IFN-γ regulates Fas/FasL expression in cholangio carcinoma cells View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2005-03

AUTHORS

Zi-yu Li, Lian-hai Zhang, Jia-fu Ji

ABSTRACT

Objective: To study the regulation of Fas receptor (Fas)/Fas ligand (FasL) expression by IFN-γ in cholangiocarcinoma cell lines. Methods: We studied the expressions of Fas and FasL gene in the human cholangiocarcinoma cell line QBC939 by RT-PCR, Western blot, and immunohistochemistry and their apoptosis effects on human T cell line Jurkat cell. At the same time, we investigated the regulative effect of IFN-γ on them. Results: Fas, FasL mRNA and protein were expressed by cholangiocarcinoma cells. We also found IFN-γ could up-regulate the expressions of these two genes. However, IFN-γ could also down-regulate the ability of them to make Jurkat cells apoptotic. With the increasing of dosage and time, the effect was enhanced. Conclusion: IFN-γ could regulate the expression of Fas and FasL in cholangiocarcinoma cells, and might influence the ability of cholangiocarcinoma to regulate immune escape. This study provides new theoretical basis for immunological therapy of cholangiocarcinoma. More... »

PAGES

40-43

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s11670-005-0008-3

DOI

http://dx.doi.org/10.1007/s11670-005-0008-3

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1014888111


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