Neo-adjuvant Chemotherapy-Induced Neutropenia Is Associated with Histological Responses and Outcomes after the Resection of Colorectal Liver Metastases View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2019-04-01

AUTHORS

Qichen Chen, Chaorui Wu, Hong Zhao, Jianxiong Wu, Jianjun Zhao, Xinyu Bi, Zhiyu Li, Zhen Huang, Yefan Zhang, Jianguo Zhou, Jianqiang Cai

ABSTRACT

BACKGROUND: Neutropenia, the major adverse event in chemotherapy, is associated with favourable clinical outcome in several solid tumours. We aimed to investigate the predictive value of neo-adjuvant chemotherapy (NAC)-induced neutropenia for the pathological response and prognosis in colorectal liver metastases (CRLM) patients. METHODS: A retrospective review was performed in 141 CRLM patients receiving NAC followed by liver resection. A logistic regression was applied to analyse potential predictors. A Cox proportional hazards analysis was used to analyse survival. RESULTS: Neutropenia due to NAC was observed in 42.6% (60/141) of all patients, and grade 3/4 neutropenia was noted in 31.7% (19/60). A pathological response (tumour regression grade (TRG) 1-3) was reported in 46.1% (65/141) of patients. Multivariate analysis showed that neutropenia significantly predicted the favourable pathological response (OR = 3.718, 95% CI 1.716-8.329, P = 0.001), as well as targeted therapy, good differentiation and preoperative CEA < 10 ng/ml as independent predictors of favourable histological response. Of the patients, 54.6% (77/141) had postoperative complications, including 28 major complications (28/77, 36.4%). Severe neutropenia significantly predicted postoperative major complications in multivariate analysis (OR = 4.077, 95% CI 1.184-14.038, P = 0.026). Compared to patients without neutropenia, patients with neutropenia had significantly better progression-free survival (PFS) (P = 0.007; mPFS, 10.2 months vs. 6.7 months). Patients with histological response had significantly better PFS than patients with no histological response (P = 0.001; mPFS, 10.0 months vs. 5.5 months). According to multivariate analyses, neutropenia was a significant predictor for better PFS (HR = 0.613, 95% CI 0.406-0.925, P = 0.020) but not OS. CONCLUSIONS: For CRLM patients receiving NAC followed by liver resection, NAC-induced neutropenia was a significant predictor of favourable pathological response, postoperative major complications and better prognosis, which makes it useful for CRLM patients in guiding treatment approaches and prognosis assessments. More... »

PAGES

1-12

References to SciGraph publications

  • 2015-12. Leucopenia and treatment efficacy in advanced nasopharyngeal carcinoma in BMC CANCER
  • 2012-01. Prognostic value of chemotherapy-induced neutropenia in early-stage breast cancer in BREAST CANCER RESEARCH AND TREATMENT
  • 2008-07. Tritherapy with fluorouracil/leucovorin, irinotecan and oxaliplatin (FOLFIRINOX): a phase II study in colorectal cancer patients with non-resectable liver metastases in CANCER CHEMOTHERAPY AND PHARMACOLOGY
  • 2010-11. Extended Preoperative Chemotherapy Does Not Improve Pathologic Response and Increases Postoperative Liver Insufficiency After Hepatic Resection for Colorectal Liver Metastases in ANNALS OF SURGICAL ONCOLOGY
  • 2016-02. Effects of neutropenia and histological responses in esophageal squamous cell carcinoma with neo-adjuvant chemotherapy in INTERNATIONAL JOURNAL OF CLINICAL ONCOLOGY
  • 2007-07. Predictive value of chemotherapy-induced neutropenia for the efficacy of oral fluoropyrimidine S-1 in advanced gastric carcinoma in BRITISH JOURNAL OF CANCER
  • 2016-12. Chemotherapy induced neutropenia at 1-month mark is a predictor of overall survival in patients receiving TAS-102 for refractory metastatic colorectal cancer: a cohort study in BMC CANCER
  • 2015-10. High-Grade Toxicity to Neoadjuvant Treatment for Upper Gastrointestinal Carcinomas: What is the Impact on Perioperative and Oncologic Outcomes? in ANNALS OF SURGICAL ONCOLOGY
  • 2015-11. Pathological responses after angiogenesis or EGFR inhibitors in metastatic colorectal cancer depend on the chemotherapy backbone in BRITISH JOURNAL OF CANCER
  • 2011-04. Effect on Outcome of Recurrence Patterns After Hepatectomy for Colorectal Metastases in ANNALS OF SURGICAL ONCOLOGY
  • 2015-09. Multivariate analysis of risk factors for postoperative complications after laparoscopic liver resection in SURGICAL ENDOSCOPY
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1007/s11605-019-04202-3

    DOI

    http://dx.doi.org/10.1007/s11605-019-04202-3

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1113171027

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/30937711


    Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
    Incoming Citations Browse incoming citations for this publication using opencitations.net

    JSON-LD is the canonical representation for SciGraph data.

    TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

    [
      {
        "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
        "about": [
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1112", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Oncology and Carcinogenesis", 
            "type": "DefinedTerm"
          }, 
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Medical and Health Sciences", 
            "type": "DefinedTerm"
          }
        ], 
        "author": [
          {
            "affiliation": {
              "alternateName": "Peking Union Medical College Hospital", 
              "id": "https://www.grid.ac/institutes/grid.413106.1", 
              "name": [
                "Department of Hepatobiliary Surgery, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, 100021, Beijing, China"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Chen", 
            "givenName": "Qichen", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Peking Union Medical College Hospital", 
              "id": "https://www.grid.ac/institutes/grid.413106.1", 
              "name": [
                "Department of Pancreatic and Gastric Surgery, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, 100021, Beijing, China"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Wu", 
            "givenName": "Chaorui", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Peking Union Medical College Hospital", 
              "id": "https://www.grid.ac/institutes/grid.413106.1", 
              "name": [
                "Department of Hepatobiliary Surgery, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, 100021, Beijing, China"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Zhao", 
            "givenName": "Hong", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Peking Union Medical College Hospital", 
              "id": "https://www.grid.ac/institutes/grid.413106.1", 
              "name": [
                "Department of Hepatobiliary Surgery, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, 100021, Beijing, China"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Wu", 
            "givenName": "Jianxiong", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Peking Union Medical College Hospital", 
              "id": "https://www.grid.ac/institutes/grid.413106.1", 
              "name": [
                "Department of Hepatobiliary Surgery, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, 100021, Beijing, China"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Zhao", 
            "givenName": "Jianjun", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Peking Union Medical College Hospital", 
              "id": "https://www.grid.ac/institutes/grid.413106.1", 
              "name": [
                "Department of Hepatobiliary Surgery, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, 100021, Beijing, China"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Bi", 
            "givenName": "Xinyu", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Peking Union Medical College Hospital", 
              "id": "https://www.grid.ac/institutes/grid.413106.1", 
              "name": [
                "Department of Hepatobiliary Surgery, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, 100021, Beijing, China"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Li", 
            "givenName": "Zhiyu", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Peking Union Medical College Hospital", 
              "id": "https://www.grid.ac/institutes/grid.413106.1", 
              "name": [
                "Department of Hepatobiliary Surgery, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, 100021, Beijing, China"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Huang", 
            "givenName": "Zhen", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Peking Union Medical College Hospital", 
              "id": "https://www.grid.ac/institutes/grid.413106.1", 
              "name": [
                "Department of Hepatobiliary Surgery, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, 100021, Beijing, China"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Zhang", 
            "givenName": "Yefan", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Peking Union Medical College Hospital", 
              "id": "https://www.grid.ac/institutes/grid.413106.1", 
              "name": [
                "Department of Hepatobiliary Surgery, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, 100021, Beijing, China"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Zhou", 
            "givenName": "Jianguo", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Peking Union Medical College Hospital", 
              "id": "https://www.grid.ac/institutes/grid.413106.1", 
              "name": [
                "Department of Hepatobiliary Surgery, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, 100021, Beijing, China"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Cai", 
            "givenName": "Jianqiang", 
            "type": "Person"
          }
        ], 
        "citation": [
          {
            "id": "sg:pub.10.1186/s12885-016-2491-y", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1003171100", 
              "https://doi.org/10.1186/s12885-016-2491-y"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/s12885-016-2491-y", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1003171100", 
              "https://doi.org/10.1186/s12885-016-2491-y"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/bjs.6947", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1003950270"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/bjs.6947", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1003950270"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/joim.12100", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1008399513"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/hpb.12327", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1008782844"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1001/jamasurg.2013.63", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1013991673"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/bjs.7823", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1016086124"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.3892/ol.2014.1822", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1017067625"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.3892/ol.2014.1822", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1017067625"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s1470-2045(05)70255-2", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1022570043"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s1470-2045(05)70255-2", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1022570043"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.ejca.2015.12.030", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1022644363"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.clcc.2016.03.007", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1023426656"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s10549-011-1799-1", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1023771662", 
              "https://doi.org/10.1007/s10549-011-1799-1"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/01.sla.0000133083.54934.ae", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1024049438"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/01.sla.0000133083.54934.ae", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1024049438"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/01.sla.0000133083.54934.ae", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1024049438"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/sla.0b013e31815aa2c2", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1026128215"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/sla.0b013e31815aa2c2", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1026128215"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.ejca.2008.10.026", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1026558254"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.3802/jgo.2009.20.3.146", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1029403173"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.ejca.2006.04.012", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1029538220"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00280-007-0588-3", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1029987674", 
              "https://doi.org/10.1007/s00280-007-0588-3"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00280-007-0588-3", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1029987674", 
              "https://doi.org/10.1007/s00280-007-0588-3"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.ejso.2016.08.019", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1031592776"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1159/000449349", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1031984064"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1200/jco.2008.17.5299", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1033537766"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1245/s10434-010-1166-1", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1034900487", 
              "https://doi.org/10.1245/s10434-010-1166-1"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1245/s10434-010-1166-1", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1034900487", 
              "https://doi.org/10.1245/s10434-010-1166-1"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1055/s-0029-1242458", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1035322968"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/annonc/mdl386", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1036275458"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0140-6736(08)60455-9", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1038419533"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1080/01635581.2014.894103", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1039365401"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/s12885-015-1442-3", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1040296750", 
              "https://doi.org/10.1186/s12885-015-1442-3"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/s12885-015-1442-3", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1040296750", 
              "https://doi.org/10.1186/s12885-015-1442-3"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/s12885-015-1442-3", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1040296750", 
              "https://doi.org/10.1186/s12885-015-1442-3"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1080/10428190701474373", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1040600664"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/ecc.12120", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1041776227"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1245/s10434-010-1409-1", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1044879140", 
              "https://doi.org/10.1245/s10434-010-1409-1"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/sj.bjc.6603831", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1044978496", 
              "https://doi.org/10.1038/sj.bjc.6603831"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/bjc.2015.321", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1045647224", 
              "https://doi.org/10.1038/bjc.2015.321"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s10147-015-0875-7", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1045934558", 
              "https://doi.org/10.1007/s10147-015-0875-7"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s10147-015-0875-7", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1045934558", 
              "https://doi.org/10.1007/s10147-015-0875-7"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00464-014-3965-0", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1049250273", 
              "https://doi.org/10.1007/s00464-014-3965-0"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.ejso.2015.03.223", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1051955566"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1245/s10434-015-4423-5", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1052036142", 
              "https://doi.org/10.1245/s10434-015-4423-5"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1158/1078-0432.ccr-09-1555", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1052297773"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1200/jco.2005.00.349", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1064204185"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.5306/wjco.v7.i1.9", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1072757684"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1077824144", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/sla.0000000000002679", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1100668089"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/sla.0000000000002679", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1100668089"
            ], 
            "type": "CreativeWork"
          }
        ], 
        "datePublished": "2019-04-01", 
        "datePublishedReg": "2019-04-01", 
        "description": "BACKGROUND: Neutropenia, the major adverse event in chemotherapy, is associated with favourable clinical outcome in several solid tumours. We aimed to investigate the predictive value of neo-adjuvant chemotherapy (NAC)-induced neutropenia for the pathological response and prognosis in colorectal liver metastases (CRLM) patients.\nMETHODS: A retrospective review was performed in 141 CRLM patients receiving NAC followed by liver resection. A logistic regression was applied to analyse potential predictors. A Cox proportional hazards analysis was used to analyse survival.\nRESULTS: Neutropenia due to NAC was observed in 42.6% (60/141) of all patients, and grade 3/4 neutropenia was noted in 31.7% (19/60). A pathological response (tumour regression grade (TRG) 1-3) was reported in 46.1% (65/141) of patients. Multivariate analysis showed that neutropenia significantly predicted the favourable pathological response (OR\u2009=\u20093.718, 95% CI 1.716-8.329, P\u2009=\u20090.001), as well as targeted therapy, good differentiation and preoperative CEA <\u200910\u00a0ng/ml as independent predictors of favourable histological response. Of the patients, 54.6% (77/141) had postoperative complications, including 28 major complications (28/77, 36.4%). Severe neutropenia significantly predicted postoperative major complications in multivariate analysis (OR\u2009=\u20094.077, 95% CI 1.184-14.038, P\u2009=\u20090.026). Compared to patients without neutropenia, patients with neutropenia had significantly better progression-free survival (PFS) (P\u2009=\u20090.007; mPFS, 10.2\u00a0months vs. 6.7\u00a0months). Patients with histological response had significantly better PFS than patients with no histological response (P\u2009=\u20090.001; mPFS, 10.0\u00a0months vs. 5.5\u00a0months). According to multivariate analyses, neutropenia was a significant predictor for better PFS (HR\u2009=\u20090.613, 95% CI 0.406-0.925, P\u2009=\u20090.020) but not OS.\nCONCLUSIONS: For CRLM patients receiving NAC followed by liver resection, NAC-induced neutropenia was a significant predictor of favourable pathological response, postoperative major complications and better prognosis, which makes it useful for CRLM patients in guiding treatment approaches and prognosis assessments.", 
        "genre": "research_article", 
        "id": "sg:pub.10.1007/s11605-019-04202-3", 
        "inLanguage": [
          "en"
        ], 
        "isAccessibleForFree": false, 
        "isPartOf": [
          {
            "id": "sg:journal.1116755", 
            "issn": [
              "1091-255X", 
              "1873-4626"
            ], 
            "name": "Journal of Gastrointestinal Surgery", 
            "type": "Periodical"
          }
        ], 
        "name": "Neo-adjuvant Chemotherapy-Induced Neutropenia Is Associated with Histological Responses and Outcomes after the Resection of Colorectal Liver Metastases", 
        "pagination": "1-12", 
        "productId": [
          {
            "name": "readcube_id", 
            "type": "PropertyValue", 
            "value": [
              "1bfb07e9a124adf0a0f3568f984f5e0d8560ac6e57172171f27f64f0d17ef64e"
            ]
          }, 
          {
            "name": "pubmed_id", 
            "type": "PropertyValue", 
            "value": [
              "30937711"
            ]
          }, 
          {
            "name": "nlm_unique_id", 
            "type": "PropertyValue", 
            "value": [
              "9706084"
            ]
          }, 
          {
            "name": "doi", 
            "type": "PropertyValue", 
            "value": [
              "10.1007/s11605-019-04202-3"
            ]
          }, 
          {
            "name": "dimensions_id", 
            "type": "PropertyValue", 
            "value": [
              "pub.1113171027"
            ]
          }
        ], 
        "sameAs": [
          "https://doi.org/10.1007/s11605-019-04202-3", 
          "https://app.dimensions.ai/details/publication/pub.1113171027"
        ], 
        "sdDataset": "articles", 
        "sdDatePublished": "2019-04-11T13:55", 
        "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
        "sdPublisher": {
          "name": "Springer Nature - SN SciGraph project", 
          "type": "Organization"
        }, 
        "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000371_0000000371/records_130811_00000006.jsonl", 
        "type": "ScholarlyArticle", 
        "url": "https://link.springer.com/10.1007%2Fs11605-019-04202-3"
      }
    ]
     

    Download the RDF metadata as:  json-ld nt turtle xml License info

    HOW TO GET THIS DATA PROGRAMMATICALLY:

    JSON-LD is a popular format for linked data which is fully compatible with JSON.

    curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s11605-019-04202-3'

    N-Triples is a line-based linked data format ideal for batch operations.

    curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s11605-019-04202-3'

    Turtle is a human-readable linked data format.

    curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s11605-019-04202-3'

    RDF/XML is a standard XML format for linked data.

    curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s11605-019-04202-3'


     

    This table displays all metadata directly associated to this object as RDF triples.

    253 TRIPLES      21 PREDICATES      66 URIs      18 LITERALS      7 BLANK NODES

    Subject Predicate Object
    1 sg:pub.10.1007/s11605-019-04202-3 schema:about anzsrc-for:11
    2 anzsrc-for:1112
    3 schema:author N0fe3a6af176e44e0a5ea9fbb2482a670
    4 schema:citation sg:pub.10.1007/s00280-007-0588-3
    5 sg:pub.10.1007/s00464-014-3965-0
    6 sg:pub.10.1007/s10147-015-0875-7
    7 sg:pub.10.1007/s10549-011-1799-1
    8 sg:pub.10.1038/bjc.2015.321
    9 sg:pub.10.1038/sj.bjc.6603831
    10 sg:pub.10.1186/s12885-015-1442-3
    11 sg:pub.10.1186/s12885-016-2491-y
    12 sg:pub.10.1245/s10434-010-1166-1
    13 sg:pub.10.1245/s10434-010-1409-1
    14 sg:pub.10.1245/s10434-015-4423-5
    15 https://app.dimensions.ai/details/publication/pub.1077824144
    16 https://doi.org/10.1001/jamasurg.2013.63
    17 https://doi.org/10.1002/bjs.6947
    18 https://doi.org/10.1002/bjs.7823
    19 https://doi.org/10.1016/j.clcc.2016.03.007
    20 https://doi.org/10.1016/j.ejca.2006.04.012
    21 https://doi.org/10.1016/j.ejca.2008.10.026
    22 https://doi.org/10.1016/j.ejca.2015.12.030
    23 https://doi.org/10.1016/j.ejso.2015.03.223
    24 https://doi.org/10.1016/j.ejso.2016.08.019
    25 https://doi.org/10.1016/s0140-6736(08)60455-9
    26 https://doi.org/10.1016/s1470-2045(05)70255-2
    27 https://doi.org/10.1055/s-0029-1242458
    28 https://doi.org/10.1080/01635581.2014.894103
    29 https://doi.org/10.1080/10428190701474373
    30 https://doi.org/10.1093/annonc/mdl386
    31 https://doi.org/10.1097/01.sla.0000133083.54934.ae
    32 https://doi.org/10.1097/sla.0000000000002679
    33 https://doi.org/10.1097/sla.0b013e31815aa2c2
    34 https://doi.org/10.1111/ecc.12120
    35 https://doi.org/10.1111/hpb.12327
    36 https://doi.org/10.1111/joim.12100
    37 https://doi.org/10.1158/1078-0432.ccr-09-1555
    38 https://doi.org/10.1159/000449349
    39 https://doi.org/10.1200/jco.2005.00.349
    40 https://doi.org/10.1200/jco.2008.17.5299
    41 https://doi.org/10.3802/jgo.2009.20.3.146
    42 https://doi.org/10.3892/ol.2014.1822
    43 https://doi.org/10.5306/wjco.v7.i1.9
    44 schema:datePublished 2019-04-01
    45 schema:datePublishedReg 2019-04-01
    46 schema:description BACKGROUND: Neutropenia, the major adverse event in chemotherapy, is associated with favourable clinical outcome in several solid tumours. We aimed to investigate the predictive value of neo-adjuvant chemotherapy (NAC)-induced neutropenia for the pathological response and prognosis in colorectal liver metastases (CRLM) patients. METHODS: A retrospective review was performed in 141 CRLM patients receiving NAC followed by liver resection. A logistic regression was applied to analyse potential predictors. A Cox proportional hazards analysis was used to analyse survival. RESULTS: Neutropenia due to NAC was observed in 42.6% (60/141) of all patients, and grade 3/4 neutropenia was noted in 31.7% (19/60). A pathological response (tumour regression grade (TRG) 1-3) was reported in 46.1% (65/141) of patients. Multivariate analysis showed that neutropenia significantly predicted the favourable pathological response (OR = 3.718, 95% CI 1.716-8.329, P = 0.001), as well as targeted therapy, good differentiation and preoperative CEA < 10 ng/ml as independent predictors of favourable histological response. Of the patients, 54.6% (77/141) had postoperative complications, including 28 major complications (28/77, 36.4%). Severe neutropenia significantly predicted postoperative major complications in multivariate analysis (OR = 4.077, 95% CI 1.184-14.038, P = 0.026). Compared to patients without neutropenia, patients with neutropenia had significantly better progression-free survival (PFS) (P = 0.007; mPFS, 10.2 months vs. 6.7 months). Patients with histological response had significantly better PFS than patients with no histological response (P = 0.001; mPFS, 10.0 months vs. 5.5 months). According to multivariate analyses, neutropenia was a significant predictor for better PFS (HR = 0.613, 95% CI 0.406-0.925, P = 0.020) but not OS. CONCLUSIONS: For CRLM patients receiving NAC followed by liver resection, NAC-induced neutropenia was a significant predictor of favourable pathological response, postoperative major complications and better prognosis, which makes it useful for CRLM patients in guiding treatment approaches and prognosis assessments.
    47 schema:genre research_article
    48 schema:inLanguage en
    49 schema:isAccessibleForFree false
    50 schema:isPartOf sg:journal.1116755
    51 schema:name Neo-adjuvant Chemotherapy-Induced Neutropenia Is Associated with Histological Responses and Outcomes after the Resection of Colorectal Liver Metastases
    52 schema:pagination 1-12
    53 schema:productId N3aa1dbd2d22b4e60955d878102632f07
    54 N4d29fb23c09f4bab80d511254b7a3421
    55 N6ea0c39e1ee249d294622208fe7c8ee6
    56 N94e35be214f34c78803160b0bd59db48
    57 Nb73205bf24b54cd8b076d0775f370a32
    58 schema:sameAs https://app.dimensions.ai/details/publication/pub.1113171027
    59 https://doi.org/10.1007/s11605-019-04202-3
    60 schema:sdDatePublished 2019-04-11T13:55
    61 schema:sdLicense https://scigraph.springernature.com/explorer/license/
    62 schema:sdPublisher N8b90d34c438f46dca1879302e600782d
    63 schema:url https://link.springer.com/10.1007%2Fs11605-019-04202-3
    64 sgo:license sg:explorer/license/
    65 sgo:sdDataset articles
    66 rdf:type schema:ScholarlyArticle
    67 N0ee2938b52f040ffacf5ba719873b5cf schema:affiliation https://www.grid.ac/institutes/grid.413106.1
    68 schema:familyName Zhou
    69 schema:givenName Jianguo
    70 rdf:type schema:Person
    71 N0fe3a6af176e44e0a5ea9fbb2482a670 rdf:first N8b1bd88d5ceb40b09fd2022439ca6346
    72 rdf:rest N35f64de60b394b4e880ba3146f756ef6
    73 N22ab073f6a2a4e89ba38d64750458182 rdf:first Ncede3cac59ea45169d307f6c7fd04080
    74 rdf:rest N888d59edc6ae4e74b5f598af2a37934c
    75 N2679dad64ddb4cd8ac62c7306e9ded6c schema:affiliation https://www.grid.ac/institutes/grid.413106.1
    76 schema:familyName Wu
    77 schema:givenName Jianxiong
    78 rdf:type schema:Person
    79 N2a10bc01a9a0459ca42ec1fab19da306 rdf:first N2679dad64ddb4cd8ac62c7306e9ded6c
    80 rdf:rest N499d264e6c5140a79d285783a0cc5e52
    81 N2f5d0eb4527948be8fc8259b48db74c9 schema:affiliation https://www.grid.ac/institutes/grid.413106.1
    82 schema:familyName Cai
    83 schema:givenName Jianqiang
    84 rdf:type schema:Person
    85 N350215811ffa471d91d08ddbdbd02fc5 schema:affiliation https://www.grid.ac/institutes/grid.413106.1
    86 schema:familyName Zhang
    87 schema:givenName Yefan
    88 rdf:type schema:Person
    89 N3579acf98e5d42d2a049cac640e76f4b rdf:first N5032188420a440968fc5623a6c16deca
    90 rdf:rest Ncfd6b26cdc7b4d70aec14708a85980c8
    91 N35f64de60b394b4e880ba3146f756ef6 rdf:first N68806d699e7a4335b6eba72f3e15a40f
    92 rdf:rest N7b19c59c6a1d45cd8208582b89902bda
    93 N3771917917254c13adb9df23839a7f6e rdf:first N0ee2938b52f040ffacf5ba719873b5cf
    94 rdf:rest N7bba2f2a88fe456bb8ee710de03360c7
    95 N3aa1dbd2d22b4e60955d878102632f07 schema:name doi
    96 schema:value 10.1007/s11605-019-04202-3
    97 rdf:type schema:PropertyValue
    98 N3cc89d8ad78a43359141cf8b013ac5bf schema:affiliation https://www.grid.ac/institutes/grid.413106.1
    99 schema:familyName Zhao
    100 schema:givenName Hong
    101 rdf:type schema:Person
    102 N3dd464dfe1e548a9b1524c2bb491975d schema:affiliation https://www.grid.ac/institutes/grid.413106.1
    103 schema:familyName Zhao
    104 schema:givenName Jianjun
    105 rdf:type schema:Person
    106 N44b363433e1e460e8c0dd778f68097ca schema:affiliation https://www.grid.ac/institutes/grid.413106.1
    107 schema:familyName Li
    108 schema:givenName Zhiyu
    109 rdf:type schema:Person
    110 N499d264e6c5140a79d285783a0cc5e52 rdf:first N3dd464dfe1e548a9b1524c2bb491975d
    111 rdf:rest N22ab073f6a2a4e89ba38d64750458182
    112 N4d29fb23c09f4bab80d511254b7a3421 schema:name pubmed_id
    113 schema:value 30937711
    114 rdf:type schema:PropertyValue
    115 N5032188420a440968fc5623a6c16deca schema:affiliation https://www.grid.ac/institutes/grid.413106.1
    116 schema:familyName Huang
    117 schema:givenName Zhen
    118 rdf:type schema:Person
    119 N68806d699e7a4335b6eba72f3e15a40f schema:affiliation https://www.grid.ac/institutes/grid.413106.1
    120 schema:familyName Wu
    121 schema:givenName Chaorui
    122 rdf:type schema:Person
    123 N6ea0c39e1ee249d294622208fe7c8ee6 schema:name readcube_id
    124 schema:value 1bfb07e9a124adf0a0f3568f984f5e0d8560ac6e57172171f27f64f0d17ef64e
    125 rdf:type schema:PropertyValue
    126 N7b19c59c6a1d45cd8208582b89902bda rdf:first N3cc89d8ad78a43359141cf8b013ac5bf
    127 rdf:rest N2a10bc01a9a0459ca42ec1fab19da306
    128 N7bba2f2a88fe456bb8ee710de03360c7 rdf:first N2f5d0eb4527948be8fc8259b48db74c9
    129 rdf:rest rdf:nil
    130 N888d59edc6ae4e74b5f598af2a37934c rdf:first N44b363433e1e460e8c0dd778f68097ca
    131 rdf:rest N3579acf98e5d42d2a049cac640e76f4b
    132 N8b1bd88d5ceb40b09fd2022439ca6346 schema:affiliation https://www.grid.ac/institutes/grid.413106.1
    133 schema:familyName Chen
    134 schema:givenName Qichen
    135 rdf:type schema:Person
    136 N8b90d34c438f46dca1879302e600782d schema:name Springer Nature - SN SciGraph project
    137 rdf:type schema:Organization
    138 N94e35be214f34c78803160b0bd59db48 schema:name nlm_unique_id
    139 schema:value 9706084
    140 rdf:type schema:PropertyValue
    141 Nb73205bf24b54cd8b076d0775f370a32 schema:name dimensions_id
    142 schema:value pub.1113171027
    143 rdf:type schema:PropertyValue
    144 Ncede3cac59ea45169d307f6c7fd04080 schema:affiliation https://www.grid.ac/institutes/grid.413106.1
    145 schema:familyName Bi
    146 schema:givenName Xinyu
    147 rdf:type schema:Person
    148 Ncfd6b26cdc7b4d70aec14708a85980c8 rdf:first N350215811ffa471d91d08ddbdbd02fc5
    149 rdf:rest N3771917917254c13adb9df23839a7f6e
    150 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
    151 schema:name Medical and Health Sciences
    152 rdf:type schema:DefinedTerm
    153 anzsrc-for:1112 schema:inDefinedTermSet anzsrc-for:
    154 schema:name Oncology and Carcinogenesis
    155 rdf:type schema:DefinedTerm
    156 sg:journal.1116755 schema:issn 1091-255X
    157 1873-4626
    158 schema:name Journal of Gastrointestinal Surgery
    159 rdf:type schema:Periodical
    160 sg:pub.10.1007/s00280-007-0588-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029987674
    161 https://doi.org/10.1007/s00280-007-0588-3
    162 rdf:type schema:CreativeWork
    163 sg:pub.10.1007/s00464-014-3965-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049250273
    164 https://doi.org/10.1007/s00464-014-3965-0
    165 rdf:type schema:CreativeWork
    166 sg:pub.10.1007/s10147-015-0875-7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045934558
    167 https://doi.org/10.1007/s10147-015-0875-7
    168 rdf:type schema:CreativeWork
    169 sg:pub.10.1007/s10549-011-1799-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023771662
    170 https://doi.org/10.1007/s10549-011-1799-1
    171 rdf:type schema:CreativeWork
    172 sg:pub.10.1038/bjc.2015.321 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045647224
    173 https://doi.org/10.1038/bjc.2015.321
    174 rdf:type schema:CreativeWork
    175 sg:pub.10.1038/sj.bjc.6603831 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044978496
    176 https://doi.org/10.1038/sj.bjc.6603831
    177 rdf:type schema:CreativeWork
    178 sg:pub.10.1186/s12885-015-1442-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040296750
    179 https://doi.org/10.1186/s12885-015-1442-3
    180 rdf:type schema:CreativeWork
    181 sg:pub.10.1186/s12885-016-2491-y schema:sameAs https://app.dimensions.ai/details/publication/pub.1003171100
    182 https://doi.org/10.1186/s12885-016-2491-y
    183 rdf:type schema:CreativeWork
    184 sg:pub.10.1245/s10434-010-1166-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034900487
    185 https://doi.org/10.1245/s10434-010-1166-1
    186 rdf:type schema:CreativeWork
    187 sg:pub.10.1245/s10434-010-1409-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044879140
    188 https://doi.org/10.1245/s10434-010-1409-1
    189 rdf:type schema:CreativeWork
    190 sg:pub.10.1245/s10434-015-4423-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052036142
    191 https://doi.org/10.1245/s10434-015-4423-5
    192 rdf:type schema:CreativeWork
    193 https://app.dimensions.ai/details/publication/pub.1077824144 schema:CreativeWork
    194 https://doi.org/10.1001/jamasurg.2013.63 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013991673
    195 rdf:type schema:CreativeWork
    196 https://doi.org/10.1002/bjs.6947 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003950270
    197 rdf:type schema:CreativeWork
    198 https://doi.org/10.1002/bjs.7823 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016086124
    199 rdf:type schema:CreativeWork
    200 https://doi.org/10.1016/j.clcc.2016.03.007 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023426656
    201 rdf:type schema:CreativeWork
    202 https://doi.org/10.1016/j.ejca.2006.04.012 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029538220
    203 rdf:type schema:CreativeWork
    204 https://doi.org/10.1016/j.ejca.2008.10.026 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026558254
    205 rdf:type schema:CreativeWork
    206 https://doi.org/10.1016/j.ejca.2015.12.030 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022644363
    207 rdf:type schema:CreativeWork
    208 https://doi.org/10.1016/j.ejso.2015.03.223 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051955566
    209 rdf:type schema:CreativeWork
    210 https://doi.org/10.1016/j.ejso.2016.08.019 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031592776
    211 rdf:type schema:CreativeWork
    212 https://doi.org/10.1016/s0140-6736(08)60455-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038419533
    213 rdf:type schema:CreativeWork
    214 https://doi.org/10.1016/s1470-2045(05)70255-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022570043
    215 rdf:type schema:CreativeWork
    216 https://doi.org/10.1055/s-0029-1242458 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035322968
    217 rdf:type schema:CreativeWork
    218 https://doi.org/10.1080/01635581.2014.894103 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039365401
    219 rdf:type schema:CreativeWork
    220 https://doi.org/10.1080/10428190701474373 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040600664
    221 rdf:type schema:CreativeWork
    222 https://doi.org/10.1093/annonc/mdl386 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036275458
    223 rdf:type schema:CreativeWork
    224 https://doi.org/10.1097/01.sla.0000133083.54934.ae schema:sameAs https://app.dimensions.ai/details/publication/pub.1024049438
    225 rdf:type schema:CreativeWork
    226 https://doi.org/10.1097/sla.0000000000002679 schema:sameAs https://app.dimensions.ai/details/publication/pub.1100668089
    227 rdf:type schema:CreativeWork
    228 https://doi.org/10.1097/sla.0b013e31815aa2c2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026128215
    229 rdf:type schema:CreativeWork
    230 https://doi.org/10.1111/ecc.12120 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041776227
    231 rdf:type schema:CreativeWork
    232 https://doi.org/10.1111/hpb.12327 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008782844
    233 rdf:type schema:CreativeWork
    234 https://doi.org/10.1111/joim.12100 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008399513
    235 rdf:type schema:CreativeWork
    236 https://doi.org/10.1158/1078-0432.ccr-09-1555 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052297773
    237 rdf:type schema:CreativeWork
    238 https://doi.org/10.1159/000449349 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031984064
    239 rdf:type schema:CreativeWork
    240 https://doi.org/10.1200/jco.2005.00.349 schema:sameAs https://app.dimensions.ai/details/publication/pub.1064204185
    241 rdf:type schema:CreativeWork
    242 https://doi.org/10.1200/jco.2008.17.5299 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033537766
    243 rdf:type schema:CreativeWork
    244 https://doi.org/10.3802/jgo.2009.20.3.146 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029403173
    245 rdf:type schema:CreativeWork
    246 https://doi.org/10.3892/ol.2014.1822 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017067625
    247 rdf:type schema:CreativeWork
    248 https://doi.org/10.5306/wjco.v7.i1.9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1072757684
    249 rdf:type schema:CreativeWork
    250 https://www.grid.ac/institutes/grid.413106.1 schema:alternateName Peking Union Medical College Hospital
    251 schema:name Department of Hepatobiliary Surgery, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, 100021, Beijing, China
    252 Department of Pancreatic and Gastric Surgery, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, 100021, Beijing, China
    253 rdf:type schema:Organization
     




    Preview window. Press ESC to close (or click here)


    ...