Liver Transplantation After Transarterial Chemoembolization and Radiotherapy for Hepatocellular Carcinoma with Vascular Invasion View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2016-10-24

AUTHORS

Yuri Jeong, Min-Ho Shin, Sang Min Yoon, Gi-Won Song, Ki-Hun Kim, Chul-Soo Ahn, Deok-Bog Moon, Shin Hwang, Jin-hong Park, Jong Hoon Kim, Sung-Gyu Lee

ABSTRACT

PurposeThe study aims to analyze the oncologic outcomes of living donor liver transplantation (LDLT) after combined transarterial chemoembolization (TACE) and radiotherapy for hepatocellular carcinoma (HCC) with major vascular invasion.MethodsWe retrospectively reviewed 17 HCC patients with major vascular invasion who underwent LDLT after combined treatment modality between May 2007 and September 2014. The LDLT timing was determined by the surgeons depending on the disease status and liver function. The intrahepatic recurrence-free survival, disease-free survival (DFS), and overall survival (OS) rates were estimated from the date of the LDLT.ResultsThe median follow-up period was 24.5 months (range, 6.4–66.0 months) after the LDLT. The interval between the combined treatment and the LDLT was a median of 5 months (range, 0.4–65.3 months). On the explanted liver, total necrosis was shown in five patients (29.4 %). The 1- and 3-year DFS rates were 70.6 and 57.8 %, respectively. The 1- and 3-year OS rates were 87.4 and 60.5 %, respectively. The major pattern of failure was distant metastasis (35.3 %), and intrahepatic recurrence occurred in three patients (17.6 %) who experienced distant metastasis.ConclusionsIn the selected HCC patients with major vascular invasion, LDLT after combined TACE and radiotherapy showed acceptable oncologic outcomes. More... »

PAGES

275-283

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s11605-016-3302-0

DOI

http://dx.doi.org/10.1007/s11605-016-3302-0

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1038797765

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/27778254


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50 function
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52 intervals
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55 invasion
56 liver
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59 major patterns
60 major vascular invasion
61 median
62 median follow
63 metastasis
64 modalities
65 months
66 necrosis
67 oncologic outcomes
68 outcomes
69 overall survival rate
70 patients
71 patterns
72 period
73 radiotherapy
74 rate
75 recurrence
76 recurrence-free survival
77 status
78 study
79 surgeons
80 survival
81 survival rate
82 timing
83 total necrosis
84 transarterial chemoembolization
85 transplantation
86 treatment
87 treatment modalities
88 vascular invasion
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