Asymptomatic Pancreatic Cancer: Does Incidental Detection Impact Long-Term Outcomes? View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2017-04-10

AUTHORS

Yoshinori Takeda, Akio Saiura, Yu Takahashi, Yosuke Inoue, Takeaki Ishizawa, Yoshihiro Mise, Masaru Matsumura, Hirofumi Ichida, Ryota Matsuki, Masayuki Tanaka, Hiromichi Ito

ABSTRACT

BackgroundDetection of pancreatic ductal adenocarcinoma (PDAC) in asymptomatic patients is very rare, and the clinical implication of early detection of asymptomatic PDAC remains unclear.MethodsThis retrospective study included 569 consecutive patients with PDAC treated in our institution (250 underwent surgical resection and 319 had unresectable PDAC). The patients’ demographics, tumor locations, pathologic stages, treatment, and overall survival (OS) were compared between the asymptomatic and symptomatic patients.ResultsIn total, 163 (29%) patients presented without subjective symptoms. These patients had an earlier stage of PDAC on presentation (p < 0.001), higher resectability rate (64 vs. 36%, p < 0.001), and higher 5-year OS rate (18 vs. 7%, p < 0.001) than patients with symptoms. Among the patients who underwent resection, asymptomatic patients did not have a significantly higher chance of complete resection (88 vs. 78%, p = 0.06) or 5-year OS rate (23 vs. 22%, p = 0.09). However, symptomatic patients more often required complex operations such as concomitant vascular resection and reconstruction (57 vs. 29%, p < 0.001).ConclusionsAsymptomatic PDAC is associated with better long-term outcomes than symptomatic PDAC because of the earlier stage at presentation and higher chance of resectability. Our findings highlight the potential implication of screening programs for early detection of PDAC in selected high-risk populations. More... »

PAGES

1287-1295

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s11605-017-3421-2

DOI

http://dx.doi.org/10.1007/s11605-017-3421-2

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1084760105

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/28397027


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1103", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Clinical Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Adult", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Aged", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Aged, 80 and over", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Asymptomatic Diseases", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Carcinoma, Pancreatic Ductal", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Early Detection of Cancer", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Female", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Follow-Up Studies", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Incidental Findings", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Male", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Middle Aged", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Pancreatectomy", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Pancreatic Neoplasms", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Retrospective Studies", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Survival Rate", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Treatment Outcome", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Department of Hepato-Biliary-Pancreatic Surgery, Cancer Institute Hospital, Japanese Foundation for Cancer Research, 3-8-31 Ariake, Koto-ku, 135-8550, Tokyo, Japan", 
          "id": "http://www.grid.ac/institutes/grid.410807.a", 
          "name": [
            "Department of Hepato-Biliary-Pancreatic Surgery, Cancer Institute Hospital, Japanese Foundation for Cancer Research, 3-8-31 Ariake, Koto-ku, 135-8550, Tokyo, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Takeda", 
        "givenName": "Yoshinori", 
        "id": "sg:person.015104775355.77", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015104775355.77"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Hepato-Biliary-Pancreatic Surgery, Cancer Institute Hospital, Japanese Foundation for Cancer Research, 3-8-31 Ariake, Koto-ku, 135-8550, Tokyo, Japan", 
          "id": "http://www.grid.ac/institutes/grid.410807.a", 
          "name": [
            "Department of Hepato-Biliary-Pancreatic Surgery, Cancer Institute Hospital, Japanese Foundation for Cancer Research, 3-8-31 Ariake, Koto-ku, 135-8550, Tokyo, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Saiura", 
        "givenName": "Akio", 
        "id": "sg:person.0612301703.87", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0612301703.87"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Hepato-Biliary-Pancreatic Surgery, Cancer Institute Hospital, Japanese Foundation for Cancer Research, 3-8-31 Ariake, Koto-ku, 135-8550, Tokyo, Japan", 
          "id": "http://www.grid.ac/institutes/grid.410807.a", 
          "name": [
            "Department of Hepato-Biliary-Pancreatic Surgery, Cancer Institute Hospital, Japanese Foundation for Cancer Research, 3-8-31 Ariake, Koto-ku, 135-8550, Tokyo, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Takahashi", 
        "givenName": "Yu", 
        "id": "sg:person.01307772440.53", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01307772440.53"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Hepato-Biliary-Pancreatic Surgery, Cancer Institute Hospital, Japanese Foundation for Cancer Research, 3-8-31 Ariake, Koto-ku, 135-8550, Tokyo, Japan", 
          "id": "http://www.grid.ac/institutes/grid.410807.a", 
          "name": [
            "Department of Hepato-Biliary-Pancreatic Surgery, Cancer Institute Hospital, Japanese Foundation for Cancer Research, 3-8-31 Ariake, Koto-ku, 135-8550, Tokyo, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Inoue", 
        "givenName": "Yosuke", 
        "id": "sg:person.0770623646.53", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0770623646.53"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Hepato-Biliary-Pancreatic Surgery, Cancer Institute Hospital, Japanese Foundation for Cancer Research, 3-8-31 Ariake, Koto-ku, 135-8550, Tokyo, Japan", 
          "id": "http://www.grid.ac/institutes/grid.410807.a", 
          "name": [
            "Department of Hepato-Biliary-Pancreatic Surgery, Cancer Institute Hospital, Japanese Foundation for Cancer Research, 3-8-31 Ariake, Koto-ku, 135-8550, Tokyo, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Ishizawa", 
        "givenName": "Takeaki", 
        "id": "sg:person.01267647573.52", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01267647573.52"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Hepato-Biliary-Pancreatic Surgery, Cancer Institute Hospital, Japanese Foundation for Cancer Research, 3-8-31 Ariake, Koto-ku, 135-8550, Tokyo, Japan", 
          "id": "http://www.grid.ac/institutes/grid.410807.a", 
          "name": [
            "Department of Hepato-Biliary-Pancreatic Surgery, Cancer Institute Hospital, Japanese Foundation for Cancer Research, 3-8-31 Ariake, Koto-ku, 135-8550, Tokyo, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Mise", 
        "givenName": "Yoshihiro", 
        "id": "sg:person.0626665021.66", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0626665021.66"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Hepato-Biliary-Pancreatic Surgery, Cancer Institute Hospital, Japanese Foundation for Cancer Research, 3-8-31 Ariake, Koto-ku, 135-8550, Tokyo, Japan", 
          "id": "http://www.grid.ac/institutes/grid.410807.a", 
          "name": [
            "Department of Hepato-Biliary-Pancreatic Surgery, Cancer Institute Hospital, Japanese Foundation for Cancer Research, 3-8-31 Ariake, Koto-ku, 135-8550, Tokyo, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Matsumura", 
        "givenName": "Masaru", 
        "id": "sg:person.01147204517.53", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01147204517.53"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Hepato-Biliary-Pancreatic Surgery, Cancer Institute Hospital, Japanese Foundation for Cancer Research, 3-8-31 Ariake, Koto-ku, 135-8550, Tokyo, Japan", 
          "id": "http://www.grid.ac/institutes/grid.410807.a", 
          "name": [
            "Department of Hepato-Biliary-Pancreatic Surgery, Cancer Institute Hospital, Japanese Foundation for Cancer Research, 3-8-31 Ariake, Koto-ku, 135-8550, Tokyo, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Ichida", 
        "givenName": "Hirofumi", 
        "id": "sg:person.012714453755.53", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012714453755.53"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Hepato-Biliary-Pancreatic Surgery, Cancer Institute Hospital, Japanese Foundation for Cancer Research, 3-8-31 Ariake, Koto-ku, 135-8550, Tokyo, Japan", 
          "id": "http://www.grid.ac/institutes/grid.410807.a", 
          "name": [
            "Department of Hepato-Biliary-Pancreatic Surgery, Cancer Institute Hospital, Japanese Foundation for Cancer Research, 3-8-31 Ariake, Koto-ku, 135-8550, Tokyo, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Matsuki", 
        "givenName": "Ryota", 
        "id": "sg:person.013512034355.66", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013512034355.66"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Hepato-Biliary-Pancreatic Surgery, Cancer Institute Hospital, Japanese Foundation for Cancer Research, 3-8-31 Ariake, Koto-ku, 135-8550, Tokyo, Japan", 
          "id": "http://www.grid.ac/institutes/grid.410807.a", 
          "name": [
            "Department of Hepato-Biliary-Pancreatic Surgery, Cancer Institute Hospital, Japanese Foundation for Cancer Research, 3-8-31 Ariake, Koto-ku, 135-8550, Tokyo, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Tanaka", 
        "givenName": "Masayuki", 
        "id": "sg:person.01175531347.07", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01175531347.07"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Hepato-Biliary-Pancreatic Surgery, Cancer Institute Hospital, Japanese Foundation for Cancer Research, 3-8-31 Ariake, Koto-ku, 135-8550, Tokyo, Japan", 
          "id": "http://www.grid.ac/institutes/grid.410807.a", 
          "name": [
            "Department of Hepato-Biliary-Pancreatic Surgery, Cancer Institute Hospital, Japanese Foundation for Cancer Research, 3-8-31 Ariake, Koto-ku, 135-8550, Tokyo, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Ito", 
        "givenName": "Hiromichi", 
        "id": "sg:person.011406547173.21", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011406547173.21"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "sg:pub.10.1007/s11605-007-0384-8", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1043513971", 
          "https://doi.org/10.1007/s11605-007-0384-8"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00268-016-3550-x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010597716", 
          "https://doi.org/10.1007/s00268-016-3550-x"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1245/s10434-008-0295-2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005006861", 
          "https://doi.org/10.1245/s10434-008-0295-2"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00268-009-0300-3", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030144262", 
          "https://doi.org/10.1007/s00268-009-0300-3"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ajg.2009.276", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037176663", 
          "https://doi.org/10.1038/ajg.2009.276"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2017-04-10", 
    "datePublishedReg": "2017-04-10", 
    "description": "BackgroundDetection of pancreatic ductal adenocarcinoma (PDAC) in asymptomatic patients is very rare, and the clinical implication of early detection of asymptomatic PDAC remains unclear.MethodsThis retrospective study included 569 consecutive patients with PDAC treated in our institution (250 underwent surgical resection and 319 had unresectable PDAC). The patients\u2019 demographics, tumor locations, pathologic stages, treatment, and overall survival (OS) were compared between the asymptomatic and symptomatic patients.ResultsIn total, 163 (29%) patients presented without subjective symptoms. These patients had an earlier stage of PDAC on presentation (p\u00a0<\u00a00.001), higher resectability rate (64 vs. 36%, p\u00a0<\u00a00.001), and higher 5-year OS rate (18 vs. 7%, p\u00a0<\u00a00.001) than patients with symptoms. Among the patients who underwent resection, asymptomatic patients did not have a significantly higher chance of complete resection (88 vs. 78%, p\u00a0=\u00a00.06) or 5-year OS rate (23 vs. 22%, p\u00a0=\u00a00.09). However, symptomatic patients more often required complex operations such as concomitant vascular resection and reconstruction (57 vs. 29%, p\u00a0<\u00a00.001).ConclusionsAsymptomatic PDAC is associated with better long-term outcomes than symptomatic PDAC because of the earlier stage at presentation and higher chance of resectability. Our findings highlight the potential implication of screening programs for early detection of PDAC in selected high-risk populations.", 
    "genre": "article", 
    "id": "sg:pub.10.1007/s11605-017-3421-2", 
    "isAccessibleForFree": false, 
    "isPartOf": [
      {
        "id": "sg:journal.1116755", 
        "issn": [
          "1091-255X", 
          "1873-4626"
        ], 
        "name": "Journal of Gastrointestinal Surgery", 
        "publisher": "Springer Nature", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "8", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "21"
      }
    ], 
    "keywords": [
      "pancreatic ductal adenocarcinoma", 
      "long-term outcomes", 
      "asymptomatic patients", 
      "overall survival", 
      "symptomatic patients", 
      "OS rates", 
      "better long-term outcomes", 
      "early detection", 
      "concomitant vascular resection", 
      "high resectability rate", 
      "MethodsThis retrospective study", 
      "high-risk population", 
      "higher chance", 
      "resectability rate", 
      "vascular resection", 
      "patient demographics", 
      "consecutive patients", 
      "complete resection", 
      "retrospective study", 
      "pathologic stage", 
      "subjective symptoms", 
      "tumor location", 
      "ResultsIn total", 
      "ductal adenocarcinoma", 
      "patients", 
      "clinical implications", 
      "resection", 
      "early stages", 
      "symptoms", 
      "demographics", 
      "outcomes", 
      "presentation", 
      "resectability", 
      "potential implications", 
      "adenocarcinoma", 
      "BackgroundDetection", 
      "survival", 
      "rate", 
      "treatment", 
      "total", 
      "chance", 
      "stage", 
      "population", 
      "findings", 
      "detection", 
      "study", 
      "implications", 
      "program", 
      "reconstruction", 
      "institutions", 
      "complex operations", 
      "location", 
      "operation"
    ], 
    "name": "Asymptomatic Pancreatic Cancer: Does Incidental Detection Impact Long-Term Outcomes?", 
    "pagination": "1287-1295", 
    "productId": [
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1084760105"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1007/s11605-017-3421-2"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "28397027"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1007/s11605-017-3421-2", 
      "https://app.dimensions.ai/details/publication/pub.1084760105"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2022-09-02T16:01", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-springernature-scigraph/baseset/20220902/entities/gbq_results/article/article_746.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://doi.org/10.1007/s11605-017-3421-2"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s11605-017-3421-2'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s11605-017-3421-2'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s11605-017-3421-2'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s11605-017-3421-2'


 

This table displays all metadata directly associated to this object as RDF triples.

272 TRIPLES      21 PREDICATES      100 URIs      87 LITERALS      24 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1007/s11605-017-3421-2 schema:about N02f4abb6cf0f48a4aca5e51dd8f780ce
2 N2026367992a942d5a0749ffcf6ff8fd5
3 N2037ed0fe6e445fb97f98598ba5fe628
4 N36887baf81644619a5160e5cddd1888d
5 N5c9c1e208a8d49588e160b1fb60a2db3
6 N63cd1e898373428ea6ba8b9bf5829b36
7 N737726688abf448aab1fa64efd5da228
8 N7bdf448625a54388bd0a4586774bb72c
9 N7d6f9e598a3442bd9c1f463e8617cd97
10 Na8b24aeb6e9945998b77f8852be45cc4
11 Nbb2238ae8f8843ef87539f697180ed2b
12 Nc5243181461449cfa47e4a2210534a02
13 Nd0760e09f9a64a04b8f16eb1dc2dbee5
14 Nd42f315291c24db4baa018feb76304d1
15 Nd7e399489c3849d0a43d8315d1d1a052
16 Ned6497299f8f40f2a25e2eb48f3b267c
17 Nf684d717282e4fa59ba2ab7255bac81c
18 anzsrc-for:11
19 anzsrc-for:1103
20 schema:author N352646acce06401f8db5cd97a0ccce4a
21 schema:citation sg:pub.10.1007/s00268-009-0300-3
22 sg:pub.10.1007/s00268-016-3550-x
23 sg:pub.10.1007/s11605-007-0384-8
24 sg:pub.10.1038/ajg.2009.276
25 sg:pub.10.1245/s10434-008-0295-2
26 schema:datePublished 2017-04-10
27 schema:datePublishedReg 2017-04-10
28 schema:description BackgroundDetection of pancreatic ductal adenocarcinoma (PDAC) in asymptomatic patients is very rare, and the clinical implication of early detection of asymptomatic PDAC remains unclear.MethodsThis retrospective study included 569 consecutive patients with PDAC treated in our institution (250 underwent surgical resection and 319 had unresectable PDAC). The patients’ demographics, tumor locations, pathologic stages, treatment, and overall survival (OS) were compared between the asymptomatic and symptomatic patients.ResultsIn total, 163 (29%) patients presented without subjective symptoms. These patients had an earlier stage of PDAC on presentation (p < 0.001), higher resectability rate (64 vs. 36%, p < 0.001), and higher 5-year OS rate (18 vs. 7%, p < 0.001) than patients with symptoms. Among the patients who underwent resection, asymptomatic patients did not have a significantly higher chance of complete resection (88 vs. 78%, p = 0.06) or 5-year OS rate (23 vs. 22%, p = 0.09). However, symptomatic patients more often required complex operations such as concomitant vascular resection and reconstruction (57 vs. 29%, p < 0.001).ConclusionsAsymptomatic PDAC is associated with better long-term outcomes than symptomatic PDAC because of the earlier stage at presentation and higher chance of resectability. Our findings highlight the potential implication of screening programs for early detection of PDAC in selected high-risk populations.
29 schema:genre article
30 schema:isAccessibleForFree false
31 schema:isPartOf N24ec62a568b940119f2a53782e74ebdd
32 Ncc8fcd1a56ba4a95aed9c4543042cb36
33 sg:journal.1116755
34 schema:keywords BackgroundDetection
35 MethodsThis retrospective study
36 OS rates
37 ResultsIn total
38 adenocarcinoma
39 asymptomatic patients
40 better long-term outcomes
41 chance
42 clinical implications
43 complete resection
44 complex operations
45 concomitant vascular resection
46 consecutive patients
47 demographics
48 detection
49 ductal adenocarcinoma
50 early detection
51 early stages
52 findings
53 high resectability rate
54 high-risk population
55 higher chance
56 implications
57 institutions
58 location
59 long-term outcomes
60 operation
61 outcomes
62 overall survival
63 pancreatic ductal adenocarcinoma
64 pathologic stage
65 patient demographics
66 patients
67 population
68 potential implications
69 presentation
70 program
71 rate
72 reconstruction
73 resectability
74 resectability rate
75 resection
76 retrospective study
77 stage
78 study
79 subjective symptoms
80 survival
81 symptomatic patients
82 symptoms
83 total
84 treatment
85 tumor location
86 vascular resection
87 schema:name Asymptomatic Pancreatic Cancer: Does Incidental Detection Impact Long-Term Outcomes?
88 schema:pagination 1287-1295
89 schema:productId N2cd9410fa1a8483ebd588e8150fdd694
90 N4325599995a245579dc25fb832432469
91 N96632390c79d4c7f969e1b21f0c96b1b
92 schema:sameAs https://app.dimensions.ai/details/publication/pub.1084760105
93 https://doi.org/10.1007/s11605-017-3421-2
94 schema:sdDatePublished 2022-09-02T16:01
95 schema:sdLicense https://scigraph.springernature.com/explorer/license/
96 schema:sdPublisher N3d17015c1f234eb0a4538bbfa96941af
97 schema:url https://doi.org/10.1007/s11605-017-3421-2
98 sgo:license sg:explorer/license/
99 sgo:sdDataset articles
100 rdf:type schema:ScholarlyArticle
101 N02f4abb6cf0f48a4aca5e51dd8f780ce schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
102 schema:name Follow-Up Studies
103 rdf:type schema:DefinedTerm
104 N1c0a4bb2896b440e888ad6ad076f0e26 rdf:first sg:person.01307772440.53
105 rdf:rest Nc8c13be475c949cfb8eb0860fbf88c09
106 N2026367992a942d5a0749ffcf6ff8fd5 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
107 schema:name Asymptomatic Diseases
108 rdf:type schema:DefinedTerm
109 N2037ed0fe6e445fb97f98598ba5fe628 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
110 schema:name Adult
111 rdf:type schema:DefinedTerm
112 N24ec62a568b940119f2a53782e74ebdd schema:issueNumber 8
113 rdf:type schema:PublicationIssue
114 N2cd9410fa1a8483ebd588e8150fdd694 schema:name doi
115 schema:value 10.1007/s11605-017-3421-2
116 rdf:type schema:PropertyValue
117 N352646acce06401f8db5cd97a0ccce4a rdf:first sg:person.015104775355.77
118 rdf:rest Na62c4c2e1ca141c1a8871f8145503e41
119 N36887baf81644619a5160e5cddd1888d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
120 schema:name Humans
121 rdf:type schema:DefinedTerm
122 N3d17015c1f234eb0a4538bbfa96941af schema:name Springer Nature - SN SciGraph project
123 rdf:type schema:Organization
124 N4325599995a245579dc25fb832432469 schema:name pubmed_id
125 schema:value 28397027
126 rdf:type schema:PropertyValue
127 N505e7ab1b65748ce8019cf46b59f3ba4 rdf:first sg:person.01175531347.07
128 rdf:rest N6b8a6e889a6b4c0dbdfff89a6fa0f3b8
129 N5c9c1e208a8d49588e160b1fb60a2db3 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
130 schema:name Incidental Findings
131 rdf:type schema:DefinedTerm
132 N5ccdfa065b05457ba41ead1ee6d1d77e rdf:first sg:person.0626665021.66
133 rdf:rest N71f74441628946e08db41a5cba0bb682
134 N63cd1e898373428ea6ba8b9bf5829b36 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
135 schema:name Carcinoma, Pancreatic Ductal
136 rdf:type schema:DefinedTerm
137 N6b8a6e889a6b4c0dbdfff89a6fa0f3b8 rdf:first sg:person.011406547173.21
138 rdf:rest rdf:nil
139 N71f74441628946e08db41a5cba0bb682 rdf:first sg:person.01147204517.53
140 rdf:rest Ne5a5b14212434fa4a2659c84e18860aa
141 N737726688abf448aab1fa64efd5da228 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
142 schema:name Female
143 rdf:type schema:DefinedTerm
144 N7bdf448625a54388bd0a4586774bb72c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
145 schema:name Treatment Outcome
146 rdf:type schema:DefinedTerm
147 N7d6f9e598a3442bd9c1f463e8617cd97 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
148 schema:name Middle Aged
149 rdf:type schema:DefinedTerm
150 N96632390c79d4c7f969e1b21f0c96b1b schema:name dimensions_id
151 schema:value pub.1084760105
152 rdf:type schema:PropertyValue
153 Na62c4c2e1ca141c1a8871f8145503e41 rdf:first sg:person.0612301703.87
154 rdf:rest N1c0a4bb2896b440e888ad6ad076f0e26
155 Na8b24aeb6e9945998b77f8852be45cc4 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
156 schema:name Aged
157 rdf:type schema:DefinedTerm
158 Nb02655dbe98649b99f6d22e5d79f7b8b rdf:first sg:person.01267647573.52
159 rdf:rest N5ccdfa065b05457ba41ead1ee6d1d77e
160 Nbb2238ae8f8843ef87539f697180ed2b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
161 schema:name Pancreatic Neoplasms
162 rdf:type schema:DefinedTerm
163 Nc5243181461449cfa47e4a2210534a02 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
164 schema:name Pancreatectomy
165 rdf:type schema:DefinedTerm
166 Nc8c13be475c949cfb8eb0860fbf88c09 rdf:first sg:person.0770623646.53
167 rdf:rest Nb02655dbe98649b99f6d22e5d79f7b8b
168 Ncc8fcd1a56ba4a95aed9c4543042cb36 schema:volumeNumber 21
169 rdf:type schema:PublicationVolume
170 Nd0760e09f9a64a04b8f16eb1dc2dbee5 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
171 schema:name Early Detection of Cancer
172 rdf:type schema:DefinedTerm
173 Nd42f315291c24db4baa018feb76304d1 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
174 schema:name Aged, 80 and over
175 rdf:type schema:DefinedTerm
176 Nd7e399489c3849d0a43d8315d1d1a052 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
177 schema:name Retrospective Studies
178 rdf:type schema:DefinedTerm
179 Ndb0530bfe56149549aafaf0edf708164 rdf:first sg:person.013512034355.66
180 rdf:rest N505e7ab1b65748ce8019cf46b59f3ba4
181 Ne5a5b14212434fa4a2659c84e18860aa rdf:first sg:person.012714453755.53
182 rdf:rest Ndb0530bfe56149549aafaf0edf708164
183 Ned6497299f8f40f2a25e2eb48f3b267c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
184 schema:name Survival Rate
185 rdf:type schema:DefinedTerm
186 Nf684d717282e4fa59ba2ab7255bac81c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
187 schema:name Male
188 rdf:type schema:DefinedTerm
189 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
190 schema:name Medical and Health Sciences
191 rdf:type schema:DefinedTerm
192 anzsrc-for:1103 schema:inDefinedTermSet anzsrc-for:
193 schema:name Clinical Sciences
194 rdf:type schema:DefinedTerm
195 sg:journal.1116755 schema:issn 1091-255X
196 1873-4626
197 schema:name Journal of Gastrointestinal Surgery
198 schema:publisher Springer Nature
199 rdf:type schema:Periodical
200 sg:person.011406547173.21 schema:affiliation grid-institutes:grid.410807.a
201 schema:familyName Ito
202 schema:givenName Hiromichi
203 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011406547173.21
204 rdf:type schema:Person
205 sg:person.01147204517.53 schema:affiliation grid-institutes:grid.410807.a
206 schema:familyName Matsumura
207 schema:givenName Masaru
208 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01147204517.53
209 rdf:type schema:Person
210 sg:person.01175531347.07 schema:affiliation grid-institutes:grid.410807.a
211 schema:familyName Tanaka
212 schema:givenName Masayuki
213 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01175531347.07
214 rdf:type schema:Person
215 sg:person.01267647573.52 schema:affiliation grid-institutes:grid.410807.a
216 schema:familyName Ishizawa
217 schema:givenName Takeaki
218 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01267647573.52
219 rdf:type schema:Person
220 sg:person.012714453755.53 schema:affiliation grid-institutes:grid.410807.a
221 schema:familyName Ichida
222 schema:givenName Hirofumi
223 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012714453755.53
224 rdf:type schema:Person
225 sg:person.01307772440.53 schema:affiliation grid-institutes:grid.410807.a
226 schema:familyName Takahashi
227 schema:givenName Yu
228 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01307772440.53
229 rdf:type schema:Person
230 sg:person.013512034355.66 schema:affiliation grid-institutes:grid.410807.a
231 schema:familyName Matsuki
232 schema:givenName Ryota
233 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013512034355.66
234 rdf:type schema:Person
235 sg:person.015104775355.77 schema:affiliation grid-institutes:grid.410807.a
236 schema:familyName Takeda
237 schema:givenName Yoshinori
238 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015104775355.77
239 rdf:type schema:Person
240 sg:person.0612301703.87 schema:affiliation grid-institutes:grid.410807.a
241 schema:familyName Saiura
242 schema:givenName Akio
243 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0612301703.87
244 rdf:type schema:Person
245 sg:person.0626665021.66 schema:affiliation grid-institutes:grid.410807.a
246 schema:familyName Mise
247 schema:givenName Yoshihiro
248 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0626665021.66
249 rdf:type schema:Person
250 sg:person.0770623646.53 schema:affiliation grid-institutes:grid.410807.a
251 schema:familyName Inoue
252 schema:givenName Yosuke
253 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0770623646.53
254 rdf:type schema:Person
255 sg:pub.10.1007/s00268-009-0300-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030144262
256 https://doi.org/10.1007/s00268-009-0300-3
257 rdf:type schema:CreativeWork
258 sg:pub.10.1007/s00268-016-3550-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1010597716
259 https://doi.org/10.1007/s00268-016-3550-x
260 rdf:type schema:CreativeWork
261 sg:pub.10.1007/s11605-007-0384-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043513971
262 https://doi.org/10.1007/s11605-007-0384-8
263 rdf:type schema:CreativeWork
264 sg:pub.10.1038/ajg.2009.276 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037176663
265 https://doi.org/10.1038/ajg.2009.276
266 rdf:type schema:CreativeWork
267 sg:pub.10.1245/s10434-008-0295-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005006861
268 https://doi.org/10.1245/s10434-008-0295-2
269 rdf:type schema:CreativeWork
270 grid-institutes:grid.410807.a schema:alternateName Department of Hepato-Biliary-Pancreatic Surgery, Cancer Institute Hospital, Japanese Foundation for Cancer Research, 3-8-31 Ariake, Koto-ku, 135-8550, Tokyo, Japan
271 schema:name Department of Hepato-Biliary-Pancreatic Surgery, Cancer Institute Hospital, Japanese Foundation for Cancer Research, 3-8-31 Ariake, Koto-ku, 135-8550, Tokyo, Japan
272 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...