Treatment of Pulmonary Embolism in an Extremely Obese Patient View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2009-08

AUTHORS

Jeroen Diepstraten, Simone van Kralingen, Repke J. Snijder, Christian M. Hackeng, Bert van Ramshorst, Catherijne A. J. Knibbe

ABSTRACT

Low-molecular-weight heparins are effective as initial therapy for pulmonary embolism (PE) in a weight-based dosing regimen up to known body weights of 160 kg. The present case reports an extremely obese man of 252 kg (body mass index (BMI) 74 kg/m2) with PE who was treated with tinzaparin, dosed on a body weight of 160 kg. Morbid obesity defined as a BMI higher than 40 kg/m2 is becoming more common in general practice, but there are no evidence-based drug dosing strategies for these patients. This case demonstrates the successful use of a maximum dose of 28,000 anti-Xa international units of tinzaparin for an extremely obese patient with proven PE, instead of the accepted doses of 175 IU/kg, as bridge therapy to a coumarin. More... »

PAGES

1186-1189

References to SciGraph publications

  • 2000-04. Obesity as a medical problem in NATURE
  • 2008-06. Individualized Compared With Conventional Dosing of Enoxaparin in CLINICAL PHARMACOLOGY & THERAPEUTICS
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1007/s11695-009-9886-7

    DOI

    http://dx.doi.org/10.1007/s11695-009-9886-7

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1045086185

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/19506978


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