Pre-emptive Treatment of HCV after Living Donor Liver Transplantation with Direct-Acting Antiviral Agents View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2018-08

AUTHORS

Jinmin Jung, Jae Hyun Kwon, Gi-Won Song, Eun-Young Tak, Vavara A. Kirchner, Sung-Gyu Lee

ABSTRACT

BACKGROUND: Hepatitis C virus (HCV) universally recurs after liver transplantation (LT). Although the introduction of direct-acting antiviral agents (DAAs) has revolutionized the treatment of HCV infection, no optimal treatment for HCV recurrence after LT has been developed. METHODS: This study retrospectively evaluated the efficacy of DAAs as a pre-emptive treatment for recurrent HCV infection after living donor liver transplantation (LDLT). From January 2010 to December 2016, 70 patients received pegylated interferon (PegIFN) and 35 patients were treated with DAA-based regimens to treat recurrent HCV after LDLT. All antiviral treatments were pre-emptive. RESULTS: Genotype 1b was the most common HCV type (61.9%). Twenty-two recipients in the DAA group were treated with ledipasvir/sofosbuvir, nine received daclatasvir plus asunaprevir, three received sofosbuvir, and one received sofosbuvir plus daclatasvir. All 35 patients (100%) in the DAA group achieved a sustained virologic response (SVR), a percentage significantly higher than that (71.4%) in the PegIFN group (p < 0.001). In the PegIFN group, the 1-, 3-, and 5-year graft survival rates were 85.7, 73.9, and 70.7%, respectively, whereas those in the DAA group were 100, 100, and 100%, respectively (p = 0.008). CONCLUSION: DAA-based regimens are an effective treatment for HCV recurrence after LDLT, resulting in an improved SVR and better graft survival than PegIFN. More... »

PAGES

1334-1342

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s11605-018-3779-9

DOI

http://dx.doi.org/10.1007/s11605-018-3779-9

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1103482813

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/29679347


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1108", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical Microbiology", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Asan Medical Center", 
          "id": "https://www.grid.ac/institutes/grid.413967.e", 
          "name": [
            "Division of Liver Transplantation and Hepatobiliary Surgery, Department of Surgery, Asan Medical Center, College of Medicine, University of Ulsan, 88, Olympic-ro 43-gil, Songpa-gu, 05505, Seoul, South Korea"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Jung", 
        "givenName": "Jinmin", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Asan Medical Center", 
          "id": "https://www.grid.ac/institutes/grid.413967.e", 
          "name": [
            "Division of Liver Transplantation and Hepatobiliary Surgery, Department of Surgery, Asan Medical Center, College of Medicine, University of Ulsan, 88, Olympic-ro 43-gil, Songpa-gu, 05505, Seoul, South Korea"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Kwon", 
        "givenName": "Jae Hyun", 
        "id": "sg:person.01040402077.90", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01040402077.90"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Asan Medical Center", 
          "id": "https://www.grid.ac/institutes/grid.413967.e", 
          "name": [
            "Division of Liver Transplantation and Hepatobiliary Surgery, Department of Surgery, Asan Medical Center, College of Medicine, University of Ulsan, 88, Olympic-ro 43-gil, Songpa-gu, 05505, Seoul, South Korea"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Song", 
        "givenName": "Gi-Won", 
        "id": "sg:person.0636772734.43", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0636772734.43"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Asan Medical Center", 
          "id": "https://www.grid.ac/institutes/grid.413967.e", 
          "name": [
            "Asan Institute for Life Sciences, Asan-Minnesota Institute for Innovating Transplantation, Asan Medical Center, College of Medicine, University of Ulsan, Seoul, South Korea"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Tak", 
        "givenName": "Eun-Young", 
        "id": "sg:person.01224364051.40", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01224364051.40"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Minnesota", 
          "id": "https://www.grid.ac/institutes/grid.17635.36", 
          "name": [
            "Division of Transplantation, Department of Surgery, Asan-Minnesota Institute for Innovating Transplantation, University of Minnesota, Minneapolis, MN, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Kirchner", 
        "givenName": "Vavara A.", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Asan Medical Center", 
          "id": "https://www.grid.ac/institutes/grid.413967.e", 
          "name": [
            "Division of Liver Transplantation and Hepatobiliary Surgery, Department of Surgery, Asan Medical Center, College of Medicine, University of Ulsan, 88, Olympic-ro 43-gil, Songpa-gu, 05505, Seoul, South Korea"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Lee", 
        "givenName": "Sung-Gyu", 
        "id": "sg:person.01141712025.28", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01141712025.28"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1016/j.transproceed.2014.10.052", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001799897"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0140-6736(16)31012-1", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003440871"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/01.mcg.0000145494.76305.11", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005671607"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/hepr.12853", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1007943023"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/hepr.12296", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1009398777"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.transproceed.2012.01.044", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1011907524"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.jhep.2004.06.029", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1013626832"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1136/gutjnl-2011-300749", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1016899568"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.jhep.2016.05.045", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018503157"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/hep.510290122", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023900955"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s12664-015-0578-z", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027969140", 
          "https://doi.org/10.1007/s12664-015-0578-z"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/lt.23555", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029847607"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/lt.20944", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035021381"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/ajt.12714", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1040159374"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/lt.20532", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1040484687"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/lt.20532", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1040484687"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1159/000447423", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1040805333"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1159/000447423", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1040805333"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/hepr.12845", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042691560"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s10620-009-0981-3", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1044055807", 
          "https://doi.org/10.1007/s10620-009-0981-3"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s10620-009-0981-3", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1044055807", 
          "https://doi.org/10.1007/s10620-009-0981-3"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3350/cmh.2012.18.3.309", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1044466643"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/tp.0b013e3181bd783c", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046616268"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/tp.0b013e3181bd783c", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046616268"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/tp.0b013e3181bd783c", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046616268"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1053/jlts.2003.50248", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047462150"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.jhep.2016.06.023", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047999066"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1053/j.gastro.2012.01.030", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048603310"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ajg.2010.110", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051174716", 
          "https://doi.org/10.1038/ajg.2010.110"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ajg.2010.110", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051174716", 
          "https://doi.org/10.1038/ajg.2010.110"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ajg.2010.110", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051174716", 
          "https://doi.org/10.1038/ajg.2010.110"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1600-6143.2007.02126.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051602849"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/tri.12329", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052161283"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1600-6143.2006.01362.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052924477"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.12659/ajcr.898594", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1064588430"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.5812/hepatmon.41933", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1073143920"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.5812/hepatmon.41933", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1073143920"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00535-017-1310-9", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1074245951", 
          "https://doi.org/10.1007/s00535-017-1310-9"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00535-017-1310-9", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1074245951", 
          "https://doi.org/10.1007/s00535-017-1310-9"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1078307062", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1078893345", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3748/wjg.v23.i9.1697", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1084440667"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1136/gutjnl-2017-313983", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1086131829"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/apt.14256", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1091101135"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/apt.14256", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1091101135"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1371/journal.pone.0182710", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1091151482"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1091438050", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/liv.13659", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1100951494"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2018-08", 
    "datePublishedReg": "2018-08-01", 
    "description": "BACKGROUND: Hepatitis C virus (HCV) universally recurs after liver transplantation (LT). Although the introduction of direct-acting antiviral agents (DAAs) has revolutionized the treatment of HCV infection, no optimal treatment for HCV recurrence after LT has been developed.\nMETHODS: This study retrospectively evaluated the efficacy of DAAs as a pre-emptive treatment for recurrent HCV infection after living donor liver transplantation (LDLT). From January 2010 to December 2016, 70 patients received pegylated interferon (PegIFN) and 35 patients were treated with DAA-based regimens to treat recurrent HCV after LDLT. All antiviral treatments were pre-emptive.\nRESULTS: Genotype 1b was the most common HCV type (61.9%). Twenty-two recipients in the DAA group were treated with ledipasvir/sofosbuvir, nine received daclatasvir plus asunaprevir, three received sofosbuvir, and one received sofosbuvir plus daclatasvir. All 35 patients (100%) in the DAA group achieved a sustained virologic response (SVR), a percentage significantly higher than that (71.4%) in the PegIFN group (p\u2009<\u20090.001). In the PegIFN group, the 1-, 3-, and 5-year graft survival rates were 85.7, 73.9, and 70.7%, respectively, whereas those in the DAA group were 100, 100, and 100%, respectively (p\u2009=\u20090.008).\nCONCLUSION: DAA-based regimens are an effective treatment for HCV recurrence after LDLT, resulting in an improved SVR and better graft survival than PegIFN.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1007/s11605-018-3779-9", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": false, 
    "isFundedItemOf": [
      {
        "id": "sg:grant.7497496", 
        "type": "MonetaryGrant"
      }
    ], 
    "isPartOf": [
      {
        "id": "sg:journal.1116755", 
        "issn": [
          "1091-255X", 
          "1873-4626"
        ], 
        "name": "Journal of Gastrointestinal Surgery", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "8", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "22"
      }
    ], 
    "name": "Pre-emptive Treatment of HCV after Living Donor Liver Transplantation with Direct-Acting Antiviral Agents", 
    "pagination": "1334-1342", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "2604017fa211519ad03297c285b0bdfd104bc938d7cffbed49453a0ccd617158"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "29679347"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "9706084"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1007/s11605-018-3779-9"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1103482813"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1007/s11605-018-3779-9", 
      "https://app.dimensions.ai/details/publication/pub.1103482813"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-11T02:23", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8700_00000564.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://link.springer.com/10.1007%2Fs11605-018-3779-9"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s11605-018-3779-9'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s11605-018-3779-9'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s11605-018-3779-9'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s11605-018-3779-9'


 

This table displays all metadata directly associated to this object as RDF triples.

223 TRIPLES      21 PREDICATES      67 URIs      21 LITERALS      9 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1007/s11605-018-3779-9 schema:about anzsrc-for:11
2 anzsrc-for:1108
3 schema:author N6ee8bd9d25284318aca90369c4395969
4 schema:citation sg:pub.10.1007/s00535-017-1310-9
5 sg:pub.10.1007/s10620-009-0981-3
6 sg:pub.10.1007/s12664-015-0578-z
7 sg:pub.10.1038/ajg.2010.110
8 https://app.dimensions.ai/details/publication/pub.1078307062
9 https://app.dimensions.ai/details/publication/pub.1078893345
10 https://app.dimensions.ai/details/publication/pub.1091438050
11 https://doi.org/10.1002/hep.510290122
12 https://doi.org/10.1002/lt.20532
13 https://doi.org/10.1002/lt.20944
14 https://doi.org/10.1002/lt.23555
15 https://doi.org/10.1016/j.jhep.2004.06.029
16 https://doi.org/10.1016/j.jhep.2016.05.045
17 https://doi.org/10.1016/j.jhep.2016.06.023
18 https://doi.org/10.1016/j.transproceed.2012.01.044
19 https://doi.org/10.1016/j.transproceed.2014.10.052
20 https://doi.org/10.1016/s0140-6736(16)31012-1
21 https://doi.org/10.1053/j.gastro.2012.01.030
22 https://doi.org/10.1053/jlts.2003.50248
23 https://doi.org/10.1097/01.mcg.0000145494.76305.11
24 https://doi.org/10.1097/tp.0b013e3181bd783c
25 https://doi.org/10.1111/ajt.12714
26 https://doi.org/10.1111/apt.14256
27 https://doi.org/10.1111/hepr.12296
28 https://doi.org/10.1111/hepr.12845
29 https://doi.org/10.1111/hepr.12853
30 https://doi.org/10.1111/j.1600-6143.2006.01362.x
31 https://doi.org/10.1111/j.1600-6143.2007.02126.x
32 https://doi.org/10.1111/liv.13659
33 https://doi.org/10.1111/tri.12329
34 https://doi.org/10.1136/gutjnl-2011-300749
35 https://doi.org/10.1136/gutjnl-2017-313983
36 https://doi.org/10.1159/000447423
37 https://doi.org/10.12659/ajcr.898594
38 https://doi.org/10.1371/journal.pone.0182710
39 https://doi.org/10.3350/cmh.2012.18.3.309
40 https://doi.org/10.3748/wjg.v23.i9.1697
41 https://doi.org/10.5812/hepatmon.41933
42 schema:datePublished 2018-08
43 schema:datePublishedReg 2018-08-01
44 schema:description BACKGROUND: Hepatitis C virus (HCV) universally recurs after liver transplantation (LT). Although the introduction of direct-acting antiviral agents (DAAs) has revolutionized the treatment of HCV infection, no optimal treatment for HCV recurrence after LT has been developed. METHODS: This study retrospectively evaluated the efficacy of DAAs as a pre-emptive treatment for recurrent HCV infection after living donor liver transplantation (LDLT). From January 2010 to December 2016, 70 patients received pegylated interferon (PegIFN) and 35 patients were treated with DAA-based regimens to treat recurrent HCV after LDLT. All antiviral treatments were pre-emptive. RESULTS: Genotype 1b was the most common HCV type (61.9%). Twenty-two recipients in the DAA group were treated with ledipasvir/sofosbuvir, nine received daclatasvir plus asunaprevir, three received sofosbuvir, and one received sofosbuvir plus daclatasvir. All 35 patients (100%) in the DAA group achieved a sustained virologic response (SVR), a percentage significantly higher than that (71.4%) in the PegIFN group (p < 0.001). In the PegIFN group, the 1-, 3-, and 5-year graft survival rates were 85.7, 73.9, and 70.7%, respectively, whereas those in the DAA group were 100, 100, and 100%, respectively (p = 0.008). CONCLUSION: DAA-based regimens are an effective treatment for HCV recurrence after LDLT, resulting in an improved SVR and better graft survival than PegIFN.
45 schema:genre research_article
46 schema:inLanguage en
47 schema:isAccessibleForFree false
48 schema:isPartOf Na0ee5d622cc94e588aaa9e31cacb2650
49 Nbd2435dc6ea44b3099bee68f84530ccc
50 sg:journal.1116755
51 schema:name Pre-emptive Treatment of HCV after Living Donor Liver Transplantation with Direct-Acting Antiviral Agents
52 schema:pagination 1334-1342
53 schema:productId N0573821e22d54a1392e98383507a7765
54 N2fc797737e1c47b38e7c8480c8b63398
55 N368282d068a34f95a84834e4afe5e443
56 N395b74080f4d42ccba874b27e74ab20f
57 Nb8a5e7443b224a59a036f5aa5478d28a
58 schema:sameAs https://app.dimensions.ai/details/publication/pub.1103482813
59 https://doi.org/10.1007/s11605-018-3779-9
60 schema:sdDatePublished 2019-04-11T02:23
61 schema:sdLicense https://scigraph.springernature.com/explorer/license/
62 schema:sdPublisher Necc4a24ced3e491194e837819f1f0f85
63 schema:url https://link.springer.com/10.1007%2Fs11605-018-3779-9
64 sgo:license sg:explorer/license/
65 sgo:sdDataset articles
66 rdf:type schema:ScholarlyArticle
67 N0573821e22d54a1392e98383507a7765 schema:name pubmed_id
68 schema:value 29679347
69 rdf:type schema:PropertyValue
70 N2fc797737e1c47b38e7c8480c8b63398 schema:name nlm_unique_id
71 schema:value 9706084
72 rdf:type schema:PropertyValue
73 N368282d068a34f95a84834e4afe5e443 schema:name dimensions_id
74 schema:value pub.1103482813
75 rdf:type schema:PropertyValue
76 N395b74080f4d42ccba874b27e74ab20f schema:name doi
77 schema:value 10.1007/s11605-018-3779-9
78 rdf:type schema:PropertyValue
79 N4b343fd0fa004059a95a57f239325546 schema:affiliation https://www.grid.ac/institutes/grid.17635.36
80 schema:familyName Kirchner
81 schema:givenName Vavara A.
82 rdf:type schema:Person
83 N4e330e3b3f8d4f46be7ab07d81b49261 rdf:first sg:person.01040402077.90
84 rdf:rest Ncb0e050844c14b87b1dd67540b5acedb
85 N4ffb4e85fdec4f5ba6856a27c4d2a007 rdf:first N4b343fd0fa004059a95a57f239325546
86 rdf:rest N8919aebdf5054726ae39cefd0cfd119e
87 N6ee8bd9d25284318aca90369c4395969 rdf:first Ned58668e22a24da1bbda07ee8607bf45
88 rdf:rest N4e330e3b3f8d4f46be7ab07d81b49261
89 N8919aebdf5054726ae39cefd0cfd119e rdf:first sg:person.01141712025.28
90 rdf:rest rdf:nil
91 Na0ee5d622cc94e588aaa9e31cacb2650 schema:issueNumber 8
92 rdf:type schema:PublicationIssue
93 Nb8a5e7443b224a59a036f5aa5478d28a schema:name readcube_id
94 schema:value 2604017fa211519ad03297c285b0bdfd104bc938d7cffbed49453a0ccd617158
95 rdf:type schema:PropertyValue
96 Nbd2435dc6ea44b3099bee68f84530ccc schema:volumeNumber 22
97 rdf:type schema:PublicationVolume
98 Ncb0e050844c14b87b1dd67540b5acedb rdf:first sg:person.0636772734.43
99 rdf:rest Ne9e7c2741b984383aeb69b102c292544
100 Ne9e7c2741b984383aeb69b102c292544 rdf:first sg:person.01224364051.40
101 rdf:rest N4ffb4e85fdec4f5ba6856a27c4d2a007
102 Necc4a24ced3e491194e837819f1f0f85 schema:name Springer Nature - SN SciGraph project
103 rdf:type schema:Organization
104 Ned58668e22a24da1bbda07ee8607bf45 schema:affiliation https://www.grid.ac/institutes/grid.413967.e
105 schema:familyName Jung
106 schema:givenName Jinmin
107 rdf:type schema:Person
108 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
109 schema:name Medical and Health Sciences
110 rdf:type schema:DefinedTerm
111 anzsrc-for:1108 schema:inDefinedTermSet anzsrc-for:
112 schema:name Medical Microbiology
113 rdf:type schema:DefinedTerm
114 sg:grant.7497496 http://pending.schema.org/fundedItem sg:pub.10.1007/s11605-018-3779-9
115 rdf:type schema:MonetaryGrant
116 sg:journal.1116755 schema:issn 1091-255X
117 1873-4626
118 schema:name Journal of Gastrointestinal Surgery
119 rdf:type schema:Periodical
120 sg:person.01040402077.90 schema:affiliation https://www.grid.ac/institutes/grid.413967.e
121 schema:familyName Kwon
122 schema:givenName Jae Hyun
123 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01040402077.90
124 rdf:type schema:Person
125 sg:person.01141712025.28 schema:affiliation https://www.grid.ac/institutes/grid.413967.e
126 schema:familyName Lee
127 schema:givenName Sung-Gyu
128 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01141712025.28
129 rdf:type schema:Person
130 sg:person.01224364051.40 schema:affiliation https://www.grid.ac/institutes/grid.413967.e
131 schema:familyName Tak
132 schema:givenName Eun-Young
133 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01224364051.40
134 rdf:type schema:Person
135 sg:person.0636772734.43 schema:affiliation https://www.grid.ac/institutes/grid.413967.e
136 schema:familyName Song
137 schema:givenName Gi-Won
138 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0636772734.43
139 rdf:type schema:Person
140 sg:pub.10.1007/s00535-017-1310-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1074245951
141 https://doi.org/10.1007/s00535-017-1310-9
142 rdf:type schema:CreativeWork
143 sg:pub.10.1007/s10620-009-0981-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044055807
144 https://doi.org/10.1007/s10620-009-0981-3
145 rdf:type schema:CreativeWork
146 sg:pub.10.1007/s12664-015-0578-z schema:sameAs https://app.dimensions.ai/details/publication/pub.1027969140
147 https://doi.org/10.1007/s12664-015-0578-z
148 rdf:type schema:CreativeWork
149 sg:pub.10.1038/ajg.2010.110 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051174716
150 https://doi.org/10.1038/ajg.2010.110
151 rdf:type schema:CreativeWork
152 https://app.dimensions.ai/details/publication/pub.1078307062 schema:CreativeWork
153 https://app.dimensions.ai/details/publication/pub.1078893345 schema:CreativeWork
154 https://app.dimensions.ai/details/publication/pub.1091438050 schema:CreativeWork
155 https://doi.org/10.1002/hep.510290122 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023900955
156 rdf:type schema:CreativeWork
157 https://doi.org/10.1002/lt.20532 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040484687
158 rdf:type schema:CreativeWork
159 https://doi.org/10.1002/lt.20944 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035021381
160 rdf:type schema:CreativeWork
161 https://doi.org/10.1002/lt.23555 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029847607
162 rdf:type schema:CreativeWork
163 https://doi.org/10.1016/j.jhep.2004.06.029 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013626832
164 rdf:type schema:CreativeWork
165 https://doi.org/10.1016/j.jhep.2016.05.045 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018503157
166 rdf:type schema:CreativeWork
167 https://doi.org/10.1016/j.jhep.2016.06.023 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047999066
168 rdf:type schema:CreativeWork
169 https://doi.org/10.1016/j.transproceed.2012.01.044 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011907524
170 rdf:type schema:CreativeWork
171 https://doi.org/10.1016/j.transproceed.2014.10.052 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001799897
172 rdf:type schema:CreativeWork
173 https://doi.org/10.1016/s0140-6736(16)31012-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003440871
174 rdf:type schema:CreativeWork
175 https://doi.org/10.1053/j.gastro.2012.01.030 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048603310
176 rdf:type schema:CreativeWork
177 https://doi.org/10.1053/jlts.2003.50248 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047462150
178 rdf:type schema:CreativeWork
179 https://doi.org/10.1097/01.mcg.0000145494.76305.11 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005671607
180 rdf:type schema:CreativeWork
181 https://doi.org/10.1097/tp.0b013e3181bd783c schema:sameAs https://app.dimensions.ai/details/publication/pub.1046616268
182 rdf:type schema:CreativeWork
183 https://doi.org/10.1111/ajt.12714 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040159374
184 rdf:type schema:CreativeWork
185 https://doi.org/10.1111/apt.14256 schema:sameAs https://app.dimensions.ai/details/publication/pub.1091101135
186 rdf:type schema:CreativeWork
187 https://doi.org/10.1111/hepr.12296 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009398777
188 rdf:type schema:CreativeWork
189 https://doi.org/10.1111/hepr.12845 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042691560
190 rdf:type schema:CreativeWork
191 https://doi.org/10.1111/hepr.12853 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007943023
192 rdf:type schema:CreativeWork
193 https://doi.org/10.1111/j.1600-6143.2006.01362.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1052924477
194 rdf:type schema:CreativeWork
195 https://doi.org/10.1111/j.1600-6143.2007.02126.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1051602849
196 rdf:type schema:CreativeWork
197 https://doi.org/10.1111/liv.13659 schema:sameAs https://app.dimensions.ai/details/publication/pub.1100951494
198 rdf:type schema:CreativeWork
199 https://doi.org/10.1111/tri.12329 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052161283
200 rdf:type schema:CreativeWork
201 https://doi.org/10.1136/gutjnl-2011-300749 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016899568
202 rdf:type schema:CreativeWork
203 https://doi.org/10.1136/gutjnl-2017-313983 schema:sameAs https://app.dimensions.ai/details/publication/pub.1086131829
204 rdf:type schema:CreativeWork
205 https://doi.org/10.1159/000447423 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040805333
206 rdf:type schema:CreativeWork
207 https://doi.org/10.12659/ajcr.898594 schema:sameAs https://app.dimensions.ai/details/publication/pub.1064588430
208 rdf:type schema:CreativeWork
209 https://doi.org/10.1371/journal.pone.0182710 schema:sameAs https://app.dimensions.ai/details/publication/pub.1091151482
210 rdf:type schema:CreativeWork
211 https://doi.org/10.3350/cmh.2012.18.3.309 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044466643
212 rdf:type schema:CreativeWork
213 https://doi.org/10.3748/wjg.v23.i9.1697 schema:sameAs https://app.dimensions.ai/details/publication/pub.1084440667
214 rdf:type schema:CreativeWork
215 https://doi.org/10.5812/hepatmon.41933 schema:sameAs https://app.dimensions.ai/details/publication/pub.1073143920
216 rdf:type schema:CreativeWork
217 https://www.grid.ac/institutes/grid.17635.36 schema:alternateName University of Minnesota
218 schema:name Division of Transplantation, Department of Surgery, Asan-Minnesota Institute for Innovating Transplantation, University of Minnesota, Minneapolis, MN, USA
219 rdf:type schema:Organization
220 https://www.grid.ac/institutes/grid.413967.e schema:alternateName Asan Medical Center
221 schema:name Asan Institute for Life Sciences, Asan-Minnesota Institute for Innovating Transplantation, Asan Medical Center, College of Medicine, University of Ulsan, Seoul, South Korea
222 Division of Liver Transplantation and Hepatobiliary Surgery, Department of Surgery, Asan Medical Center, College of Medicine, University of Ulsan, 88, Olympic-ro 43-gil, Songpa-gu, 05505, Seoul, South Korea
223 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...