Systemic Immune-Inflammation Index (SII) Predicts Poor Survival in Pancreatic Cancer Patients Undergoing Resection View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2019-03-28

AUTHORS

Gerd Jomrich, Elisabeth S. Gruber, Daniel Winkler, Marlene Hollenstein, Michael Gnant, Klaus Sahora, Martin Schindl

ABSTRACT

BACKGROUND: The systemic immune-inflammation index based on peripheral neutrophil, lymphocyte, and platelet counts has shown a prognostic impact in several malignancies. The aim of this study was to determine the prognostic role of systemic immune-inflammation index in patients with pancreatic ductal adenocarcinoma undergoing resection. METHODS: Consecutive patients who underwent surgical resection at the department of surgery at the Medical University of Vienna between 1995 and 2014 were included into this study. The systemic immune-inflammation index was calculated by the formula platelet*neutrophil/lymphocyte. Optimal cutoffs were determined using Youden's index. Uni- and multivariate analyses were calculated by the Cox proportional hazard regression model for overall survival. RESULTS: Three hundred twenty-one patients were included in this study. Clinical data was achieved from a prospective patient database. In univariate survival analysis, elevated systemic immune-inflammation index was found to be significantly associated with shortened patients' overall survival (p = 0.007). In multivariate survival analysis, systemic immune-inflammation index remained an independent prognostic factor for overall survival (p = 0.004). No statistical significance could be found for platelet to lymphocyte ratio and neutrophil to lymphocyte ratio in multivariate analysis. Furthermore, area under the curve analysis showed a higher prognostic significance for systemic immune-inflammation index, compared to platelet to lymphocyte ratio and neutrophil to lymphocyte ratio. CONCLUSION: A high systemic immune-inflammation index is an independent, preoperative available prognostic factor in patients with resectable pancreatic ductal adenocarcinoma and is superior to platelet to lymphocyte ratio and neutrophil to lymphocyte ratio for predicting overall survival in pancreatic ductal adenocarcinoma patients. More... »

PAGES

1-9

References to SciGraph publications

  • 2013-07. Comparison of the prognostic value of longitudinal measurements of systemic inflammation in patients undergoing curative resection of colorectal cancer in BRITISH JOURNAL OF CANCER
  • 2016-12. Systemic Immune-Inflammation Index Predicts Prognosis of Patients with Esophageal Squamous Cell Carcinoma: A Propensity Score-matched Analysis in SCIENTIFIC REPORTS
  • 2013-08. Cancer and systemic inflammation: stage the tumour and stage the host in BRITISH JOURNAL OF CANCER
  • 2011-02. An inflammation-based prognostic score (mGPS) predicts cancer survival independent of tumour site: a Glasgow Inflammation Outcome Study in BRITISH JOURNAL OF CANCER
  • 2008-07. Cancer-related inflammation in NATURE
  • 2011-12. pROC: an open-source package for R and S+ to analyze and compare ROC curves in BMC BIOINFORMATICS
  • 2014-04. Prognostic performance of inflammation-based prognostic indices in primary operable non-small cell lung cancer in BRITISH JOURNAL OF CANCER
  • 2010-02. Neutrophil elastase–mediated degradation of IRS-1 accelerates lung tumor growth in NATURE MEDICINE
  • 2004-01. Neutrophil elastase induces IL-8 synthesis by lung epithelial cells via the mitogen-activated protein kinase pathway in JOURNAL OF BIOMEDICAL SCIENCE
  • 2009-01. Pre-treatment neutrophil to lymphocyte ratio is elevated in epithelial ovarian cancer and predicts survival after treatment in CANCER IMMUNOLOGY, IMMUNOTHERAPY
  • 2017-12. Systemic immune-inflammation index predicting chemoradiation resistance and poor outcome in patients with stage III non-small cell lung cancer in JOURNAL OF TRANSLATIONAL MEDICINE
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1007/s11605-019-04187-z

    DOI

    http://dx.doi.org/10.1007/s11605-019-04187-z

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1113059570

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/30923999


    Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
    Incoming Citations Browse incoming citations for this publication using opencitations.net

    JSON-LD is the canonical representation for SciGraph data.

    TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

    [
      {
        "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
        "about": [
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1107", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Immunology", 
            "type": "DefinedTerm"
          }, 
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Medical and Health Sciences", 
            "type": "DefinedTerm"
          }
        ], 
        "author": [
          {
            "affiliation": {
              "name": [
                "Department of Surgery, Comprehensive Cancer Center (CCC), Medical University Vienna and Pancreatic Cancer Unit, Spitalgasse 23, 1090, Vienna, Austria"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Jomrich", 
            "givenName": "Gerd", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "name": [
                "Department of Surgery, Comprehensive Cancer Center (CCC), Medical University Vienna and Pancreatic Cancer Unit, Spitalgasse 23, 1090, Vienna, Austria"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Gruber", 
            "givenName": "Elisabeth S.", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Vienna University of Economics and Business", 
              "id": "https://www.grid.ac/institutes/grid.15788.33", 
              "name": [
                "Vienna University of Economics and Business, Welthandelsplatz 1, AD 1020, Vienna, Austria"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Winkler", 
            "givenName": "Daniel", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "name": [
                "Department of Surgery, Comprehensive Cancer Center (CCC), Medical University Vienna and Pancreatic Cancer Unit, Spitalgasse 23, 1090, Vienna, Austria"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Hollenstein", 
            "givenName": "Marlene", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "name": [
                "Department of Surgery, Comprehensive Cancer Center (CCC), Medical University Vienna and Pancreatic Cancer Unit, Spitalgasse 23, 1090, Vienna, Austria"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Gnant", 
            "givenName": "Michael", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "name": [
                "Department of Surgery, Comprehensive Cancer Center (CCC), Medical University Vienna and Pancreatic Cancer Unit, Spitalgasse 23, 1090, Vienna, Austria"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Sahora", 
            "givenName": "Klaus", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "name": [
                "Department of Surgery, Comprehensive Cancer Center (CCC), Medical University Vienna and Pancreatic Cancer Unit, Spitalgasse 23, 1090, Vienna, Austria"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Schindl", 
            "givenName": "Martin", 
            "type": "Person"
          }
        ], 
        "citation": [
          {
            "id": "https://doi.org/10.1002/jso.20329", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1000041674"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/jso.20329", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1000041674"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/bjc.2013.330", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1002283754", 
              "https://doi.org/10.1038/bjc.2013.330"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/sj.bjc.6606087", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1003536381", 
              "https://doi.org/10.1038/sj.bjc.6606087"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1080/13651820802140752", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1006855070"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.3389/fphar.2016.00376", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1007521557"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/bjc.2013.418", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1007903310", 
              "https://doi.org/10.1038/bjc.2013.418"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00262-008-0516-3", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1009026832", 
              "https://doi.org/10.1007/s00262-008-0516-3"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00262-008-0516-3", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1009026832", 
              "https://doi.org/10.1007/s00262-008-0516-3"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.3322/caac.20107", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1009055747"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/srep39482", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1013301058", 
              "https://doi.org/10.1038/srep39482"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/srep39482", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1013301058", 
              "https://doi.org/10.1038/srep39482"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/1471-2105-12-77", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1014582441", 
              "https://doi.org/10.1186/1471-2105-12-77"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/1471-2105-12-77", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1014582441", 
              "https://doi.org/10.1186/1471-2105-12-77"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.cell.2010.01.025", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1016166048"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1158/1078-0432.ccr-03-0760", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1016396177"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.ejca.2009.01.023", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1017080870"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.amjsurg.2007.12.057", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1020597447"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.ejca.2009.12.014", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1021779666"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1158/1078-0432.ccr-14-0442", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1022536696"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.cell.2011.02.013", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1023540354"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature07205", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1024729982", 
              "https://doi.org/10.1038/nature07205"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/1097-0142(1950)3:1<32::aid-cncr2820030106>3.0.co;2-3", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1024768178"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1620/tjem.236.297", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1025022130"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1158/1078-0432.ccr-10-2245", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1026726521"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nm.2084", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1026729604", 
              "https://doi.org/10.1038/nm.2084"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nm.2084", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1026729604", 
              "https://doi.org/10.1038/nm.2084"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.18632/oncotarget.10515", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1027487036"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1159/000075288", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1027610193"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1056/nejm198612253152606", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1030598947"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.jtcvs.2008.05.046", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1031018108"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/bf02256548", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1033825486", 
              "https://doi.org/10.1007/bf02256548"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/bf02256548", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1033825486", 
              "https://doi.org/10.1007/bf02256548"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.ccr.2011.09.009", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1041179796"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/bjc.2014.145", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1045557480", 
              "https://doi.org/10.1038/bjc.2014.145"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0140-6736(00)04046-0", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1047972304"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s1470-2045(08)70201-8", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1050114265"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1136/gutjnl-2015-311256", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1062813709"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.18637/jss.v061.i08", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1068672912"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/md.0000000000005886", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1074231683"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/md.0000000000005886", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1074231683"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/md.0000000000005886", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1074231683"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1155/2017/1678584", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1086350916"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.6004/jnccn.2017.0131", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1091089483"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.6004/jnccn.2017.0131", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1091089483"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/s12967-017-1326-1", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1092465870", 
              "https://doi.org/10.1186/s12967-017-1326-1"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.3390/biomedicines5040065", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1092751744"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.hpb.2017.10.011", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1099600585"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.18632/oncotarget.24087", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1100282436"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.hpb.2017.12.009", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1100318689"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/sla.0000000000002660", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1100399794"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/sla.0000000000002660", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1100399794"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/sla.0000000000002660", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1100399794"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/sla.0000000000002660", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1100399794"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/sla.0000000000002660", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1100399794"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/sla.0000000000002660", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1100399794"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/sla.0000000000002660", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1100399794"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/sla.0000000000002660", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1100399794"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/sla.0000000000002660", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1100399794"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.2217/fon-2017-0635", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1103181475"
            ], 
            "type": "CreativeWork"
          }
        ], 
        "datePublished": "2019-03-28", 
        "datePublishedReg": "2019-03-28", 
        "description": "BACKGROUND: The systemic immune-inflammation index based on peripheral neutrophil, lymphocyte, and platelet counts has shown a prognostic impact in several malignancies. The aim of this study was to determine the prognostic role of systemic immune-inflammation index in patients with pancreatic ductal adenocarcinoma undergoing resection.\nMETHODS: Consecutive patients who underwent surgical resection at the department of surgery at the Medical University of Vienna between 1995 and 2014 were included into this study. The systemic immune-inflammation index was calculated by the formula platelet*neutrophil/lymphocyte. Optimal cutoffs were determined using Youden's index. Uni- and multivariate analyses were calculated by the Cox proportional hazard regression model for overall survival.\nRESULTS: Three hundred twenty-one patients were included in this study. Clinical data was achieved from a prospective patient database. In univariate survival analysis, elevated systemic immune-inflammation index was found to be significantly associated with shortened patients' overall survival (p\u2009=\u20090.007). In multivariate survival analysis, systemic immune-inflammation index remained an independent prognostic factor for overall survival (p\u2009=\u20090.004). No statistical significance could be found for platelet to lymphocyte ratio and neutrophil to lymphocyte ratio in multivariate analysis. Furthermore, area under the curve analysis showed a higher prognostic significance for systemic immune-inflammation index, compared to platelet to lymphocyte ratio and neutrophil to lymphocyte ratio.\nCONCLUSION: A high systemic immune-inflammation index is an independent, preoperative available prognostic factor in patients with resectable pancreatic ductal adenocarcinoma and is superior to platelet to lymphocyte ratio and neutrophil to lymphocyte ratio for predicting overall survival in pancreatic ductal adenocarcinoma patients.", 
        "genre": "research_article", 
        "id": "sg:pub.10.1007/s11605-019-04187-z", 
        "inLanguage": [
          "en"
        ], 
        "isAccessibleForFree": false, 
        "isPartOf": [
          {
            "id": "sg:journal.1116755", 
            "issn": [
              "1091-255X", 
              "1873-4626"
            ], 
            "name": "Journal of Gastrointestinal Surgery", 
            "type": "Periodical"
          }
        ], 
        "name": "Systemic Immune-Inflammation Index (SII) Predicts Poor Survival in Pancreatic Cancer Patients Undergoing Resection", 
        "pagination": "1-9", 
        "productId": [
          {
            "name": "readcube_id", 
            "type": "PropertyValue", 
            "value": [
              "d0ef9f8f61f03dd64fe77d103c16363aa9d2568c11c078248f005f010e7f2594"
            ]
          }, 
          {
            "name": "pubmed_id", 
            "type": "PropertyValue", 
            "value": [
              "30923999"
            ]
          }, 
          {
            "name": "nlm_unique_id", 
            "type": "PropertyValue", 
            "value": [
              "9706084"
            ]
          }, 
          {
            "name": "doi", 
            "type": "PropertyValue", 
            "value": [
              "10.1007/s11605-019-04187-z"
            ]
          }, 
          {
            "name": "dimensions_id", 
            "type": "PropertyValue", 
            "value": [
              "pub.1113059570"
            ]
          }
        ], 
        "sameAs": [
          "https://doi.org/10.1007/s11605-019-04187-z", 
          "https://app.dimensions.ai/details/publication/pub.1113059570"
        ], 
        "sdDataset": "articles", 
        "sdDatePublished": "2019-04-11T13:19", 
        "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
        "sdPublisher": {
          "name": "Springer Nature - SN SciGraph project", 
          "type": "Organization"
        }, 
        "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000368_0000000368/records_78956_00000001.jsonl", 
        "type": "ScholarlyArticle", 
        "url": "https://link.springer.com/10.1007%2Fs11605-019-04187-z"
      }
    ]
     

    Download the RDF metadata as:  json-ld nt turtle xml License info

    HOW TO GET THIS DATA PROGRAMMATICALLY:

    JSON-LD is a popular format for linked data which is fully compatible with JSON.

    curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s11605-019-04187-z'

    N-Triples is a line-based linked data format ideal for batch operations.

    curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s11605-019-04187-z'

    Turtle is a human-readable linked data format.

    curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s11605-019-04187-z'

    RDF/XML is a standard XML format for linked data.

    curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s11605-019-04187-z'


     

    This table displays all metadata directly associated to this object as RDF triples.

    250 TRIPLES      21 PREDICATES      69 URIs      18 LITERALS      7 BLANK NODES

    Subject Predicate Object
    1 sg:pub.10.1007/s11605-019-04187-z schema:about anzsrc-for:11
    2 anzsrc-for:1107
    3 schema:author Nce082972cfa34c45a8a7650b4760e9f3
    4 schema:citation sg:pub.10.1007/bf02256548
    5 sg:pub.10.1007/s00262-008-0516-3
    6 sg:pub.10.1038/bjc.2013.330
    7 sg:pub.10.1038/bjc.2013.418
    8 sg:pub.10.1038/bjc.2014.145
    9 sg:pub.10.1038/nature07205
    10 sg:pub.10.1038/nm.2084
    11 sg:pub.10.1038/sj.bjc.6606087
    12 sg:pub.10.1038/srep39482
    13 sg:pub.10.1186/1471-2105-12-77
    14 sg:pub.10.1186/s12967-017-1326-1
    15 https://doi.org/10.1002/1097-0142(1950)3:1<32::aid-cncr2820030106>3.0.co;2-3
    16 https://doi.org/10.1002/jso.20329
    17 https://doi.org/10.1016/j.amjsurg.2007.12.057
    18 https://doi.org/10.1016/j.ccr.2011.09.009
    19 https://doi.org/10.1016/j.cell.2010.01.025
    20 https://doi.org/10.1016/j.cell.2011.02.013
    21 https://doi.org/10.1016/j.ejca.2009.01.023
    22 https://doi.org/10.1016/j.ejca.2009.12.014
    23 https://doi.org/10.1016/j.hpb.2017.10.011
    24 https://doi.org/10.1016/j.hpb.2017.12.009
    25 https://doi.org/10.1016/j.jtcvs.2008.05.046
    26 https://doi.org/10.1016/s0140-6736(00)04046-0
    27 https://doi.org/10.1016/s1470-2045(08)70201-8
    28 https://doi.org/10.1056/nejm198612253152606
    29 https://doi.org/10.1080/13651820802140752
    30 https://doi.org/10.1097/md.0000000000005886
    31 https://doi.org/10.1097/sla.0000000000002660
    32 https://doi.org/10.1136/gutjnl-2015-311256
    33 https://doi.org/10.1155/2017/1678584
    34 https://doi.org/10.1158/1078-0432.ccr-03-0760
    35 https://doi.org/10.1158/1078-0432.ccr-10-2245
    36 https://doi.org/10.1158/1078-0432.ccr-14-0442
    37 https://doi.org/10.1159/000075288
    38 https://doi.org/10.1620/tjem.236.297
    39 https://doi.org/10.18632/oncotarget.10515
    40 https://doi.org/10.18632/oncotarget.24087
    41 https://doi.org/10.18637/jss.v061.i08
    42 https://doi.org/10.2217/fon-2017-0635
    43 https://doi.org/10.3322/caac.20107
    44 https://doi.org/10.3389/fphar.2016.00376
    45 https://doi.org/10.3390/biomedicines5040065
    46 https://doi.org/10.6004/jnccn.2017.0131
    47 schema:datePublished 2019-03-28
    48 schema:datePublishedReg 2019-03-28
    49 schema:description BACKGROUND: The systemic immune-inflammation index based on peripheral neutrophil, lymphocyte, and platelet counts has shown a prognostic impact in several malignancies. The aim of this study was to determine the prognostic role of systemic immune-inflammation index in patients with pancreatic ductal adenocarcinoma undergoing resection. METHODS: Consecutive patients who underwent surgical resection at the department of surgery at the Medical University of Vienna between 1995 and 2014 were included into this study. The systemic immune-inflammation index was calculated by the formula platelet*neutrophil/lymphocyte. Optimal cutoffs were determined using Youden's index. Uni- and multivariate analyses were calculated by the Cox proportional hazard regression model for overall survival. RESULTS: Three hundred twenty-one patients were included in this study. Clinical data was achieved from a prospective patient database. In univariate survival analysis, elevated systemic immune-inflammation index was found to be significantly associated with shortened patients' overall survival (p = 0.007). In multivariate survival analysis, systemic immune-inflammation index remained an independent prognostic factor for overall survival (p = 0.004). No statistical significance could be found for platelet to lymphocyte ratio and neutrophil to lymphocyte ratio in multivariate analysis. Furthermore, area under the curve analysis showed a higher prognostic significance for systemic immune-inflammation index, compared to platelet to lymphocyte ratio and neutrophil to lymphocyte ratio. CONCLUSION: A high systemic immune-inflammation index is an independent, preoperative available prognostic factor in patients with resectable pancreatic ductal adenocarcinoma and is superior to platelet to lymphocyte ratio and neutrophil to lymphocyte ratio for predicting overall survival in pancreatic ductal adenocarcinoma patients.
    50 schema:genre research_article
    51 schema:inLanguage en
    52 schema:isAccessibleForFree false
    53 schema:isPartOf sg:journal.1116755
    54 schema:name Systemic Immune-Inflammation Index (SII) Predicts Poor Survival in Pancreatic Cancer Patients Undergoing Resection
    55 schema:pagination 1-9
    56 schema:productId N297c3162b8024cb99d59adf52fc6533c
    57 N38e1e88873314392bae16e01031d553f
    58 N63fc47a15ae24a47afd51b828c4f3c72
    59 Nd55eb8cfcdfa467ea3151fd456d528bb
    60 Nf60ed57d0f054a47b93eec8f2bbef252
    61 schema:sameAs https://app.dimensions.ai/details/publication/pub.1113059570
    62 https://doi.org/10.1007/s11605-019-04187-z
    63 schema:sdDatePublished 2019-04-11T13:19
    64 schema:sdLicense https://scigraph.springernature.com/explorer/license/
    65 schema:sdPublisher N821f635f924046568dcb0854a199500a
    66 schema:url https://link.springer.com/10.1007%2Fs11605-019-04187-z
    67 sgo:license sg:explorer/license/
    68 sgo:sdDataset articles
    69 rdf:type schema:ScholarlyArticle
    70 N13d2e0b854374d55a048bc41ba04cb4d schema:name Department of Surgery, Comprehensive Cancer Center (CCC), Medical University Vienna and Pancreatic Cancer Unit, Spitalgasse 23, 1090, Vienna, Austria
    71 rdf:type schema:Organization
    72 N2287c13c7b2d4755be01777f05e806eb rdf:first N30efd1496f43469ca8bc5ca48c922365
    73 rdf:rest Nefc464df5254438db625372dba98b8e8
    74 N297c3162b8024cb99d59adf52fc6533c schema:name doi
    75 schema:value 10.1007/s11605-019-04187-z
    76 rdf:type schema:PropertyValue
    77 N2ab15693e0604948a9bf2484464b335c schema:name Department of Surgery, Comprehensive Cancer Center (CCC), Medical University Vienna and Pancreatic Cancer Unit, Spitalgasse 23, 1090, Vienna, Austria
    78 rdf:type schema:Organization
    79 N30efd1496f43469ca8bc5ca48c922365 schema:affiliation Nc92f847976eb405e8a4ab2ab7031a036
    80 schema:familyName Sahora
    81 schema:givenName Klaus
    82 rdf:type schema:Person
    83 N3626a0f4dc9c4d55bd00544e3f38c848 schema:affiliation https://www.grid.ac/institutes/grid.15788.33
    84 schema:familyName Winkler
    85 schema:givenName Daniel
    86 rdf:type schema:Person
    87 N38e1e88873314392bae16e01031d553f schema:name nlm_unique_id
    88 schema:value 9706084
    89 rdf:type schema:PropertyValue
    90 N39a70e00ec5845189880733c0a35cc5d schema:name Department of Surgery, Comprehensive Cancer Center (CCC), Medical University Vienna and Pancreatic Cancer Unit, Spitalgasse 23, 1090, Vienna, Austria
    91 rdf:type schema:Organization
    92 N60d0c3dff0124766b4dce5be18ae86e0 rdf:first Ned132695aff84fceb5a9de32a084dcae
    93 rdf:rest N2287c13c7b2d4755be01777f05e806eb
    94 N63fc47a15ae24a47afd51b828c4f3c72 schema:name dimensions_id
    95 schema:value pub.1113059570
    96 rdf:type schema:PropertyValue
    97 N6c3e4ecc067144dc994820c30239b8c7 schema:name Department of Surgery, Comprehensive Cancer Center (CCC), Medical University Vienna and Pancreatic Cancer Unit, Spitalgasse 23, 1090, Vienna, Austria
    98 rdf:type schema:Organization
    99 N6cc74b8c49f7463292f730ef19087f90 schema:affiliation N13d2e0b854374d55a048bc41ba04cb4d
    100 schema:familyName Schindl
    101 schema:givenName Martin
    102 rdf:type schema:Person
    103 N725e9894c5f846139bf2545d64a2d023 schema:affiliation N39a70e00ec5845189880733c0a35cc5d
    104 schema:familyName Gruber
    105 schema:givenName Elisabeth S.
    106 rdf:type schema:Person
    107 N821f635f924046568dcb0854a199500a schema:name Springer Nature - SN SciGraph project
    108 rdf:type schema:Organization
    109 N9be0838abec4452c8bb64261fd6c6efc schema:affiliation N6c3e4ecc067144dc994820c30239b8c7
    110 schema:familyName Hollenstein
    111 schema:givenName Marlene
    112 rdf:type schema:Person
    113 Nbbe66f76c8f84b72a3c21dd1df9b8589 schema:affiliation Nf8c080b9978744df9e8e053fc164e5e4
    114 schema:familyName Jomrich
    115 schema:givenName Gerd
    116 rdf:type schema:Person
    117 Nc92f847976eb405e8a4ab2ab7031a036 schema:name Department of Surgery, Comprehensive Cancer Center (CCC), Medical University Vienna and Pancreatic Cancer Unit, Spitalgasse 23, 1090, Vienna, Austria
    118 rdf:type schema:Organization
    119 Nc9c65698a7b54edcbcdc2ed52dc1109a rdf:first N3626a0f4dc9c4d55bd00544e3f38c848
    120 rdf:rest Nd0812ffe194f428088ee63adcd589dd3
    121 Nce082972cfa34c45a8a7650b4760e9f3 rdf:first Nbbe66f76c8f84b72a3c21dd1df9b8589
    122 rdf:rest Nfc1de029cd334074be51696fc0e45df9
    123 Nd0812ffe194f428088ee63adcd589dd3 rdf:first N9be0838abec4452c8bb64261fd6c6efc
    124 rdf:rest N60d0c3dff0124766b4dce5be18ae86e0
    125 Nd55eb8cfcdfa467ea3151fd456d528bb schema:name pubmed_id
    126 schema:value 30923999
    127 rdf:type schema:PropertyValue
    128 Ned132695aff84fceb5a9de32a084dcae schema:affiliation N2ab15693e0604948a9bf2484464b335c
    129 schema:familyName Gnant
    130 schema:givenName Michael
    131 rdf:type schema:Person
    132 Nefc464df5254438db625372dba98b8e8 rdf:first N6cc74b8c49f7463292f730ef19087f90
    133 rdf:rest rdf:nil
    134 Nf60ed57d0f054a47b93eec8f2bbef252 schema:name readcube_id
    135 schema:value d0ef9f8f61f03dd64fe77d103c16363aa9d2568c11c078248f005f010e7f2594
    136 rdf:type schema:PropertyValue
    137 Nf8c080b9978744df9e8e053fc164e5e4 schema:name Department of Surgery, Comprehensive Cancer Center (CCC), Medical University Vienna and Pancreatic Cancer Unit, Spitalgasse 23, 1090, Vienna, Austria
    138 rdf:type schema:Organization
    139 Nfc1de029cd334074be51696fc0e45df9 rdf:first N725e9894c5f846139bf2545d64a2d023
    140 rdf:rest Nc9c65698a7b54edcbcdc2ed52dc1109a
    141 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
    142 schema:name Medical and Health Sciences
    143 rdf:type schema:DefinedTerm
    144 anzsrc-for:1107 schema:inDefinedTermSet anzsrc-for:
    145 schema:name Immunology
    146 rdf:type schema:DefinedTerm
    147 sg:journal.1116755 schema:issn 1091-255X
    148 1873-4626
    149 schema:name Journal of Gastrointestinal Surgery
    150 rdf:type schema:Periodical
    151 sg:pub.10.1007/bf02256548 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033825486
    152 https://doi.org/10.1007/bf02256548
    153 rdf:type schema:CreativeWork
    154 sg:pub.10.1007/s00262-008-0516-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009026832
    155 https://doi.org/10.1007/s00262-008-0516-3
    156 rdf:type schema:CreativeWork
    157 sg:pub.10.1038/bjc.2013.330 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002283754
    158 https://doi.org/10.1038/bjc.2013.330
    159 rdf:type schema:CreativeWork
    160 sg:pub.10.1038/bjc.2013.418 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007903310
    161 https://doi.org/10.1038/bjc.2013.418
    162 rdf:type schema:CreativeWork
    163 sg:pub.10.1038/bjc.2014.145 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045557480
    164 https://doi.org/10.1038/bjc.2014.145
    165 rdf:type schema:CreativeWork
    166 sg:pub.10.1038/nature07205 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024729982
    167 https://doi.org/10.1038/nature07205
    168 rdf:type schema:CreativeWork
    169 sg:pub.10.1038/nm.2084 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026729604
    170 https://doi.org/10.1038/nm.2084
    171 rdf:type schema:CreativeWork
    172 sg:pub.10.1038/sj.bjc.6606087 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003536381
    173 https://doi.org/10.1038/sj.bjc.6606087
    174 rdf:type schema:CreativeWork
    175 sg:pub.10.1038/srep39482 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013301058
    176 https://doi.org/10.1038/srep39482
    177 rdf:type schema:CreativeWork
    178 sg:pub.10.1186/1471-2105-12-77 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014582441
    179 https://doi.org/10.1186/1471-2105-12-77
    180 rdf:type schema:CreativeWork
    181 sg:pub.10.1186/s12967-017-1326-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1092465870
    182 https://doi.org/10.1186/s12967-017-1326-1
    183 rdf:type schema:CreativeWork
    184 https://doi.org/10.1002/1097-0142(1950)3:1<32::aid-cncr2820030106>3.0.co;2-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024768178
    185 rdf:type schema:CreativeWork
    186 https://doi.org/10.1002/jso.20329 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000041674
    187 rdf:type schema:CreativeWork
    188 https://doi.org/10.1016/j.amjsurg.2007.12.057 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020597447
    189 rdf:type schema:CreativeWork
    190 https://doi.org/10.1016/j.ccr.2011.09.009 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041179796
    191 rdf:type schema:CreativeWork
    192 https://doi.org/10.1016/j.cell.2010.01.025 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016166048
    193 rdf:type schema:CreativeWork
    194 https://doi.org/10.1016/j.cell.2011.02.013 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023540354
    195 rdf:type schema:CreativeWork
    196 https://doi.org/10.1016/j.ejca.2009.01.023 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017080870
    197 rdf:type schema:CreativeWork
    198 https://doi.org/10.1016/j.ejca.2009.12.014 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021779666
    199 rdf:type schema:CreativeWork
    200 https://doi.org/10.1016/j.hpb.2017.10.011 schema:sameAs https://app.dimensions.ai/details/publication/pub.1099600585
    201 rdf:type schema:CreativeWork
    202 https://doi.org/10.1016/j.hpb.2017.12.009 schema:sameAs https://app.dimensions.ai/details/publication/pub.1100318689
    203 rdf:type schema:CreativeWork
    204 https://doi.org/10.1016/j.jtcvs.2008.05.046 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031018108
    205 rdf:type schema:CreativeWork
    206 https://doi.org/10.1016/s0140-6736(00)04046-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047972304
    207 rdf:type schema:CreativeWork
    208 https://doi.org/10.1016/s1470-2045(08)70201-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050114265
    209 rdf:type schema:CreativeWork
    210 https://doi.org/10.1056/nejm198612253152606 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030598947
    211 rdf:type schema:CreativeWork
    212 https://doi.org/10.1080/13651820802140752 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006855070
    213 rdf:type schema:CreativeWork
    214 https://doi.org/10.1097/md.0000000000005886 schema:sameAs https://app.dimensions.ai/details/publication/pub.1074231683
    215 rdf:type schema:CreativeWork
    216 https://doi.org/10.1097/sla.0000000000002660 schema:sameAs https://app.dimensions.ai/details/publication/pub.1100399794
    217 rdf:type schema:CreativeWork
    218 https://doi.org/10.1136/gutjnl-2015-311256 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062813709
    219 rdf:type schema:CreativeWork
    220 https://doi.org/10.1155/2017/1678584 schema:sameAs https://app.dimensions.ai/details/publication/pub.1086350916
    221 rdf:type schema:CreativeWork
    222 https://doi.org/10.1158/1078-0432.ccr-03-0760 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016396177
    223 rdf:type schema:CreativeWork
    224 https://doi.org/10.1158/1078-0432.ccr-10-2245 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026726521
    225 rdf:type schema:CreativeWork
    226 https://doi.org/10.1158/1078-0432.ccr-14-0442 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022536696
    227 rdf:type schema:CreativeWork
    228 https://doi.org/10.1159/000075288 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027610193
    229 rdf:type schema:CreativeWork
    230 https://doi.org/10.1620/tjem.236.297 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025022130
    231 rdf:type schema:CreativeWork
    232 https://doi.org/10.18632/oncotarget.10515 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027487036
    233 rdf:type schema:CreativeWork
    234 https://doi.org/10.18632/oncotarget.24087 schema:sameAs https://app.dimensions.ai/details/publication/pub.1100282436
    235 rdf:type schema:CreativeWork
    236 https://doi.org/10.18637/jss.v061.i08 schema:sameAs https://app.dimensions.ai/details/publication/pub.1068672912
    237 rdf:type schema:CreativeWork
    238 https://doi.org/10.2217/fon-2017-0635 schema:sameAs https://app.dimensions.ai/details/publication/pub.1103181475
    239 rdf:type schema:CreativeWork
    240 https://doi.org/10.3322/caac.20107 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009055747
    241 rdf:type schema:CreativeWork
    242 https://doi.org/10.3389/fphar.2016.00376 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007521557
    243 rdf:type schema:CreativeWork
    244 https://doi.org/10.3390/biomedicines5040065 schema:sameAs https://app.dimensions.ai/details/publication/pub.1092751744
    245 rdf:type schema:CreativeWork
    246 https://doi.org/10.6004/jnccn.2017.0131 schema:sameAs https://app.dimensions.ai/details/publication/pub.1091089483
    247 rdf:type schema:CreativeWork
    248 https://www.grid.ac/institutes/grid.15788.33 schema:alternateName Vienna University of Economics and Business
    249 schema:name Vienna University of Economics and Business, Welthandelsplatz 1, AD 1020, Vienna, Austria
    250 rdf:type schema:Organization
     




    Preview window. Press ESC to close (or click here)


    ...