Diagnostik und Therapie der chronischen myelomonozytären Leukämie im Jahr 2020 View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2021-01-04

AUTHORS

J. Kaivers, C. Rautenberg, B. Betz, P. Czyborra, R. Haas, M. Rudelius, M. Lübbert, G. Kobbe, U. Germing

ABSTRACT

Chronic myelomonocytic leukemias (CMML) are clonal stem cell disorders characterized by persistent monocytosis in the peripheral blood. The classification into CMML‑0, CMML‑I, and CMML-II depends on peripheral and bone marrow blast counts. Furthermore, differentiation into myelodysplastic or myeloproliferative CMML depends on white blood cell counts (variant, myeloproliferative CMML is associated with a worse outcome. Of all patients, 70% present with a normal karyotype, whereas somatic mutations occur in 90% of all cases and may have prognostic impact. For prognostic assessment, the CMML Prognostic Scoring System (CPSS) and the CPSS incorporating molecular parameters (CPSS-mol) are recommended. Allogeneic hematopoietic stem cell transplantation is the only curative treatment approach. The only approved treatment for myelodysplastic CMML with more than 10% bone marrow blasts is 5‑azacytidine. Treatment of CMML patients within clinical trials is highly recommended. More... »

PAGES

20-28

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s11654-020-00278-5

DOI

http://dx.doi.org/10.1007/s11654-020-00278-5

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1134305142


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