Impact of Blood Transfusions and Transfusion Practices on Long-Term Outcome Following Hepatopancreaticobiliary Surgery View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2015-05

AUTHORS

Aslam Ejaz, Gaya Spolverato, Yuhree Kim, Georgios A. Margonis, Rohan Gupta, Neda Amini, Steven M. Frank, Timothy M. Pawlik

ABSTRACT

BACKGROUND: The long-term impact of transfusions with packed red blood cells (PRBC) among patients undergoing hepatopancreaticobiliary (HPB) surgery remains ill-defined. We sought to determine the impact of overall blood utilization, as well as a restrictive transfusion strategy, on long-term outcomes among patients undergoing an HPB resection for a malignancy. METHODS: Data on overall blood utilization and hemoglobin (Hb) levels that triggered a transfusion were obtained for patients with cancer undergoing pancreas or liver surgery between 2009 and 2013. Risk-adjusted recurrence-free (RFS) and overall survival (OS) were assessed based on receipt of PRBC and whether the patient received a transfusion using a restrictive transfusion strategy (intraoperative: Hb <10 g/dL; postoperative: Hb <8 g/dL). RESULTS: Four hundred forty-two patients underwent either a pancreas (58.1 %) or liver (41.9 %) resection. Most tumors were pancreatic in origin (41.8 %), while a subset were primary (23.1 %) or secondary (18.8 %) liver tumors. One hundred seventy-five (39.6 %) patients received ≥1 PRBC transfusion either intraoperatively (16.7 %), postoperatively (12.7 %), or both (10.2 %). There was a higher incidence of PRBC transfusion among patients undergoing a pancreas resection, those with higher comorbidities, and those with lower preoperative Hb levels. Perioperative morbidity was higher among patients receiving either 1-2 units (OR 3.14) or 3 or more units of PRBC (OR 8.54). Median OS was 31.9 months. Receipt of a blood transfusion was associated with a worse OS (1-2 units: HR 1.76; 3+units: HR 2.50; both P<0.05), and RFS (3+units: HR 2.91; P=0.02). Utilization of a restrictive transfusion strategy did not impact perioperative morbidity or long-term RFS or OS. CONCLUSIONS: Adoption of a more restrictive transfusion strategy in patients undergoing resection for cancer may preserve a limited resource, reduce costs, as well as avoid exposing oncology patients to the unnecessary risks associated with a transfusion. More... »

PAGES

887-896

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s11605-015-2776-5

DOI

http://dx.doi.org/10.1007/s11605-015-2776-5

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1048073455

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/25707813


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1112", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Oncology and Carcinogenesis", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Duodenum", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Erythrocyte Transfusion", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Female", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Hepatectomy", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Liver Neoplasms", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Male", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Middle Aged", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Pancreatectomy", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Pancreatic Neoplasms", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Treatment Outcome", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "University of Illinois Hospital & Health Sciences System", 
          "id": "https://www.grid.ac/institutes/grid.412973.a", 
          "name": [
            "Department of Surgery, University of Illinois Hospital and Health Sciences System, Chicago, IL, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Ejaz", 
        "givenName": "Aslam", 
        "id": "sg:person.01034600372.57", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01034600372.57"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Johns Hopkins University", 
          "id": "https://www.grid.ac/institutes/grid.21107.35", 
          "name": [
            "Department of Surgery, The Johns Hopkins University School of Medicine, 600 N. Wolfe Street, Blalock 665, 21287, Baltimore, MD, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Spolverato", 
        "givenName": "Gaya", 
        "id": "sg:person.01246062107.35", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01246062107.35"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Johns Hopkins University", 
          "id": "https://www.grid.ac/institutes/grid.21107.35", 
          "name": [
            "Department of Surgery, The Johns Hopkins University School of Medicine, 600 N. Wolfe Street, Blalock 665, 21287, Baltimore, MD, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Kim", 
        "givenName": "Yuhree", 
        "id": "sg:person.01153651444.32", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01153651444.32"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Johns Hopkins University", 
          "id": "https://www.grid.ac/institutes/grid.21107.35", 
          "name": [
            "Department of Surgery, The Johns Hopkins University School of Medicine, 600 N. Wolfe Street, Blalock 665, 21287, Baltimore, MD, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Margonis", 
        "givenName": "Georgios A.", 
        "id": "sg:person.01164067760.10", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01164067760.10"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Johns Hopkins University", 
          "id": "https://www.grid.ac/institutes/grid.21107.35", 
          "name": [
            "Department of Surgery, The Johns Hopkins University School of Medicine, 600 N. Wolfe Street, Blalock 665, 21287, Baltimore, MD, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Gupta", 
        "givenName": "Rohan", 
        "id": "sg:person.01106556750.77", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01106556750.77"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Johns Hopkins University", 
          "id": "https://www.grid.ac/institutes/grid.21107.35", 
          "name": [
            "Department of Surgery, The Johns Hopkins University School of Medicine, 600 N. Wolfe Street, Blalock 665, 21287, Baltimore, MD, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Amini", 
        "givenName": "Neda", 
        "id": "sg:person.0756027210.94", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0756027210.94"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Johns Hopkins University", 
          "id": "https://www.grid.ac/institutes/grid.21107.35", 
          "name": [
            "Department of Anesthesiology, The Johns Hopkins University School of Medicine, Baltimore, MD, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Frank", 
        "givenName": "Steven M.", 
        "id": "sg:person.015104051717.12", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015104051717.12"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Johns Hopkins University", 
          "id": "https://www.grid.ac/institutes/grid.21107.35", 
          "name": [
            "Department of Surgery, The Johns Hopkins University School of Medicine, 600 N. Wolfe Street, Blalock 665, 21287, Baltimore, MD, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Pawlik", 
        "givenName": "Timothy M.", 
        "id": "sg:person.0721627074.41", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0721627074.41"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1378/chest.116.5.1149", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002737176"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1378/chest.116.5.1149", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002737176"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3109/00365529309101570", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003871507"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1046/j.1537-2995.1990.30790385527.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005370652"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.ejcts.2005.01.030", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005491294"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.athoracsur.2013.12.044", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005758605"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/ccm.0b013e3181b39f1b", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006156927"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/ccm.0b013e3181b39f1b", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006156927"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/14651858.cd002042.pub3", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006949590"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1056/nejmoa1211801", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1008600953"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1056/nejm199305133281902", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010344565"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/aln.0b013e3182054d06", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012682698"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/aln.0b013e3182054d06", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012682698"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1056/nejmoa1012452", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015210523"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.athoracsur.2005.12.037", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1016525723"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/14651858.cd005033.pub2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017436803"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/s13054-014-0487-z", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018558316", 
          "https://doi.org/10.1186/s13054-014-0487-z"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/s13054-014-0487-z", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018558316", 
          "https://doi.org/10.1186/s13054-014-0487-z"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/trf.12227", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019235562"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.surg.2012.06.008", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021385808"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0140-6736(82)92764-7", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022524237"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0140-6736(82)92764-7", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022524237"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0003-4975(02)03766-9", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023466764"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1001/jamasurg.2015.81", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024610050"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/1097-0142(19850315)55:6<1195::aid-cncr2820550610>3.0.co;2-h", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1026509053"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1477-2574.2011.00326.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027728430"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.jacc.2006.02.028", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028486950"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.surg.2013.06.012", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029804566"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/aln.0b013e318255e550", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033549295"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/aln.0b013e318255e550", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033549295"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.athoracsur.2010.11.078", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038100089"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0002-9610(85)80047-7", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039555172"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.jamcollsurg.2014.02.033", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042691116"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1001/jama.1995.03520420055038", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042973064"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1056/nejm199902113400601", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1044018868"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/bjs.9617", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1044984505"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1056/nejmoa1406617", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045548924"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1001/jama.2010.1446", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046887971"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1001/jama.273.18.1439", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1054158236"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.7326/0003-4819-157-1-201206190-00429", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1073712932"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1083173386", 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2015-05", 
    "datePublishedReg": "2015-05-01", 
    "description": "BACKGROUND: The long-term impact of transfusions with packed red blood cells (PRBC) among patients undergoing hepatopancreaticobiliary (HPB) surgery remains ill-defined. We sought to determine the impact of overall blood utilization, as well as a restrictive transfusion strategy, on long-term outcomes among patients undergoing an HPB resection for a malignancy.\nMETHODS: Data on overall blood utilization and hemoglobin (Hb) levels that triggered a transfusion were obtained for patients with cancer undergoing pancreas or liver surgery between 2009 and 2013. Risk-adjusted recurrence-free (RFS) and overall survival (OS) were assessed based on receipt of PRBC and whether the patient received a transfusion using a restrictive transfusion strategy (intraoperative: Hb <10 g/dL; postoperative: Hb <8 g/dL).\nRESULTS: Four hundred forty-two patients underwent either a pancreas (58.1 %) or liver (41.9 %) resection. Most tumors were pancreatic in origin (41.8 %), while a subset were primary (23.1 %) or secondary (18.8 %) liver tumors. One hundred seventy-five (39.6 %) patients received \u22651 PRBC transfusion either intraoperatively (16.7 %), postoperatively (12.7 %), or both (10.2 %). There was a higher incidence of PRBC transfusion among patients undergoing a pancreas resection, those with higher comorbidities, and those with lower preoperative Hb levels. Perioperative morbidity was higher among patients receiving either 1-2 units (OR 3.14) or 3 or more units of PRBC (OR 8.54). Median OS was 31.9 months. Receipt of a blood transfusion was associated with a worse OS (1-2 units: HR 1.76; 3+units: HR 2.50; both P<0.05), and RFS (3+units: HR 2.91; P=0.02). Utilization of a restrictive transfusion strategy did not impact perioperative morbidity or long-term RFS or OS.\nCONCLUSIONS: Adoption of a more restrictive transfusion strategy in patients undergoing resection for cancer may preserve a limited resource, reduce costs, as well as avoid exposing oncology patients to the unnecessary risks associated with a transfusion.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1007/s11605-015-2776-5", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": false, 
    "isPartOf": [
      {
        "id": "sg:journal.1116755", 
        "issn": [
          "1091-255X", 
          "1873-4626"
        ], 
        "name": "Journal of Gastrointestinal Surgery", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "5", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "19"
      }
    ], 
    "name": "Impact of Blood Transfusions and Transfusion Practices on Long-Term Outcome Following Hepatopancreaticobiliary Surgery", 
    "pagination": "887-896", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "e5036fc1933b983683fc8a22f1341856267fdac3124ffa3f66936f59cb0172e8"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "25707813"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "9706084"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1007/s11605-015-2776-5"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1048073455"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1007/s11605-015-2776-5", 
      "https://app.dimensions.ai/details/publication/pub.1048073455"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-10T20:00", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8681_00000524.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "http://link.springer.com/10.1007%2Fs11605-015-2776-5"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s11605-015-2776-5'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s11605-015-2776-5'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s11605-015-2776-5'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s11605-015-2776-5'


 

This table displays all metadata directly associated to this object as RDF triples.

271 TRIPLES      21 PREDICATES      75 URIs      32 LITERALS      20 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1007/s11605-015-2776-5 schema:about N0006b7b14b0745918bcd26df18a9c220
2 N38fcb8f3ad614be2bd0c5bd9561ffefe
3 N519ada4a38284ad8ad1754ebd17044a9
4 N5785cd6e146941b9a38112a272d87de2
5 N636acd95ada84adda437329196f7f34a
6 N733db373a33f463bacb25c6022912960
7 N818c75209a9840278e1d6e36cb06e732
8 N8ae3813b459c4ba8a4cdbe48ccfa3031
9 Nab32874297944483b45762444176fa8e
10 Ne782f44148f74067ae2d5d3cf665f943
11 Nea7fade8b44c453c91977b4b63baf95b
12 anzsrc-for:11
13 anzsrc-for:1112
14 schema:author N231e1841f5a1419386c35282f002e59e
15 schema:citation sg:pub.10.1186/s13054-014-0487-z
16 https://app.dimensions.ai/details/publication/pub.1083173386
17 https://doi.org/10.1001/jama.1995.03520420055038
18 https://doi.org/10.1001/jama.2010.1446
19 https://doi.org/10.1001/jama.273.18.1439
20 https://doi.org/10.1001/jamasurg.2015.81
21 https://doi.org/10.1002/1097-0142(19850315)55:6<1195::aid-cncr2820550610>3.0.co;2-h
22 https://doi.org/10.1002/14651858.cd002042.pub3
23 https://doi.org/10.1002/14651858.cd005033.pub2
24 https://doi.org/10.1002/bjs.9617
25 https://doi.org/10.1016/j.athoracsur.2005.12.037
26 https://doi.org/10.1016/j.athoracsur.2010.11.078
27 https://doi.org/10.1016/j.athoracsur.2013.12.044
28 https://doi.org/10.1016/j.ejcts.2005.01.030
29 https://doi.org/10.1016/j.jacc.2006.02.028
30 https://doi.org/10.1016/j.jamcollsurg.2014.02.033
31 https://doi.org/10.1016/j.surg.2012.06.008
32 https://doi.org/10.1016/j.surg.2013.06.012
33 https://doi.org/10.1016/s0002-9610(85)80047-7
34 https://doi.org/10.1016/s0003-4975(02)03766-9
35 https://doi.org/10.1016/s0140-6736(82)92764-7
36 https://doi.org/10.1046/j.1537-2995.1990.30790385527.x
37 https://doi.org/10.1056/nejm199305133281902
38 https://doi.org/10.1056/nejm199902113400601
39 https://doi.org/10.1056/nejmoa1012452
40 https://doi.org/10.1056/nejmoa1211801
41 https://doi.org/10.1056/nejmoa1406617
42 https://doi.org/10.1097/aln.0b013e3182054d06
43 https://doi.org/10.1097/aln.0b013e318255e550
44 https://doi.org/10.1097/ccm.0b013e3181b39f1b
45 https://doi.org/10.1111/j.1477-2574.2011.00326.x
46 https://doi.org/10.1111/trf.12227
47 https://doi.org/10.1378/chest.116.5.1149
48 https://doi.org/10.3109/00365529309101570
49 https://doi.org/10.7326/0003-4819-157-1-201206190-00429
50 schema:datePublished 2015-05
51 schema:datePublishedReg 2015-05-01
52 schema:description BACKGROUND: The long-term impact of transfusions with packed red blood cells (PRBC) among patients undergoing hepatopancreaticobiliary (HPB) surgery remains ill-defined. We sought to determine the impact of overall blood utilization, as well as a restrictive transfusion strategy, on long-term outcomes among patients undergoing an HPB resection for a malignancy. METHODS: Data on overall blood utilization and hemoglobin (Hb) levels that triggered a transfusion were obtained for patients with cancer undergoing pancreas or liver surgery between 2009 and 2013. Risk-adjusted recurrence-free (RFS) and overall survival (OS) were assessed based on receipt of PRBC and whether the patient received a transfusion using a restrictive transfusion strategy (intraoperative: Hb <10 g/dL; postoperative: Hb <8 g/dL). RESULTS: Four hundred forty-two patients underwent either a pancreas (58.1 %) or liver (41.9 %) resection. Most tumors were pancreatic in origin (41.8 %), while a subset were primary (23.1 %) or secondary (18.8 %) liver tumors. One hundred seventy-five (39.6 %) patients received ≥1 PRBC transfusion either intraoperatively (16.7 %), postoperatively (12.7 %), or both (10.2 %). There was a higher incidence of PRBC transfusion among patients undergoing a pancreas resection, those with higher comorbidities, and those with lower preoperative Hb levels. Perioperative morbidity was higher among patients receiving either 1-2 units (OR 3.14) or 3 or more units of PRBC (OR 8.54). Median OS was 31.9 months. Receipt of a blood transfusion was associated with a worse OS (1-2 units: HR 1.76; 3+units: HR 2.50; both P<0.05), and RFS (3+units: HR 2.91; P=0.02). Utilization of a restrictive transfusion strategy did not impact perioperative morbidity or long-term RFS or OS. CONCLUSIONS: Adoption of a more restrictive transfusion strategy in patients undergoing resection for cancer may preserve a limited resource, reduce costs, as well as avoid exposing oncology patients to the unnecessary risks associated with a transfusion.
53 schema:genre research_article
54 schema:inLanguage en
55 schema:isAccessibleForFree false
56 schema:isPartOf N2d1fe3df7c7747ce806e07d74b36a13a
57 N3064ca7955664a8eaea6117e468b6037
58 sg:journal.1116755
59 schema:name Impact of Blood Transfusions and Transfusion Practices on Long-Term Outcome Following Hepatopancreaticobiliary Surgery
60 schema:pagination 887-896
61 schema:productId N0570430b69fc49618abac5adc7cba3b7
62 N22afdb30a7124c7fb79eda1067a0e87b
63 N75d6babc4e3f4ef68ab58b433c6c16a9
64 Nc281695c85854fe2a4d92644361302e7
65 Nf8ca199843844a4b801f2cefad6fb8b9
66 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048073455
67 https://doi.org/10.1007/s11605-015-2776-5
68 schema:sdDatePublished 2019-04-10T20:00
69 schema:sdLicense https://scigraph.springernature.com/explorer/license/
70 schema:sdPublisher N838f5118a1c8431cabf2404594d53bbc
71 schema:url http://link.springer.com/10.1007%2Fs11605-015-2776-5
72 sgo:license sg:explorer/license/
73 sgo:sdDataset articles
74 rdf:type schema:ScholarlyArticle
75 N0006b7b14b0745918bcd26df18a9c220 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
76 schema:name Liver Neoplasms
77 rdf:type schema:DefinedTerm
78 N0570430b69fc49618abac5adc7cba3b7 schema:name readcube_id
79 schema:value e5036fc1933b983683fc8a22f1341856267fdac3124ffa3f66936f59cb0172e8
80 rdf:type schema:PropertyValue
81 N119dd51fdc914f1cba6e0153f6e3b9aa rdf:first sg:person.0721627074.41
82 rdf:rest rdf:nil
83 N1a208d44c4974e139d47a0039b44fed6 rdf:first sg:person.01153651444.32
84 rdf:rest Nf1ccf7dda4d84d56a06462d98eae1ed7
85 N22afdb30a7124c7fb79eda1067a0e87b schema:name dimensions_id
86 schema:value pub.1048073455
87 rdf:type schema:PropertyValue
88 N231e1841f5a1419386c35282f002e59e rdf:first sg:person.01034600372.57
89 rdf:rest N28eb13a16bb34113b1e5ae84afb5493f
90 N28eb13a16bb34113b1e5ae84afb5493f rdf:first sg:person.01246062107.35
91 rdf:rest N1a208d44c4974e139d47a0039b44fed6
92 N2d1fe3df7c7747ce806e07d74b36a13a schema:issueNumber 5
93 rdf:type schema:PublicationIssue
94 N3064ca7955664a8eaea6117e468b6037 schema:volumeNumber 19
95 rdf:type schema:PublicationVolume
96 N38fcb8f3ad614be2bd0c5bd9561ffefe schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
97 schema:name Female
98 rdf:type schema:DefinedTerm
99 N3b70e5009d2d4bf486bd58e5afc5bfc8 rdf:first sg:person.0756027210.94
100 rdf:rest Nf60b9b35a6d44a69be9fe6f028c18f85
101 N519ada4a38284ad8ad1754ebd17044a9 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
102 schema:name Treatment Outcome
103 rdf:type schema:DefinedTerm
104 N5785cd6e146941b9a38112a272d87de2 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
105 schema:name Male
106 rdf:type schema:DefinedTerm
107 N5f3515878e464f12a3048851ee3697cf rdf:first sg:person.01106556750.77
108 rdf:rest N3b70e5009d2d4bf486bd58e5afc5bfc8
109 N636acd95ada84adda437329196f7f34a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
110 schema:name Pancreatic Neoplasms
111 rdf:type schema:DefinedTerm
112 N733db373a33f463bacb25c6022912960 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
113 schema:name Hepatectomy
114 rdf:type schema:DefinedTerm
115 N75d6babc4e3f4ef68ab58b433c6c16a9 schema:name nlm_unique_id
116 schema:value 9706084
117 rdf:type schema:PropertyValue
118 N818c75209a9840278e1d6e36cb06e732 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
119 schema:name Pancreatectomy
120 rdf:type schema:DefinedTerm
121 N838f5118a1c8431cabf2404594d53bbc schema:name Springer Nature - SN SciGraph project
122 rdf:type schema:Organization
123 N8ae3813b459c4ba8a4cdbe48ccfa3031 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
124 schema:name Middle Aged
125 rdf:type schema:DefinedTerm
126 Nab32874297944483b45762444176fa8e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
127 schema:name Duodenum
128 rdf:type schema:DefinedTerm
129 Nc281695c85854fe2a4d92644361302e7 schema:name doi
130 schema:value 10.1007/s11605-015-2776-5
131 rdf:type schema:PropertyValue
132 Ne782f44148f74067ae2d5d3cf665f943 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
133 schema:name Humans
134 rdf:type schema:DefinedTerm
135 Nea7fade8b44c453c91977b4b63baf95b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
136 schema:name Erythrocyte Transfusion
137 rdf:type schema:DefinedTerm
138 Nf1ccf7dda4d84d56a06462d98eae1ed7 rdf:first sg:person.01164067760.10
139 rdf:rest N5f3515878e464f12a3048851ee3697cf
140 Nf60b9b35a6d44a69be9fe6f028c18f85 rdf:first sg:person.015104051717.12
141 rdf:rest N119dd51fdc914f1cba6e0153f6e3b9aa
142 Nf8ca199843844a4b801f2cefad6fb8b9 schema:name pubmed_id
143 schema:value 25707813
144 rdf:type schema:PropertyValue
145 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
146 schema:name Medical and Health Sciences
147 rdf:type schema:DefinedTerm
148 anzsrc-for:1112 schema:inDefinedTermSet anzsrc-for:
149 schema:name Oncology and Carcinogenesis
150 rdf:type schema:DefinedTerm
151 sg:journal.1116755 schema:issn 1091-255X
152 1873-4626
153 schema:name Journal of Gastrointestinal Surgery
154 rdf:type schema:Periodical
155 sg:person.01034600372.57 schema:affiliation https://www.grid.ac/institutes/grid.412973.a
156 schema:familyName Ejaz
157 schema:givenName Aslam
158 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01034600372.57
159 rdf:type schema:Person
160 sg:person.01106556750.77 schema:affiliation https://www.grid.ac/institutes/grid.21107.35
161 schema:familyName Gupta
162 schema:givenName Rohan
163 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01106556750.77
164 rdf:type schema:Person
165 sg:person.01153651444.32 schema:affiliation https://www.grid.ac/institutes/grid.21107.35
166 schema:familyName Kim
167 schema:givenName Yuhree
168 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01153651444.32
169 rdf:type schema:Person
170 sg:person.01164067760.10 schema:affiliation https://www.grid.ac/institutes/grid.21107.35
171 schema:familyName Margonis
172 schema:givenName Georgios A.
173 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01164067760.10
174 rdf:type schema:Person
175 sg:person.01246062107.35 schema:affiliation https://www.grid.ac/institutes/grid.21107.35
176 schema:familyName Spolverato
177 schema:givenName Gaya
178 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01246062107.35
179 rdf:type schema:Person
180 sg:person.015104051717.12 schema:affiliation https://www.grid.ac/institutes/grid.21107.35
181 schema:familyName Frank
182 schema:givenName Steven M.
183 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015104051717.12
184 rdf:type schema:Person
185 sg:person.0721627074.41 schema:affiliation https://www.grid.ac/institutes/grid.21107.35
186 schema:familyName Pawlik
187 schema:givenName Timothy M.
188 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0721627074.41
189 rdf:type schema:Person
190 sg:person.0756027210.94 schema:affiliation https://www.grid.ac/institutes/grid.21107.35
191 schema:familyName Amini
192 schema:givenName Neda
193 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0756027210.94
194 rdf:type schema:Person
195 sg:pub.10.1186/s13054-014-0487-z schema:sameAs https://app.dimensions.ai/details/publication/pub.1018558316
196 https://doi.org/10.1186/s13054-014-0487-z
197 rdf:type schema:CreativeWork
198 https://app.dimensions.ai/details/publication/pub.1083173386 schema:CreativeWork
199 https://doi.org/10.1001/jama.1995.03520420055038 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042973064
200 rdf:type schema:CreativeWork
201 https://doi.org/10.1001/jama.2010.1446 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046887971
202 rdf:type schema:CreativeWork
203 https://doi.org/10.1001/jama.273.18.1439 schema:sameAs https://app.dimensions.ai/details/publication/pub.1054158236
204 rdf:type schema:CreativeWork
205 https://doi.org/10.1001/jamasurg.2015.81 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024610050
206 rdf:type schema:CreativeWork
207 https://doi.org/10.1002/1097-0142(19850315)55:6<1195::aid-cncr2820550610>3.0.co;2-h schema:sameAs https://app.dimensions.ai/details/publication/pub.1026509053
208 rdf:type schema:CreativeWork
209 https://doi.org/10.1002/14651858.cd002042.pub3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006949590
210 rdf:type schema:CreativeWork
211 https://doi.org/10.1002/14651858.cd005033.pub2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017436803
212 rdf:type schema:CreativeWork
213 https://doi.org/10.1002/bjs.9617 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044984505
214 rdf:type schema:CreativeWork
215 https://doi.org/10.1016/j.athoracsur.2005.12.037 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016525723
216 rdf:type schema:CreativeWork
217 https://doi.org/10.1016/j.athoracsur.2010.11.078 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038100089
218 rdf:type schema:CreativeWork
219 https://doi.org/10.1016/j.athoracsur.2013.12.044 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005758605
220 rdf:type schema:CreativeWork
221 https://doi.org/10.1016/j.ejcts.2005.01.030 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005491294
222 rdf:type schema:CreativeWork
223 https://doi.org/10.1016/j.jacc.2006.02.028 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028486950
224 rdf:type schema:CreativeWork
225 https://doi.org/10.1016/j.jamcollsurg.2014.02.033 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042691116
226 rdf:type schema:CreativeWork
227 https://doi.org/10.1016/j.surg.2012.06.008 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021385808
228 rdf:type schema:CreativeWork
229 https://doi.org/10.1016/j.surg.2013.06.012 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029804566
230 rdf:type schema:CreativeWork
231 https://doi.org/10.1016/s0002-9610(85)80047-7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039555172
232 rdf:type schema:CreativeWork
233 https://doi.org/10.1016/s0003-4975(02)03766-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023466764
234 rdf:type schema:CreativeWork
235 https://doi.org/10.1016/s0140-6736(82)92764-7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022524237
236 rdf:type schema:CreativeWork
237 https://doi.org/10.1046/j.1537-2995.1990.30790385527.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1005370652
238 rdf:type schema:CreativeWork
239 https://doi.org/10.1056/nejm199305133281902 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010344565
240 rdf:type schema:CreativeWork
241 https://doi.org/10.1056/nejm199902113400601 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044018868
242 rdf:type schema:CreativeWork
243 https://doi.org/10.1056/nejmoa1012452 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015210523
244 rdf:type schema:CreativeWork
245 https://doi.org/10.1056/nejmoa1211801 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008600953
246 rdf:type schema:CreativeWork
247 https://doi.org/10.1056/nejmoa1406617 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045548924
248 rdf:type schema:CreativeWork
249 https://doi.org/10.1097/aln.0b013e3182054d06 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012682698
250 rdf:type schema:CreativeWork
251 https://doi.org/10.1097/aln.0b013e318255e550 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033549295
252 rdf:type schema:CreativeWork
253 https://doi.org/10.1097/ccm.0b013e3181b39f1b schema:sameAs https://app.dimensions.ai/details/publication/pub.1006156927
254 rdf:type schema:CreativeWork
255 https://doi.org/10.1111/j.1477-2574.2011.00326.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1027728430
256 rdf:type schema:CreativeWork
257 https://doi.org/10.1111/trf.12227 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019235562
258 rdf:type schema:CreativeWork
259 https://doi.org/10.1378/chest.116.5.1149 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002737176
260 rdf:type schema:CreativeWork
261 https://doi.org/10.3109/00365529309101570 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003871507
262 rdf:type schema:CreativeWork
263 https://doi.org/10.7326/0003-4819-157-1-201206190-00429 schema:sameAs https://app.dimensions.ai/details/publication/pub.1073712932
264 rdf:type schema:CreativeWork
265 https://www.grid.ac/institutes/grid.21107.35 schema:alternateName Johns Hopkins University
266 schema:name Department of Anesthesiology, The Johns Hopkins University School of Medicine, Baltimore, MD, USA
267 Department of Surgery, The Johns Hopkins University School of Medicine, 600 N. Wolfe Street, Blalock 665, 21287, Baltimore, MD, USA
268 rdf:type schema:Organization
269 https://www.grid.ac/institutes/grid.412973.a schema:alternateName University of Illinois Hospital & Health Sciences System
270 schema:name Department of Surgery, University of Illinois Hospital and Health Sciences System, Chicago, IL, USA
271 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...