Biotransformation effect of Bombyx Mori L. may play an important role in treating diabetic nephropathy View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2016-11

AUTHORS

Lei Zhang, La Zhang, Yin Li, Xin-feng Guo, Xu-sheng Liu

ABSTRACT

Compared with herbal drugs, medicine processed from animals (animal medicine) was thought to have more bioactive substances and higher activities. Biotransformation effect often plays an important role in their effect. However, researches about effect of animal medicine on diabetic nephropathy and applying animal medicine as natural bio-transformer were seldom reported. The purpose of this paper was to reveal the use of Bombyx Mori L. on diabetic nephropathy from ancient to modern times. The classical literature indicated that Saosi Decoction (), which contains Bombyx Mori L. or silkworm cocoon, was applied to treat disorders congruent with modern disease diabetic nephropathy from the Ming to Qing Dynasty in ancient China. Modern studies showed that Bombyx Mori L. contains four main active constituents. Among these, 1-deoxynojirimycin (1-DNJ) and quercetin showed promising potential to be new agents in diabetic nephropathy treatment. The concentrations of 1-DNJ and the activities of quercetin in Bombyx Mori L. are higher than in mulberry leaves, because of the biotransformation in the Bombyx Mori L. body. However, these specifific components need further human and mechanistic studies to determine their therapeutic potential for this challenging condition. More... »

PAGES

872-879

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s11655-015-2128-z

DOI

http://dx.doi.org/10.1007/s11655-015-2128-z

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1017591187

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/26688181


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