Ontology type: schema:ScholarlyArticle
2011-05
AUTHORSConstantinos Nastos, Konstantinos Kalimeris, Nikolaos Papoutsidakis, George Defterevos, Agathi Pafiti, Helen Kalogeropoulou, Loukia Zerva, Tzortzis Nomikos, Georgia Kostopanagiotou, Vasillios Smyrniotis, Nikolaos Arkadopoulos
ABSTRACTBACKGROUND: This study aims to evaluate whether injury of gut mucosa in a porcine model of post-hepatectomy liver dysfunction can be prevented using antioxidant treatment with desferrioxamine. METHODS: Post-hepatectomy liver failure was induced in pigs combining major (70%) liver resection and ischemia/reperfusion injury. An ischemic period of 150 minutes, was followed by reperfusion for 24 h. Animals were randomly divided into a control group (n = 6) and a desferrioxamine group (DFX, n = 6). DFX animals were treated with continuous IV infusion of desferrioxamine 100 mg/kg. Intestinal mucosal injury (IMI), bacterial and endotoxin translocation (BT) were evaluated in all animals. Intestinal mucosa was also evaluated for oxidative markers. RESULTS: DFX animals had significantly lower IMI score (3.3 ± 1.2 vs. 1.8 ± 0.9, p < 0.05), decreased BT in the portal circulation at 0 and 12 h of reperfusion (p = 0.007 and p = 0.008, respectively), decreased portal endotoxin levels at 6 (p = 0.006) and 24 h (p = 0.004), decreased systemic endotoxin levels (p = 0.01) at 24 h compared to controls. Also, 24 h post-reperfusion mucosal malondialdehyde and protein carbonyls were decreased in DFX animals compared to controls (4.1 ± 1.2 vs. 2.5 ± 1.2, p = 0.05 and 0.5 ± 0.1 vs. 0.4 ± 0.1, p = 0.04 respectively). CONCLUSION: Desferrioxamine seems to attenuate mucosal injury from post-hepatectomy liver dysfunction possibly through blockage of iron-catalyzed oxidative reactions. More... »
PAGES809-817
http://scigraph.springernature.com/pub.10.1007/s11605-011-1475-0
DOIhttp://dx.doi.org/10.1007/s11605-011-1475-0
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PUBMEDhttps://www.ncbi.nlm.nih.gov/pubmed/21380631
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"description": "BACKGROUND: This study aims to evaluate whether injury of gut mucosa in a porcine model of post-hepatectomy liver dysfunction can be prevented using antioxidant treatment with desferrioxamine.\nMETHODS: Post-hepatectomy liver failure was induced in pigs combining major (70%) liver resection and ischemia/reperfusion injury. An ischemic period of 150 minutes, was followed by reperfusion for 24 h. Animals were randomly divided into a control group (n\u2009=\u20096) and a desferrioxamine group (DFX, n\u2009=\u20096). DFX animals were treated with continuous IV infusion of desferrioxamine 100 mg/kg. Intestinal mucosal injury (IMI), bacterial and endotoxin translocation (BT) were evaluated in all animals. Intestinal mucosa was also evaluated for oxidative markers.\nRESULTS: DFX animals had significantly lower IMI score (3.3\u2009\u00b1\u20091.2 vs. 1.8\u2009\u00b1\u20090.9, p\u2009<\u20090.05), decreased BT in the portal circulation at 0 and 12 h of reperfusion (p\u2009=\u20090.007 and p\u2009=\u20090.008, respectively), decreased portal endotoxin levels at 6 (p\u2009=\u20090.006) and 24 h (p\u2009=\u20090.004), decreased systemic endotoxin levels (p\u2009=\u20090.01) at 24 h compared to controls. Also, 24 h post-reperfusion mucosal malondialdehyde and protein carbonyls were decreased in DFX animals compared to controls (4.1\u2009\u00b1\u20091.2 vs. 2.5\u2009\u00b1\u20091.2, p\u2009=\u20090.05 and 0.5\u2009\u00b1\u20090.1 vs. 0.4\u2009\u00b1\u20090.1, p\u2009=\u20090.04 respectively).\nCONCLUSION: Desferrioxamine seems to attenuate mucosal injury from post-hepatectomy liver dysfunction possibly through blockage of iron-catalyzed oxidative reactions.",
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]Download the RDF metadata as: json-ld nt turtle xml License info
JSON-LD is a popular format for linked data which is fully compatible with JSON.
curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s11605-011-1475-0'
N-Triples is a line-based linked data format ideal for batch operations.
curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s11605-011-1475-0'
Turtle is a human-readable linked data format.
curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s11605-011-1475-0'
RDF/XML is a standard XML format for linked data.
curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s11605-011-1475-0'
This table displays all metadata directly associated to this object as RDF triples.
329 TRIPLES
21 PREDICATES
84 URIs
36 LITERALS
24 BLANK NODES