La cystite interstitielle: clinique, diagnostic et réponse au traitement par cimétidine View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2009-09

AUTHORS

P. Mouracade, A. Ej-Jennane, H. Lang, D. Jacqmin, C. Saussine

ABSTRACT

ObjectivesDescribe the features characterising patients diagnosed with interstitial cystitis (IC). Assess the results of the various diagnostic tests and patient response to treatment with cimetidine (Tagamet®).Equipment and methodsCohort study of 139 female patients treated for IC between 1998 and 2007. Diagnosis was suspected during questioning and confirmed by bladder hydrodistention, urodynamic assessment, voiding diary, KCl test and an O’Leary-Sant questionnaire once other pathologies had been eliminated. First line therapy was cimetidine, 1 × 200 mg tablet morning and evening. We studied patient demographic characteristics, described the clinical aspects and determined the results of the various diagnostic tests and patient response to cimetidine treatment.ResultsTime elapsed between onset of symptoms and diagnosis averaged 7.5 years. Hundred percent of patients experienced troublesome urgency, 86% daytime pollakiuria, 65% nycturia and a pelvic burning sensation was experienced by 52%. The pain was felt in the perineum by 76% of patients, the genitals by 40% and above the pubic bone by 85%. Cystoscopy and/or histology were abnormal in 92% of patients and Hunner’s ulcers were found in 2.2% of patients. At diagnosis, the median score on the O’Leary-Sant symptom questionnaire was 14.98 ± 3.38 (7–20), the median score on the O’Leary-Sant problem questionnaire was 13.5 ± 2.42 (8–16). Bladder capacity was over 350 cc in 20% of cases. The KCl test was positive in 80.5% of patients. Patients presenting abnormal cystoscopy/histology results received cimetidine as first-line treatment. During follow-up, 77 patients (60%) had improved O’Leary-Sant scores, with 38 patients (30%) showing an improvement of over 50%.ConclusionsPatients suffering from IC experience symptoms for an average of 7.5 years before the condition is diagnosed. Symptoms vary, but all patients experience troublesome feelings of urgency, which is thus the main symptom to suggest a diagnosis of IVC, rather than pain above the pubic bone. Cimetidine is an effective treatment for some patients. More... »

PAGES

184-187

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s11608-009-0246-9

DOI

http://dx.doi.org/10.1007/s11608-009-0246-9

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1028813636


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1103", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Clinical Sciences", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Service d\u2019urologie, facult\u00e9 de m\u00e9decine, h\u00f4pitaux universitaires de Strasbourg, universit\u00e9 de Strasbourg, 1, place de l\u2019H\u00f4pital, F-67000, Strasbourg, France", 
          "id": "http://www.grid.ac/institutes/grid.412220.7", 
          "name": [
            "Service d\u2019urologie, facult\u00e9 de m\u00e9decine, h\u00f4pitaux universitaires de Strasbourg, universit\u00e9 de Strasbourg, 1, place de l\u2019H\u00f4pital, F-67000, Strasbourg, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Mouracade", 
        "givenName": "P.", 
        "id": "sg:person.0664541743.39", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0664541743.39"
        ], 
        "type": "Person"
      }, 
      {
        "familyName": "Ej-Jennane", 
        "givenName": "A.", 
        "id": "sg:person.01113051435.81", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01113051435.81"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Service d\u2019urologie, facult\u00e9 de m\u00e9decine, h\u00f4pitaux universitaires de Strasbourg, universit\u00e9 de Strasbourg, 1, place de l\u2019H\u00f4pital, F-67000, Strasbourg, France", 
          "id": "http://www.grid.ac/institutes/grid.412220.7", 
          "name": [
            "Service d\u2019urologie, facult\u00e9 de m\u00e9decine, h\u00f4pitaux universitaires de Strasbourg, universit\u00e9 de Strasbourg, 1, place de l\u2019H\u00f4pital, F-67000, Strasbourg, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Lang", 
        "givenName": "H.", 
        "id": "sg:person.01350132425.91", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01350132425.91"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Service d\u2019urologie, facult\u00e9 de m\u00e9decine, h\u00f4pitaux universitaires de Strasbourg, universit\u00e9 de Strasbourg, 1, place de l\u2019H\u00f4pital, F-67000, Strasbourg, France", 
          "id": "http://www.grid.ac/institutes/grid.412220.7", 
          "name": [
            "Service d\u2019urologie, facult\u00e9 de m\u00e9decine, h\u00f4pitaux universitaires de Strasbourg, universit\u00e9 de Strasbourg, 1, place de l\u2019H\u00f4pital, F-67000, Strasbourg, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Jacqmin", 
        "givenName": "D.", 
        "id": "sg:person.0660662557.41", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0660662557.41"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Service d\u2019urologie, facult\u00e9 de m\u00e9decine, h\u00f4pitaux universitaires de Strasbourg, universit\u00e9 de Strasbourg, 1, place de l\u2019H\u00f4pital, F-67000, Strasbourg, France", 
          "id": "http://www.grid.ac/institutes/grid.412220.7", 
          "name": [
            "Service d\u2019urologie, facult\u00e9 de m\u00e9decine, h\u00f4pitaux universitaires de Strasbourg, universit\u00e9 de Strasbourg, 1, place de l\u2019H\u00f4pital, F-67000, Strasbourg, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Saussine", 
        "givenName": "C.", 
        "id": "sg:person.0675466517.55", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0675466517.55"
        ], 
        "type": "Person"
      }
    ], 
    "datePublished": "2009-09", 
    "datePublishedReg": "2009-09-01", 
    "description": "ObjectivesDescribe the features characterising patients diagnosed with interstitial cystitis (IC). Assess the results of the various diagnostic tests and patient response to treatment with cimetidine (Tagamet\u00ae).Equipment and methodsCohort study of 139 female patients treated for IC between 1998 and 2007. Diagnosis was suspected during questioning and confirmed by bladder hydrodistention, urodynamic assessment, voiding diary, KCl test and an O\u2019Leary-Sant questionnaire once other pathologies had been eliminated. First line therapy was cimetidine, 1 \u00d7 200 mg tablet morning and evening. We studied patient demographic characteristics, described the clinical aspects and determined the results of the various diagnostic tests and patient response to cimetidine treatment.ResultsTime elapsed between onset of symptoms and diagnosis averaged 7.5 years. Hundred percent of patients experienced troublesome urgency, 86% daytime pollakiuria, 65% nycturia and a pelvic burning sensation was experienced by 52%. The pain was felt in the perineum by 76% of patients, the genitals by 40% and above the pubic bone by 85%. Cystoscopy and/or histology were abnormal in 92% of patients and Hunner\u2019s ulcers were found in 2.2% of patients. At diagnosis, the median score on the O\u2019Leary-Sant symptom questionnaire was 14.98 \u00b1 3.38 (7\u201320), the median score on the O\u2019Leary-Sant problem questionnaire was 13.5 \u00b1 2.42 (8\u201316). Bladder capacity was over 350 cc in 20% of cases. The KCl test was positive in 80.5% of patients. Patients presenting abnormal cystoscopy/histology results received cimetidine as first-line treatment. During follow-up, 77 patients (60%) had improved O\u2019Leary-Sant scores, with 38 patients (30%) showing an improvement of over 50%.ConclusionsPatients suffering from IC experience symptoms for an average of 7.5 years before the condition is diagnosed. Symptoms vary, but all patients experience troublesome feelings of urgency, which is thus the main symptom to suggest a diagnosis of IVC, rather than pain above the pubic bone. Cimetidine is an effective treatment for some patients.", 
    "genre": "article", 
    "id": "sg:pub.10.1007/s11608-009-0246-9", 
    "inLanguage": "en", 
    "isAccessibleForFree": false, 
    "isPartOf": [
      {
        "id": "sg:journal.1040392", 
        "issn": [
          "1778-3712", 
          "1778-3720"
        ], 
        "name": "Pelvi-p\u00e9rin\u00e9ologie", 
        "publisher": "Springer Nature", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "3", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "4"
      }
    ], 
    "keywords": [
      "interstitial cystitis", 
      "patient response", 
      "pubic bone", 
      "KCl test", 
      "diagnostic tests", 
      "median score", 
      "percent of patients", 
      "first-line therapy", 
      "first-line treatment", 
      "patient demographic characteristics", 
      "onset of symptoms", 
      "bladder hydrodistention", 
      "urodynamic assessment", 
      "MethodsCohort study", 
      "line therapy", 
      "bladder capacity", 
      "female patients", 
      "Hunner's ulcer", 
      "symptom questionnaire", 
      "main symptoms", 
      "clinical aspects", 
      "histology results", 
      "experience symptoms", 
      "effective treatment", 
      "patients", 
      "cimetidine", 
      "symptoms", 
      "diagnosis", 
      "demographic characteristics", 
      "pain", 
      "ulcers", 
      "Problems Questionnaire", 
      "treatment", 
      "scores", 
      "questionnaire", 
      "bone", 
      "hydrodistention", 
      "pollakiuria", 
      "ConclusionsPatients", 
      "cystitis", 
      "nycturia", 
      "cystoscopy", 
      "perineum", 
      "therapy", 
      "histology", 
      "ResultsTime", 
      "years", 
      "pathology", 
      "response", 
      "test", 
      "IVC", 
      "urgency", 
      "clinique", 
      "ObjectivesDescribe", 
      "genitals", 
      "sensation", 
      "onset", 
      "diary", 
      "percent", 
      "morning", 
      "CC", 
      "assessment", 
      "evening", 
      "study", 
      "cases", 
      "results", 
      "improvement", 
      "troublesome feelings", 
      "average", 
      "feelings", 
      "features", 
      "capacity", 
      "characteristics", 
      "aspects", 
      "conditions", 
      "equipment"
    ], 
    "name": "La cystite interstitielle: clinique, diagnostic et r\u00e9ponse au traitement par cim\u00e9tidine", 
    "pagination": "184-187", 
    "productId": [
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1028813636"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1007/s11608-009-0246-9"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1007/s11608-009-0246-9", 
      "https://app.dimensions.ai/details/publication/pub.1028813636"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2022-05-20T07:25", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-springernature-scigraph/baseset/20220519/entities/gbq_results/article/article_490.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://doi.org/10.1007/s11608-009-0246-9"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s11608-009-0246-9'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s11608-009-0246-9'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s11608-009-0246-9'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s11608-009-0246-9'


 

This table displays all metadata directly associated to this object as RDF triples.

161 TRIPLES      21 PREDICATES      102 URIs      94 LITERALS      6 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1007/s11608-009-0246-9 schema:about anzsrc-for:11
2 anzsrc-for:1103
3 schema:author Nd7c41b75033e45de87e6ba3b8b833b50
4 schema:datePublished 2009-09
5 schema:datePublishedReg 2009-09-01
6 schema:description ObjectivesDescribe the features characterising patients diagnosed with interstitial cystitis (IC). Assess the results of the various diagnostic tests and patient response to treatment with cimetidine (Tagamet®).Equipment and methodsCohort study of 139 female patients treated for IC between 1998 and 2007. Diagnosis was suspected during questioning and confirmed by bladder hydrodistention, urodynamic assessment, voiding diary, KCl test and an O’Leary-Sant questionnaire once other pathologies had been eliminated. First line therapy was cimetidine, 1 × 200 mg tablet morning and evening. We studied patient demographic characteristics, described the clinical aspects and determined the results of the various diagnostic tests and patient response to cimetidine treatment.ResultsTime elapsed between onset of symptoms and diagnosis averaged 7.5 years. Hundred percent of patients experienced troublesome urgency, 86% daytime pollakiuria, 65% nycturia and a pelvic burning sensation was experienced by 52%. The pain was felt in the perineum by 76% of patients, the genitals by 40% and above the pubic bone by 85%. Cystoscopy and/or histology were abnormal in 92% of patients and Hunner’s ulcers were found in 2.2% of patients. At diagnosis, the median score on the O’Leary-Sant symptom questionnaire was 14.98 ± 3.38 (7–20), the median score on the O’Leary-Sant problem questionnaire was 13.5 ± 2.42 (8–16). Bladder capacity was over 350 cc in 20% of cases. The KCl test was positive in 80.5% of patients. Patients presenting abnormal cystoscopy/histology results received cimetidine as first-line treatment. During follow-up, 77 patients (60%) had improved O’Leary-Sant scores, with 38 patients (30%) showing an improvement of over 50%.ConclusionsPatients suffering from IC experience symptoms for an average of 7.5 years before the condition is diagnosed. Symptoms vary, but all patients experience troublesome feelings of urgency, which is thus the main symptom to suggest a diagnosis of IVC, rather than pain above the pubic bone. Cimetidine is an effective treatment for some patients.
7 schema:genre article
8 schema:inLanguage en
9 schema:isAccessibleForFree false
10 schema:isPartOf N7e41971d701e4b4cab9dccc4652f7d51
11 Nb6f9581f4f8d47dcbc8f6792f026de4c
12 sg:journal.1040392
13 schema:keywords CC
14 ConclusionsPatients
15 Hunner's ulcer
16 IVC
17 KCl test
18 MethodsCohort study
19 ObjectivesDescribe
20 Problems Questionnaire
21 ResultsTime
22 aspects
23 assessment
24 average
25 bladder capacity
26 bladder hydrodistention
27 bone
28 capacity
29 cases
30 characteristics
31 cimetidine
32 clinical aspects
33 clinique
34 conditions
35 cystitis
36 cystoscopy
37 demographic characteristics
38 diagnosis
39 diagnostic tests
40 diary
41 effective treatment
42 equipment
43 evening
44 experience symptoms
45 features
46 feelings
47 female patients
48 first-line therapy
49 first-line treatment
50 genitals
51 histology
52 histology results
53 hydrodistention
54 improvement
55 interstitial cystitis
56 line therapy
57 main symptoms
58 median score
59 morning
60 nycturia
61 onset
62 onset of symptoms
63 pain
64 pathology
65 patient demographic characteristics
66 patient response
67 patients
68 percent
69 percent of patients
70 perineum
71 pollakiuria
72 pubic bone
73 questionnaire
74 response
75 results
76 scores
77 sensation
78 study
79 symptom questionnaire
80 symptoms
81 test
82 therapy
83 treatment
84 troublesome feelings
85 ulcers
86 urgency
87 urodynamic assessment
88 years
89 schema:name La cystite interstitielle: clinique, diagnostic et réponse au traitement par cimétidine
90 schema:pagination 184-187
91 schema:productId N66d99fa7744940709be36ea94139f718
92 N8094cf06914647a0a5642b07b4969255
93 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028813636
94 https://doi.org/10.1007/s11608-009-0246-9
95 schema:sdDatePublished 2022-05-20T07:25
96 schema:sdLicense https://scigraph.springernature.com/explorer/license/
97 schema:sdPublisher N72a0335c44c24d5f9dbc2f0993bcd2e4
98 schema:url https://doi.org/10.1007/s11608-009-0246-9
99 sgo:license sg:explorer/license/
100 sgo:sdDataset articles
101 rdf:type schema:ScholarlyArticle
102 N239512bcadb44d389f0b2f88cf06c0fd rdf:first sg:person.01113051435.81
103 rdf:rest N452a8d3138534ffaa889f62bc4f4cdf7
104 N452a8d3138534ffaa889f62bc4f4cdf7 rdf:first sg:person.01350132425.91
105 rdf:rest Nd89023f9302f4f48b2fa3f918c1b8014
106 N66d99fa7744940709be36ea94139f718 schema:name dimensions_id
107 schema:value pub.1028813636
108 rdf:type schema:PropertyValue
109 N72a0335c44c24d5f9dbc2f0993bcd2e4 schema:name Springer Nature - SN SciGraph project
110 rdf:type schema:Organization
111 N7e41971d701e4b4cab9dccc4652f7d51 schema:volumeNumber 4
112 rdf:type schema:PublicationVolume
113 N8094cf06914647a0a5642b07b4969255 schema:name doi
114 schema:value 10.1007/s11608-009-0246-9
115 rdf:type schema:PropertyValue
116 Nb6f9581f4f8d47dcbc8f6792f026de4c schema:issueNumber 3
117 rdf:type schema:PublicationIssue
118 Nd7c41b75033e45de87e6ba3b8b833b50 rdf:first sg:person.0664541743.39
119 rdf:rest N239512bcadb44d389f0b2f88cf06c0fd
120 Nd89023f9302f4f48b2fa3f918c1b8014 rdf:first sg:person.0660662557.41
121 rdf:rest Ndfd1e0fe911c4ca5a7d5587a2a88baff
122 Ndfd1e0fe911c4ca5a7d5587a2a88baff rdf:first sg:person.0675466517.55
123 rdf:rest rdf:nil
124 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
125 schema:name Medical and Health Sciences
126 rdf:type schema:DefinedTerm
127 anzsrc-for:1103 schema:inDefinedTermSet anzsrc-for:
128 schema:name Clinical Sciences
129 rdf:type schema:DefinedTerm
130 sg:journal.1040392 schema:issn 1778-3712
131 1778-3720
132 schema:name Pelvi-périnéologie
133 schema:publisher Springer Nature
134 rdf:type schema:Periodical
135 sg:person.01113051435.81 schema:familyName Ej-Jennane
136 schema:givenName A.
137 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01113051435.81
138 rdf:type schema:Person
139 sg:person.01350132425.91 schema:affiliation grid-institutes:grid.412220.7
140 schema:familyName Lang
141 schema:givenName H.
142 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01350132425.91
143 rdf:type schema:Person
144 sg:person.0660662557.41 schema:affiliation grid-institutes:grid.412220.7
145 schema:familyName Jacqmin
146 schema:givenName D.
147 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0660662557.41
148 rdf:type schema:Person
149 sg:person.0664541743.39 schema:affiliation grid-institutes:grid.412220.7
150 schema:familyName Mouracade
151 schema:givenName P.
152 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0664541743.39
153 rdf:type schema:Person
154 sg:person.0675466517.55 schema:affiliation grid-institutes:grid.412220.7
155 schema:familyName Saussine
156 schema:givenName C.
157 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0675466517.55
158 rdf:type schema:Person
159 grid-institutes:grid.412220.7 schema:alternateName Service d’urologie, faculté de médecine, hôpitaux universitaires de Strasbourg, université de Strasbourg, 1, place de l’Hôpital, F-67000, Strasbourg, France
160 schema:name Service d’urologie, faculté de médecine, hôpitaux universitaires de Strasbourg, université de Strasbourg, 1, place de l’Hôpital, F-67000, Strasbourg, France
161 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...