Ontology type: schema:ScholarlyArticle
2016-08
AUTHORSHong Chang Tan, Chin Meng Khoo, Matthew Zhen-Wei Tan, Jean-Paul Kovalik, Alvin Choong Meng Ng, Alvin Kim Hock Eng, Oi Fah Lai, Jian Hong Ching, Kwang Wei Tham, Shanker Pasupathy
ABSTRACTBACKGROUND: Weight loss, early after Roux-en-Y gastric bypass (GB) surgery, is associated with reduced concentrations of plasma branched-chain amino acids (BCAAs) and improved insulin sensitivity. Herein, we evaluated whether changes in BCAAs and insulin sensitivity persist with weight stabilization (1 year) after GB or sleeve gastrectomy (SG). METHODS: We prospectively examined 22 severely obese patients (mean age 40.6 ± 2.1 years, BMI 38.8 ± 1.3 kg/m(2), and 59.1 % female) who underwent SG (n = 12) or GB (n = 10) for morbid obesity. Body fat composition was measured with dual X-Ray absorptiometry and abdominal fat volume with computed tomography. BCAAs and acylcarnitines were profiled using liquid chromatography with tandem mass spectrometry. Insulin resistance was calculated using the homeostasis model assessment for insulin resistance (HOMA-IR) formula. RESULTS: At 1-year follow-up, the decrease in BMI, body weight, total fat mass (TFM), fat free mass, and visceral adipose tissue (VAT) was similar between SG and GB. HOMA-IR was associated with BCAA concentrations, and both were decreased equally in both surgical groups. In multivariate analysis with BCAAs, TFM, and VAT as independent factors, only VAT remained significantly associated with insulin resistance. CONCLUSIONS: The metabolic benefits from bariatric surgery, including the changes in BCAA profile, are comparable between SG and GB. The reduction in BCAAs and improvement in the AC profiles after bariatric surgery persists up to 12 months after surgery and may not be surgical related but is influenced primarily by the amount of weight loss, in particular the reduction in visceral adiposity. More... »
PAGES1830-1835
http://scigraph.springernature.com/pub.10.1007/s11695-015-2023-x
DOIhttp://dx.doi.org/10.1007/s11695-015-2023-x
DIMENSIONShttps://app.dimensions.ai/details/publication/pub.1038503352
PUBMEDhttps://www.ncbi.nlm.nih.gov/pubmed/26729279
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