Irradiation injury temporarily induces enhancement of APN/CD13 peptidase activity on aorta-gonads-mesonephros (AGM)-derived stromal cells View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2007-04

AUTHORS

Yan Zhu, Lifang Huang, Xiaohua Luo, Hanying Sun, Dan Ran, Kejie Zhang, Miao Zheng, Kun Zhou, Wenli Liu

ABSTRACT

This study was designed to investigate the expression of aminopeptidase N (APN)/CD13 on intraembryonic AGM stromal cells, and the change of its enzymatic activity after irradiation injury. The expression of APN/CD13 on AGM stromal cells was assayed by RT-PCR and immunihistochemistry. After the stromal cells in AGM region were irradiated with 8.0 Gy of 60Co γ-rays, APN/CD13 enzymatic activity was measured by spectrophotometer at different time points. The result showed that AGM stromal cells strongly expressed APN/CD13. The enzymatic activity of APN/CD13 decreased temporarily after irradiation injury, then increased to higher level 4 h after irradiation, and it returned to the pre-irradiation level 24 to 48 h after the irradiation. The enzymatic activity of APN/CD13 was temporarily enhanced after irradiation injury, which might be one of the compensatory mechanisms that promote the hematopoietic recovery after irradiation. More... »

PAGES

145-148

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s11596-007-0209-8

DOI

http://dx.doi.org/10.1007/s11596-007-0209-8

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1037945177

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/17497281


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