Bromodeoxyuridine Labeling Index as an Indicator of Early Tumor Response to Preoperative Radiotherapy in Patients with Rectal Cancer View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2007-04-12

AUTHORS

Anna Gasinska, Jan Skolyszewski, Tadeusz Popiela, Piotr Richter, Zbigniew Darasz, Krystyna Nowak, Joanna Niemiec, Beata Biesaga, Agnieszka Adamczyk, Krzysztof Bucki, Krzysztof Malecki, Marian Reinfuss, Teresa Kowalska

ABSTRACT

PURPOSE: Assessment of tumor proliferation rate using Bromodeoxyuridine labeling index (BrdUrdLI) as a possible predictor of rectal cancer response to preoperative radiotherapy (RT). METHODS AND MATERIAL: Ninety-two patients were qualified either to short RT (5 Gy/fraction/5 days) and surgery about 1 week after RT (schedule I), or to short RT and 4-5 weeks interval before surgery (schedule II). Tumor samples were taken twice from each patient: before RT and at the time of surgery. The samples were incubated with BrdUrd for 1 h at 37 degrees C, and the BrdUrdLI was calculated as a percentage of BrdUrd-labeled cells. RESULTS: Thirty-eight patients were treated according to schedule I and 54 patients according to schedule II. Mean BrdUrdLI before RT was 8.5% and its value did not differ between the patients in the two compared groups. After RT tumors showed statistically significant growth inhibition (reduction of BrdUrdLI). As the pretreatment BrdUrd LI was not predictive for early clinical and pathologic tumor response, prognostic role of the ratio of BrdUrdLI after to BrdUrdLI before RT was considered. The ratios were calculated separately for fast (BrdUrd LI>8.5%) and slowly (BrdUrd LI More... »

PAGES

520-528

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s11605-007-0127-x

DOI

http://dx.doi.org/10.1007/s11605-007-0127-x

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1044700778

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/17436139


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