Anti-proliferative effects of ginsenosides extracted from mountain ginseng on lung cancer View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2014-08-26

AUTHORS

Dong Gyu Lee, Sung-Il Jang, Young-Rang Kim, Kyeong Eun Yang, So Jung Yoon, Zee-Won Lee, Hyun Joo An, Ik-Soon Jang, Jong-Soon Choi, Hwa-Seung Yoo

ABSTRACT

ObjectiveTo investigate the effect of three major ginsenosides from mountain ginseng as anticancer substance and explore the underlying mechanism involved in lung cancer.MethodsThe inhibitory proliferation of lung cancer by major five ginsenosides (Rb1, Rb2, Rg1, Rc, and Re) was examined using 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide assay. Calculated 50% inhibition (IC50) values of five ginsenosides were determined and compared each other. Apoptosis by the treatment of single ginsenoside was performed by fluorescence-assisted cytometric spectroscopy. The alterations of apoptosis-related proteins were evaluated by Western blot analysis.ResultsThe abundance of ginsenosides in butanol extract of mountain ginseng (BX-MG) was revealed in the order of Rb1, Rg1, Re, Rc and Rb2. Among them, Rb1 was the most effective to lung cancer cell, followed by Rb2 and Rg1 on the basis of relative IC50 values of IMR90 versus A549 cell. The alterations of apoptotic proteins were confirmed in lung cancer A549 cells according to the administration of Rb1, Rb2 and Rg1. The expression levels of caspase-3 and caspase-8 were increased upon the treatment of three ginsenosides, however, the levels of caspase-9 and anti-apoptotic protein Bax were not changed.ConclusionMajor ginsenosides such as Rb1, Rb2 and Rg1 comprising BX-MG induced apoptosis in lung cancer cells via extrinsic apoptotic pathway rather than intrinsic mitochondrial pathway. More... »

PAGES

344-352

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s11655-014-1789-8

DOI

http://dx.doi.org/10.1007/s11655-014-1789-8

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1001076523

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/25159864


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68 cancer
69 cancer A549 cells
70 cancer cells
71 caspase-3
72 caspase-8
73 caspase-9
74 cells
75 cytometric spectroscopy
76 dimethylthiazol-2
77 diphenyl tetrazolium bromide (MTT) assay
78 effect
79 expression levels
80 extract
81 extrinsic apoptotic pathway
82 fluorescence-assisted cytometric spectroscopy
83 ginseng
84 ginsenosides
85 inhibition values
86 inhibitory proliferation
87 intrinsic mitochondrial pathway
88 levels
89 lung cancer
90 lung cancer A549 cells
91 lung cancer cells
92 major ginsenosides
93 mechanism
94 mitochondrial pathway
95 mountain ginseng
96 order
97 order of Rb1
98 pathway
99 proliferation
100 protein
101 protein Bax
102 relative IC50 values
103 single ginsenoside
104 spectroscopy
105 substances
106 tetrazolium bromide assay
107 treatment
108 underlying mechanism
109 values
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