed a significant decrease in serum UAL (p\u00a0<\u00a00.001 and p\u00a0=\u00a00.00175, respectively). However, serum UAL decreased more significantly with the LPD compared to the NPD (p\u00a0<\u00a00.001). Furthermore, while NPD group showed a significant decrease in allopurinol requirements (p\u00a0=\u00a00.00130) and on the frequency in gouty attacks (p\u00a0<\u00a00.001), LPD group were off allopurinol therapy and had no gouty attacks 12\u00a0months after SG. Both groups showed high compliance in following the prescribed diets.\nCONCLUSION: LPD is more effective in reducing the frequency of gouty attacks after SG compared with NPD in patients suffering of gout before surgery.", 
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