Reevaluation of the effect of Dianxianning on seizure rate of refractory epilepsy as additive treatment in clinical practice View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2011-06

AUTHORS

Liyun He, Tiancai Wen, Shiyan Yan, Runjin Li, Zufa Liu, Hui Ren, Jinmin Liu, Fengshan Zhang, Jianzhong Wu, Jian Liu

ABSTRACT

We observed the effect of Dianxianning, which was used as additive treatment to treat 206 epilepsy patients, on the epilepsy seizure rate. Based on a multicenter, prospective, randomized, and controlled clinical trial design, we used the seizure rate of epilepsy as the main index. For the treatment group comprising 137 patients, we combined Dianxianning with chemical medicine, which is the basic treatment. For the control group with 69 patients, we added placebo. The results showed that 1) Effect on seizure rate: After a three-month treatment, the seizure rate of the treatment group decreased by 37.84% on average, whereas that of the control group decreased by 13.18% on average. Statistically comparing the two groups, there was a significant difference between these groups (P < 0.05). 2) Effect on seizure frequency: As time passed, the frequency in each group gradually decreased. After a three-month treatment, there was a significant difference between the two groups (P < 0.05). 3) Comparison between the before and after treatment of each group: There was a very significant difference between the two groups (P < 0.0001). The results indicated that, as an additive treatment, Dianxianning has a good effect on controlling the epilepsy seizure rate and frequency management. It is more effective than using chemical medicine alone. More... »

PAGES

229-234

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s11684-011-0139-5

DOI

http://dx.doi.org/10.1007/s11684-011-0139-5

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1000847670

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/21695630


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