Does hip structural analysis confer additional benefit to routine BMD assessment in postmenopausal women with hip fracture? A study from ... View Full Text


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DATE

2022-02-05

AUTHORS

Johns T. Johnson, Kripa Elizabeth Cherian, Nitin Kapoor, Felix K. Jebasingh, Hesarghatta Shyamsunder Asha, Thomas Mathai, Manasseh Nithyananth, Anil Thomas Oommen, Alfred Job Daniel, Nihal Thomas, Thomas Vizhalil Paul

ABSTRACT

Summary This study from southern India showed that proximal hip geometry was significantly impaired in postmenopausal women with femoral neck fracture. The trabecular bone score (TBS), which is reflective of bone microarchitecture, was also significantly impaired in patients with fracture.IntroductionThere is limited information with regard to comprehensive bone health in Indian postmenopausal women with neck of femur fracture. We studied the bone mineral density (BMD), trabecular bone score (TBS), proximal hip geometry, and bone mineral biochemistry in postmenopausal women with and without femoral neck fractures.MethodsThis was a cross-sectional study conducted at a tertiary care center in South India. BMD, TBS, and hip structural analysis (HSA) were assessed using a dual-energy X-ray absorptiometry (DXA) scanner. Bone mineral biochemical profiles were also studied.ResultsA total of 90 postmenopausal women with acute femoral neck fracture with mean (SD) age of 63.2 (6.1) years and 90 age-matched controls were included. The prevalence of osteoporosis was higher among cases as compared to controls (83.3% vs 47.8%; P < 0.001). Degraded bone microarchitecture (TBS value < 1.200) was more frequent among women with hip fracture as compared to controls (46.7% vs 31.1%; P = 0.032). Cross-sectional moment of inertia (CSMI) was significantly lower at the narrow neck (NN) and inter-trochanteric (IT) region in cases (P < 0.05) and buckling ratio (BR) was significantly higher at all three sites in postmenopausal women with femoral neck fracture as compared controls. Multivariate logistic regression analysis showed that femoral neck osteoporosis, low CSMI at NN and high BR at NN and femoral shaft emerged as factors significantly associated with femoral neck fractures.ConclusionThis study highlights that impaired parameters of proximal hip geometry and a low trabecular bone score may be significantly associated with femoral neck fractures in postmenopausal women. More... »

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32

References to SciGraph publications

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  • 2017-10-07. The Trabecular Bone Score (TBS) Complements DXA and the FRAX as a Fracture Risk Assessment Tool in Routine Clinical Practice in CURRENT OSTEOPOROSIS REPORTS
  • Identifiers

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    http://scigraph.springernature.com/pub.10.1007/s11657-022-01070-4

    DOI

    http://dx.doi.org/10.1007/s11657-022-01070-4

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    28 schema:description Abstract Summary This study from southern India showed that proximal hip geometry was significantly impaired in postmenopausal women with femoral neck fracture. The trabecular bone score (TBS), which is reflective of bone microarchitecture, was also significantly impaired in patients with fracture.IntroductionThere is limited information with regard to comprehensive bone health in Indian postmenopausal women with neck of femur fracture. We studied the bone mineral density (BMD), trabecular bone score (TBS), proximal hip geometry, and bone mineral biochemistry in postmenopausal women with and without femoral neck fractures.MethodsThis was a cross-sectional study conducted at a tertiary care center in South India. BMD, TBS, and hip structural analysis (HSA) were assessed using a dual-energy X-ray absorptiometry (DXA) scanner. Bone mineral biochemical profiles were also studied.ResultsA total of 90 postmenopausal women with acute femoral neck fracture with mean (SD) age of 63.2 (6.1) years and 90 age-matched controls were included. The prevalence of osteoporosis was higher among cases as compared to controls (83.3% vs 47.8%; P < 0.001). Degraded bone microarchitecture (TBS value < 1.200) was more frequent among women with hip fracture as compared to controls (46.7% vs 31.1%; P = 0.032). Cross-sectional moment of inertia (CSMI) was significantly lower at the narrow neck (NN) and inter-trochanteric (IT) region in cases (P < 0.05) and buckling ratio (BR) was significantly higher at all three sites in postmenopausal women with femoral neck fracture as compared controls. Multivariate logistic regression analysis showed that femoral neck osteoporosis, low CSMI at NN and high BR at NN and femoral shaft emerged as factors significantly associated with femoral neck fractures.ConclusionThis study highlights that impaired parameters of proximal hip geometry and a low trabecular bone score may be significantly associated with femoral neck fractures in postmenopausal women.
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    35 Br
    36 CSMI
    37 ConclusionThis study highlights
    38 India
    39 Indian postmenopausal women
    40 IntroductionThere
    41 MethodsThis
    42 ResultsA total
    43 South India
    44 acute femoral neck fractures
    45 additional benefit
    46 age
    47 age-matched controls
    48 analysis
    49 assessment
    50 benefits
    51 biochemical profile
    52 biochemistry
    53 bone health
    54 bone microarchitecture
    55 bone mineral density
    56 bone score
    57 care center
    58 cases
    59 center
    60 control
    61 cross-sectional moment
    62 cross-sectional study
    63 density
    64 dual-energy X-ray absorptiometry scanner
    65 factors
    66 femoral neck fractures
    67 femoral neck osteoporosis
    68 femoral shaft
    69 femur fractures
    70 fractures
    71 geometry
    72 health
    73 high Br
    74 highlights
    75 hip fracture
    76 hip geometry
    77 hip structural analysis
    78 inertia
    79 information
    80 inter-trochanteric region
    81 limited information
    82 logistic regression analysis
    83 lower CSMI
    84 lower trabecular bone score
    85 mean age
    86 microarchitecture
    87 mineral density
    88 moment
    89 multivariate logistic regression analysis
    90 narrow neck
    91 neck
    92 neck fractures
    93 osteoporosis
    94 parameters
    95 patients
    96 postmenopausal women
    97 prevalence
    98 prevalence of osteoporosis
    99 profile
    100 proximal hip geometry
    101 ratio
    102 regard
    103 region
    104 regression analysis
    105 scanner
    106 scores
    107 shaft
    108 sites
    109 southern India
    110 structural analysis
    111 study
    112 study highlight
    113 summary
    114 tertiary care center
    115 tertiary center
    116 total
    117 trabecular bone score
    118 women
    119 years
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