A New Drug Delivery System Targeting Ileal Epithelial Cells Induced Electrogenic Sodium Absorption: Possible Promotion of Intestinal Adaptation View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2007-03-24

AUTHORS

Sho Haneda, Kouhei Fukushima, Yuji Funayama, Chikashi Shibata, Ken-Ichi Takahashi, Yasuhiko Tabata, Iwao Sasaki

ABSTRACT

We previously demonstrated the induction of the epithelial sodium channel, prostasin, and 11β-hydroxysteroid dehydrogenase type 2 and activation of sodium transport mediated by those molecules in the remnant ileum after total proctocolectomy. The aims of the present study were to develop a new drug delivery system that targets ileal epithelial cells and to enhance local mineralocorticoid action without systemic effects. Orally administered d-aldosterone-containing d,l-lactide/glycolide acid copolymer microspheres are absorbed in the rat terminal ileum and released aldosterone. Blood and terminal ileal tissues were collected 2 weeks after the administration of the microspheres, and the aldosterone concentrations, mRNA, and protein expressions of the above molecules and sodium transport were evaluated. Significantly high levels of tissue aldosterone in the absence of elevated plasma levels were detected in the microspheres-treated rats. Epithelial mRNA and protein expression of the above molecules increased significantly in the microspheres-treated animals. Electrogenic sodium transport in the ileum was enhanced in the microspheres-treated rats. Aldosterone-containing microspheres successfully induced the expression of the above molecules and activated sodium transport in the ileal mucosa, both of which are essential for intestinal adaptation. Pre- and/or postoperative treatment with this drug may compensate for the excessive loss of sodium and water following proctocolectomy. More... »

PAGES

568-577

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s11605-007-0145-8

DOI

http://dx.doi.org/10.1007/s11605-007-0145-8

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1022305892

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/17468916


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81 intestinal adaptation
82 levels
83 loss
84 mRNA
85 microspheres
86 mineralocorticoid action
87 molecules
88 mucosa
89 new drug delivery systems
90 plasma levels
91 possible promotion
92 postoperative treatment
93 present study
94 proctocolectomy
95 promotion
96 prostasin
97 protein expression
98 rat terminal ileum
99 rats
100 remnant ileum
101 sodium
102 sodium absorption
103 sodium channels
104 sodium transport
105 study
106 system
107 systemic effects
108 terminal ileum
109 tissue
110 total proctocolectomy
111 transport
112 treatment
113 type 2
114 water
115 weeks
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