FRAX® with or without BMD and TBS predicts fragility fractures in community-dwelling rural southern Indian postmenopausal women View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2020-06-01

AUTHORS

Remya Rajan, Jinson Paul, Kripa Elizabeth Cherian, Hesarghatta S Asha, Nitin Kapoor, Thomas V Paul

ABSTRACT

This study from southern India showed that FRAX® with or without BMD or TBS predicted fragility vertebral fractures at a cut-off of ≥ 9% for major osteoporotic fracture and ≥ 2.5% for hip fracture with sensitivities of 77–88% and specificities of 55–72%.PurposeThere is limited information available with regard to utility of Fracture Risk Assessment Tool (FRAX® tool) in predicting fragility fractures in Indian postmenopausal women. We studied the performance of 3 categories: FRAX® (without BMD), FRAX® (with BMD), and FRAX® (with BMD and TBS) in predicting fragility vertebral fractures in rural postmenopausal women.Material and methodsIt was a cross-sectional study conducted at a south Indian tertiary care center. Rural postmenopausal women (n = 301) were recruited by simple random sampling. The risk for major osteoporotic fracture (MOF) and hip fracture (HF) was calculated individually for the 3 categories. The BMD (at lumbar spine and femoral neck) and vertebral fractures were assessed by a DXA (dual energy X-ray absorptiometry) scanner and TBS by TBS iNsight software. ROC curves were constructed, and area under curve (AUC), sensitivity and specificity of FRAX® scores, which would best predict prevalent vertebral fractures (moderate to severe), was computed.ResultsThe mean (SD) age was 65.6(5.1) years. The prevalence of osteoporosis at spine was 45%, and femoral neck was 32.6%. Moderate to severe vertebral fractures was seen in 29.2% of subjects. The performance of all 3 categories for FRAX® (MOF) and FRAX® (HF) were good (AUC was 0.798, 0.806, and 0.800, respectively, for MOF) at a cut-off score of ≥ 9, and at a cut-off of ≥ 2.5 for HF, it was 0.818, 0.775, and 0.770, respectively. At these cut-offs, sensitivities were 77–89%, and specificities were 55–72% for predicting prevalent vertebral fractures.ConclusionAll three categories of FRAX® showed good performance in predicting fractures in Indian postmenopausal women. Thus, it may be utilized for decision regarding treatment and referral for osteoporosis. More... »

PAGES

82

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s11657-020-00756-x

DOI

http://dx.doi.org/10.1007/s11657-020-00756-x

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1128123770

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/32483672


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