Coordinate based meta-analysis of motor functional imaging in Parkinson’s: disease-specific patterns and modulation by dopamine replacement and deep brain stimulation View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2019-02-27

AUTHORS

YUE Xing, Christopher Tench, Monton Wongwandee, Stefan T. Schwarz, Nin Bajaj, Dorothee P. Auer

ABSTRACT

OBJECTIVE: To investigate factors affecting the pattern of motor brain activation reported in people with Parkinson's (PwP), aiming to differentiate disease-specific features from treatment effects. METHODS: A co-ordinate-based-meta-analysis (CBMA) of functional motor neuroimaging studies involving patients with Parkinson's (PwP), and healthy controls (HC) identified 126 suitable articles. The experiments were grouped based on subject feature, medication status (onMed/offMed), deep brain stimulation (DBS) status (DBSon/DBSoff) and type of motor initiation. RESULTS: HC and PwP shared similar neural networks during upper extremity motor tasks but with differences of reported frequency in mainly bilateral putamen, insula and ipsilateral inferior parietal and precentral gyri. The activation height was significantly reduced in the bilateral putamen, left SMA, left subthalamus nucleus, right thalamus and right midial global pallidum in PwPoffMed (vs. HC), and pre-SMA hypoactivation correlated with disease severity. These changes were not found in patients on dopamine replacement therapy (PwPonMed vs. HC) in line with a restorative function. By contrast, left SMA and primary motor cortex showed hyperactivation in the medicated state (vs. HC) suggesting dopaminergic overcompensation. Deep-brain stimulation (PwP during the high frequency subthalamus nucleus (STN) DBS vs. no stimulation) induced a decrease in left SMA activity and the expected increase in the left subthalamic/thalamic region regardless of hand movement. We further demonstrated a disease related effect of motor intention with only PwPoffMed showing increased activation in the medial frontal lobe in self-initiated studies. CONCLUSION: We describe a consistent disease-specific pattern of putaminal hypoactivation during motor tasks that appears reversed by dopamine replacement. Inconsistent reports of altered SMA/pre-SMA activation can be explained by task- and medication-specific variation in intention. Moreover, SMA activity was reduced during STN-DBS, while dopamine-induced hyperactivation of SMA which might underpin hyperdynamic L-dopa related overcompensation. More... »

PAGES

1-18

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s11682-019-00061-3

DOI

http://dx.doi.org/10.1007/s11682-019-00061-3

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1112399971

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/30809759


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1109", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Neurosciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "University of Nottingham", 
          "id": "https://www.grid.ac/institutes/grid.4563.4", 
          "name": [
            "Radiological Sciences, Division of Clinical Neuroscience, University of Nottingham, NG7 2UH, Nottingham, UK", 
            "Sir Peter Mansfield Imaging Centre, University of Nottingham, NG7 2UH, Nottingham, UK", 
            "NIHR Nottingham Biomedical Research Centre, University of Nottingham, NG7 2UH, Nottingham, UK", 
            "Radiological Sciences, Sir Peter Mansfield Imaging Centre, NIHR Nottingham BRC, University of Nottingham, NG7 2UH, Nottingham, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Xing", 
        "givenName": "YUE", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Division of Clinical Neurology, Queen\u2019s Medical Centre, University of Nottingham, Nottingham, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Tench", 
        "givenName": "Christopher", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Srinakharinwirot University", 
          "id": "https://www.grid.ac/institutes/grid.412739.a", 
          "name": [
            "Department of Medicine, Srinakharinwirot University, Nakhon Nayok, Thailand"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Wongwandee", 
        "givenName": "Monton", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Cardiff and Vale University Health Board", 
          "id": "https://www.grid.ac/institutes/grid.273109.e", 
          "name": [
            "Radiological Sciences, Division of Clinical Neuroscience, University of Nottingham, NG7 2UH, Nottingham, UK", 
            "Department of Radiology, Cardiff and Vale University Health Board, Cardiff, Wales"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Schwarz", 
        "givenName": "Stefan T.", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Nottingham University Hospitals NHS Trust", 
          "id": "https://www.grid.ac/institutes/grid.240404.6", 
          "name": [
            "Department of Neurology, Nottingham University Hospitals, NG7 2UH, Nottingham, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Bajaj", 
        "givenName": "Nin", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Nottingham", 
          "id": "https://www.grid.ac/institutes/grid.4563.4", 
          "name": [
            "Radiological Sciences, Division of Clinical Neuroscience, University of Nottingham, NG7 2UH, Nottingham, UK", 
            "Sir Peter Mansfield Imaging Centre, University of Nottingham, NG7 2UH, Nottingham, UK", 
            "NIHR Nottingham Biomedical Research Centre, University of Nottingham, NG7 2UH, Nottingham, UK", 
            "Radiological Sciences, Sir Peter Mansfield Imaging Centre, NIHR Nottingham BRC, University of Nottingham, NG7 2UH, Nottingham, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Auer", 
        "givenName": "Dorothee P.", 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1002/mds.22635", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000224813"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/mds.22635", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000224813"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.tins.2007.05.004", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000719333"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/brain/124.3.558", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001042359"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1136/pgmj.2006.054759", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002297707"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1136/pgmj.2006.054759", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002297707"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1371/journal.pone.0059717", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002466851"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3389/fnsys.2015.00023", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002851529"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1001/jama.284.15.1931", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002894278"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/md.0000000000002206", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003204713"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/md.0000000000002206", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003204713"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/brain/awg268", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004603134"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/mds.23695", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1007354138"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/mds.24017", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1008843448"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nrneurol.2014.205", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1009908711", 
          "https://doi.org/10.1038/nrneurol.2014.205"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1371/journal.pone.0106735", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010264248"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1001/archneurol.2012.33", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010810289"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/mds.22662", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012906495"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/mds.22662", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012906495"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/mds.20962", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012933183"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0079-6123(10)84016-6", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1013209786"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/hbm.22561", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015217597"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0166-2236(90)90110-v", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017015109"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0166-2236(90)90110-v", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017015109"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00001756-200005150-00044", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017476748"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00001756-200005150-00044", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017476748"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00001756-200005150-00044", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017476748"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.brainres.2013.03.027", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017668898"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1038/sj.jcbfm.9600358", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018063970"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1038/sj.jcbfm.9600358", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018063970"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/hbm.22397", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018164360"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/brain/awg033", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019158239"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/mds.10297", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019218433"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/ana.410320206", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021014879"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/brain/120.6.963", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023064437"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nn.3743", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023700682", 
          "https://doi.org/10.1038/nn.3743"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0022-510x(94)00237-i", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024202844"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1371/journal.pone.0070143", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024465079"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0028-3932(95)00008-q", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024610545"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/brain/awh572", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024905499"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/brain/awh572", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024905499"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3389/fnsys.2010.00143", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025548634"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.brainres.2007.02.046", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025714831"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.tins.2009.06.003", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1026406274"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/ana.410230112", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1026415240"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/ana.24138", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1026447632"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.neuroimage.2006.02.005", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1026542450"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/mds.20855", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028039409"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/mds.1139", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028533316"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1371/journal.pone.0066910", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028732025"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/978-3-319-25721-1_9", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030382636", 
          "https://doi.org/10.1007/978-3-319-25721-1_9"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/brain/118.4.913", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031547519"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0896-6273(03)00677-9", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031661051"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1152/jn.00055.2005", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033947389"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1056/nejmoa033447", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035458376"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1146/annurev.ne.09.030186.002041", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035901217"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/brain/awr233", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036232062"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/01.wco.0000236623.68625.54", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036355990"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/01.wco.0000236623.68625.54", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036355990"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1136/jnnp.57.5.567", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036929703"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1136/jnnp.74.7.844", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036999539"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1001/archneur.1984.04050190062015", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037118861"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nrn4038", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037577844", 
          "https://doi.org/10.1038/nrn4038"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.neulet.2009.05.046", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039477326"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s1474-4422(06)70471-9", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039529917"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature09159", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039789576", 
          "https://doi.org/10.1038/nature09159"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature09159", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039789576", 
          "https://doi.org/10.1038/nature09159"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/brain/awl162", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039928405"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nrn2337", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039938718", 
          "https://doi.org/10.1038/nrn2337"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00001756-200307010-00020", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1040149572"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00001756-200307010-00020", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1040149572"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3233/nre-151237", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1040892521"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1038/jcbfm.1994.99", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041971430"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1038/jcbfm.1994.99", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041971430"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1523/jneurosci.0582-08.2008", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042397628"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.neuroimage.2006.11.047", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042878660"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/cercor/bhs397", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1044059935"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0168-0102(02)00027-5", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1044487127"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1136/jnnp.49.11.1301", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1044575237"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/brain/aws281", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1044682127"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/brain/114.5.2283", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045332348"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1159/000330658", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045377552"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/mds.1212", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045914879"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.neubiorev.2016.04.001", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046467865"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.neubiorev.2016.04.001", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046467865"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1001/archneur.59.12.1937", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046569323"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/ana.410320608", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046685624"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/brain/awt007", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046918087"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/cercor/bhp178", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047978151"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00415-014-7254-6", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048592969", 
          "https://doi.org/10.1007/s00415-014-7254-6"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.neuron.2008.04.017", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1049396201"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/mds.10142", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051764194"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.neurobiolaging.2014.05.032", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051931547"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/brain/awm086", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052550672"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0166-2236(03)00038-9", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1053282103"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.cortex.2015.08.005", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1053635476"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/cercor/5.2.95", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1059458400"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1212/01.wnl.0000338699.56379.11", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1064350803"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1212/01.wnl.0000338699.56379.11", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1064350803"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1212/01.wnl.0000338699.56379.11", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1064350803"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1212/wnl.0b013e318198e0e9", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1064354266"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1212/wnl.0b013e318198e0e9", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1064354266"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1212/wnl.0b013e318198e0e9", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1064354266"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3171/jns.2003.98.1.0057", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1071100616"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3171/jns.2003.98.1.0057", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1071100616"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3171/jns.2003.98.1.0057", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1071100616"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1152/jn.1999.81.6.3065", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1074476163"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1523/jneurosci.22-11-04639.2002", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1075061976"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1152/jn.1994.72.2.507", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1082594364"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/srep43571", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1084131491", 
          "https://doi.org/10.1038/srep43571"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/brain/awx010", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1084182907"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1155/2017/5124328", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1090358501"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/brain/awx252", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1091952510"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2019-02-27", 
    "datePublishedReg": "2019-02-27", 
    "description": "OBJECTIVE: To investigate factors affecting the pattern of motor brain activation reported in people with Parkinson's (PwP), aiming to differentiate disease-specific features from treatment effects.\nMETHODS: A co-ordinate-based-meta-analysis (CBMA) of functional motor neuroimaging studies involving patients with Parkinson's (PwP), and healthy controls (HC) identified 126 suitable articles. The experiments were grouped based on subject feature, medication status (onMed/offMed), deep brain stimulation (DBS) status (DBSon/DBSoff) and type of motor initiation.\nRESULTS: HC and PwP shared similar neural networks during upper extremity motor tasks but with differences of reported frequency in mainly bilateral putamen, insula and ipsilateral inferior parietal and precentral gyri. The activation height was significantly reduced in the bilateral\u00a0putamen, left SMA, left subthalamus nucleus, right thalamus and right midial global pallidum in PwPoffMed (vs. HC), and pre-SMA hypoactivation correlated with disease severity. These changes were not found in patients on dopamine replacement therapy (PwPonMed vs. HC) in line with a restorative function. By contrast, left SMA and primary motor cortex showed hyperactivation in the medicated state (vs. HC) suggesting dopaminergic overcompensation. Deep-brain stimulation (PwP during the high frequency subthalamus nucleus (STN) DBS vs. no stimulation) induced a decrease in left SMA activity and the expected increase in the left subthalamic/thalamic region regardless of hand movement. We further demonstrated a disease related effect of motor intention with only PwPoffMed showing increased activation in the medial frontal lobe in self-initiated studies.\nCONCLUSION: We describe a consistent disease-specific pattern of putaminal hypoactivation during motor tasks that appears reversed by dopamine replacement. Inconsistent reports of altered SMA/pre-SMA activation can be explained by task- and medication-specific variation in intention. Moreover, SMA activity was reduced during STN-DBS, while dopamine-induced hyperactivation of SMA\u00a0which might underpin hyperdynamic L-dopa related overcompensation.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1007/s11682-019-00061-3", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": false, 
    "isPartOf": [
      {
        "id": "sg:journal.1038420", 
        "issn": [
          "1931-7557", 
          "1931-7565"
        ], 
        "name": "Brain Imaging and Behavior", 
        "type": "Periodical"
      }
    ], 
    "name": "Coordinate based meta-analysis of motor functional imaging in Parkinson\u2019s: disease-specific patterns and modulation by dopamine replacement and deep brain stimulation", 
    "pagination": "1-18", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "7793af9f302c3c0de53bc2766635cb29f8c7ccac3465b782ddf8c9c21d80531b"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "30809759"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "101300405"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1007/s11682-019-00061-3"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1112399971"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1007/s11682-019-00061-3", 
      "https://app.dimensions.ai/details/publication/pub.1112399971"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-11T10:17", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000348_0000000348/records_54307_00000002.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://link.springer.com/10.1007%2Fs11682-019-00061-3"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s11682-019-00061-3'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s11682-019-00061-3'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s11682-019-00061-3'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s11682-019-00061-3'


 

This table displays all metadata directly associated to this object as RDF triples.

394 TRIPLES      21 PREDICATES      119 URIs      18 LITERALS      7 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1007/s11682-019-00061-3 schema:about anzsrc-for:11
2 anzsrc-for:1109
3 schema:author N3587ad92f98149ebbaca060d31fdd6d6
4 schema:citation sg:pub.10.1007/978-3-319-25721-1_9
5 sg:pub.10.1007/s00415-014-7254-6
6 sg:pub.10.1038/nature09159
7 sg:pub.10.1038/nn.3743
8 sg:pub.10.1038/nrn2337
9 sg:pub.10.1038/nrn4038
10 sg:pub.10.1038/nrneurol.2014.205
11 sg:pub.10.1038/srep43571
12 https://doi.org/10.1001/archneur.1984.04050190062015
13 https://doi.org/10.1001/archneur.59.12.1937
14 https://doi.org/10.1001/archneurol.2012.33
15 https://doi.org/10.1001/jama.284.15.1931
16 https://doi.org/10.1002/ana.24138
17 https://doi.org/10.1002/ana.410230112
18 https://doi.org/10.1002/ana.410320206
19 https://doi.org/10.1002/ana.410320608
20 https://doi.org/10.1002/hbm.22397
21 https://doi.org/10.1002/hbm.22561
22 https://doi.org/10.1002/mds.10142
23 https://doi.org/10.1002/mds.10297
24 https://doi.org/10.1002/mds.1139
25 https://doi.org/10.1002/mds.1212
26 https://doi.org/10.1002/mds.20855
27 https://doi.org/10.1002/mds.20962
28 https://doi.org/10.1002/mds.22635
29 https://doi.org/10.1002/mds.22662
30 https://doi.org/10.1002/mds.23695
31 https://doi.org/10.1002/mds.24017
32 https://doi.org/10.1016/0022-510x(94)00237-i
33 https://doi.org/10.1016/0028-3932(95)00008-q
34 https://doi.org/10.1016/0166-2236(90)90110-v
35 https://doi.org/10.1016/j.brainres.2007.02.046
36 https://doi.org/10.1016/j.brainres.2013.03.027
37 https://doi.org/10.1016/j.cortex.2015.08.005
38 https://doi.org/10.1016/j.neubiorev.2016.04.001
39 https://doi.org/10.1016/j.neulet.2009.05.046
40 https://doi.org/10.1016/j.neurobiolaging.2014.05.032
41 https://doi.org/10.1016/j.neuroimage.2006.02.005
42 https://doi.org/10.1016/j.neuroimage.2006.11.047
43 https://doi.org/10.1016/j.neuron.2008.04.017
44 https://doi.org/10.1016/j.tins.2007.05.004
45 https://doi.org/10.1016/j.tins.2009.06.003
46 https://doi.org/10.1016/s0079-6123(10)84016-6
47 https://doi.org/10.1016/s0166-2236(03)00038-9
48 https://doi.org/10.1016/s0168-0102(02)00027-5
49 https://doi.org/10.1016/s0896-6273(03)00677-9
50 https://doi.org/10.1016/s1474-4422(06)70471-9
51 https://doi.org/10.1038/jcbfm.1994.99
52 https://doi.org/10.1038/sj.jcbfm.9600358
53 https://doi.org/10.1056/nejmoa033447
54 https://doi.org/10.1093/brain/114.5.2283
55 https://doi.org/10.1093/brain/118.4.913
56 https://doi.org/10.1093/brain/120.6.963
57 https://doi.org/10.1093/brain/124.3.558
58 https://doi.org/10.1093/brain/awg033
59 https://doi.org/10.1093/brain/awg268
60 https://doi.org/10.1093/brain/awh572
61 https://doi.org/10.1093/brain/awl162
62 https://doi.org/10.1093/brain/awm086
63 https://doi.org/10.1093/brain/awr233
64 https://doi.org/10.1093/brain/aws281
65 https://doi.org/10.1093/brain/awt007
66 https://doi.org/10.1093/brain/awx010
67 https://doi.org/10.1093/brain/awx252
68 https://doi.org/10.1093/cercor/5.2.95
69 https://doi.org/10.1093/cercor/bhp178
70 https://doi.org/10.1093/cercor/bhs397
71 https://doi.org/10.1097/00001756-200005150-00044
72 https://doi.org/10.1097/00001756-200307010-00020
73 https://doi.org/10.1097/01.wco.0000236623.68625.54
74 https://doi.org/10.1097/md.0000000000002206
75 https://doi.org/10.1136/jnnp.49.11.1301
76 https://doi.org/10.1136/jnnp.57.5.567
77 https://doi.org/10.1136/jnnp.74.7.844
78 https://doi.org/10.1136/pgmj.2006.054759
79 https://doi.org/10.1146/annurev.ne.09.030186.002041
80 https://doi.org/10.1152/jn.00055.2005
81 https://doi.org/10.1152/jn.1994.72.2.507
82 https://doi.org/10.1152/jn.1999.81.6.3065
83 https://doi.org/10.1155/2017/5124328
84 https://doi.org/10.1159/000330658
85 https://doi.org/10.1212/01.wnl.0000338699.56379.11
86 https://doi.org/10.1212/wnl.0b013e318198e0e9
87 https://doi.org/10.1371/journal.pone.0059717
88 https://doi.org/10.1371/journal.pone.0066910
89 https://doi.org/10.1371/journal.pone.0070143
90 https://doi.org/10.1371/journal.pone.0106735
91 https://doi.org/10.1523/jneurosci.0582-08.2008
92 https://doi.org/10.1523/jneurosci.22-11-04639.2002
93 https://doi.org/10.3171/jns.2003.98.1.0057
94 https://doi.org/10.3233/nre-151237
95 https://doi.org/10.3389/fnsys.2010.00143
96 https://doi.org/10.3389/fnsys.2015.00023
97 schema:datePublished 2019-02-27
98 schema:datePublishedReg 2019-02-27
99 schema:description OBJECTIVE: To investigate factors affecting the pattern of motor brain activation reported in people with Parkinson's (PwP), aiming to differentiate disease-specific features from treatment effects. METHODS: A co-ordinate-based-meta-analysis (CBMA) of functional motor neuroimaging studies involving patients with Parkinson's (PwP), and healthy controls (HC) identified 126 suitable articles. The experiments were grouped based on subject feature, medication status (onMed/offMed), deep brain stimulation (DBS) status (DBSon/DBSoff) and type of motor initiation. RESULTS: HC and PwP shared similar neural networks during upper extremity motor tasks but with differences of reported frequency in mainly bilateral putamen, insula and ipsilateral inferior parietal and precentral gyri. The activation height was significantly reduced in the bilateral putamen, left SMA, left subthalamus nucleus, right thalamus and right midial global pallidum in PwPoffMed (vs. HC), and pre-SMA hypoactivation correlated with disease severity. These changes were not found in patients on dopamine replacement therapy (PwPonMed vs. HC) in line with a restorative function. By contrast, left SMA and primary motor cortex showed hyperactivation in the medicated state (vs. HC) suggesting dopaminergic overcompensation. Deep-brain stimulation (PwP during the high frequency subthalamus nucleus (STN) DBS vs. no stimulation) induced a decrease in left SMA activity and the expected increase in the left subthalamic/thalamic region regardless of hand movement. We further demonstrated a disease related effect of motor intention with only PwPoffMed showing increased activation in the medial frontal lobe in self-initiated studies. CONCLUSION: We describe a consistent disease-specific pattern of putaminal hypoactivation during motor tasks that appears reversed by dopamine replacement. Inconsistent reports of altered SMA/pre-SMA activation can be explained by task- and medication-specific variation in intention. Moreover, SMA activity was reduced during STN-DBS, while dopamine-induced hyperactivation of SMA which might underpin hyperdynamic L-dopa related overcompensation.
100 schema:genre research_article
101 schema:inLanguage en
102 schema:isAccessibleForFree false
103 schema:isPartOf sg:journal.1038420
104 schema:name Coordinate based meta-analysis of motor functional imaging in Parkinson’s: disease-specific patterns and modulation by dopamine replacement and deep brain stimulation
105 schema:pagination 1-18
106 schema:productId N4f0cdbcf1ff740d9aa13bd07f3c14560
107 N5188c4f3a7c54938b9f506720e17635f
108 N89ff2e81c7024cc6a3d55a6f72cb3282
109 Nd1cb9ad9b8744a3c8ca304d2e31b92e1
110 Nf5bb86feeb46449fbfc5e3204dd7ee10
111 schema:sameAs https://app.dimensions.ai/details/publication/pub.1112399971
112 https://doi.org/10.1007/s11682-019-00061-3
113 schema:sdDatePublished 2019-04-11T10:17
114 schema:sdLicense https://scigraph.springernature.com/explorer/license/
115 schema:sdPublisher Nb19721be81e74e569264cbd06df99c4b
116 schema:url https://link.springer.com/10.1007%2Fs11682-019-00061-3
117 sgo:license sg:explorer/license/
118 sgo:sdDataset articles
119 rdf:type schema:ScholarlyArticle
120 N04ea3511c4604ff4912ca0d4152fb981 schema:affiliation https://www.grid.ac/institutes/grid.4563.4
121 schema:familyName Auer
122 schema:givenName Dorothee P.
123 rdf:type schema:Person
124 N3587ad92f98149ebbaca060d31fdd6d6 rdf:first Ndee9d3b22f09470488c6b3fafc3579bc
125 rdf:rest N423ff512f86640f3bac6cf2cd65faf79
126 N423ff512f86640f3bac6cf2cd65faf79 rdf:first N5721c1f497e74f7096c80338ab1a0d15
127 rdf:rest N5ce91091f6df4024806052011aee51fa
128 N46c81bad71ed45f09875d3f6ec979048 schema:name Division of Clinical Neurology, Queen’s Medical Centre, University of Nottingham, Nottingham, UK
129 rdf:type schema:Organization
130 N4f0cdbcf1ff740d9aa13bd07f3c14560 schema:name pubmed_id
131 schema:value 30809759
132 rdf:type schema:PropertyValue
133 N5188c4f3a7c54938b9f506720e17635f schema:name dimensions_id
134 schema:value pub.1112399971
135 rdf:type schema:PropertyValue
136 N5721c1f497e74f7096c80338ab1a0d15 schema:affiliation N46c81bad71ed45f09875d3f6ec979048
137 schema:familyName Tench
138 schema:givenName Christopher
139 rdf:type schema:Person
140 N5ce91091f6df4024806052011aee51fa rdf:first Nd0d15538050843e093bba93b039bcdfa
141 rdf:rest Nd903b9e8e7e548ac9fe81e24c47fcdb7
142 N73da44db5fe7477782deb89516f4d62f schema:affiliation https://www.grid.ac/institutes/grid.273109.e
143 schema:familyName Schwarz
144 schema:givenName Stefan T.
145 rdf:type schema:Person
146 N89ff2e81c7024cc6a3d55a6f72cb3282 schema:name readcube_id
147 schema:value 7793af9f302c3c0de53bc2766635cb29f8c7ccac3465b782ddf8c9c21d80531b
148 rdf:type schema:PropertyValue
149 Na86fd6f8931548ddb97051c9f95657ad rdf:first N04ea3511c4604ff4912ca0d4152fb981
150 rdf:rest rdf:nil
151 Nb19721be81e74e569264cbd06df99c4b schema:name Springer Nature - SN SciGraph project
152 rdf:type schema:Organization
153 Nc93afd025a834cec970a1e32a9e8ae2b rdf:first Nefc6259f76bc4ca59934c6a9e7dc2d1a
154 rdf:rest Na86fd6f8931548ddb97051c9f95657ad
155 Nd0d15538050843e093bba93b039bcdfa schema:affiliation https://www.grid.ac/institutes/grid.412739.a
156 schema:familyName Wongwandee
157 schema:givenName Monton
158 rdf:type schema:Person
159 Nd1cb9ad9b8744a3c8ca304d2e31b92e1 schema:name nlm_unique_id
160 schema:value 101300405
161 rdf:type schema:PropertyValue
162 Nd903b9e8e7e548ac9fe81e24c47fcdb7 rdf:first N73da44db5fe7477782deb89516f4d62f
163 rdf:rest Nc93afd025a834cec970a1e32a9e8ae2b
164 Ndee9d3b22f09470488c6b3fafc3579bc schema:affiliation https://www.grid.ac/institutes/grid.4563.4
165 schema:familyName Xing
166 schema:givenName YUE
167 rdf:type schema:Person
168 Nefc6259f76bc4ca59934c6a9e7dc2d1a schema:affiliation https://www.grid.ac/institutes/grid.240404.6
169 schema:familyName Bajaj
170 schema:givenName Nin
171 rdf:type schema:Person
172 Nf5bb86feeb46449fbfc5e3204dd7ee10 schema:name doi
173 schema:value 10.1007/s11682-019-00061-3
174 rdf:type schema:PropertyValue
175 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
176 schema:name Medical and Health Sciences
177 rdf:type schema:DefinedTerm
178 anzsrc-for:1109 schema:inDefinedTermSet anzsrc-for:
179 schema:name Neurosciences
180 rdf:type schema:DefinedTerm
181 sg:journal.1038420 schema:issn 1931-7557
182 1931-7565
183 schema:name Brain Imaging and Behavior
184 rdf:type schema:Periodical
185 sg:pub.10.1007/978-3-319-25721-1_9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030382636
186 https://doi.org/10.1007/978-3-319-25721-1_9
187 rdf:type schema:CreativeWork
188 sg:pub.10.1007/s00415-014-7254-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048592969
189 https://doi.org/10.1007/s00415-014-7254-6
190 rdf:type schema:CreativeWork
191 sg:pub.10.1038/nature09159 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039789576
192 https://doi.org/10.1038/nature09159
193 rdf:type schema:CreativeWork
194 sg:pub.10.1038/nn.3743 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023700682
195 https://doi.org/10.1038/nn.3743
196 rdf:type schema:CreativeWork
197 sg:pub.10.1038/nrn2337 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039938718
198 https://doi.org/10.1038/nrn2337
199 rdf:type schema:CreativeWork
200 sg:pub.10.1038/nrn4038 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037577844
201 https://doi.org/10.1038/nrn4038
202 rdf:type schema:CreativeWork
203 sg:pub.10.1038/nrneurol.2014.205 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009908711
204 https://doi.org/10.1038/nrneurol.2014.205
205 rdf:type schema:CreativeWork
206 sg:pub.10.1038/srep43571 schema:sameAs https://app.dimensions.ai/details/publication/pub.1084131491
207 https://doi.org/10.1038/srep43571
208 rdf:type schema:CreativeWork
209 https://doi.org/10.1001/archneur.1984.04050190062015 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037118861
210 rdf:type schema:CreativeWork
211 https://doi.org/10.1001/archneur.59.12.1937 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046569323
212 rdf:type schema:CreativeWork
213 https://doi.org/10.1001/archneurol.2012.33 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010810289
214 rdf:type schema:CreativeWork
215 https://doi.org/10.1001/jama.284.15.1931 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002894278
216 rdf:type schema:CreativeWork
217 https://doi.org/10.1002/ana.24138 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026447632
218 rdf:type schema:CreativeWork
219 https://doi.org/10.1002/ana.410230112 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026415240
220 rdf:type schema:CreativeWork
221 https://doi.org/10.1002/ana.410320206 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021014879
222 rdf:type schema:CreativeWork
223 https://doi.org/10.1002/ana.410320608 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046685624
224 rdf:type schema:CreativeWork
225 https://doi.org/10.1002/hbm.22397 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018164360
226 rdf:type schema:CreativeWork
227 https://doi.org/10.1002/hbm.22561 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015217597
228 rdf:type schema:CreativeWork
229 https://doi.org/10.1002/mds.10142 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051764194
230 rdf:type schema:CreativeWork
231 https://doi.org/10.1002/mds.10297 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019218433
232 rdf:type schema:CreativeWork
233 https://doi.org/10.1002/mds.1139 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028533316
234 rdf:type schema:CreativeWork
235 https://doi.org/10.1002/mds.1212 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045914879
236 rdf:type schema:CreativeWork
237 https://doi.org/10.1002/mds.20855 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028039409
238 rdf:type schema:CreativeWork
239 https://doi.org/10.1002/mds.20962 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012933183
240 rdf:type schema:CreativeWork
241 https://doi.org/10.1002/mds.22635 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000224813
242 rdf:type schema:CreativeWork
243 https://doi.org/10.1002/mds.22662 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012906495
244 rdf:type schema:CreativeWork
245 https://doi.org/10.1002/mds.23695 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007354138
246 rdf:type schema:CreativeWork
247 https://doi.org/10.1002/mds.24017 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008843448
248 rdf:type schema:CreativeWork
249 https://doi.org/10.1016/0022-510x(94)00237-i schema:sameAs https://app.dimensions.ai/details/publication/pub.1024202844
250 rdf:type schema:CreativeWork
251 https://doi.org/10.1016/0028-3932(95)00008-q schema:sameAs https://app.dimensions.ai/details/publication/pub.1024610545
252 rdf:type schema:CreativeWork
253 https://doi.org/10.1016/0166-2236(90)90110-v schema:sameAs https://app.dimensions.ai/details/publication/pub.1017015109
254 rdf:type schema:CreativeWork
255 https://doi.org/10.1016/j.brainres.2007.02.046 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025714831
256 rdf:type schema:CreativeWork
257 https://doi.org/10.1016/j.brainres.2013.03.027 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017668898
258 rdf:type schema:CreativeWork
259 https://doi.org/10.1016/j.cortex.2015.08.005 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053635476
260 rdf:type schema:CreativeWork
261 https://doi.org/10.1016/j.neubiorev.2016.04.001 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046467865
262 rdf:type schema:CreativeWork
263 https://doi.org/10.1016/j.neulet.2009.05.046 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039477326
264 rdf:type schema:CreativeWork
265 https://doi.org/10.1016/j.neurobiolaging.2014.05.032 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051931547
266 rdf:type schema:CreativeWork
267 https://doi.org/10.1016/j.neuroimage.2006.02.005 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026542450
268 rdf:type schema:CreativeWork
269 https://doi.org/10.1016/j.neuroimage.2006.11.047 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042878660
270 rdf:type schema:CreativeWork
271 https://doi.org/10.1016/j.neuron.2008.04.017 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049396201
272 rdf:type schema:CreativeWork
273 https://doi.org/10.1016/j.tins.2007.05.004 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000719333
274 rdf:type schema:CreativeWork
275 https://doi.org/10.1016/j.tins.2009.06.003 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026406274
276 rdf:type schema:CreativeWork
277 https://doi.org/10.1016/s0079-6123(10)84016-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013209786
278 rdf:type schema:CreativeWork
279 https://doi.org/10.1016/s0166-2236(03)00038-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053282103
280 rdf:type schema:CreativeWork
281 https://doi.org/10.1016/s0168-0102(02)00027-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044487127
282 rdf:type schema:CreativeWork
283 https://doi.org/10.1016/s0896-6273(03)00677-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031661051
284 rdf:type schema:CreativeWork
285 https://doi.org/10.1016/s1474-4422(06)70471-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039529917
286 rdf:type schema:CreativeWork
287 https://doi.org/10.1038/jcbfm.1994.99 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041971430
288 rdf:type schema:CreativeWork
289 https://doi.org/10.1038/sj.jcbfm.9600358 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018063970
290 rdf:type schema:CreativeWork
291 https://doi.org/10.1056/nejmoa033447 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035458376
292 rdf:type schema:CreativeWork
293 https://doi.org/10.1093/brain/114.5.2283 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045332348
294 rdf:type schema:CreativeWork
295 https://doi.org/10.1093/brain/118.4.913 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031547519
296 rdf:type schema:CreativeWork
297 https://doi.org/10.1093/brain/120.6.963 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023064437
298 rdf:type schema:CreativeWork
299 https://doi.org/10.1093/brain/124.3.558 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001042359
300 rdf:type schema:CreativeWork
301 https://doi.org/10.1093/brain/awg033 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019158239
302 rdf:type schema:CreativeWork
303 https://doi.org/10.1093/brain/awg268 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004603134
304 rdf:type schema:CreativeWork
305 https://doi.org/10.1093/brain/awh572 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024905499
306 rdf:type schema:CreativeWork
307 https://doi.org/10.1093/brain/awl162 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039928405
308 rdf:type schema:CreativeWork
309 https://doi.org/10.1093/brain/awm086 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052550672
310 rdf:type schema:CreativeWork
311 https://doi.org/10.1093/brain/awr233 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036232062
312 rdf:type schema:CreativeWork
313 https://doi.org/10.1093/brain/aws281 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044682127
314 rdf:type schema:CreativeWork
315 https://doi.org/10.1093/brain/awt007 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046918087
316 rdf:type schema:CreativeWork
317 https://doi.org/10.1093/brain/awx010 schema:sameAs https://app.dimensions.ai/details/publication/pub.1084182907
318 rdf:type schema:CreativeWork
319 https://doi.org/10.1093/brain/awx252 schema:sameAs https://app.dimensions.ai/details/publication/pub.1091952510
320 rdf:type schema:CreativeWork
321 https://doi.org/10.1093/cercor/5.2.95 schema:sameAs https://app.dimensions.ai/details/publication/pub.1059458400
322 rdf:type schema:CreativeWork
323 https://doi.org/10.1093/cercor/bhp178 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047978151
324 rdf:type schema:CreativeWork
325 https://doi.org/10.1093/cercor/bhs397 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044059935
326 rdf:type schema:CreativeWork
327 https://doi.org/10.1097/00001756-200005150-00044 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017476748
328 rdf:type schema:CreativeWork
329 https://doi.org/10.1097/00001756-200307010-00020 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040149572
330 rdf:type schema:CreativeWork
331 https://doi.org/10.1097/01.wco.0000236623.68625.54 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036355990
332 rdf:type schema:CreativeWork
333 https://doi.org/10.1097/md.0000000000002206 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003204713
334 rdf:type schema:CreativeWork
335 https://doi.org/10.1136/jnnp.49.11.1301 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044575237
336 rdf:type schema:CreativeWork
337 https://doi.org/10.1136/jnnp.57.5.567 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036929703
338 rdf:type schema:CreativeWork
339 https://doi.org/10.1136/jnnp.74.7.844 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036999539
340 rdf:type schema:CreativeWork
341 https://doi.org/10.1136/pgmj.2006.054759 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002297707
342 rdf:type schema:CreativeWork
343 https://doi.org/10.1146/annurev.ne.09.030186.002041 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035901217
344 rdf:type schema:CreativeWork
345 https://doi.org/10.1152/jn.00055.2005 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033947389
346 rdf:type schema:CreativeWork
347 https://doi.org/10.1152/jn.1994.72.2.507 schema:sameAs https://app.dimensions.ai/details/publication/pub.1082594364
348 rdf:type schema:CreativeWork
349 https://doi.org/10.1152/jn.1999.81.6.3065 schema:sameAs https://app.dimensions.ai/details/publication/pub.1074476163
350 rdf:type schema:CreativeWork
351 https://doi.org/10.1155/2017/5124328 schema:sameAs https://app.dimensions.ai/details/publication/pub.1090358501
352 rdf:type schema:CreativeWork
353 https://doi.org/10.1159/000330658 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045377552
354 rdf:type schema:CreativeWork
355 https://doi.org/10.1212/01.wnl.0000338699.56379.11 schema:sameAs https://app.dimensions.ai/details/publication/pub.1064350803
356 rdf:type schema:CreativeWork
357 https://doi.org/10.1212/wnl.0b013e318198e0e9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1064354266
358 rdf:type schema:CreativeWork
359 https://doi.org/10.1371/journal.pone.0059717 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002466851
360 rdf:type schema:CreativeWork
361 https://doi.org/10.1371/journal.pone.0066910 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028732025
362 rdf:type schema:CreativeWork
363 https://doi.org/10.1371/journal.pone.0070143 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024465079
364 rdf:type schema:CreativeWork
365 https://doi.org/10.1371/journal.pone.0106735 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010264248
366 rdf:type schema:CreativeWork
367 https://doi.org/10.1523/jneurosci.0582-08.2008 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042397628
368 rdf:type schema:CreativeWork
369 https://doi.org/10.1523/jneurosci.22-11-04639.2002 schema:sameAs https://app.dimensions.ai/details/publication/pub.1075061976
370 rdf:type schema:CreativeWork
371 https://doi.org/10.3171/jns.2003.98.1.0057 schema:sameAs https://app.dimensions.ai/details/publication/pub.1071100616
372 rdf:type schema:CreativeWork
373 https://doi.org/10.3233/nre-151237 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040892521
374 rdf:type schema:CreativeWork
375 https://doi.org/10.3389/fnsys.2010.00143 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025548634
376 rdf:type schema:CreativeWork
377 https://doi.org/10.3389/fnsys.2015.00023 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002851529
378 rdf:type schema:CreativeWork
379 https://www.grid.ac/institutes/grid.240404.6 schema:alternateName Nottingham University Hospitals NHS Trust
380 schema:name Department of Neurology, Nottingham University Hospitals, NG7 2UH, Nottingham, UK
381 rdf:type schema:Organization
382 https://www.grid.ac/institutes/grid.273109.e schema:alternateName Cardiff and Vale University Health Board
383 schema:name Department of Radiology, Cardiff and Vale University Health Board, Cardiff, Wales
384 Radiological Sciences, Division of Clinical Neuroscience, University of Nottingham, NG7 2UH, Nottingham, UK
385 rdf:type schema:Organization
386 https://www.grid.ac/institutes/grid.412739.a schema:alternateName Srinakharinwirot University
387 schema:name Department of Medicine, Srinakharinwirot University, Nakhon Nayok, Thailand
388 rdf:type schema:Organization
389 https://www.grid.ac/institutes/grid.4563.4 schema:alternateName University of Nottingham
390 schema:name NIHR Nottingham Biomedical Research Centre, University of Nottingham, NG7 2UH, Nottingham, UK
391 Radiological Sciences, Division of Clinical Neuroscience, University of Nottingham, NG7 2UH, Nottingham, UK
392 Radiological Sciences, Sir Peter Mansfield Imaging Centre, NIHR Nottingham BRC, University of Nottingham, NG7 2UH, Nottingham, UK
393 Sir Peter Mansfield Imaging Centre, University of Nottingham, NG7 2UH, Nottingham, UK
394 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...