Does a History of Non-Vertebral Fracture Identify Women Without Osteoporosis for Treatment? View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2008-08

AUTHORS

Kathryn M. Ryder, Steven R. Cummings, Lisa Palermo, Suzanne Satterfield, Douglas C. Bauer, Adrianne C. Feldstein, John T. Schousboe, Ann V. Schwartz, Kristine Ensrud, for the Fracture Intervention Trial Research Group

ABSTRACT

BACKGROUND: Postmenopausal women with a prior fracture have an increased risk for future fracture. Whether a history of non-vertebral fracture defines a group of women with low bone mass but without osteoporosis for whom alendronate would prevent new non-vertebral fracture is not known. SUBJECTS AND METHODS: Secondary analysis of data from the Fracture Intervention Trial (FIT). Of 2,785 postmenopausal women with a T-score at the femoral neck between -1 and -2.5 and without prevalent radiographic vertebral deformity, 880 (31.6%) reported experiencing a fracture after 45 years of age. Women were randomized to placebo or alendronate (5 mg/day years for the first 2 years and 10 mg/day thereafter) and were followed for an average of 4.2 +/- 0.5 years. Incident non-vertebral fractures were confirmed by x-rays and radiology reports. RESULTS: In the placebo arm, a self-report of prior fracture identified women with a 1.5-fold (hazard ratio [RH] 1.46, 95% C.I. 1.04-2.04) increased risk for incident non-vertebral fracture. However, there was no evidence that the effect of alendronate differed across subgroups of women with (RH 1.26 for alendronate vs placebo, 95% C.I. 0.89-1.79) and without prior fracture (RH 1.02 for alendronate vs placebo, 95% C.I. 0.76-1.38; P = 0.37 for interaction). CONCLUSION: Assessing a clinical risk factor, prior non-vertebral fracture, did not identify women with low bone mass for whom alendronate reduced future non-vertebral fracture risk. More... »

PAGES

1177

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s11606-008-0622-0

DOI

http://dx.doi.org/10.1007/s11606-008-0622-0

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1040197149

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/18459010


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