Multifocal alterations of white matter accompany the transition from normal cognition to dementia in Parkinson’s disease patients View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2019-02

AUTHORS

Maria Chondrogiorgi, Loukas G. Astrakas, Anastasia K. Zikou, Luca Weis, Vassilios G. Xydis, Angelo Antonini, Maria I. Argyropoulou, Spiridon Konitsiotis

ABSTRACT

The purpose of the present study was to investigate the pattern of white matter (WM) changes associated with Parkinson's disease (PD)-related cognitive impairment by using fractional anisotropy (FA), mean diffusivity (MD), axial diffusivity (AD) and radial diffusivity (RD) measures. Diffusion Tensor Imaging (DTI) was performed in 21 PD-patients with dementia (PDD) and in an age-matched control group including 40 PD-patients without dementia (PD-CTRL). The Parkinson's disease-Cognitive Rating Scale (PD-CRS) was used for patients' neuropsychological assessment. Local microstructural WM differences associated with the presence of cognitive impairment were tested using tract-based spatial statistics analysis. Multiple regression models investigated the association of DTI indices with total PD-CRS score, PD-CRS raw items and other clinical measures across the whole study sample. Significant FA decreases were found in PDD compared to PD-CTRL patients mainly in the body of corpus callosum, corona radiata and cingulum. Lower PD-CRS score was significantly associated with decreased FA, MD and AD values in multiple WM tracts primarily located in prefrontal and limbic areas as well as across the corpus callosum. Lower performance in specific PD-CRS raw items was also associated with FA decreases in major WM tracts. The results suggest that multifocal microstructural changes of WM accompany the transition from normal to demented cognitive state in PD-patients. The corpus callosum, the corona radiata and the cingulum are among the regions mostly affected during this course. A progressive axonal degeneration is proposed as a key underlying mechanism. More... »

PAGES

232-240

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s11682-018-9863-7

DOI

http://dx.doi.org/10.1007/s11682-018-9863-7

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1103186359

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/29629498


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1109", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Neurosciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "University of Ioannina", 
          "id": "https://www.grid.ac/institutes/grid.9594.1", 
          "name": [
            "Department of Neurology, Medical School, University of Ioannina, Stavrou Niarchou Av., University Campus, 45110, Ioannina, Greece"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Chondrogiorgi", 
        "givenName": "Maria", 
        "id": "sg:person.01352145034.62", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01352145034.62"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Ioannina", 
          "id": "https://www.grid.ac/institutes/grid.9594.1", 
          "name": [
            "Department of Medical Physics, Medical School, University of Ioannina, Stavrou Niarchou Av., University Campus, 45110, Ioannina, Greece"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Astrakas", 
        "givenName": "Loukas G.", 
        "id": "sg:person.0700210224.61", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0700210224.61"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Ioannina", 
          "id": "https://www.grid.ac/institutes/grid.9594.1", 
          "name": [
            "Department of Radiology, Medical School, University of Ioannina, Stavrou Niarchou Av., University Campus, 45110, Ioannina, Greece"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Zikou", 
        "givenName": "Anastasia K.", 
        "id": "sg:person.01230371215.88", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01230371215.88"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Ospedale San Camillo", 
          "id": "https://www.grid.ac/institutes/grid.416308.8", 
          "name": [
            "Parkinson Disease and Movement Disorders Unit, IRCCS San Camillo Hospital Foundation, via Alberoni, 70, 30126, Venice-Lido, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Weis", 
        "givenName": "Luca", 
        "id": "sg:person.01331477174.13", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01331477174.13"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Ioannina", 
          "id": "https://www.grid.ac/institutes/grid.9594.1", 
          "name": [
            "Department of Radiology, Medical School, University of Ioannina, Stavrou Niarchou Av., University Campus, 45110, Ioannina, Greece"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Xydis", 
        "givenName": "Vassilios G.", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Ospedale San Camillo", 
          "id": "https://www.grid.ac/institutes/grid.416308.8", 
          "name": [
            "Parkinson Disease and Movement Disorders Unit, IRCCS San Camillo Hospital Foundation, via Alberoni, 70, 30126, Venice-Lido, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Antonini", 
        "givenName": "Angelo", 
        "id": "sg:person.01206755015.46", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01206755015.46"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Ioannina", 
          "id": "https://www.grid.ac/institutes/grid.9594.1", 
          "name": [
            "Department of Radiology, Medical School, University of Ioannina, Stavrou Niarchou Av., University Campus, 45110, Ioannina, Greece"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Argyropoulou", 
        "givenName": "Maria I.", 
        "id": "sg:person.0740567732.79", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0740567732.79"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Ioannina", 
          "id": "https://www.grid.ac/institutes/grid.9594.1", 
          "name": [
            "Department of Neurology, Medical School, University of Ioannina, Stavrou Niarchou Av., University Campus, 45110, Ioannina, Greece"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Konitsiotis", 
        "givenName": "Spiridon", 
        "id": "sg:person.015411674024.29", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015411674024.29"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1002/hbm.22302", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000488020"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/mds.21844", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000997385"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1159/000341998", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002450347"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/ane.12532", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002542321"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1177/1533317512470207", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002621964"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1177/1533317512470207", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002621964"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.jns.2006.05.011", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003549802"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1136/jnnp.2009.184747", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006124920"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/hbm.21245", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1007387340"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3174/ajnr.a2860", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1009137990"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/mds.23429", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1009574356"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.1004841107", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010088908"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/brain/awt065", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010777294"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.neuroimage.2003.07.005", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1011402998"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.neuroimage.2003.07.005", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1011402998"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3389/fneur.2013.00037", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1011428702"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.4172/2161-0460.1000123", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012076461"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0197-4580(02)00065-9", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1016528708"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0197-4580(02)00065-9", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1016528708"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/mds.22007", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017019541"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/mds.22506", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018972286"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/mds.22506", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018972286"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.ejrad.2015.04.014", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021044024"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00247-010-1677-8", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021746168", 
          "https://doi.org/10.1007/s00247-010-1677-8"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00247-010-1677-8", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021746168", 
          "https://doi.org/10.1007/s00247-010-1677-8"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.neuroimage.2006.02.024", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023372670"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00429-014-0785-x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024100164", 
          "https://doi.org/10.1007/s00429-014-0785-x"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.neuroimage.2004.07.051", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024629846"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3389/fnana.2016.00017", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028273503"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/mds.21507", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028873866"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.neubiorev.2006.06.003", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030028140"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.nicl.2014.02.001", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030674840"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1159/000088526", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032481314"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1159/000088526", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032481314"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/hbm.22256", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1034272190"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00330-013-2775-4", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036056631", 
          "https://doi.org/10.1007/s00330-013-2775-4"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00330-013-2775-4", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036056631", 
          "https://doi.org/10.1007/s00330-013-2775-4"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.neuroimage.2012.06.012", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038331188"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1136/jnnp.55.3.181", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038938753"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.expneurol.2004.09.006", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046447821"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1600-0404.2007.00838.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048401076"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1600-0404.2007.00838.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048401076"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1371/journal.pone.0165540", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052877790"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1089/neu.2009.1110", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1059301081"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1212/01.wnl.0000158422.41380.82", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1064346990"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1212/01.wnl.0000158422.41380.82", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1064346990"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1212/01.wnl.0000158422.41380.82", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1064346990"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1212/wnl.0b013e318259e1c5", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1064356991"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1212/wnl.0b013e318259e1c5", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1064356991"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1212/wnl.0b013e318259e1c5", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1064356991"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1212/wnl.0b013e3182929f62", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1064357737"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1212/wnl.0b013e3182929f62", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1064357737"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1212/wnl.0b013e3182929f62", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1064357737"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1212/wnl.40.10.1529", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1064368879"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3233/jad-2010-100678", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1078222647"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2019-02", 
    "datePublishedReg": "2019-02-01", 
    "description": "The purpose of the present study was to investigate the pattern of white matter (WM) changes associated with Parkinson's disease (PD)-related cognitive impairment by using fractional anisotropy (FA), mean diffusivity (MD), axial diffusivity (AD) and radial diffusivity (RD) measures. Diffusion Tensor Imaging (DTI) was performed in 21 PD-patients with dementia (PDD) and in an age-matched control group including 40 PD-patients without dementia (PD-CTRL). The Parkinson's disease-Cognitive Rating Scale (PD-CRS) was used for patients' neuropsychological assessment. Local microstructural WM differences associated with the presence of cognitive impairment were tested using tract-based spatial statistics analysis. Multiple regression models investigated the association of DTI indices with total PD-CRS score, PD-CRS raw items and other clinical measures across the whole study sample. Significant FA decreases were found in PDD compared to PD-CTRL patients mainly in the body of corpus callosum, corona radiata and cingulum. Lower PD-CRS score was significantly associated with decreased FA, MD and AD values in multiple WM tracts primarily located in prefrontal and limbic areas as well as across the corpus callosum. Lower performance in specific PD-CRS raw items was also associated with FA decreases in major WM tracts. The results suggest that multifocal microstructural changes of WM accompany the transition from normal to demented cognitive state in PD-patients. The corpus callosum, the corona radiata and the cingulum are among the regions mostly affected during this course. A progressive axonal degeneration is proposed as a key underlying mechanism.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1007/s11682-018-9863-7", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": false, 
    "isPartOf": [
      {
        "id": "sg:journal.1038420", 
        "issn": [
          "1931-7557", 
          "1931-7565"
        ], 
        "name": "Brain Imaging and Behavior", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "1", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "13"
      }
    ], 
    "name": "Multifocal alterations of white matter accompany the transition from normal cognition to dementia in Parkinson\u2019s disease patients", 
    "pagination": "232-240", 
    "productId": [
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1007/s11682-018-9863-7"
        ]
      }, 
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "1e5a4b8e38b6cec04c78065951d1ccea6bd39eaf354cc1e526f0650d9f028602"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1103186359"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "101300405"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "29629498"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1007/s11682-018-9863-7", 
      "https://app.dimensions.ai/details/publication/pub.1103186359"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-15T09:01", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000375_0000000375/records_91444_00000001.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://link.springer.com/10.1007%2Fs11682-018-9863-7"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s11682-018-9863-7'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s11682-018-9863-7'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s11682-018-9863-7'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s11682-018-9863-7'


 

This table displays all metadata directly associated to this object as RDF triples.

248 TRIPLES      21 PREDICATES      70 URIs      21 LITERALS      9 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1007/s11682-018-9863-7 schema:about anzsrc-for:11
2 anzsrc-for:1109
3 schema:author N1ed3a36032df448587a5d55cf93780ce
4 schema:citation sg:pub.10.1007/s00247-010-1677-8
5 sg:pub.10.1007/s00330-013-2775-4
6 sg:pub.10.1007/s00429-014-0785-x
7 https://doi.org/10.1002/hbm.21245
8 https://doi.org/10.1002/hbm.22256
9 https://doi.org/10.1002/hbm.22302
10 https://doi.org/10.1002/mds.21507
11 https://doi.org/10.1002/mds.21844
12 https://doi.org/10.1002/mds.22007
13 https://doi.org/10.1002/mds.22506
14 https://doi.org/10.1002/mds.23429
15 https://doi.org/10.1016/j.ejrad.2015.04.014
16 https://doi.org/10.1016/j.expneurol.2004.09.006
17 https://doi.org/10.1016/j.jns.2006.05.011
18 https://doi.org/10.1016/j.neubiorev.2006.06.003
19 https://doi.org/10.1016/j.neuroimage.2003.07.005
20 https://doi.org/10.1016/j.neuroimage.2004.07.051
21 https://doi.org/10.1016/j.neuroimage.2006.02.024
22 https://doi.org/10.1016/j.neuroimage.2012.06.012
23 https://doi.org/10.1016/j.nicl.2014.02.001
24 https://doi.org/10.1016/s0197-4580(02)00065-9
25 https://doi.org/10.1073/pnas.1004841107
26 https://doi.org/10.1089/neu.2009.1110
27 https://doi.org/10.1093/brain/awt065
28 https://doi.org/10.1111/ane.12532
29 https://doi.org/10.1111/j.1600-0404.2007.00838.x
30 https://doi.org/10.1136/jnnp.2009.184747
31 https://doi.org/10.1136/jnnp.55.3.181
32 https://doi.org/10.1159/000088526
33 https://doi.org/10.1159/000341998
34 https://doi.org/10.1177/1533317512470207
35 https://doi.org/10.1212/01.wnl.0000158422.41380.82
36 https://doi.org/10.1212/wnl.0b013e318259e1c5
37 https://doi.org/10.1212/wnl.0b013e3182929f62
38 https://doi.org/10.1212/wnl.40.10.1529
39 https://doi.org/10.1371/journal.pone.0165540
40 https://doi.org/10.3174/ajnr.a2860
41 https://doi.org/10.3233/jad-2010-100678
42 https://doi.org/10.3389/fnana.2016.00017
43 https://doi.org/10.3389/fneur.2013.00037
44 https://doi.org/10.4172/2161-0460.1000123
45 schema:datePublished 2019-02
46 schema:datePublishedReg 2019-02-01
47 schema:description The purpose of the present study was to investigate the pattern of white matter (WM) changes associated with Parkinson's disease (PD)-related cognitive impairment by using fractional anisotropy (FA), mean diffusivity (MD), axial diffusivity (AD) and radial diffusivity (RD) measures. Diffusion Tensor Imaging (DTI) was performed in 21 PD-patients with dementia (PDD) and in an age-matched control group including 40 PD-patients without dementia (PD-CTRL). The Parkinson's disease-Cognitive Rating Scale (PD-CRS) was used for patients' neuropsychological assessment. Local microstructural WM differences associated with the presence of cognitive impairment were tested using tract-based spatial statistics analysis. Multiple regression models investigated the association of DTI indices with total PD-CRS score, PD-CRS raw items and other clinical measures across the whole study sample. Significant FA decreases were found in PDD compared to PD-CTRL patients mainly in the body of corpus callosum, corona radiata and cingulum. Lower PD-CRS score was significantly associated with decreased FA, MD and AD values in multiple WM tracts primarily located in prefrontal and limbic areas as well as across the corpus callosum. Lower performance in specific PD-CRS raw items was also associated with FA decreases in major WM tracts. The results suggest that multifocal microstructural changes of WM accompany the transition from normal to demented cognitive state in PD-patients. The corpus callosum, the corona radiata and the cingulum are among the regions mostly affected during this course. A progressive axonal degeneration is proposed as a key underlying mechanism.
48 schema:genre research_article
49 schema:inLanguage en
50 schema:isAccessibleForFree false
51 schema:isPartOf N64c39514b21b419e87d0c191d94ed88c
52 N7f219c4c49604c29b200af7db9a6a7bf
53 sg:journal.1038420
54 schema:name Multifocal alterations of white matter accompany the transition from normal cognition to dementia in Parkinson’s disease patients
55 schema:pagination 232-240
56 schema:productId N00ed73302de84060a89945c9245949df
57 N057759651b9441b280b0879e9c7c1f04
58 N077235165d7c4f4f85c788c5a811a1ee
59 N79780605fcd44840a719356fd2dbe3fa
60 N87d64a08df564beb8a32a4f66dfaf97e
61 schema:sameAs https://app.dimensions.ai/details/publication/pub.1103186359
62 https://doi.org/10.1007/s11682-018-9863-7
63 schema:sdDatePublished 2019-04-15T09:01
64 schema:sdLicense https://scigraph.springernature.com/explorer/license/
65 schema:sdPublisher Nc4b8409a1e6346a990f03335709b71d1
66 schema:url https://link.springer.com/10.1007%2Fs11682-018-9863-7
67 sgo:license sg:explorer/license/
68 sgo:sdDataset articles
69 rdf:type schema:ScholarlyArticle
70 N00ed73302de84060a89945c9245949df schema:name doi
71 schema:value 10.1007/s11682-018-9863-7
72 rdf:type schema:PropertyValue
73 N057759651b9441b280b0879e9c7c1f04 schema:name dimensions_id
74 schema:value pub.1103186359
75 rdf:type schema:PropertyValue
76 N077235165d7c4f4f85c788c5a811a1ee schema:name pubmed_id
77 schema:value 29629498
78 rdf:type schema:PropertyValue
79 N1ed3a36032df448587a5d55cf93780ce rdf:first sg:person.01352145034.62
80 rdf:rest N481ea5b3269e45db948d5f39d79b72fa
81 N3c3debec346847528dd6fe26ab7d8a71 rdf:first sg:person.015411674024.29
82 rdf:rest rdf:nil
83 N481ea5b3269e45db948d5f39d79b72fa rdf:first sg:person.0700210224.61
84 rdf:rest N6f21ee48e9534ec8a9372c1b2aa6404f
85 N64c39514b21b419e87d0c191d94ed88c schema:volumeNumber 13
86 rdf:type schema:PublicationVolume
87 N669bcaf776eb4006906da317b0ebdadb schema:affiliation https://www.grid.ac/institutes/grid.9594.1
88 schema:familyName Xydis
89 schema:givenName Vassilios G.
90 rdf:type schema:Person
91 N6f21ee48e9534ec8a9372c1b2aa6404f rdf:first sg:person.01230371215.88
92 rdf:rest Nb690ea0a217a4e73b5c2923b9c5fff57
93 N79780605fcd44840a719356fd2dbe3fa schema:name readcube_id
94 schema:value 1e5a4b8e38b6cec04c78065951d1ccea6bd39eaf354cc1e526f0650d9f028602
95 rdf:type schema:PropertyValue
96 N7f219c4c49604c29b200af7db9a6a7bf schema:issueNumber 1
97 rdf:type schema:PublicationIssue
98 N87d64a08df564beb8a32a4f66dfaf97e schema:name nlm_unique_id
99 schema:value 101300405
100 rdf:type schema:PropertyValue
101 N8e9af0de3d234d55b8352e3127739770 rdf:first N669bcaf776eb4006906da317b0ebdadb
102 rdf:rest Ndb3626e6cc604b17bd1388d77621552f
103 Nb690ea0a217a4e73b5c2923b9c5fff57 rdf:first sg:person.01331477174.13
104 rdf:rest N8e9af0de3d234d55b8352e3127739770
105 Nc4b8409a1e6346a990f03335709b71d1 schema:name Springer Nature - SN SciGraph project
106 rdf:type schema:Organization
107 Ndb3626e6cc604b17bd1388d77621552f rdf:first sg:person.01206755015.46
108 rdf:rest Nf5093717dda0466e814e0a91263b20d3
109 Nf5093717dda0466e814e0a91263b20d3 rdf:first sg:person.0740567732.79
110 rdf:rest N3c3debec346847528dd6fe26ab7d8a71
111 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
112 schema:name Medical and Health Sciences
113 rdf:type schema:DefinedTerm
114 anzsrc-for:1109 schema:inDefinedTermSet anzsrc-for:
115 schema:name Neurosciences
116 rdf:type schema:DefinedTerm
117 sg:journal.1038420 schema:issn 1931-7557
118 1931-7565
119 schema:name Brain Imaging and Behavior
120 rdf:type schema:Periodical
121 sg:person.01206755015.46 schema:affiliation https://www.grid.ac/institutes/grid.416308.8
122 schema:familyName Antonini
123 schema:givenName Angelo
124 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01206755015.46
125 rdf:type schema:Person
126 sg:person.01230371215.88 schema:affiliation https://www.grid.ac/institutes/grid.9594.1
127 schema:familyName Zikou
128 schema:givenName Anastasia K.
129 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01230371215.88
130 rdf:type schema:Person
131 sg:person.01331477174.13 schema:affiliation https://www.grid.ac/institutes/grid.416308.8
132 schema:familyName Weis
133 schema:givenName Luca
134 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01331477174.13
135 rdf:type schema:Person
136 sg:person.01352145034.62 schema:affiliation https://www.grid.ac/institutes/grid.9594.1
137 schema:familyName Chondrogiorgi
138 schema:givenName Maria
139 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01352145034.62
140 rdf:type schema:Person
141 sg:person.015411674024.29 schema:affiliation https://www.grid.ac/institutes/grid.9594.1
142 schema:familyName Konitsiotis
143 schema:givenName Spiridon
144 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015411674024.29
145 rdf:type schema:Person
146 sg:person.0700210224.61 schema:affiliation https://www.grid.ac/institutes/grid.9594.1
147 schema:familyName Astrakas
148 schema:givenName Loukas G.
149 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0700210224.61
150 rdf:type schema:Person
151 sg:person.0740567732.79 schema:affiliation https://www.grid.ac/institutes/grid.9594.1
152 schema:familyName Argyropoulou
153 schema:givenName Maria I.
154 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0740567732.79
155 rdf:type schema:Person
156 sg:pub.10.1007/s00247-010-1677-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021746168
157 https://doi.org/10.1007/s00247-010-1677-8
158 rdf:type schema:CreativeWork
159 sg:pub.10.1007/s00330-013-2775-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036056631
160 https://doi.org/10.1007/s00330-013-2775-4
161 rdf:type schema:CreativeWork
162 sg:pub.10.1007/s00429-014-0785-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1024100164
163 https://doi.org/10.1007/s00429-014-0785-x
164 rdf:type schema:CreativeWork
165 https://doi.org/10.1002/hbm.21245 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007387340
166 rdf:type schema:CreativeWork
167 https://doi.org/10.1002/hbm.22256 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034272190
168 rdf:type schema:CreativeWork
169 https://doi.org/10.1002/hbm.22302 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000488020
170 rdf:type schema:CreativeWork
171 https://doi.org/10.1002/mds.21507 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028873866
172 rdf:type schema:CreativeWork
173 https://doi.org/10.1002/mds.21844 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000997385
174 rdf:type schema:CreativeWork
175 https://doi.org/10.1002/mds.22007 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017019541
176 rdf:type schema:CreativeWork
177 https://doi.org/10.1002/mds.22506 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018972286
178 rdf:type schema:CreativeWork
179 https://doi.org/10.1002/mds.23429 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009574356
180 rdf:type schema:CreativeWork
181 https://doi.org/10.1016/j.ejrad.2015.04.014 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021044024
182 rdf:type schema:CreativeWork
183 https://doi.org/10.1016/j.expneurol.2004.09.006 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046447821
184 rdf:type schema:CreativeWork
185 https://doi.org/10.1016/j.jns.2006.05.011 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003549802
186 rdf:type schema:CreativeWork
187 https://doi.org/10.1016/j.neubiorev.2006.06.003 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030028140
188 rdf:type schema:CreativeWork
189 https://doi.org/10.1016/j.neuroimage.2003.07.005 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011402998
190 rdf:type schema:CreativeWork
191 https://doi.org/10.1016/j.neuroimage.2004.07.051 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024629846
192 rdf:type schema:CreativeWork
193 https://doi.org/10.1016/j.neuroimage.2006.02.024 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023372670
194 rdf:type schema:CreativeWork
195 https://doi.org/10.1016/j.neuroimage.2012.06.012 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038331188
196 rdf:type schema:CreativeWork
197 https://doi.org/10.1016/j.nicl.2014.02.001 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030674840
198 rdf:type schema:CreativeWork
199 https://doi.org/10.1016/s0197-4580(02)00065-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016528708
200 rdf:type schema:CreativeWork
201 https://doi.org/10.1073/pnas.1004841107 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010088908
202 rdf:type schema:CreativeWork
203 https://doi.org/10.1089/neu.2009.1110 schema:sameAs https://app.dimensions.ai/details/publication/pub.1059301081
204 rdf:type schema:CreativeWork
205 https://doi.org/10.1093/brain/awt065 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010777294
206 rdf:type schema:CreativeWork
207 https://doi.org/10.1111/ane.12532 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002542321
208 rdf:type schema:CreativeWork
209 https://doi.org/10.1111/j.1600-0404.2007.00838.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1048401076
210 rdf:type schema:CreativeWork
211 https://doi.org/10.1136/jnnp.2009.184747 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006124920
212 rdf:type schema:CreativeWork
213 https://doi.org/10.1136/jnnp.55.3.181 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038938753
214 rdf:type schema:CreativeWork
215 https://doi.org/10.1159/000088526 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032481314
216 rdf:type schema:CreativeWork
217 https://doi.org/10.1159/000341998 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002450347
218 rdf:type schema:CreativeWork
219 https://doi.org/10.1177/1533317512470207 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002621964
220 rdf:type schema:CreativeWork
221 https://doi.org/10.1212/01.wnl.0000158422.41380.82 schema:sameAs https://app.dimensions.ai/details/publication/pub.1064346990
222 rdf:type schema:CreativeWork
223 https://doi.org/10.1212/wnl.0b013e318259e1c5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1064356991
224 rdf:type schema:CreativeWork
225 https://doi.org/10.1212/wnl.0b013e3182929f62 schema:sameAs https://app.dimensions.ai/details/publication/pub.1064357737
226 rdf:type schema:CreativeWork
227 https://doi.org/10.1212/wnl.40.10.1529 schema:sameAs https://app.dimensions.ai/details/publication/pub.1064368879
228 rdf:type schema:CreativeWork
229 https://doi.org/10.1371/journal.pone.0165540 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052877790
230 rdf:type schema:CreativeWork
231 https://doi.org/10.3174/ajnr.a2860 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009137990
232 rdf:type schema:CreativeWork
233 https://doi.org/10.3233/jad-2010-100678 schema:sameAs https://app.dimensions.ai/details/publication/pub.1078222647
234 rdf:type schema:CreativeWork
235 https://doi.org/10.3389/fnana.2016.00017 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028273503
236 rdf:type schema:CreativeWork
237 https://doi.org/10.3389/fneur.2013.00037 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011428702
238 rdf:type schema:CreativeWork
239 https://doi.org/10.4172/2161-0460.1000123 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012076461
240 rdf:type schema:CreativeWork
241 https://www.grid.ac/institutes/grid.416308.8 schema:alternateName Ospedale San Camillo
242 schema:name Parkinson Disease and Movement Disorders Unit, IRCCS San Camillo Hospital Foundation, via Alberoni, 70, 30126, Venice-Lido, Italy
243 rdf:type schema:Organization
244 https://www.grid.ac/institutes/grid.9594.1 schema:alternateName University of Ioannina
245 schema:name Department of Medical Physics, Medical School, University of Ioannina, Stavrou Niarchou Av., University Campus, 45110, Ioannina, Greece
246 Department of Neurology, Medical School, University of Ioannina, Stavrou Niarchou Av., University Campus, 45110, Ioannina, Greece
247 Department of Radiology, Medical School, University of Ioannina, Stavrou Niarchou Av., University Campus, 45110, Ioannina, Greece
248 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...