Antioxidant Treatment Attenuates Intestinal Mucosal Damage and Gut Barrier Dysfunction After Major Hepatectomy. Study in a Porcine Model View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2011-05

AUTHORS

Constantinos Nastos, Konstantinos Kalimeris, Nikolaos Papoutsidakis, George Defterevos, Agathi Pafiti, Helen Kalogeropoulou, Loukia Zerva, Tzortzis Nomikos, Georgia Kostopanagiotou, Vasillios Smyrniotis, Nikolaos Arkadopoulos

ABSTRACT

BACKGROUND: This study aims to evaluate whether injury of gut mucosa in a porcine model of post-hepatectomy liver dysfunction can be prevented using antioxidant treatment with desferrioxamine. METHODS: Post-hepatectomy liver failure was induced in pigs combining major (70%) liver resection and ischemia/reperfusion injury. An ischemic period of 150 minutes, was followed by reperfusion for 24 h. Animals were randomly divided into a control group (n = 6) and a desferrioxamine group (DFX, n = 6). DFX animals were treated with continuous IV infusion of desferrioxamine 100 mg/kg. Intestinal mucosal injury (IMI), bacterial and endotoxin translocation (BT) were evaluated in all animals. Intestinal mucosa was also evaluated for oxidative markers. RESULTS: DFX animals had significantly lower IMI score (3.3 ± 1.2 vs. 1.8 ± 0.9, p < 0.05), decreased BT in the portal circulation at 0 and 12 h of reperfusion (p = 0.007 and p = 0.008, respectively), decreased portal endotoxin levels at 6 (p = 0.006) and 24 h (p = 0.004), decreased systemic endotoxin levels (p = 0.01) at 24 h compared to controls. Also, 24 h post-reperfusion mucosal malondialdehyde and protein carbonyls were decreased in DFX animals compared to controls (4.1 ± 1.2 vs. 2.5 ± 1.2, p = 0.05 and 0.5 ± 0.1 vs. 0.4 ± 0.1, p = 0.04 respectively). CONCLUSION: Desferrioxamine seems to attenuate mucosal injury from post-hepatectomy liver dysfunction possibly through blockage of iron-catalyzed oxidative reactions. More... »

PAGES

809-817

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s11605-011-1475-0

DOI

http://dx.doi.org/10.1007/s11605-011-1475-0

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1041128158

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/21380631


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