Midodrine, un traitement oral des érections prolongées induites par injection intracaverneuse de substances vasoactives chez le blessé médullaire View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2011-06

AUTHORS

J. -M. Soler, J. -G. Prévinaire, R. Mieusset, P. Plante

ABSTRACT

Les blessés médullaires ont un dysfonctionnement érectile. Le rétablissement de l’érection nécessite habituellement un traitement pharmacologique. Les injections intracaverneuses (IIC) de substances vasoactives peuvent induire une érection prolongée pour un priapisme. Le traitement recommandé des priapismes est une ponction du corps caverneux et/ou une IIC de substance alphamimétique. Nous proposons un traitement des érections prolongées et des priapismes par midodrine per os (alphamimétique). Notre étude concerne 354 blessés médullaires présentant un dysfonctionnement érectile et traités par IIC de substances vasoactives (prostaglandine et/ou Papavérine®). Quatorze blessés médullaires ont présenté un priapisme traité par midodrine per os. Une évaluation de la détumescence et une surveillance de la tension et du pouls ont été réalisées pour tous les patients. Pour les 14 patients, le traitement a entraîné une détumescence 30 à 45 minutes après la prise de 15 mg de midodrine per os, sans effet secondaire gênant. Le traitement des dysfonctionnements érectiles du blessé médullaire par IIC de substances vasoactives a considérablement augmenté l’incidence des érections prolongées et des priapismes. Le traitement recommandé des priapismes consiste à réaliser une ponction des corps caverneux et/ou une injection de substance alphamimétique intracaverneuse. Ces traitements sont efficaces, mais peuvent entraîner des troubles de l’érection définitifs. Les traitements per os des priapismes ne sont pas recommandés. Le traitement par midodrine per os des priapismes induits par IIC de substances vasoactives chez le blessé médullaire est efficace, non invasif et n’entraîne pas d’effet secondaire gênant. La midodrine per os est un nouveau traitement efficace non invasif des érections prolongées et des priapismes induits par IIC de substances vasoactives chez le blessé médullaire. Il pourrait être proposé comme traitement de première intention des priapismes ischémiques. More... »

PAGES

97-102

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s11608-010-0345-7

DOI

http://dx.doi.org/10.1007/s11608-010-0345-7

DIMENSIONS

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33 schema:description Les blessés médullaires ont un dysfonctionnement érectile. Le rétablissement de l’érection nécessite habituellement un traitement pharmacologique. Les injections intracaverneuses (IIC) de substances vasoactives peuvent induire une érection prolongée pour un priapisme. Le traitement recommandé des priapismes est une ponction du corps caverneux et/ou une IIC de substance alphamimétique. Nous proposons un traitement des érections prolongées et des priapismes par midodrine per os (alphamimétique). Notre étude concerne 354 blessés médullaires présentant un dysfonctionnement érectile et traités par IIC de substances vasoactives (prostaglandine et/ou Papavérine®). Quatorze blessés médullaires ont présenté un priapisme traité par midodrine per os. Une évaluation de la détumescence et une surveillance de la tension et du pouls ont été réalisées pour tous les patients. Pour les 14 patients, le traitement a entraîné une détumescence 30 à 45 minutes après la prise de 15 mg de midodrine per os, sans effet secondaire gênant. Le traitement des dysfonctionnements érectiles du blessé médullaire par IIC de substances vasoactives a considérablement augmenté l’incidence des érections prolongées et des priapismes. Le traitement recommandé des priapismes consiste à réaliser une ponction des corps caverneux et/ou une injection de substance alphamimétique intracaverneuse. Ces traitements sont efficaces, mais peuvent entraîner des troubles de l’érection définitifs. Les traitements per os des priapismes ne sont pas recommandés. Le traitement par midodrine per os des priapismes induits par IIC de substances vasoactives chez le blessé médullaire est efficace, non invasif et n’entraîne pas d’effet secondaire gênant. La midodrine per os est un nouveau traitement efficace non invasif des érections prolongées et des priapismes induits par IIC de substances vasoactives chez le blessé médullaire. Il pourrait être proposé comme traitement de première intention des priapismes ischémiques.
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