Ontology type: schema:ScholarlyArticle
2021-01-04
AUTHORSJ. Kaivers, C. Rautenberg, B. Betz, P. Czyborra, R. Haas, M. Rudelius, M. Lübbert, G. Kobbe, U. Germing
ABSTRACTChronic myelomonocytic leukemias (CMML) are clonal stem cell disorders characterized by persistent monocytosis in the peripheral blood. The classification into CMML‑0, CMML‑I, and CMML-II depends on peripheral and bone marrow blast counts. Furthermore, differentiation into myelodysplastic or myeloproliferative CMML depends on white blood cell counts (variant, myeloproliferative CMML is associated with a worse outcome. Of all patients, 70% present with a normal karyotype, whereas somatic mutations occur in 90% of all cases and may have prognostic impact. For prognostic assessment, the CMML Prognostic Scoring System (CPSS) and the CPSS incorporating molecular parameters (CPSS-mol) are recommended. Allogeneic hematopoietic stem cell transplantation is the only curative treatment approach. The only approved treatment for myelodysplastic CMML with more than 10% bone marrow blasts is 5‑azacytidine. Treatment of CMML patients within clinical trials is highly recommended. More... »
PAGES20-28
http://scigraph.springernature.com/pub.10.1007/s11654-020-00278-5
DOIhttp://dx.doi.org/10.1007/s11654-020-00278-5
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"description": "Chronic myelomonocytic leukemias (CMML) are clonal stem cell disorders characterized by persistent monocytosis in the peripheral blood. The classification into CMML\u20110, CMML\u2011I, and CMML-II depends on peripheral and bone marrow blast counts. Furthermore, differentiation into myelodysplastic or myeloproliferative CMML depends on white blood cell counts (Download the RDF metadata as: json-ld nt turtle xml License info
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