Ontology type: schema:ScholarlyArticle
2011-06
AUTHORSJung Wook Huh, Sang Woo Lim, Hyeong Rok Kim, Young Jin Kim
ABSTRACTBACKGROUND: The aim of this study is to evaluate whether the addition of radiotherapy to chemotherapy would enhance the benefits obtained with chemotherapy alone, in stage III rectal cancer in the era of preoperative chemoradiotherapy and total mesorectal excision (TME). METHODS: From January 1999 to January 2008, 300 stage III rectal cancer patients who underwent TME were prospectively identified; a total of 46 patients who received preoperative chemoradiotherapy or did not receive adjuvant therapy were excluded. Patients who received postoperative chemotherapy alone (n=190) and those who received postoperative chemoradiotherapy (n=64) were compared. RESULTS: The median follow-up period was 52 (range, 4-129) months. Patients receiving radiotherapy were younger and had a higher percentage of advanced pT category or perineural invasion than patients who did not. The estimated 5-year local recurrence-free survival rate was radiotherapy 92% with radiotherapy and 86% without. The disease-free survival rate was 55% with radiotherapy compared to 57% without and the overall survival rates were similar (63% vs. 68%, all P>0.05). In patients with a positive circumferential resection margin or insufficient distal resection margin, the local recurrence-free, disease-free, and overall survival rates were unaffected by radiotherapy. CONCLUSIONS: The addition of postoperative radiotherapy to chemotherapy did not reduce the recurrence or mortality in node-positive rectal cancer when compared with chemotherapy alone. Moreover, this approach may not compensate for a positive circumferential resection margin or insufficient distal resection margin following rectal cancer surgery. More... »
PAGES963
http://scigraph.springernature.com/pub.10.1007/s11605-011-1497-7
DOIhttp://dx.doi.org/10.1007/s11605-011-1497-7
DIMENSIONShttps://app.dimensions.ai/details/publication/pub.1035488956
PUBMEDhttps://www.ncbi.nlm.nih.gov/pubmed/21479672
JSON-LD is the canonical representation for SciGraph data.
TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT
[
{
"@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json",
"about": [
{
"id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1112",
"inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/",
"name": "Oncology and Carcinogenesis",
"type": "DefinedTerm"
},
{
"id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11",
"inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/",
"name": "Medical and Health Sciences",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Adult",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Aged",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Aged, 80 and over",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Carcinoembryonic Antigen",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Chemotherapy, Adjuvant",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Disease-Free Survival",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Female",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Humans",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Kaplan-Meier Estimate",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Lymphatic Metastasis",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Male",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Middle Aged",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Neoplasm Recurrence, Local",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Neoplasm Staging",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Proportional Hazards Models",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Radiotherapy, Adjuvant",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Rectal Neoplasms",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Retrospective Studies",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Survival Rate",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Treatment Outcome",
"type": "DefinedTerm"
}
],
"author": [
{
"affiliation": {
"name": [
"Department of Surgery, Chonnam National University Hwasun Hospital and Medical School, 160 Ilsimri, Hwasun-eup, Hwasun-gun, Gwangju, Jeonnam, South Korea"
],
"type": "Organization"
},
"familyName": "Huh",
"givenName": "Jung Wook",
"id": "sg:person.01310235260.89",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01310235260.89"
],
"type": "Person"
},
{
"affiliation": {
"name": [
"Department of Surgery, Chonnam National University Hwasun Hospital and Medical School, 160 Ilsimri, Hwasun-eup, Hwasun-gun, Gwangju, Jeonnam, South Korea"
],
"type": "Organization"
},
"familyName": "Lim",
"givenName": "Sang Woo",
"id": "sg:person.0620347012.56",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0620347012.56"
],
"type": "Person"
},
{
"affiliation": {
"name": [
"Department of Surgery, Chonnam National University Hwasun Hospital and Medical School, 160 Ilsimri, Hwasun-eup, Hwasun-gun, Gwangju, Jeonnam, South Korea"
],
"type": "Organization"
},
"familyName": "Kim",
"givenName": "Hyeong Rok",
"id": "sg:person.0726026302.07",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0726026302.07"
],
"type": "Person"
},
{
"affiliation": {
"name": [
"Department of Surgery, Chonnam National University Hwasun Hospital and Medical School, 160 Ilsimri, Hwasun-eup, Hwasun-gun, Gwangju, Jeonnam, South Korea"
],
"type": "Organization"
},
"familyName": "Kim",
"givenName": "Young Jin",
"id": "sg:person.01042531610.61",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01042531610.61"
],
"type": "Person"
}
],
"citation": [
{
"id": "sg:pub.10.1245/s10434-006-9171-0",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1001744042",
"https://doi.org/10.1245/s10434-006-9171-0"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/j.amjsurg.2009.01.018",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1006761087"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/s0360-3016(02)04291-8",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1013238384"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/s0360-3016(02)04291-8",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1013238384"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1245/s10434-007-9643-x",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1015793333",
"https://doi.org/10.1245/s10434-007-9643-x"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1245/s10434-009-0424-6",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1021285289",
"https://doi.org/10.1245/s10434-009-0424-6"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1245/s10434-009-0424-6",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1021285289",
"https://doi.org/10.1245/s10434-009-0424-6"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1056/nejmoa060829",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1021609703"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1002/jso.21342",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1023193069"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1002/jso.21342",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1023193069"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1007/s10350-008-9346-9",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1023331698",
"https://doi.org/10.1007/s10350-008-9346-9"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1007/s10350-008-9346-9",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1023331698"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1200/jco.2004.07.015",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1023482925"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/s0140-6736(09)60484-0",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1024121015"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1007/s00268-008-9520-1",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1027660668",
"https://doi.org/10.1007/s00268-008-9520-1"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1007/s00268-008-9520-1",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1027660668",
"https://doi.org/10.1007/s00268-008-9520-1"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/s1072-7515(99)00298-7",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1029631774"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1056/nejmoa040694",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1031672074"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1056/nejm198506063122301",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1033381548"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1093/jnci/92.5.388",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1033424814"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/s0140-6736(86)92612-7",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1037907625"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/s0140-6736(86)92612-7",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1037907625"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1001/archsurg.133.8.894",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1039940137"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/s0140-6736(94)92206-3",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1047557316"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/s0140-6736(94)92206-3",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1047557316"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1097/00000658-199411000-00012",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1050583230"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1097/00000658-199411000-00012",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1050583230"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1001/jama.264.11.1444",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1054151754"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1093/jnci/80.1.21",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1059814614"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1200/jco.1992.10.4.549",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1076951220"
],
"type": "CreativeWork"
},
{
"id": "https://app.dimensions.ai/details/publication/pub.1082409412",
"type": "CreativeWork"
}
],
"datePublished": "2011-06",
"datePublishedReg": "2011-06-01",
"description": "BACKGROUND: The aim of this study is to evaluate whether the addition of radiotherapy to chemotherapy would enhance the benefits obtained with chemotherapy alone, in stage III rectal cancer in the era of preoperative chemoradiotherapy and total mesorectal excision (TME).\nMETHODS: From January 1999 to January 2008, 300 stage III rectal cancer patients who underwent TME were prospectively identified; a total of 46 patients who received preoperative chemoradiotherapy or did not receive adjuvant therapy were excluded. Patients who received postoperative chemotherapy alone (n=190) and those who received postoperative chemoradiotherapy (n=64) were compared.\nRESULTS: The median follow-up period was 52 (range, 4-129) months. Patients receiving radiotherapy were younger and had a higher percentage of advanced pT category or perineural invasion than patients who did not. The estimated 5-year local recurrence-free survival rate was radiotherapy 92% with radiotherapy and 86% without. The disease-free survival rate was 55% with radiotherapy compared to 57% without and the overall survival rates were similar (63% vs. 68%, all P>0.05). In patients with a positive circumferential resection margin or insufficient distal resection margin, the local recurrence-free, disease-free, and overall survival rates were unaffected by radiotherapy.\nCONCLUSIONS: The addition of postoperative radiotherapy to chemotherapy did not reduce the recurrence or mortality in node-positive rectal cancer when compared with chemotherapy alone. Moreover, this approach may not compensate for a positive circumferential resection margin or insufficient distal resection margin following rectal cancer surgery.",
"genre": "research_article",
"id": "sg:pub.10.1007/s11605-011-1497-7",
"inLanguage": [
"en"
],
"isAccessibleForFree": false,
"isPartOf": [
{
"id": "sg:journal.1116755",
"issn": [
"1091-255X",
"1873-4626"
],
"name": "Journal of Gastrointestinal Surgery",
"type": "Periodical"
},
{
"issueNumber": "6",
"type": "PublicationIssue"
},
{
"type": "PublicationVolume",
"volumeNumber": "15"
}
],
"name": "Effects of Postoperative Adjuvant Radiotherapy on Recurrence and Survival in Stage III Rectal Cancer",
"pagination": "963",
"productId": [
{
"name": "readcube_id",
"type": "PropertyValue",
"value": [
"a90e00fe1d877b43579560ad9e9d5c734c1c45bd86cb79c4f8006a7ec1651e2b"
]
},
{
"name": "pubmed_id",
"type": "PropertyValue",
"value": [
"21479672"
]
},
{
"name": "nlm_unique_id",
"type": "PropertyValue",
"value": [
"9706084"
]
},
{
"name": "doi",
"type": "PropertyValue",
"value": [
"10.1007/s11605-011-1497-7"
]
},
{
"name": "dimensions_id",
"type": "PropertyValue",
"value": [
"pub.1035488956"
]
}
],
"sameAs": [
"https://doi.org/10.1007/s11605-011-1497-7",
"https://app.dimensions.ai/details/publication/pub.1035488956"
],
"sdDataset": "articles",
"sdDatePublished": "2019-04-11T01:10",
"sdLicense": "https://scigraph.springernature.com/explorer/license/",
"sdPublisher": {
"name": "Springer Nature - SN SciGraph project",
"type": "Organization"
},
"sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8697_00000523.jsonl",
"type": "ScholarlyArticle",
"url": "http://link.springer.com/10.1007%2Fs11605-011-1497-7"
}
]Download the RDF metadata as: json-ld nt turtle xml License info
JSON-LD is a popular format for linked data which is fully compatible with JSON.
curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s11605-011-1497-7'
N-Triples is a line-based linked data format ideal for batch operations.
curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s11605-011-1497-7'
Turtle is a human-readable linked data format.
curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s11605-011-1497-7'
RDF/XML is a standard XML format for linked data.
curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s11605-011-1497-7'
This table displays all metadata directly associated to this object as RDF triples.
251 TRIPLES
21 PREDICATES
73 URIs
41 LITERALS
29 BLANK NODES