Prenatal exposure to β2-adrenergic receptor agonists and risk of autism spectrum disorders View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2011-12

AUTHORS

Lisa A. Croen, Susan L. Connors, Marilyn Matevia, Yinge Qian, Craig Newschaffer, Andrew W. Zimmerman

ABSTRACT

This study aims to investigate the association between prenatal exposure to terbutaline and other β2 adrenergic receptor (B2AR) agonists and autism spectrum disorders (ASDs). The methodology used is a case-control study among children born from 1995 to 1999 at Kaiser Permanente Northern California hospitals. Cases (n = 291) were children with an ASD diagnosis; controls (n = 284) were children without ASDs, randomly sampled and frequency-matched to cases on sex, birth year, and delivery hospital. Exposure to B2AR agonists during 30 days prior to conception and each trimester of pregnancy was ascertained from prenatal medical records and health plan databases. The frequency of exposure to any B2AR agonist during pregnancy was similar for mothers of children with ASD and mothers of controls (18.9% vs. 14.8%, P = 0.19). Exposure to B2AR agonists other than terbutaline was not associated with an increased risk for ASDs. However, terbutaline exposure for >2 days during the third trimester was associated with more than a fourfold increased risk for ASDs independent of indication although the limited sample size resulted in an imprecise and nonsignificant effect estimate (OR(adj) = 4.4; 95% confidence interval, 0.8-24.6). This analysis does not offer evidence linking B2AR exposure in pregnancy with autism risk. However, exposure to terbutaline during the third trimester for >2 days may be associated with an increased risk of autism. Should this result be confirmed in larger samples, it would point to late pregnancy as an etiologic window of interest in autism risk factor research. More... »

PAGES

307-315

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s11689-011-9093-4

DOI

http://dx.doi.org/10.1007/s11689-011-9093-4

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1001691752

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/21874331


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1117", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Public Health and Health Services", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Kaiser Permanente", 
          "id": "https://www.grid.ac/institutes/grid.280062.e", 
          "name": [
            "Division of Research, Kaiser Permanente Northern California, 2000 Broadway, 94612, Oakland, CA, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Croen", 
        "givenName": "Lisa A.", 
        "id": "sg:person.0746746106.97", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0746746106.97"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Kennedy Krieger Institute", 
          "id": "https://www.grid.ac/institutes/grid.240023.7", 
          "name": [
            "Department of Neurology and Developmental Medicine, Kennedy Krieger Institute, 707 North Broadway, 21205, Baltimore, MD, USA", 
            "Departments of Medicine and Pediatrics, Massachusetts General Hospital/LADDERS Clinic, 1 Maguire Road, 02142, Lexington, MA, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Connors", 
        "givenName": "Susan L.", 
        "id": "sg:person.0664074604.87", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0664074604.87"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Kaiser Permanente", 
          "id": "https://www.grid.ac/institutes/grid.280062.e", 
          "name": [
            "Division of Research, Kaiser Permanente Northern California, 2000 Broadway, 94612, Oakland, CA, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Matevia", 
        "givenName": "Marilyn", 
        "id": "sg:person.0607767052.11", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0607767052.11"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Kaiser Permanente", 
          "id": "https://www.grid.ac/institutes/grid.280062.e", 
          "name": [
            "Division of Research, Kaiser Permanente Northern California, 2000 Broadway, 94612, Oakland, CA, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Qian", 
        "givenName": "Yinge", 
        "id": "sg:person.0656102252.49", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0656102252.49"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Drexel University", 
          "id": "https://www.grid.ac/institutes/grid.166341.7", 
          "name": [
            "Department of Epidemiology and Biostatistics, Drexel University School of Public Health, 1505 Race Street-Mail Stop 1033, 19102-1192, Philadelphia, PA, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Newschaffer", 
        "givenName": "Craig", 
        "id": "sg:person.01277214133.60", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01277214133.60"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Johns Hopkins University", 
          "id": "https://www.grid.ac/institutes/grid.21107.35", 
          "name": [
            "Department of Neurology and Developmental Medicine, Kennedy Krieger Institute, 707 North Broadway, 21205, Baltimore, MD, USA", 
            "Center for Autism and Related Disorders, Kennedy Krieger Institute, Baltimore, MD, USA", 
            "Departments of Neurology, Psychiatry and Pediatrics, Johns Hopkins University School of Medicine, Baltimore, MD, USA", 
            "Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Zimmerman", 
        "givenName": "Andrew W.", 
        "id": "sg:person.01174070656.19", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01174070656.19"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1289/ehp.10168", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001123021"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0024-3205(94)90013-2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002441795"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0024-3205(94)90013-2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002441795"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature07458", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002940116", 
          "https://doi.org/10.1038/nature07458"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00401-006-0085-5", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003552120", 
          "https://doi.org/10.1007/s00401-006-0085-5"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/978-1-60327-489-0_7", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005292983", 
          "https://doi.org/10.1007/978-1-60327-489-0_7"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/978-1-60327-489-0_7", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005292983", 
          "https://doi.org/10.1007/978-1-60327-489-0_7"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/ana.20315", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005495799"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.mp.4001940", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005894207", 
          "https://doi.org/10.1038/sj.mp.4001940"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.mp.4001940", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005894207", 
          "https://doi.org/10.1038/sj.mp.4001940"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1001/archpedi.159.2.151", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1007904961"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1006/taap.1994.1140", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1009569044"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0002-9378(93)90376-t", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1011087284"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/aog.0b013e318176158e", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012309906"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/aog.0b013e318176158e", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012309906"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.ajog.2009.07.010", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1013204162"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1124/jpet.103.060095", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1013853310"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00006250-198605000-00001", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017066893"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00006250-198605000-00001", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017066893"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00006250-198605000-00001", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017066893"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf02172145", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017747169", 
          "https://doi.org/10.1007/bf02172145"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf02172145", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017747169", 
          "https://doi.org/10.1007/bf02172145"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0165-3806(01)00282-6", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018571218"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1177/08830738050200110401", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021943256"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1177/08830738050200110401", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021943256"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.brainres.2006.01.047", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022416250"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s10803-005-5037-8", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023998041", 
          "https://doi.org/10.1007/s10803-005-5037-8"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s10803-005-5037-8", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023998041", 
          "https://doi.org/10.1007/s10803-005-5037-8"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0002-9378(93)90144-8", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025639314"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.ijdevneu.2004.09.006", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025643536"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0020-7292(03)00247-9", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028989081"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.ajog.2008.04.044", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031048691"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1124/jpet.107.121483", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033170799"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1124/jpet.102.048421", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1034153466"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1023/a:1005592401947", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036427450", 
          "https://doi.org/10.1023/a:1005592401947"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1056/nejm199207303270503", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039539326"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1750-3639.2007.00100.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1043582512"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nrg2346", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1044248970", 
          "https://doi.org/10.1038/nrg2346"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/aog.0b013e31817c50fc", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050915402"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/aog.0b013e31817c50fc", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050915402"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.taap.2004.08.005", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1053254036"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0029-7844(03)00621-5", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1054596548"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/scientificamerican0200-56", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1056483123", 
          "https://doi.org/10.1038/scientificamerican0200-56"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1210/jc.2004-1732", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1064288056"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1212/wnl.35.6.866", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1064366041"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1289/ehp.00108s3511", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1064737182"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.2105/ajph.82.5.703", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1068874222"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1075308375", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1081841232", 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2011-12", 
    "datePublishedReg": "2011-12-01", 
    "description": "This study aims to investigate the association between prenatal exposure to terbutaline and other \u03b22 adrenergic receptor (B2AR) agonists and autism spectrum disorders (ASDs). The methodology used is a case-control study among children born from 1995 to 1999 at Kaiser Permanente Northern California hospitals. Cases (n\u2009=\u2009291) were children with an ASD diagnosis; controls (n\u2009=\u2009284) were children without ASDs, randomly sampled and frequency-matched to cases on sex, birth year, and delivery hospital. Exposure to B2AR agonists during 30\u00a0days prior to conception and each trimester of pregnancy was ascertained from prenatal medical records and health plan databases. The frequency of exposure to any B2AR agonist during pregnancy was similar for mothers of children with ASD and mothers of controls (18.9% vs. 14.8%, P\u2009=\u20090.19). Exposure to B2AR agonists other than terbutaline was not associated with an increased risk for ASDs. However, terbutaline exposure for >2\u00a0days during the third trimester was associated with more than a fourfold increased risk for ASDs independent of indication although the limited sample size resulted in an imprecise and nonsignificant effect estimate (OR(adj)\u2009=\u20094.4; 95% confidence interval, 0.8-24.6). This analysis does not offer evidence linking B2AR exposure in pregnancy with autism risk. However, exposure to terbutaline during the third trimester for >2\u00a0days may be associated with an increased risk of autism. Should this result be confirmed in larger samples, it would point to late pregnancy as an etiologic window of interest in autism risk factor research.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1007/s11689-011-9093-4", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": true, 
    "isPartOf": [
      {
        "id": "sg:journal.1040543", 
        "issn": [
          "1866-1947", 
          "1866-1955"
        ], 
        "name": "Journal of Neurodevelopmental Disorders", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "4", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "3"
      }
    ], 
    "name": "Prenatal exposure to \u03b22-adrenergic receptor agonists and risk of autism spectrum disorders", 
    "pagination": "307-315", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "080e7564b8bc1895101285eb910f3564cbaa6485c6d1fcae4c78001d7d20efe7"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "21874331"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "101483832"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1007/s11689-011-9093-4"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1001691752"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1007/s11689-011-9093-4", 
      "https://app.dimensions.ai/details/publication/pub.1001691752"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-10T20:48", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8684_00000519.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "http://link.springer.com/10.1007%2Fs11689-011-9093-4"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s11689-011-9093-4'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s11689-011-9093-4'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s11689-011-9093-4'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s11689-011-9093-4'


 

This table displays all metadata directly associated to this object as RDF triples.

241 TRIPLES      21 PREDICATES      68 URIs      21 LITERALS      9 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1007/s11689-011-9093-4 schema:about anzsrc-for:11
2 anzsrc-for:1117
3 schema:author N2ceaf483044a4886a407adf62fbe00a9
4 schema:citation sg:pub.10.1007/978-1-60327-489-0_7
5 sg:pub.10.1007/bf02172145
6 sg:pub.10.1007/s00401-006-0085-5
7 sg:pub.10.1007/s10803-005-5037-8
8 sg:pub.10.1023/a:1005592401947
9 sg:pub.10.1038/nature07458
10 sg:pub.10.1038/nrg2346
11 sg:pub.10.1038/scientificamerican0200-56
12 sg:pub.10.1038/sj.mp.4001940
13 https://app.dimensions.ai/details/publication/pub.1075308375
14 https://app.dimensions.ai/details/publication/pub.1081841232
15 https://doi.org/10.1001/archpedi.159.2.151
16 https://doi.org/10.1002/ana.20315
17 https://doi.org/10.1006/taap.1994.1140
18 https://doi.org/10.1016/0002-9378(93)90144-8
19 https://doi.org/10.1016/0002-9378(93)90376-t
20 https://doi.org/10.1016/0024-3205(94)90013-2
21 https://doi.org/10.1016/j.ajog.2008.04.044
22 https://doi.org/10.1016/j.ajog.2009.07.010
23 https://doi.org/10.1016/j.brainres.2006.01.047
24 https://doi.org/10.1016/j.ijdevneu.2004.09.006
25 https://doi.org/10.1016/j.taap.2004.08.005
26 https://doi.org/10.1016/s0020-7292(03)00247-9
27 https://doi.org/10.1016/s0029-7844(03)00621-5
28 https://doi.org/10.1016/s0165-3806(01)00282-6
29 https://doi.org/10.1056/nejm199207303270503
30 https://doi.org/10.1097/00006250-198605000-00001
31 https://doi.org/10.1097/aog.0b013e318176158e
32 https://doi.org/10.1097/aog.0b013e31817c50fc
33 https://doi.org/10.1111/j.1750-3639.2007.00100.x
34 https://doi.org/10.1124/jpet.102.048421
35 https://doi.org/10.1124/jpet.103.060095
36 https://doi.org/10.1124/jpet.107.121483
37 https://doi.org/10.1177/08830738050200110401
38 https://doi.org/10.1210/jc.2004-1732
39 https://doi.org/10.1212/wnl.35.6.866
40 https://doi.org/10.1289/ehp.00108s3511
41 https://doi.org/10.1289/ehp.10168
42 https://doi.org/10.2105/ajph.82.5.703
43 schema:datePublished 2011-12
44 schema:datePublishedReg 2011-12-01
45 schema:description This study aims to investigate the association between prenatal exposure to terbutaline and other β2 adrenergic receptor (B2AR) agonists and autism spectrum disorders (ASDs). The methodology used is a case-control study among children born from 1995 to 1999 at Kaiser Permanente Northern California hospitals. Cases (n = 291) were children with an ASD diagnosis; controls (n = 284) were children without ASDs, randomly sampled and frequency-matched to cases on sex, birth year, and delivery hospital. Exposure to B2AR agonists during 30 days prior to conception and each trimester of pregnancy was ascertained from prenatal medical records and health plan databases. The frequency of exposure to any B2AR agonist during pregnancy was similar for mothers of children with ASD and mothers of controls (18.9% vs. 14.8%, P = 0.19). Exposure to B2AR agonists other than terbutaline was not associated with an increased risk for ASDs. However, terbutaline exposure for >2 days during the third trimester was associated with more than a fourfold increased risk for ASDs independent of indication although the limited sample size resulted in an imprecise and nonsignificant effect estimate (OR(adj) = 4.4; 95% confidence interval, 0.8-24.6). This analysis does not offer evidence linking B2AR exposure in pregnancy with autism risk. However, exposure to terbutaline during the third trimester for >2 days may be associated with an increased risk of autism. Should this result be confirmed in larger samples, it would point to late pregnancy as an etiologic window of interest in autism risk factor research.
46 schema:genre research_article
47 schema:inLanguage en
48 schema:isAccessibleForFree true
49 schema:isPartOf Ne29c1dece55a4440a03588f2ae5f433b
50 Nea8557b1d50b4cbc80fe03dbbd92ddba
51 sg:journal.1040543
52 schema:name Prenatal exposure to β2-adrenergic receptor agonists and risk of autism spectrum disorders
53 schema:pagination 307-315
54 schema:productId N47ee474427be45a69ec2b204bc59628c
55 N7cd9c07d11144e60ac001fd6057135c9
56 Na0d03c0990e54a219b8947766335cb6b
57 Na92078c6dfcf41c7bd1b387b9f4332e0
58 Nc2fbf9bc72774b1b9ca3af359900f4a8
59 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001691752
60 https://doi.org/10.1007/s11689-011-9093-4
61 schema:sdDatePublished 2019-04-10T20:48
62 schema:sdLicense https://scigraph.springernature.com/explorer/license/
63 schema:sdPublisher N0599494ae48f4ba283ed1bdff1a09070
64 schema:url http://link.springer.com/10.1007%2Fs11689-011-9093-4
65 sgo:license sg:explorer/license/
66 sgo:sdDataset articles
67 rdf:type schema:ScholarlyArticle
68 N0599494ae48f4ba283ed1bdff1a09070 schema:name Springer Nature - SN SciGraph project
69 rdf:type schema:Organization
70 N0604549cdbb64fd5afe664a979e22ce4 rdf:first sg:person.0656102252.49
71 rdf:rest N92d4f17536b6427fa88a406e9c0e23af
72 N2ceaf483044a4886a407adf62fbe00a9 rdf:first sg:person.0746746106.97
73 rdf:rest N92625d454ea3441681e8d04b07af924f
74 N47ee474427be45a69ec2b204bc59628c schema:name pubmed_id
75 schema:value 21874331
76 rdf:type schema:PropertyValue
77 N4c896be32e5d4e73af99ba6ae83825f0 rdf:first sg:person.0607767052.11
78 rdf:rest N0604549cdbb64fd5afe664a979e22ce4
79 N692d45a4846a49aabe737026891ca873 rdf:first sg:person.01174070656.19
80 rdf:rest rdf:nil
81 N7cd9c07d11144e60ac001fd6057135c9 schema:name doi
82 schema:value 10.1007/s11689-011-9093-4
83 rdf:type schema:PropertyValue
84 N92625d454ea3441681e8d04b07af924f rdf:first sg:person.0664074604.87
85 rdf:rest N4c896be32e5d4e73af99ba6ae83825f0
86 N92d4f17536b6427fa88a406e9c0e23af rdf:first sg:person.01277214133.60
87 rdf:rest N692d45a4846a49aabe737026891ca873
88 Na0d03c0990e54a219b8947766335cb6b schema:name dimensions_id
89 schema:value pub.1001691752
90 rdf:type schema:PropertyValue
91 Na92078c6dfcf41c7bd1b387b9f4332e0 schema:name nlm_unique_id
92 schema:value 101483832
93 rdf:type schema:PropertyValue
94 Nc2fbf9bc72774b1b9ca3af359900f4a8 schema:name readcube_id
95 schema:value 080e7564b8bc1895101285eb910f3564cbaa6485c6d1fcae4c78001d7d20efe7
96 rdf:type schema:PropertyValue
97 Ne29c1dece55a4440a03588f2ae5f433b schema:issueNumber 4
98 rdf:type schema:PublicationIssue
99 Nea8557b1d50b4cbc80fe03dbbd92ddba schema:volumeNumber 3
100 rdf:type schema:PublicationVolume
101 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
102 schema:name Medical and Health Sciences
103 rdf:type schema:DefinedTerm
104 anzsrc-for:1117 schema:inDefinedTermSet anzsrc-for:
105 schema:name Public Health and Health Services
106 rdf:type schema:DefinedTerm
107 sg:journal.1040543 schema:issn 1866-1947
108 1866-1955
109 schema:name Journal of Neurodevelopmental Disorders
110 rdf:type schema:Periodical
111 sg:person.01174070656.19 schema:affiliation https://www.grid.ac/institutes/grid.21107.35
112 schema:familyName Zimmerman
113 schema:givenName Andrew W.
114 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01174070656.19
115 rdf:type schema:Person
116 sg:person.01277214133.60 schema:affiliation https://www.grid.ac/institutes/grid.166341.7
117 schema:familyName Newschaffer
118 schema:givenName Craig
119 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01277214133.60
120 rdf:type schema:Person
121 sg:person.0607767052.11 schema:affiliation https://www.grid.ac/institutes/grid.280062.e
122 schema:familyName Matevia
123 schema:givenName Marilyn
124 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0607767052.11
125 rdf:type schema:Person
126 sg:person.0656102252.49 schema:affiliation https://www.grid.ac/institutes/grid.280062.e
127 schema:familyName Qian
128 schema:givenName Yinge
129 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0656102252.49
130 rdf:type schema:Person
131 sg:person.0664074604.87 schema:affiliation https://www.grid.ac/institutes/grid.240023.7
132 schema:familyName Connors
133 schema:givenName Susan L.
134 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0664074604.87
135 rdf:type schema:Person
136 sg:person.0746746106.97 schema:affiliation https://www.grid.ac/institutes/grid.280062.e
137 schema:familyName Croen
138 schema:givenName Lisa A.
139 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0746746106.97
140 rdf:type schema:Person
141 sg:pub.10.1007/978-1-60327-489-0_7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005292983
142 https://doi.org/10.1007/978-1-60327-489-0_7
143 rdf:type schema:CreativeWork
144 sg:pub.10.1007/bf02172145 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017747169
145 https://doi.org/10.1007/bf02172145
146 rdf:type schema:CreativeWork
147 sg:pub.10.1007/s00401-006-0085-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003552120
148 https://doi.org/10.1007/s00401-006-0085-5
149 rdf:type schema:CreativeWork
150 sg:pub.10.1007/s10803-005-5037-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023998041
151 https://doi.org/10.1007/s10803-005-5037-8
152 rdf:type schema:CreativeWork
153 sg:pub.10.1023/a:1005592401947 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036427450
154 https://doi.org/10.1023/a:1005592401947
155 rdf:type schema:CreativeWork
156 sg:pub.10.1038/nature07458 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002940116
157 https://doi.org/10.1038/nature07458
158 rdf:type schema:CreativeWork
159 sg:pub.10.1038/nrg2346 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044248970
160 https://doi.org/10.1038/nrg2346
161 rdf:type schema:CreativeWork
162 sg:pub.10.1038/scientificamerican0200-56 schema:sameAs https://app.dimensions.ai/details/publication/pub.1056483123
163 https://doi.org/10.1038/scientificamerican0200-56
164 rdf:type schema:CreativeWork
165 sg:pub.10.1038/sj.mp.4001940 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005894207
166 https://doi.org/10.1038/sj.mp.4001940
167 rdf:type schema:CreativeWork
168 https://app.dimensions.ai/details/publication/pub.1075308375 schema:CreativeWork
169 https://app.dimensions.ai/details/publication/pub.1081841232 schema:CreativeWork
170 https://doi.org/10.1001/archpedi.159.2.151 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007904961
171 rdf:type schema:CreativeWork
172 https://doi.org/10.1002/ana.20315 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005495799
173 rdf:type schema:CreativeWork
174 https://doi.org/10.1006/taap.1994.1140 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009569044
175 rdf:type schema:CreativeWork
176 https://doi.org/10.1016/0002-9378(93)90144-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025639314
177 rdf:type schema:CreativeWork
178 https://doi.org/10.1016/0002-9378(93)90376-t schema:sameAs https://app.dimensions.ai/details/publication/pub.1011087284
179 rdf:type schema:CreativeWork
180 https://doi.org/10.1016/0024-3205(94)90013-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002441795
181 rdf:type schema:CreativeWork
182 https://doi.org/10.1016/j.ajog.2008.04.044 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031048691
183 rdf:type schema:CreativeWork
184 https://doi.org/10.1016/j.ajog.2009.07.010 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013204162
185 rdf:type schema:CreativeWork
186 https://doi.org/10.1016/j.brainres.2006.01.047 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022416250
187 rdf:type schema:CreativeWork
188 https://doi.org/10.1016/j.ijdevneu.2004.09.006 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025643536
189 rdf:type schema:CreativeWork
190 https://doi.org/10.1016/j.taap.2004.08.005 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053254036
191 rdf:type schema:CreativeWork
192 https://doi.org/10.1016/s0020-7292(03)00247-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028989081
193 rdf:type schema:CreativeWork
194 https://doi.org/10.1016/s0029-7844(03)00621-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1054596548
195 rdf:type schema:CreativeWork
196 https://doi.org/10.1016/s0165-3806(01)00282-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018571218
197 rdf:type schema:CreativeWork
198 https://doi.org/10.1056/nejm199207303270503 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039539326
199 rdf:type schema:CreativeWork
200 https://doi.org/10.1097/00006250-198605000-00001 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017066893
201 rdf:type schema:CreativeWork
202 https://doi.org/10.1097/aog.0b013e318176158e schema:sameAs https://app.dimensions.ai/details/publication/pub.1012309906
203 rdf:type schema:CreativeWork
204 https://doi.org/10.1097/aog.0b013e31817c50fc schema:sameAs https://app.dimensions.ai/details/publication/pub.1050915402
205 rdf:type schema:CreativeWork
206 https://doi.org/10.1111/j.1750-3639.2007.00100.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1043582512
207 rdf:type schema:CreativeWork
208 https://doi.org/10.1124/jpet.102.048421 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034153466
209 rdf:type schema:CreativeWork
210 https://doi.org/10.1124/jpet.103.060095 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013853310
211 rdf:type schema:CreativeWork
212 https://doi.org/10.1124/jpet.107.121483 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033170799
213 rdf:type schema:CreativeWork
214 https://doi.org/10.1177/08830738050200110401 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021943256
215 rdf:type schema:CreativeWork
216 https://doi.org/10.1210/jc.2004-1732 schema:sameAs https://app.dimensions.ai/details/publication/pub.1064288056
217 rdf:type schema:CreativeWork
218 https://doi.org/10.1212/wnl.35.6.866 schema:sameAs https://app.dimensions.ai/details/publication/pub.1064366041
219 rdf:type schema:CreativeWork
220 https://doi.org/10.1289/ehp.00108s3511 schema:sameAs https://app.dimensions.ai/details/publication/pub.1064737182
221 rdf:type schema:CreativeWork
222 https://doi.org/10.1289/ehp.10168 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001123021
223 rdf:type schema:CreativeWork
224 https://doi.org/10.2105/ajph.82.5.703 schema:sameAs https://app.dimensions.ai/details/publication/pub.1068874222
225 rdf:type schema:CreativeWork
226 https://www.grid.ac/institutes/grid.166341.7 schema:alternateName Drexel University
227 schema:name Department of Epidemiology and Biostatistics, Drexel University School of Public Health, 1505 Race Street-Mail Stop 1033, 19102-1192, Philadelphia, PA, USA
228 rdf:type schema:Organization
229 https://www.grid.ac/institutes/grid.21107.35 schema:alternateName Johns Hopkins University
230 schema:name Center for Autism and Related Disorders, Kennedy Krieger Institute, Baltimore, MD, USA
231 Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA
232 Department of Neurology and Developmental Medicine, Kennedy Krieger Institute, 707 North Broadway, 21205, Baltimore, MD, USA
233 Departments of Neurology, Psychiatry and Pediatrics, Johns Hopkins University School of Medicine, Baltimore, MD, USA
234 rdf:type schema:Organization
235 https://www.grid.ac/institutes/grid.240023.7 schema:alternateName Kennedy Krieger Institute
236 schema:name Department of Neurology and Developmental Medicine, Kennedy Krieger Institute, 707 North Broadway, 21205, Baltimore, MD, USA
237 Departments of Medicine and Pediatrics, Massachusetts General Hospital/LADDERS Clinic, 1 Maguire Road, 02142, Lexington, MA, USA
238 rdf:type schema:Organization
239 https://www.grid.ac/institutes/grid.280062.e schema:alternateName Kaiser Permanente
240 schema:name Division of Research, Kaiser Permanente Northern California, 2000 Broadway, 94612, Oakland, CA, USA
241 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...