Follow-up magnetic resonance imaging findings in patients with progressive multifocal leukoencephalopathy: evaluation of long-term survivors under highly active antiretroviral therapy View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2009-02

AUTHORS

Mio Sakai, Yusuke Inoue, Shigeki Aoki, Takuma Sirasaka, Tomoko Uehira, Soichiro Takahama, Hideaki Nagai, Kenji Yutani, Kohki Yoshikawa, Hironobu Nakamura

ABSTRACT

PurposeThe aim of this study was to clarify the early magnetic resonance imaging (MRI) findings of progressive multifocal leukoencephalopathy (PML) and to evaluate the relations of the clinical course and serial MRI findings in patients with acquired immunodeficiency syndrome (AIDS)-related PML treated with highly active antiretroviral therapy (HAART).Materials and methodsThe clinical course and serial MRI findings in five patients with AIDS-related PML who were treated with HAART are described.ResultsAlthough all five patients were serologically naive to the therapy and alive at the end of the observation period, the lesions showed rapid extension on MRI for up to 3 months after the start of the therapy, and clinical symptoms progressed rapidly for a month after the start of the therapy. Newer margins in spreading lesions showed a diffuse pale hyperintensity and/or many discrete hyperintense dots on T2-weighted imagesConclusionEarly PML lesions may show a characteristic appearance on T2-weighted images. We should be aware of the progression of AIDS-related PML even under serologically effective HAART. More... »

PAGES

69-77

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s11604-008-0302-3

DOI

http://dx.doi.org/10.1007/s11604-008-0302-3

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1023019506

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/19373535


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