Effect of selected dimethylaminochalcones on some mitochondrial activities View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2013-04-19

AUTHORS

Janka Vašková, Renáta Reisch, Ladislav Vaško, Martina Poškrobová, Ivan Kron, Juraj Guzy, Pál Perjési

ABSTRACT

Chalcones and their synthetic cyclic analogues have been shown to possess a full scale of biological activities in a variety of experimental systems. They were assessed to be mostly effective in defense against free radicals in the organism, but several compounds exhibited cytotoxic pro-oxidant activities. The respiratory response and antioxidant status in mitochondria were investigated upon addition of 4′-dimethylaminochalcone (1a) and its cyclic analogues, (E)-2-(4′-((CH3)2 N)-benzylidene)-1-indanone (1b), -1-tetralone (1c), and -1-benzosuberone (1d). Selected structures were able to change the respiratory response of mitochondria and showed an ability to modify mitochondrial metabolic and redox efficiency, though they did not indicate redox reactivity towards glutathione in adduct-free incubations. The results of the study indicate that -chalcone and -tetralone derivatives cause suppression of reactive oxygen species affecting mitochondrial respiration by mild uncoupling. In addition, (E)-2-(4′-((CH3)2 N)-indanone (1b), and to a greater extent, -benzosuberone (1d), showed pro-oxidant effects, which partially explain their cytotoxicity. More... »

PAGES

354-359

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s11626-013-9600-x

DOI

http://dx.doi.org/10.1007/s11626-013-9600-x

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1046681839

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/23605609


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