Cognitive performance in mid-stage Parkinson’s disease: functional connectivity under chronic antiparkinson treatment View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2017-09-23

AUTHORS

Roxana Vancea, Kristina Simonyan, Maria Petracca, Miroslaw Brys, Alessandro Di Rocco, Maria Felice Ghilardi, Matilde Inglese

ABSTRACT

Cognitive impairment in Parkinson’s disease (PD) is related to the reorganization of brain topology. Although drug challenge studies have proven how levodopa treatment can modulate functional connectivity in brain circuits, the role of chronic dopaminergic therapy on cognitive status and functional connectivity has never been investigated. We sought to characterize brain functional topology in mid-stage PD patients under chronic antiparkinson treatment and explore the presence of correlation between reorganization of brain architecture and specific cognitive deficits. We explored networks topology and functional connectivity in 16 patients with PD and 16 matched controls through a graph theoretical analysis of resting state-functional MRI data, and evaluated the relationships between network metrics and cognitive performance. PD patients showed a preserved small-world network topology but a lower clustering coefficient in comparison with healthy controls. Locally, PD patients showed lower degree of connectivity and local efficiency in many hubs corresponding to functionally relevant areas. Four disconnected subnetworks were also identified in regions responsible for executive control, sensory-motor control and planning, motor coordination and visual elaboration. Executive functions and information processing speed were directly correlated with degree of connectivity and local efficiency in frontal, parietal and occipital areas. While functional reorganization appears in both motor and cognitive areas, the clinical expression of network imbalance seems to be partially compensated by the chronic levodopa treatment with regards to the motor but not to the cognitive performance. In a context of reduced network segregation, the presence of higher local efficiency in hubs regions correlates with a better cognitive performance. More... »

PAGES

200-209

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s11682-017-9765-0

DOI

http://dx.doi.org/10.1007/s11682-017-9765-0

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1091907237

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/28942477


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/17", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Psychology and Cognitive Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1109", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Neurosciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1701", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Psychology", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Antiparkinson Agents", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Brain", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Brain Mapping", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cognition", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cognitive Dysfunction", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Female", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Magnetic Resonance Imaging", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Male", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Middle Aged", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Neural Pathways", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Parkinson Disease", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Prospective Studies", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Rest", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Department of Neurology, Icahn School of Medicine, Mount Sinai, One Gustave L. Levy Place Box 1137, 10029, New York, NY, USA", 
          "id": "http://www.grid.ac/institutes/grid.36425.36", 
          "name": [
            "Department of Neurology, Icahn School of Medicine, Mount Sinai, One Gustave L. Levy Place Box 1137, 10029, New York, NY, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Vancea", 
        "givenName": "Roxana", 
        "id": "sg:person.01103126107.10", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01103126107.10"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Annenberg Building Floor 20 Room 82, 1468 Madison Avenue, 10029, New York, NY, USA", 
          "id": "http://www.grid.ac/institutes/None", 
          "name": [
            "Department of Neurology, Icahn School of Medicine, Mount Sinai, One Gustave L. Levy Place Box 1137, 10029, New York, NY, USA", 
            "Annenberg Building Floor 20 Room 82, 1468 Madison Avenue, 10029, New York, NY, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Simonyan", 
        "givenName": "Kristina", 
        "id": "sg:person.01162613732.37", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01162613732.37"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Neuroscience, Universita\u2019 \u201cFederico II\u201d, Napoli, Italy", 
          "id": "http://www.grid.ac/institutes/grid.4691.a", 
          "name": [
            "Department of Neurology, Icahn School of Medicine, Mount Sinai, One Gustave L. Levy Place Box 1137, 10029, New York, NY, USA", 
            "Department of Neuroscience, Universita\u2019 \u201cFederico II\u201d, Napoli, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Petracca", 
        "givenName": "Maria", 
        "id": "sg:person.01235052027.86", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01235052027.86"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Neurology, New York University School of Medicine, NYU Movement Disorders, 240 East 38th Street, 20th Floor, 10016, New York, NY, USA", 
          "id": "http://www.grid.ac/institutes/grid.137628.9", 
          "name": [
            "Department of Neurology, New York University School of Medicine, NYU Movement Disorders, 240 East 38th Street, 20th Floor, 10016, New York, NY, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Brys", 
        "givenName": "Miroslaw", 
        "id": "sg:person.0743014463.20", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0743014463.20"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Neurology, New York University School of Medicine, NYU Movement Disorders, 240 East 38th Street, 20th Floor, 10016, New York, NY, USA", 
          "id": "http://www.grid.ac/institutes/grid.137628.9", 
          "name": [
            "Department of Neurology, New York University School of Medicine, NYU Movement Disorders, 240 East 38th Street, 20th Floor, 10016, New York, NY, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Di Rocco", 
        "givenName": "Alessandro", 
        "id": "sg:person.01035113714.42", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01035113714.42"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Physiology and Pharmacology, City University of New York Medical School, 138th and Convent Ave, 10031, New York, NY, USA", 
          "id": "http://www.grid.ac/institutes/grid.254250.4", 
          "name": [
            "Department of Physiology and Pharmacology, City University of New York Medical School, 138th and Convent Ave, 10031, New York, NY, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Ghilardi", 
        "givenName": "Maria Felice", 
        "id": "sg:person.01014442234.44", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01014442234.44"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Neuroscience, Rehabilitation, Ophthalmology, Genetics, Maternal and Child Health, University of Genova and IRCCS AOU San Martino-IST, Genova, Italy", 
          "id": "http://www.grid.ac/institutes/grid.410345.7", 
          "name": [
            "Department of Neurology, Icahn School of Medicine, Mount Sinai, One Gustave L. Levy Place Box 1137, 10029, New York, NY, USA", 
            "Department of Radiology, Icahn School of Medicine, Mount Sinai, New York, NY, USA", 
            "Department of Neuroscience, Icahn School of Medicine, Mount Sinai, New York, NY, USA", 
            "Department of Neuroscience, Rehabilitation, Ophthalmology, Genetics, Maternal and Child Health, University of Genova and IRCCS AOU San Martino-IST, Genova, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Inglese", 
        "givenName": "Matilde", 
        "id": "sg:person.013671065077.45", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013671065077.45"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "sg:pub.10.1038/nrn2575", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004953014", 
          "https://doi.org/10.1038/nrn2575"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00415-015-7750-3", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006888044", 
          "https://doi.org/10.1007/s00415-015-7750-3"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2017-09-23", 
    "datePublishedReg": "2017-09-23", 
    "description": "Cognitive impairment in Parkinson\u2019s disease (PD) is related to the reorganization of brain topology. Although drug challenge studies have proven how levodopa treatment can modulate functional connectivity in brain circuits, the role of chronic dopaminergic therapy on cognitive status and functional connectivity has never been investigated. We sought to characterize brain functional topology in mid-stage PD patients under chronic antiparkinson treatment and explore the presence of correlation between reorganization of brain architecture and specific cognitive deficits. We explored networks topology and functional connectivity in 16 patients with PD and 16 matched controls through a graph theoretical analysis of resting state-functional MRI data, and evaluated the relationships between network metrics and cognitive performance. PD patients showed a preserved small-world network topology but a lower clustering coefficient in comparison with healthy controls. Locally, PD patients showed lower degree of connectivity and local efficiency in many hubs corresponding to functionally relevant areas. Four disconnected subnetworks were also identified in regions responsible for executive control, sensory-motor control and planning, motor coordination and visual elaboration. Executive functions and information processing speed were directly correlated with degree of connectivity and local efficiency in frontal, parietal and occipital areas. While functional reorganization appears in both motor and cognitive areas, the clinical expression of network imbalance seems to be partially compensated by the chronic levodopa treatment with regards to the motor but not to the cognitive performance. In a context of reduced network segregation, the presence of higher local efficiency in hubs regions correlates with a better cognitive performance.", 
    "genre": "article", 
    "id": "sg:pub.10.1007/s11682-017-9765-0", 
    "isAccessibleForFree": true, 
    "isFundedItemOf": [
      {
        "id": "sg:grant.2561692", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.2489415", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.4242796", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.2441650", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.2489358", 
        "type": "MonetaryGrant"
      }
    ], 
    "isPartOf": [
      {
        "id": "sg:journal.1038420", 
        "issn": [
          "1931-7557", 
          "1931-7565"
        ], 
        "name": "Brain Imaging and Behavior", 
        "publisher": "Springer Nature", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "1", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "13"
      }
    ], 
    "keywords": [
      "Parkinson's disease", 
      "PD patients", 
      "functional connectivity", 
      "antiparkinson treatment", 
      "levodopa treatment", 
      "cognitive performance", 
      "mid-stage PD patients", 
      "mid-stage Parkinson's disease", 
      "chronic levodopa treatment", 
      "chronic dopaminergic therapy", 
      "state functional MRI data", 
      "local efficiency", 
      "drug challenge studies", 
      "dopaminergic therapy", 
      "healthy controls", 
      "information processing speed", 
      "clinical expression", 
      "motor coordination", 
      "functional reorganization", 
      "specific cognitive deficits", 
      "sensory-motor control", 
      "higher local efficiency", 
      "cognitive impairment", 
      "patients", 
      "challenge studies", 
      "cognitive status", 
      "brain circuits", 
      "cognitive deficits", 
      "occipital areas", 
      "disease", 
      "graph theoretical analysis", 
      "treatment", 
      "executive function", 
      "brain architecture", 
      "brain functional topology", 
      "MRI data", 
      "cognitive areas", 
      "network segregation", 
      "hub regions", 
      "brain topology", 
      "executive control", 
      "visual elaboration", 
      "therapy", 
      "control", 
      "processing speed", 
      "impairment", 
      "functional topology", 
      "deficits", 
      "network imbalance", 
      "status", 
      "presence", 
      "reorganization", 
      "expression", 
      "small-world network topology", 
      "imbalance", 
      "connectivity", 
      "study", 
      "area", 
      "role", 
      "degree", 
      "correlation", 
      "disconnected subnetworks", 
      "low degree", 
      "relevant areas", 
      "motor", 
      "regard", 
      "function", 
      "data", 
      "performance", 
      "relationship", 
      "region", 
      "network metrics", 
      "comparison", 
      "analysis", 
      "presence of correlations", 
      "context", 
      "clustering coefficient", 
      "elaboration", 
      "planning", 
      "coordination", 
      "subnetworks", 
      "degree of connectivity", 
      "hub", 
      "speed", 
      "circuit", 
      "metrics", 
      "architecture", 
      "network topology", 
      "coefficient", 
      "segregation", 
      "efficiency", 
      "theoretical analysis", 
      "topology"
    ], 
    "name": "Cognitive performance in mid-stage Parkinson\u2019s disease: functional connectivity under chronic antiparkinson treatment", 
    "pagination": "200-209", 
    "productId": [
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1091907237"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1007/s11682-017-9765-0"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "28942477"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1007/s11682-017-9765-0", 
      "https://app.dimensions.ai/details/publication/pub.1091907237"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2022-11-24T21:01", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-springernature-scigraph/baseset/20221124/entities/gbq_results/article/article_719.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://doi.org/10.1007/s11682-017-9765-0"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s11682-017-9765-0'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s11682-017-9765-0'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s11682-017-9765-0'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s11682-017-9765-0'


 

This table displays all metadata directly associated to this object as RDF triples.

298 TRIPLES      21 PREDICATES      136 URIs      124 LITERALS      21 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1007/s11682-017-9765-0 schema:about N07f78654c90a468bafb43fc1c1a46a0b
2 N2d957861b14145f3bbaafdc40d8a67ad
3 N403cea47a8a946458d924b6b17f9df05
4 N666e7ea540a74339a0b75e32b9566777
5 N7590c600d8824858bdff8f1539ab90e3
6 N7c7ae7f951b044b6ae8887bfee32e214
7 N7eb2066592434efabcaf53c42b596f2c
8 N92d1a5ada4f04f51b3698d39b405aadf
9 Na46cdf2550e4416b8f7b2aa1e0295416
10 Nc380dd951d444b49810868b772940874
11 Nc6f7882b111642d6afaf2b6393352f67
12 Nd978a153d390473bbf727351227a056c
13 Nf27cffc7f4e74c09b94f0fa0635dbd8e
14 Nf7678f111f714a87a963236e730afb8c
15 anzsrc-for:11
16 anzsrc-for:1109
17 anzsrc-for:17
18 anzsrc-for:1701
19 schema:author Nb7083828b8034b69bed17c77c3be4332
20 schema:citation sg:pub.10.1007/s00415-015-7750-3
21 sg:pub.10.1038/nrn2575
22 schema:datePublished 2017-09-23
23 schema:datePublishedReg 2017-09-23
24 schema:description Cognitive impairment in Parkinson’s disease (PD) is related to the reorganization of brain topology. Although drug challenge studies have proven how levodopa treatment can modulate functional connectivity in brain circuits, the role of chronic dopaminergic therapy on cognitive status and functional connectivity has never been investigated. We sought to characterize brain functional topology in mid-stage PD patients under chronic antiparkinson treatment and explore the presence of correlation between reorganization of brain architecture and specific cognitive deficits. We explored networks topology and functional connectivity in 16 patients with PD and 16 matched controls through a graph theoretical analysis of resting state-functional MRI data, and evaluated the relationships between network metrics and cognitive performance. PD patients showed a preserved small-world network topology but a lower clustering coefficient in comparison with healthy controls. Locally, PD patients showed lower degree of connectivity and local efficiency in many hubs corresponding to functionally relevant areas. Four disconnected subnetworks were also identified in regions responsible for executive control, sensory-motor control and planning, motor coordination and visual elaboration. Executive functions and information processing speed were directly correlated with degree of connectivity and local efficiency in frontal, parietal and occipital areas. While functional reorganization appears in both motor and cognitive areas, the clinical expression of network imbalance seems to be partially compensated by the chronic levodopa treatment with regards to the motor but not to the cognitive performance. In a context of reduced network segregation, the presence of higher local efficiency in hubs regions correlates with a better cognitive performance.
25 schema:genre article
26 schema:isAccessibleForFree true
27 schema:isPartOf N473b2e0ee2314d32b6535fb9ed9b4edf
28 Nbecc498c3b104d5cb7155c9c6a5a3986
29 sg:journal.1038420
30 schema:keywords MRI data
31 PD patients
32 Parkinson's disease
33 analysis
34 antiparkinson treatment
35 architecture
36 area
37 brain architecture
38 brain circuits
39 brain functional topology
40 brain topology
41 challenge studies
42 chronic dopaminergic therapy
43 chronic levodopa treatment
44 circuit
45 clinical expression
46 clustering coefficient
47 coefficient
48 cognitive areas
49 cognitive deficits
50 cognitive impairment
51 cognitive performance
52 cognitive status
53 comparison
54 connectivity
55 context
56 control
57 coordination
58 correlation
59 data
60 deficits
61 degree
62 degree of connectivity
63 disconnected subnetworks
64 disease
65 dopaminergic therapy
66 drug challenge studies
67 efficiency
68 elaboration
69 executive control
70 executive function
71 expression
72 function
73 functional connectivity
74 functional reorganization
75 functional topology
76 graph theoretical analysis
77 healthy controls
78 higher local efficiency
79 hub
80 hub regions
81 imbalance
82 impairment
83 information processing speed
84 levodopa treatment
85 local efficiency
86 low degree
87 metrics
88 mid-stage PD patients
89 mid-stage Parkinson's disease
90 motor
91 motor coordination
92 network imbalance
93 network metrics
94 network segregation
95 network topology
96 occipital areas
97 patients
98 performance
99 planning
100 presence
101 presence of correlations
102 processing speed
103 regard
104 region
105 relationship
106 relevant areas
107 reorganization
108 role
109 segregation
110 sensory-motor control
111 small-world network topology
112 specific cognitive deficits
113 speed
114 state functional MRI data
115 status
116 study
117 subnetworks
118 theoretical analysis
119 therapy
120 topology
121 treatment
122 visual elaboration
123 schema:name Cognitive performance in mid-stage Parkinson’s disease: functional connectivity under chronic antiparkinson treatment
124 schema:pagination 200-209
125 schema:productId N3722d885032c4848b7915fd10c02f6bc
126 N95b3927ef96547bfa014b533f477d843
127 Nb0fe5f41042e41e0a562291182ebc31c
128 schema:sameAs https://app.dimensions.ai/details/publication/pub.1091907237
129 https://doi.org/10.1007/s11682-017-9765-0
130 schema:sdDatePublished 2022-11-24T21:01
131 schema:sdLicense https://scigraph.springernature.com/explorer/license/
132 schema:sdPublisher N545335255eba4565b64f4dd681abad11
133 schema:url https://doi.org/10.1007/s11682-017-9765-0
134 sgo:license sg:explorer/license/
135 sgo:sdDataset articles
136 rdf:type schema:ScholarlyArticle
137 N07a97b6265174b84be153cea0ac50950 rdf:first sg:person.01014442234.44
138 rdf:rest N090fcbf448ef461385621da8e185b642
139 N07f78654c90a468bafb43fc1c1a46a0b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
140 schema:name Rest
141 rdf:type schema:DefinedTerm
142 N090fcbf448ef461385621da8e185b642 rdf:first sg:person.013671065077.45
143 rdf:rest rdf:nil
144 N2d957861b14145f3bbaafdc40d8a67ad schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
145 schema:name Brain
146 rdf:type schema:DefinedTerm
147 N3722d885032c4848b7915fd10c02f6bc schema:name doi
148 schema:value 10.1007/s11682-017-9765-0
149 rdf:type schema:PropertyValue
150 N403cea47a8a946458d924b6b17f9df05 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
151 schema:name Cognition
152 rdf:type schema:DefinedTerm
153 N473b2e0ee2314d32b6535fb9ed9b4edf schema:volumeNumber 13
154 rdf:type schema:PublicationVolume
155 N48228bde902e4f39b467562ecb097b14 rdf:first sg:person.0743014463.20
156 rdf:rest Nf25cc1a6f6684c0c952e3f60cecdab1e
157 N545335255eba4565b64f4dd681abad11 schema:name Springer Nature - SN SciGraph project
158 rdf:type schema:Organization
159 N666e7ea540a74339a0b75e32b9566777 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
160 schema:name Middle Aged
161 rdf:type schema:DefinedTerm
162 N716240dac86c43659001ac2520f4476f rdf:first sg:person.01162613732.37
163 rdf:rest Nad9a54f1ec35454886869486d2a2ff86
164 N7590c600d8824858bdff8f1539ab90e3 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
165 schema:name Antiparkinson Agents
166 rdf:type schema:DefinedTerm
167 N7c7ae7f951b044b6ae8887bfee32e214 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
168 schema:name Neural Pathways
169 rdf:type schema:DefinedTerm
170 N7eb2066592434efabcaf53c42b596f2c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
171 schema:name Prospective Studies
172 rdf:type schema:DefinedTerm
173 N92d1a5ada4f04f51b3698d39b405aadf schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
174 schema:name Parkinson Disease
175 rdf:type schema:DefinedTerm
176 N95b3927ef96547bfa014b533f477d843 schema:name pubmed_id
177 schema:value 28942477
178 rdf:type schema:PropertyValue
179 Na46cdf2550e4416b8f7b2aa1e0295416 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
180 schema:name Male
181 rdf:type schema:DefinedTerm
182 Nad9a54f1ec35454886869486d2a2ff86 rdf:first sg:person.01235052027.86
183 rdf:rest N48228bde902e4f39b467562ecb097b14
184 Nb0fe5f41042e41e0a562291182ebc31c schema:name dimensions_id
185 schema:value pub.1091907237
186 rdf:type schema:PropertyValue
187 Nb7083828b8034b69bed17c77c3be4332 rdf:first sg:person.01103126107.10
188 rdf:rest N716240dac86c43659001ac2520f4476f
189 Nbecc498c3b104d5cb7155c9c6a5a3986 schema:issueNumber 1
190 rdf:type schema:PublicationIssue
191 Nc380dd951d444b49810868b772940874 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
192 schema:name Brain Mapping
193 rdf:type schema:DefinedTerm
194 Nc6f7882b111642d6afaf2b6393352f67 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
195 schema:name Female
196 rdf:type schema:DefinedTerm
197 Nd978a153d390473bbf727351227a056c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
198 schema:name Magnetic Resonance Imaging
199 rdf:type schema:DefinedTerm
200 Nf25cc1a6f6684c0c952e3f60cecdab1e rdf:first sg:person.01035113714.42
201 rdf:rest N07a97b6265174b84be153cea0ac50950
202 Nf27cffc7f4e74c09b94f0fa0635dbd8e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
203 schema:name Cognitive Dysfunction
204 rdf:type schema:DefinedTerm
205 Nf7678f111f714a87a963236e730afb8c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
206 schema:name Humans
207 rdf:type schema:DefinedTerm
208 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
209 schema:name Medical and Health Sciences
210 rdf:type schema:DefinedTerm
211 anzsrc-for:1109 schema:inDefinedTermSet anzsrc-for:
212 schema:name Neurosciences
213 rdf:type schema:DefinedTerm
214 anzsrc-for:17 schema:inDefinedTermSet anzsrc-for:
215 schema:name Psychology and Cognitive Sciences
216 rdf:type schema:DefinedTerm
217 anzsrc-for:1701 schema:inDefinedTermSet anzsrc-for:
218 schema:name Psychology
219 rdf:type schema:DefinedTerm
220 sg:grant.2441650 http://pending.schema.org/fundedItem sg:pub.10.1007/s11682-017-9765-0
221 rdf:type schema:MonetaryGrant
222 sg:grant.2489358 http://pending.schema.org/fundedItem sg:pub.10.1007/s11682-017-9765-0
223 rdf:type schema:MonetaryGrant
224 sg:grant.2489415 http://pending.schema.org/fundedItem sg:pub.10.1007/s11682-017-9765-0
225 rdf:type schema:MonetaryGrant
226 sg:grant.2561692 http://pending.schema.org/fundedItem sg:pub.10.1007/s11682-017-9765-0
227 rdf:type schema:MonetaryGrant
228 sg:grant.4242796 http://pending.schema.org/fundedItem sg:pub.10.1007/s11682-017-9765-0
229 rdf:type schema:MonetaryGrant
230 sg:journal.1038420 schema:issn 1931-7557
231 1931-7565
232 schema:name Brain Imaging and Behavior
233 schema:publisher Springer Nature
234 rdf:type schema:Periodical
235 sg:person.01014442234.44 schema:affiliation grid-institutes:grid.254250.4
236 schema:familyName Ghilardi
237 schema:givenName Maria Felice
238 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01014442234.44
239 rdf:type schema:Person
240 sg:person.01035113714.42 schema:affiliation grid-institutes:grid.137628.9
241 schema:familyName Di Rocco
242 schema:givenName Alessandro
243 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01035113714.42
244 rdf:type schema:Person
245 sg:person.01103126107.10 schema:affiliation grid-institutes:grid.36425.36
246 schema:familyName Vancea
247 schema:givenName Roxana
248 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01103126107.10
249 rdf:type schema:Person
250 sg:person.01162613732.37 schema:affiliation grid-institutes:None
251 schema:familyName Simonyan
252 schema:givenName Kristina
253 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01162613732.37
254 rdf:type schema:Person
255 sg:person.01235052027.86 schema:affiliation grid-institutes:grid.4691.a
256 schema:familyName Petracca
257 schema:givenName Maria
258 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01235052027.86
259 rdf:type schema:Person
260 sg:person.013671065077.45 schema:affiliation grid-institutes:grid.410345.7
261 schema:familyName Inglese
262 schema:givenName Matilde
263 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013671065077.45
264 rdf:type schema:Person
265 sg:person.0743014463.20 schema:affiliation grid-institutes:grid.137628.9
266 schema:familyName Brys
267 schema:givenName Miroslaw
268 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0743014463.20
269 rdf:type schema:Person
270 sg:pub.10.1007/s00415-015-7750-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006888044
271 https://doi.org/10.1007/s00415-015-7750-3
272 rdf:type schema:CreativeWork
273 sg:pub.10.1038/nrn2575 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004953014
274 https://doi.org/10.1038/nrn2575
275 rdf:type schema:CreativeWork
276 grid-institutes:None schema:alternateName Annenberg Building Floor 20 Room 82, 1468 Madison Avenue, 10029, New York, NY, USA
277 schema:name Annenberg Building Floor 20 Room 82, 1468 Madison Avenue, 10029, New York, NY, USA
278 Department of Neurology, Icahn School of Medicine, Mount Sinai, One Gustave L. Levy Place Box 1137, 10029, New York, NY, USA
279 rdf:type schema:Organization
280 grid-institutes:grid.137628.9 schema:alternateName Department of Neurology, New York University School of Medicine, NYU Movement Disorders, 240 East 38th Street, 20th Floor, 10016, New York, NY, USA
281 schema:name Department of Neurology, New York University School of Medicine, NYU Movement Disorders, 240 East 38th Street, 20th Floor, 10016, New York, NY, USA
282 rdf:type schema:Organization
283 grid-institutes:grid.254250.4 schema:alternateName Department of Physiology and Pharmacology, City University of New York Medical School, 138th and Convent Ave, 10031, New York, NY, USA
284 schema:name Department of Physiology and Pharmacology, City University of New York Medical School, 138th and Convent Ave, 10031, New York, NY, USA
285 rdf:type schema:Organization
286 grid-institutes:grid.36425.36 schema:alternateName Department of Neurology, Icahn School of Medicine, Mount Sinai, One Gustave L. Levy Place Box 1137, 10029, New York, NY, USA
287 schema:name Department of Neurology, Icahn School of Medicine, Mount Sinai, One Gustave L. Levy Place Box 1137, 10029, New York, NY, USA
288 rdf:type schema:Organization
289 grid-institutes:grid.410345.7 schema:alternateName Department of Neuroscience, Rehabilitation, Ophthalmology, Genetics, Maternal and Child Health, University of Genova and IRCCS AOU San Martino-IST, Genova, Italy
290 schema:name Department of Neurology, Icahn School of Medicine, Mount Sinai, One Gustave L. Levy Place Box 1137, 10029, New York, NY, USA
291 Department of Neuroscience, Icahn School of Medicine, Mount Sinai, New York, NY, USA
292 Department of Neuroscience, Rehabilitation, Ophthalmology, Genetics, Maternal and Child Health, University of Genova and IRCCS AOU San Martino-IST, Genova, Italy
293 Department of Radiology, Icahn School of Medicine, Mount Sinai, New York, NY, USA
294 rdf:type schema:Organization
295 grid-institutes:grid.4691.a schema:alternateName Department of Neuroscience, Universita’ “Federico II”, Napoli, Italy
296 schema:name Department of Neurology, Icahn School of Medicine, Mount Sinai, One Gustave L. Levy Place Box 1137, 10029, New York, NY, USA
297 Department of Neuroscience, Universita’ “Federico II”, Napoli, Italy
298 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...