Anti-Xa Levels 4 h After Subcutaneous Administration of 5,700 IU Nadroparin Strongly Correlate with Lean Body Weight in Morbidly Obese ... View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2012-05

AUTHORS

Jeroen Diepstraten, Christian M. Hackeng, Simone van Kralingen, Jiri Zapletal, Eric P. A. van Dongen, René J. Wiezer, Bert van Ramshorst, Catherijne A. J. Knibbe

ABSTRACT

BACKGROUND: Morbidly obese patients (BMI > 40 kg/m(2)) are at increased risk for venous thromboembolism, especially after surgery. Despite limited evidence, morbidly obese patients are often administered a double dose of nadroparin for thromboprophylaxis compared to non-obese patients. The aim of this study was to evaluate the influence of different body size descriptors on anti-Xa levels after a double dose of nadroparin (5,700 IU) in morbidly obese patients. METHODS: In 27 morbidly obese patients with a mean total body weight of 148 kg (range 107-260 kg), anti-Xa levels were determined peri-operatively until 24 h after administration of a subcutaneous dose of 5,700 IU of nadroparin. RESULTS: Anti-Xa level 4 h after administration (A(4h), mean 0.22 ± 0.07 IU/ml) negatively correlated strongly with lean body weight (r = -0.66 (p < 0.001)) and moderately with total body weight (r = -0.56 (p = 0.003)) and did not correlate with body mass index (r = -0.26 (p = 0.187)). The area under the anti-Xa level-time curve from 0 to 24 h (AUA(0-24h), mean 2.80 ± 0.97 h IU/ml) correlated with lean body weight (r = -0.63 (p = 0.007)), but did not correlate with total body weight (r = -0.44 (p = 0.075)) or body mass index (r = -0.10 (p = 0.709)). CONCLUCIONS: Following a subcutaneous dose of nadroparin 5,700 IU, A(4h) and AUA(0-24h) were found to negatively correlate strongly with lean body weight. From these results, individualized dosing of nadroparin based on lean body weight should be considered in morbidly obese patients. More... »

PAGES

791-796

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s11695-012-0602-7

DOI

http://dx.doi.org/10.1007/s11695-012-0602-7

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1008408722

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/22302439


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    "description": "BACKGROUND:                       Morbidly obese patients (BMI\u2009>\u200940\u00a0kg/m(2)) are at increased risk for venous thromboembolism, especially after surgery. Despite limited evidence, morbidly obese patients are often administered a double dose of nadroparin for thromboprophylaxis compared to non-obese patients. The aim of this study was to evaluate the influence of different body size descriptors on anti-Xa levels after a double dose of nadroparin (5,700\u00a0IU) in morbidly obese patients.                                         METHODS:                       In 27 morbidly obese patients with a mean total body weight of 148\u00a0kg (range 107-260\u00a0kg), anti-Xa levels were determined peri-operatively until 24\u00a0h after administration of a subcutaneous dose of 5,700\u00a0IU of nadroparin.                                         RESULTS:                       Anti-Xa level 4\u00a0h after administration (A(4h), mean 0.22\u2009\u00b1\u20090.07\u00a0IU/ml) negatively correlated strongly with lean body weight (r\u2009=\u2009-0.66 (p\u2009<\u20090.001)) and moderately with total body weight (r\u2009=\u2009-0.56 (p\u2009=\u20090.003)) and did not correlate with body mass index (r\u2009=\u2009-0.26 (p\u2009=\u20090.187)). The area under the anti-Xa level-time curve from 0 to 24\u00a0h (AUA(0-24h), mean 2.80\u2009\u00b1\u20090.97\u00a0h\u2009IU/ml) correlated with lean body weight (r\u2009=\u2009-0.63 (p\u2009=\u20090.007)), but did not correlate with total body weight (r\u2009=\u2009-0.44 (p\u2009=\u20090.075)) or body mass index (r\u2009=\u2009-0.10 (p\u2009=\u20090.709)).                                         CONCLUCIONS:                       Following a subcutaneous dose of nadroparin 5,700\u00a0IU, A(4h) and AUA(0-24h) were found to negatively correlate strongly with lean body weight. From these results, individualized dosing of nadroparin based on lean body weight should be considered in morbidly obese patients.", 
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32 schema:description BACKGROUND: Morbidly obese patients (BMI > 40 kg/m(2)) are at increased risk for venous thromboembolism, especially after surgery. Despite limited evidence, morbidly obese patients are often administered a double dose of nadroparin for thromboprophylaxis compared to non-obese patients. The aim of this study was to evaluate the influence of different body size descriptors on anti-Xa levels after a double dose of nadroparin (5,700 IU) in morbidly obese patients. METHODS: In 27 morbidly obese patients with a mean total body weight of 148 kg (range 107-260 kg), anti-Xa levels were determined peri-operatively until 24 h after administration of a subcutaneous dose of 5,700 IU of nadroparin. RESULTS: Anti-Xa level 4 h after administration (A(4h), mean 0.22 ± 0.07 IU/ml) negatively correlated strongly with lean body weight (r = -0.66 (p < 0.001)) and moderately with total body weight (r = -0.56 (p = 0.003)) and did not correlate with body mass index (r = -0.26 (p = 0.187)). The area under the anti-Xa level-time curve from 0 to 24 h (AUA(0-24h), mean 2.80 ± 0.97 h IU/ml) correlated with lean body weight (r = -0.63 (p = 0.007)), but did not correlate with total body weight (r = -0.44 (p = 0.075)) or body mass index (r = -0.10 (p = 0.709)). CONCLUCIONS: Following a subcutaneous dose of nadroparin 5,700 IU, A(4h) and AUA(0-24h) were found to negatively correlate strongly with lean body weight. From these results, individualized dosing of nadroparin based on lean body weight should be considered in morbidly obese patients.
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