Young Patients Undergoing Resection of Pancreatic Cancer Fare Better than their Older Counterparts View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2013-02

AUTHORS

Jin He, Barish H. Edil, John L. Cameron, Richard D. Schulick, Ralph H. Hruban, Joseph M. Herman, Lei Zheng, Christine Iacobuzio-Donahue, Nita Ahuja, Timothy M. Pawlik, Christopher L. Wolfgang

ABSTRACT

BACKGROUND: The median age of pancreatic ductal adenocarcinoma (PDAC) patients is 71 years. PDAC rarely affects individuals under the age of 45. We investigated features of PDAC occurring in young patients (≤45 years) who underwent surgical resection in order to determine if any difference exists in comparison to elderly patients (≥70 years). METHODS: A retrospective analysis of patients with PDAC who were ≤ 45 years on the date of surgery between 1975 and 2009 was performed. This cohort was compared with PDAC patients whose ages were over 70 years on the date of surgery over the same time interval. Information reviewed included demographics, Charlson Age-Comorbidity Index (CACI), pathological staging, surgical management, and death or last follow-up. RESULTS: Seventy five patients with PDAC of age ≤ 45 years at surgery were identified. The reference group consisted of 870 patients with a median age of 75. The most common symptoms of young patients were jaundice (45 %), abdominal pain (32 %), or weight loss (33 %). This did not differ significantly from older patients. Among the younger patients, 7 (9 %) underwent total pancreatectomy, 60 (80 %) underwent pancreaticoduodenectomy, and 8 (11 %) had distal pancreatectomy. The distribution of type of surgery was similar between two groups. Fifty-two of the young patients (69 %) had an R0 resection and this did not differ from the older age group (n = 616; 71 %). The rate of lymph node positivity was 68 % for younger patients and 74 % for older patients (p = 0.27). Of the younger patients, 11, 13, 49, and 2 were classified as stage I, IIA, IIB, and III, respectively, and did not differ from the older age group. The median overall survival for the young patients cohort was 19 months (95 % CI 15-22 months) which is longer than 16 months (95 % CI 14-17 months) of the older group (p = 0.007). The actual 5- and 10- year survival in young age group (24 and 17 %) was longer than that in old age group (11 and 3 %) (p < 0.05). The median CACI of the younger patients was 0.5 and was lower than 4.1 of the older patients (p < 0.0001). CONCLUSIONS: The demographic, pathologic, and treatment characteristics of PDAC patients younger than 45 years were similar to those older than 70 years. Younger patients had fewer complications after curative resections. The better survival among younger patients is likely related to fewer comorbidities in this group. These findings will be useful in counseling young patients with resectable pancreatic cancer. More... »

PAGES

339-344

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s11605-012-2066-4

DOI

http://dx.doi.org/10.1007/s11605-012-2066-4

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1037936761

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/23184271


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1103", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Clinical Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Adult", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Age Factors", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Aged", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Carcinoma, Pancreatic Ductal", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Female", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Male", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Middle Aged", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Pancreatic Neoplasms", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Retrospective Studies", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Survival Rate", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Johns Hopkins University", 
          "id": "https://www.grid.ac/institutes/grid.21107.35", 
          "name": [
            "Department of Surgery, Johns Hopkins University School of Medicine, 600 N Wolfe St, Osler 624, 21287, Baltimore, MD, USA", 
            "The Sol Goldman Pancreatic Cancer Research Center, Johns Hopkins University School of Medicine, 600 N Wolfe St, Osler 624, 21287, Baltimore, MD, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "He", 
        "givenName": "Jin", 
        "id": "sg:person.013034564317.14", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013034564317.14"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Johns Hopkins University", 
          "id": "https://www.grid.ac/institutes/grid.21107.35", 
          "name": [
            "Department of Surgery, Johns Hopkins University School of Medicine, 600 N Wolfe St, Osler 624, 21287, Baltimore, MD, USA", 
            "The Sol Goldman Pancreatic Cancer Research Center, Johns Hopkins University School of Medicine, 600 N Wolfe St, Osler 624, 21287, Baltimore, MD, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Edil", 
        "givenName": "Barish H.", 
        "id": "sg:person.01116422516.18", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01116422516.18"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Johns Hopkins University", 
          "id": "https://www.grid.ac/institutes/grid.21107.35", 
          "name": [
            "Department of Surgery, Johns Hopkins University School of Medicine, 600 N Wolfe St, Osler 624, 21287, Baltimore, MD, USA", 
            "The Sol Goldman Pancreatic Cancer Research Center, Johns Hopkins University School of Medicine, 600 N Wolfe St, Osler 624, 21287, Baltimore, MD, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Cameron", 
        "givenName": "John L.", 
        "id": "sg:person.011317137122.71", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011317137122.71"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Johns Hopkins University", 
          "id": "https://www.grid.ac/institutes/grid.21107.35", 
          "name": [
            "Department of Surgery, Johns Hopkins University School of Medicine, 600 N Wolfe St, Osler 624, 21287, Baltimore, MD, USA", 
            "The Sol Goldman Pancreatic Cancer Research Center, Johns Hopkins University School of Medicine, 600 N Wolfe St, Osler 624, 21287, Baltimore, MD, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Schulick", 
        "givenName": "Richard D.", 
        "id": "sg:person.013701724657.77", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013701724657.77"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Johns Hopkins University", 
          "id": "https://www.grid.ac/institutes/grid.21107.35", 
          "name": [
            "Department of Pathology, Johns Hopkins University School of Medicine, 600 N Wolfe St, Osler 624, 21287, Baltimore, MD, USA", 
            "The Sol Goldman Pancreatic Cancer Research Center, Johns Hopkins University School of Medicine, 600 N Wolfe St, Osler 624, 21287, Baltimore, MD, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Hruban", 
        "givenName": "Ralph H.", 
        "id": "sg:person.07624111077.08", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.07624111077.08"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Johns Hopkins University", 
          "id": "https://www.grid.ac/institutes/grid.21107.35", 
          "name": [
            "Department of Radiation Oncology, Johns Hopkins University School of Medicine, 600 N Wolfe St, Osler 624, 21287, Baltimore, MD, USA", 
            "The Sol Goldman Pancreatic Cancer Research Center, Johns Hopkins University School of Medicine, 600 N Wolfe St, Osler 624, 21287, Baltimore, MD, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Herman", 
        "givenName": "Joseph M.", 
        "id": "sg:person.015567603732.54", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015567603732.54"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Johns Hopkins University", 
          "id": "https://www.grid.ac/institutes/grid.21107.35", 
          "name": [
            "Department of Medical Oncology, Johns Hopkins University School of Medicine, 600 N Wolfe St, Osler 624, 21287, Baltimore, MD, USA", 
            "The Sol Goldman Pancreatic Cancer Research Center, Johns Hopkins University School of Medicine, 600 N Wolfe St, Osler 624, 21287, Baltimore, MD, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Zheng", 
        "givenName": "Lei", 
        "id": "sg:person.07434460107.76", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.07434460107.76"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Johns Hopkins University", 
          "id": "https://www.grid.ac/institutes/grid.21107.35", 
          "name": [
            "Department of Pathology, Johns Hopkins University School of Medicine, 600 N Wolfe St, Osler 624, 21287, Baltimore, MD, USA", 
            "The Sol Goldman Pancreatic Cancer Research Center, Johns Hopkins University School of Medicine, 600 N Wolfe St, Osler 624, 21287, Baltimore, MD, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Iacobuzio-Donahue", 
        "givenName": "Christine", 
        "id": "sg:person.016324315037.55", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016324315037.55"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Johns Hopkins University", 
          "id": "https://www.grid.ac/institutes/grid.21107.35", 
          "name": [
            "Department of Surgery, Johns Hopkins University School of Medicine, 600 N Wolfe St, Osler 624, 21287, Baltimore, MD, USA", 
            "The Sol Goldman Pancreatic Cancer Research Center, Johns Hopkins University School of Medicine, 600 N Wolfe St, Osler 624, 21287, Baltimore, MD, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Ahuja", 
        "givenName": "Nita", 
        "id": "sg:person.01043401657.70", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01043401657.70"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Johns Hopkins University", 
          "id": "https://www.grid.ac/institutes/grid.21107.35", 
          "name": [
            "Department of Surgery, Johns Hopkins University School of Medicine, 600 N Wolfe St, Osler 624, 21287, Baltimore, MD, USA", 
            "The Sol Goldman Pancreatic Cancer Research Center, Johns Hopkins University School of Medicine, 600 N Wolfe St, Osler 624, 21287, Baltimore, MD, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Pawlik", 
        "givenName": "Timothy M.", 
        "id": "sg:person.0721627074.41", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0721627074.41"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Johns Hopkins University", 
          "id": "https://www.grid.ac/institutes/grid.21107.35", 
          "name": [
            "Department of Surgery, Johns Hopkins University School of Medicine, 600 N Wolfe St, Osler 624, 21287, Baltimore, MD, USA", 
            "The Sol Goldman Pancreatic Cancer Research Center, Johns Hopkins University School of Medicine, 600 N Wolfe St, Osler 624, 21287, Baltimore, MD, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Wolfgang", 
        "givenName": "Christopher L.", 
        "id": "sg:person.013555514237.73", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013555514237.73"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1016/j.jamcollsurg.2004.01.008", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003983120"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1385/ijgc:32:2-3:143", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1007975074", 
          "https://doi.org/10.1385/ijgc:32:2-3:143"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1136/jcp.2005.027292", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018051262"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/jso.21883", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018622305"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/01.sla.0000217673.04165.ea", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019489294"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/01.sla.0000217673.04165.ea", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019489294"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0021-9681(87)90171-8", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020988115"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1016/j.gassur.2006.08.018", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031265211", 
          "https://doi.org/10.1016/j.gassur.2006.08.018"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/(sici)1097-0142(19980315)82:6<1197::aid-cncr26>3.0.co;2-0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032032131"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/jso.21292", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035921817"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/jso.21292", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035921817"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1245/s10434-006-9249-8", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036249058", 
          "https://doi.org/10.1245/s10434-006-9249-8"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/01.mpa.0000202953.87740.93", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038327126"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/01.mpa.0000202953.87740.93", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038327126"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.yasu.2010.05.011", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039522004"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3322/caac.20073", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042069193"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/cncr.11860", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042645381"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s11605-007-0384-8", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1043513971", 
          "https://doi.org/10.1007/s11605-007-0384-8"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1111/j.1572-0241.2001.04123.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048426932", 
          "https://doi.org/10.1111/j.1572-0241.2001.04123.x"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1016/j.gassur.2004.09.045", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051424040", 
          "https://doi.org/10.1016/j.gassur.2004.09.045"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2013-02", 
    "datePublishedReg": "2013-02-01", 
    "description": "BACKGROUND: The median age of pancreatic ductal adenocarcinoma (PDAC) patients is 71\u00a0years. PDAC rarely affects individuals under the age of 45. We investigated features of PDAC occurring in young patients (\u226445\u00a0years) who underwent surgical resection in order to determine if any difference exists in comparison to elderly patients (\u226570\u00a0years).\nMETHODS: A retrospective analysis of patients with PDAC who were\u2009\u2264\u200945\u00a0years on the date of surgery between 1975 and 2009 was performed. This cohort was compared with PDAC patients whose ages were over 70\u00a0years on the date of surgery over the same time interval. Information reviewed included demographics, Charlson Age-Comorbidity Index (CACI), pathological staging, surgical management, and death or last follow-up.\nRESULTS: Seventy five patients with PDAC of age\u2009\u2264\u200945\u00a0years at surgery were identified. The reference group consisted of 870 patients with a median age of 75. The most common symptoms of young patients were jaundice (45\u00a0%), abdominal pain (32\u00a0%), or weight loss (33\u00a0%). This did not differ significantly from older patients. Among the younger patients, 7 (9\u00a0%) underwent total pancreatectomy, 60 (80\u00a0%) underwent pancreaticoduodenectomy, and 8 (11\u00a0%) had distal pancreatectomy. The distribution of type of surgery was similar between two groups. Fifty-two of the young patients (69\u00a0%) had an R0 resection and this did not differ from the older age group (n\u2009=\u2009616; 71\u00a0%). The rate of lymph node positivity was 68\u00a0% for younger patients and 74\u00a0% for older patients (p\u2009=\u20090.27). Of the younger patients, 11, 13, 49, and 2 were classified as stage I, IIA, IIB, and III, respectively, and did not differ from the older age group. The median overall survival for the young patients cohort was 19\u00a0months (95\u00a0% CI 15-22\u00a0months) which is longer than 16\u00a0months (95\u00a0% CI 14-17\u00a0months) of the older group (p\u2009=\u20090.007). The actual 5- and 10- year survival in young age group (24 and 17\u00a0%) was longer than that in old age group (11 and 3\u00a0%) (p\u2009<\u20090.05). The median CACI of the younger patients was 0.5 and was lower than 4.1 of the older patients (p\u2009<\u20090.0001).\nCONCLUSIONS: The demographic, pathologic, and treatment characteristics of PDAC patients younger than 45\u00a0years were similar to those older than 70\u00a0years. Younger patients had fewer complications after curative resections. The better survival among younger patients is likely related to fewer comorbidities in this group. These findings will be useful in counseling young patients with resectable pancreatic cancer.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1007/s11605-012-2066-4", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": true, 
    "isFundedItemOf": [
      {
        "id": "sg:grant.2438791", 
        "type": "MonetaryGrant"
      }
    ], 
    "isPartOf": [
      {
        "id": "sg:journal.1116755", 
        "issn": [
          "1091-255X", 
          "1873-4626"
        ], 
        "name": "Journal of Gastrointestinal Surgery", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "2", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "17"
      }
    ], 
    "name": "Young Patients Undergoing Resection of Pancreatic Cancer Fare Better than their Older Counterparts", 
    "pagination": "339-344", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "b4b7c9982cd7aa11a04ee7b539f2c8683c3c89be75427879a58a178548e9fef6"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "23184271"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "9706084"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1007/s11605-012-2066-4"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1037936761"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1007/s11605-012-2066-4", 
      "https://app.dimensions.ai/details/publication/pub.1037936761"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-10T15:04", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8663_00000523.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "http://link.springer.com/10.1007%2Fs11605-012-2066-4"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s11605-012-2066-4'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s11605-012-2066-4'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s11605-012-2066-4'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s11605-012-2066-4'


 

This table displays all metadata directly associated to this object as RDF triples.

246 TRIPLES      21 PREDICATES      57 URIs      32 LITERALS      20 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1007/s11605-012-2066-4 schema:about N09d95d90ad6b4d848bf4e243894c936b
2 N0df02528367f4b50b983c95b2ccdee3d
3 N2a50b60193014404947ec6dd3f00a40c
4 N42588db2e96c440c8cfd67fb4ecb2cb6
5 N5f93645745ba427687f5d4dcda0b8bb9
6 N6945877105004e319a22c7a7327590dc
7 Nafe5b542e2264d9b958cfb69a4d2b11b
8 Ne162d04b6b8e4de3a2120b754472142b
9 Ne8d65c85a870461da106c84d7fd77432
10 Ned989ba2cbb54c1ebf5cd91ce989ef6a
11 Nf9c6913817ef4a2da9e8ad162ae1d8ac
12 anzsrc-for:11
13 anzsrc-for:1103
14 schema:author N14ee1b6a91994745942f3b3464271b59
15 schema:citation sg:pub.10.1007/s11605-007-0384-8
16 sg:pub.10.1016/j.gassur.2004.09.045
17 sg:pub.10.1016/j.gassur.2006.08.018
18 sg:pub.10.1111/j.1572-0241.2001.04123.x
19 sg:pub.10.1245/s10434-006-9249-8
20 sg:pub.10.1385/ijgc:32:2-3:143
21 https://doi.org/10.1002/(sici)1097-0142(19980315)82:6<1197::aid-cncr26>3.0.co;2-0
22 https://doi.org/10.1002/cncr.11860
23 https://doi.org/10.1002/jso.21292
24 https://doi.org/10.1002/jso.21883
25 https://doi.org/10.1016/0021-9681(87)90171-8
26 https://doi.org/10.1016/j.jamcollsurg.2004.01.008
27 https://doi.org/10.1016/j.yasu.2010.05.011
28 https://doi.org/10.1097/01.mpa.0000202953.87740.93
29 https://doi.org/10.1097/01.sla.0000217673.04165.ea
30 https://doi.org/10.1136/jcp.2005.027292
31 https://doi.org/10.3322/caac.20073
32 schema:datePublished 2013-02
33 schema:datePublishedReg 2013-02-01
34 schema:description BACKGROUND: The median age of pancreatic ductal adenocarcinoma (PDAC) patients is 71 years. PDAC rarely affects individuals under the age of 45. We investigated features of PDAC occurring in young patients (≤45 years) who underwent surgical resection in order to determine if any difference exists in comparison to elderly patients (≥70 years). METHODS: A retrospective analysis of patients with PDAC who were ≤ 45 years on the date of surgery between 1975 and 2009 was performed. This cohort was compared with PDAC patients whose ages were over 70 years on the date of surgery over the same time interval. Information reviewed included demographics, Charlson Age-Comorbidity Index (CACI), pathological staging, surgical management, and death or last follow-up. RESULTS: Seventy five patients with PDAC of age ≤ 45 years at surgery were identified. The reference group consisted of 870 patients with a median age of 75. The most common symptoms of young patients were jaundice (45 %), abdominal pain (32 %), or weight loss (33 %). This did not differ significantly from older patients. Among the younger patients, 7 (9 %) underwent total pancreatectomy, 60 (80 %) underwent pancreaticoduodenectomy, and 8 (11 %) had distal pancreatectomy. The distribution of type of surgery was similar between two groups. Fifty-two of the young patients (69 %) had an R0 resection and this did not differ from the older age group (n = 616; 71 %). The rate of lymph node positivity was 68 % for younger patients and 74 % for older patients (p = 0.27). Of the younger patients, 11, 13, 49, and 2 were classified as stage I, IIA, IIB, and III, respectively, and did not differ from the older age group. The median overall survival for the young patients cohort was 19 months (95 % CI 15-22 months) which is longer than 16 months (95 % CI 14-17 months) of the older group (p = 0.007). The actual 5- and 10- year survival in young age group (24 and 17 %) was longer than that in old age group (11 and 3 %) (p < 0.05). The median CACI of the younger patients was 0.5 and was lower than 4.1 of the older patients (p < 0.0001). CONCLUSIONS: The demographic, pathologic, and treatment characteristics of PDAC patients younger than 45 years were similar to those older than 70 years. Younger patients had fewer complications after curative resections. The better survival among younger patients is likely related to fewer comorbidities in this group. These findings will be useful in counseling young patients with resectable pancreatic cancer.
35 schema:genre research_article
36 schema:inLanguage en
37 schema:isAccessibleForFree true
38 schema:isPartOf N39db8c9821b04cf6b91f392b40c43267
39 Nc0425a6c438f47d4be1bce2faa3ba0b7
40 sg:journal.1116755
41 schema:name Young Patients Undergoing Resection of Pancreatic Cancer Fare Better than their Older Counterparts
42 schema:pagination 339-344
43 schema:productId N1b39014f97164459b61a48e8b8f6e777
44 N358b75d07cc54408b072d4fd272004b2
45 N8043ff7d12454328aa127f7922d4797d
46 Nae810542098e4e73b5554ab7ce0882f9
47 Nea59e0bc2af14adf955b095b04d5ed55
48 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037936761
49 https://doi.org/10.1007/s11605-012-2066-4
50 schema:sdDatePublished 2019-04-10T15:04
51 schema:sdLicense https://scigraph.springernature.com/explorer/license/
52 schema:sdPublisher N65f8d5767f6f42bab47df4e59d18918d
53 schema:url http://link.springer.com/10.1007%2Fs11605-012-2066-4
54 sgo:license sg:explorer/license/
55 sgo:sdDataset articles
56 rdf:type schema:ScholarlyArticle
57 N09d95d90ad6b4d848bf4e243894c936b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
58 schema:name Middle Aged
59 rdf:type schema:DefinedTerm
60 N0df02528367f4b50b983c95b2ccdee3d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
61 schema:name Retrospective Studies
62 rdf:type schema:DefinedTerm
63 N13bcda3e7a4a4493bf8c270b6dd58e7e rdf:first sg:person.016324315037.55
64 rdf:rest Nbe641c3da5e94ab49f0a68199b17e102
65 N14ee1b6a91994745942f3b3464271b59 rdf:first sg:person.013034564317.14
66 rdf:rest Nd666d29a08324c629431d6d44a9757f3
67 N1b39014f97164459b61a48e8b8f6e777 schema:name pubmed_id
68 schema:value 23184271
69 rdf:type schema:PropertyValue
70 N2866985871d844978867beb3fe2f2dee rdf:first sg:person.013701724657.77
71 rdf:rest N5a1bc2ed12254e86a8f18169736f0a77
72 N2a50b60193014404947ec6dd3f00a40c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
73 schema:name Humans
74 rdf:type schema:DefinedTerm
75 N358b75d07cc54408b072d4fd272004b2 schema:name dimensions_id
76 schema:value pub.1037936761
77 rdf:type schema:PropertyValue
78 N39db8c9821b04cf6b91f392b40c43267 schema:issueNumber 2
79 rdf:type schema:PublicationIssue
80 N42588db2e96c440c8cfd67fb4ecb2cb6 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
81 schema:name Carcinoma, Pancreatic Ductal
82 rdf:type schema:DefinedTerm
83 N5a1bc2ed12254e86a8f18169736f0a77 rdf:first sg:person.07624111077.08
84 rdf:rest Nf76c3658d9494366a7137bb7afc4d242
85 N5f45ffb96f1f4fe48b195decfbc08c46 rdf:first sg:person.013555514237.73
86 rdf:rest rdf:nil
87 N5f93645745ba427687f5d4dcda0b8bb9 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
88 schema:name Age Factors
89 rdf:type schema:DefinedTerm
90 N6569f540cb0848aea7cb9df322720794 rdf:first sg:person.011317137122.71
91 rdf:rest N2866985871d844978867beb3fe2f2dee
92 N65f8d5767f6f42bab47df4e59d18918d schema:name Springer Nature - SN SciGraph project
93 rdf:type schema:Organization
94 N6945877105004e319a22c7a7327590dc schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
95 schema:name Pancreatic Neoplasms
96 rdf:type schema:DefinedTerm
97 N8043ff7d12454328aa127f7922d4797d schema:name readcube_id
98 schema:value b4b7c9982cd7aa11a04ee7b539f2c8683c3c89be75427879a58a178548e9fef6
99 rdf:type schema:PropertyValue
100 Nad5dab505c084802b20e4c55a83dae48 rdf:first sg:person.0721627074.41
101 rdf:rest N5f45ffb96f1f4fe48b195decfbc08c46
102 Nae810542098e4e73b5554ab7ce0882f9 schema:name doi
103 schema:value 10.1007/s11605-012-2066-4
104 rdf:type schema:PropertyValue
105 Nafe5b542e2264d9b958cfb69a4d2b11b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
106 schema:name Adult
107 rdf:type schema:DefinedTerm
108 Nbe641c3da5e94ab49f0a68199b17e102 rdf:first sg:person.01043401657.70
109 rdf:rest Nad5dab505c084802b20e4c55a83dae48
110 Nc0425a6c438f47d4be1bce2faa3ba0b7 schema:volumeNumber 17
111 rdf:type schema:PublicationVolume
112 Nd666d29a08324c629431d6d44a9757f3 rdf:first sg:person.01116422516.18
113 rdf:rest N6569f540cb0848aea7cb9df322720794
114 Ne04aa8213a3248b58326baa276d37c66 rdf:first sg:person.07434460107.76
115 rdf:rest N13bcda3e7a4a4493bf8c270b6dd58e7e
116 Ne162d04b6b8e4de3a2120b754472142b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
117 schema:name Female
118 rdf:type schema:DefinedTerm
119 Ne8d65c85a870461da106c84d7fd77432 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
120 schema:name Aged
121 rdf:type schema:DefinedTerm
122 Nea59e0bc2af14adf955b095b04d5ed55 schema:name nlm_unique_id
123 schema:value 9706084
124 rdf:type schema:PropertyValue
125 Ned989ba2cbb54c1ebf5cd91ce989ef6a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
126 schema:name Male
127 rdf:type schema:DefinedTerm
128 Nf76c3658d9494366a7137bb7afc4d242 rdf:first sg:person.015567603732.54
129 rdf:rest Ne04aa8213a3248b58326baa276d37c66
130 Nf9c6913817ef4a2da9e8ad162ae1d8ac schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
131 schema:name Survival Rate
132 rdf:type schema:DefinedTerm
133 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
134 schema:name Medical and Health Sciences
135 rdf:type schema:DefinedTerm
136 anzsrc-for:1103 schema:inDefinedTermSet anzsrc-for:
137 schema:name Clinical Sciences
138 rdf:type schema:DefinedTerm
139 sg:grant.2438791 http://pending.schema.org/fundedItem sg:pub.10.1007/s11605-012-2066-4
140 rdf:type schema:MonetaryGrant
141 sg:journal.1116755 schema:issn 1091-255X
142 1873-4626
143 schema:name Journal of Gastrointestinal Surgery
144 rdf:type schema:Periodical
145 sg:person.01043401657.70 schema:affiliation https://www.grid.ac/institutes/grid.21107.35
146 schema:familyName Ahuja
147 schema:givenName Nita
148 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01043401657.70
149 rdf:type schema:Person
150 sg:person.01116422516.18 schema:affiliation https://www.grid.ac/institutes/grid.21107.35
151 schema:familyName Edil
152 schema:givenName Barish H.
153 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01116422516.18
154 rdf:type schema:Person
155 sg:person.011317137122.71 schema:affiliation https://www.grid.ac/institutes/grid.21107.35
156 schema:familyName Cameron
157 schema:givenName John L.
158 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011317137122.71
159 rdf:type schema:Person
160 sg:person.013034564317.14 schema:affiliation https://www.grid.ac/institutes/grid.21107.35
161 schema:familyName He
162 schema:givenName Jin
163 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013034564317.14
164 rdf:type schema:Person
165 sg:person.013555514237.73 schema:affiliation https://www.grid.ac/institutes/grid.21107.35
166 schema:familyName Wolfgang
167 schema:givenName Christopher L.
168 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013555514237.73
169 rdf:type schema:Person
170 sg:person.013701724657.77 schema:affiliation https://www.grid.ac/institutes/grid.21107.35
171 schema:familyName Schulick
172 schema:givenName Richard D.
173 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013701724657.77
174 rdf:type schema:Person
175 sg:person.015567603732.54 schema:affiliation https://www.grid.ac/institutes/grid.21107.35
176 schema:familyName Herman
177 schema:givenName Joseph M.
178 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015567603732.54
179 rdf:type schema:Person
180 sg:person.016324315037.55 schema:affiliation https://www.grid.ac/institutes/grid.21107.35
181 schema:familyName Iacobuzio-Donahue
182 schema:givenName Christine
183 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016324315037.55
184 rdf:type schema:Person
185 sg:person.0721627074.41 schema:affiliation https://www.grid.ac/institutes/grid.21107.35
186 schema:familyName Pawlik
187 schema:givenName Timothy M.
188 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0721627074.41
189 rdf:type schema:Person
190 sg:person.07434460107.76 schema:affiliation https://www.grid.ac/institutes/grid.21107.35
191 schema:familyName Zheng
192 schema:givenName Lei
193 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.07434460107.76
194 rdf:type schema:Person
195 sg:person.07624111077.08 schema:affiliation https://www.grid.ac/institutes/grid.21107.35
196 schema:familyName Hruban
197 schema:givenName Ralph H.
198 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.07624111077.08
199 rdf:type schema:Person
200 sg:pub.10.1007/s11605-007-0384-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043513971
201 https://doi.org/10.1007/s11605-007-0384-8
202 rdf:type schema:CreativeWork
203 sg:pub.10.1016/j.gassur.2004.09.045 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051424040
204 https://doi.org/10.1016/j.gassur.2004.09.045
205 rdf:type schema:CreativeWork
206 sg:pub.10.1016/j.gassur.2006.08.018 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031265211
207 https://doi.org/10.1016/j.gassur.2006.08.018
208 rdf:type schema:CreativeWork
209 sg:pub.10.1111/j.1572-0241.2001.04123.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1048426932
210 https://doi.org/10.1111/j.1572-0241.2001.04123.x
211 rdf:type schema:CreativeWork
212 sg:pub.10.1245/s10434-006-9249-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036249058
213 https://doi.org/10.1245/s10434-006-9249-8
214 rdf:type schema:CreativeWork
215 sg:pub.10.1385/ijgc:32:2-3:143 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007975074
216 https://doi.org/10.1385/ijgc:32:2-3:143
217 rdf:type schema:CreativeWork
218 https://doi.org/10.1002/(sici)1097-0142(19980315)82:6<1197::aid-cncr26>3.0.co;2-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032032131
219 rdf:type schema:CreativeWork
220 https://doi.org/10.1002/cncr.11860 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042645381
221 rdf:type schema:CreativeWork
222 https://doi.org/10.1002/jso.21292 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035921817
223 rdf:type schema:CreativeWork
224 https://doi.org/10.1002/jso.21883 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018622305
225 rdf:type schema:CreativeWork
226 https://doi.org/10.1016/0021-9681(87)90171-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020988115
227 rdf:type schema:CreativeWork
228 https://doi.org/10.1016/j.jamcollsurg.2004.01.008 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003983120
229 rdf:type schema:CreativeWork
230 https://doi.org/10.1016/j.yasu.2010.05.011 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039522004
231 rdf:type schema:CreativeWork
232 https://doi.org/10.1097/01.mpa.0000202953.87740.93 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038327126
233 rdf:type schema:CreativeWork
234 https://doi.org/10.1097/01.sla.0000217673.04165.ea schema:sameAs https://app.dimensions.ai/details/publication/pub.1019489294
235 rdf:type schema:CreativeWork
236 https://doi.org/10.1136/jcp.2005.027292 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018051262
237 rdf:type schema:CreativeWork
238 https://doi.org/10.3322/caac.20073 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042069193
239 rdf:type schema:CreativeWork
240 https://www.grid.ac/institutes/grid.21107.35 schema:alternateName Johns Hopkins University
241 schema:name Department of Medical Oncology, Johns Hopkins University School of Medicine, 600 N Wolfe St, Osler 624, 21287, Baltimore, MD, USA
242 Department of Pathology, Johns Hopkins University School of Medicine, 600 N Wolfe St, Osler 624, 21287, Baltimore, MD, USA
243 Department of Radiation Oncology, Johns Hopkins University School of Medicine, 600 N Wolfe St, Osler 624, 21287, Baltimore, MD, USA
244 Department of Surgery, Johns Hopkins University School of Medicine, 600 N Wolfe St, Osler 624, 21287, Baltimore, MD, USA
245 The Sol Goldman Pancreatic Cancer Research Center, Johns Hopkins University School of Medicine, 600 N Wolfe St, Osler 624, 21287, Baltimore, MD, USA
246 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...