Brain white matter structural networks in patients with non-neuropsychiatric systemic lupus erythematosus View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2017-02-11

AUTHORS

Ling Zhao, Xiangliang Tan, Junjing Wang, Kai Han, Meiqi Niu, Jun Xu, Xiaojin Liu, Xixi Zhao, Miao Zhong, Qin Huang, Yikai Xu, Ruiwang Huang

ABSTRACT

Previous neuroimaging studies have revealed cognitive dysfunction in patients with systemic lupus erythematosus (SLE) and suggested that it may be related to disrupted brain white matter (WM) connectivity. However, no study has examined the topological properties of brain WM structural networks in SLE patients, especially in patients with non-neuropsychiatric SLE (non-NPSLE). In this study, we acquired DTI datasets from 28 non-NPSLE patients and 24 healthy controls, constructed their brain WM structural networks by using a deterministic fiber tracking approach, estimated the topological parameters of their structural networks, and compared their group differences. We reached the following results: 1) At the global level, the non-NPSLE patients showed significantly increased characteristic path length, normalized clustering coefficient and small-worldness, but significantly decreased global efficiency and local efficiency compared to the controls; 2) At the nodal level, the non-NPSLE patients had significantly decreased nodal efficiency in regions related to movement control, executive control, and working memory (bilateral precentral gyri, bilateral middle frontal gyri, bilateral inferior parietal lobes, left median cingulate gyrus and paracingulate gyrus, and right middle temporal gyrus). In addition, to pinpointing the injured WM fiber tracts in the non-NPSLE patients, we reconstructed the major brain WM pathways connecting the abnormal regions at the nodal level with the corticospinal tract (CST), superior longitudinal fasciculus-parietal terminations (SLFP), and superior longitudinal fasciculus-temporal terminations (SLFT). By analyzing the diffusion parameters along these WM fiber pathways, we detected abnormal diffusion parameters in the bilateral CST and right SLFT in the non-NPSLE patients. These results seem to indicate that injured brain WM connectivity exists in SLE patients even in the absence of neuropsychiatric symptoms. More... »

PAGES

142-155

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s11682-017-9681-3

DOI

http://dx.doi.org/10.1007/s11682-017-9681-3

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1083765965

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/28190161


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25 schema:description Previous neuroimaging studies have revealed cognitive dysfunction in patients with systemic lupus erythematosus (SLE) and suggested that it may be related to disrupted brain white matter (WM) connectivity. However, no study has examined the topological properties of brain WM structural networks in SLE patients, especially in patients with non-neuropsychiatric SLE (non-NPSLE). In this study, we acquired DTI datasets from 28 non-NPSLE patients and 24 healthy controls, constructed their brain WM structural networks by using a deterministic fiber tracking approach, estimated the topological parameters of their structural networks, and compared their group differences. We reached the following results: 1) At the global level, the non-NPSLE patients showed significantly increased characteristic path length, normalized clustering coefficient and small-worldness, but significantly decreased global efficiency and local efficiency compared to the controls; 2) At the nodal level, the non-NPSLE patients had significantly decreased nodal efficiency in regions related to movement control, executive control, and working memory (bilateral precentral gyri, bilateral middle frontal gyri, bilateral inferior parietal lobes, left median cingulate gyrus and paracingulate gyrus, and right middle temporal gyrus). In addition, to pinpointing the injured WM fiber tracts in the non-NPSLE patients, we reconstructed the major brain WM pathways connecting the abnormal regions at the nodal level with the corticospinal tract (CST), superior longitudinal fasciculus-parietal terminations (SLFP), and superior longitudinal fasciculus-temporal terminations (SLFT). By analyzing the diffusion parameters along these WM fiber pathways, we detected abnormal diffusion parameters in the bilateral CST and right SLFT in the non-NPSLE patients. These results seem to indicate that injured brain WM connectivity exists in SLE patients even in the absence of neuropsychiatric symptoms.
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31 schema:keywords DTI datasets
32 Previous neuroimaging studies
33 SLE patients
34 WM connectivity
35 WM fiber pathways
36 WM fiber tracts
37 WM pathways
38 WM structural networks
39 abnormal regions
40 absence
41 addition
42 approach
43 bilateral corticospinal tracts
44 brain white matter connectivity
45 brain white matter structural networks
46 characteristic path length
47 coefficient
48 cognitive dysfunction
49 connectivity
50 control
51 corticospinal tract
52 dataset
53 deterministic fiber tracking approach
54 differences
55 diffusion parameters
56 dysfunction
57 efficiency
58 erythematosus
59 executive control
60 fiber pathways
61 fiber tracking approach
62 fiber tracts
63 following results
64 global efficiency
65 global level
66 group differences
67 healthy controls
68 length
69 levels
70 local efficiency
71 lupus erythematosus
72 memory
73 movement control
74 network
75 neuroimaging studies
76 neuropsychiatric symptoms
77 nodal efficiency
78 nodal level
79 non-NPSLE patients
80 non-neuropsychiatric systemic lupus erythematosus
81 parameters
82 path length
83 pathway
84 patients
85 properties
86 region
87 results
88 structural network
89 study
90 symptoms
91 systemic lupus erythematosus
92 termination
93 topological parameters
94 topological properties
95 tracking approach
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