Current status and future potential of somatic mutation testing from circulating free DNA in patients with solid tumours View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2010-12

AUTHORS

K. L. Aung, R. E. Board, G. Ellison, E. Donald, T. Ward, G. Clack, M. Ranson, A. Hughes, W. Newman, C. Dive

ABSTRACT

Genetic alterations can determine the natural history of cancer and its treatment response. With further advances in DNA sequencing technology, multiple novel genetic alterations will be discovered which could be exploited as prognostic, predictive and pharmacodynamic biomarkers in the development and use of cancer therapeutics. As such, the importance in clinical practice of efficient and robust somatic mutation testing in solid tumours cannot be overemphasized in the current era of personalized medicine. However, significant challenges remain regarding the testing of genetic biomarkers in clinical practice. Reliance on archived formalin fixed, paraffin embedded tumour, obtained from diagnostic biopsies, for testing somatic genetic alterations could restrict the scientific community in asking relevant questions about a patient's cancer biology. Problems inherent with using formalin fixed, archival tissue are well recognized and difficult to resolve. It could be argued that to achieve rapid and efficient incorporation of genetic biomarkers into clinical practice, somatic mutation testing in cancer patients should be simpler, less invasive using a readily available clinical sample, whilst maintaining robustness and reproducibility. In this regard, use of circulating free DNA (cfDNA) from plasma or serum as an alternative and/or additional source of DNA to test cancer specific genetic alterations is an attractive proposition. In light of encouraging results from recent studies, this mini review will discuss the current role and future potential of somatic mutation testing from circulating or cell free DNA derived from the blood of patients with solid tumours. More... »

PAGES

11-21

References to SciGraph publications

  • 2008-03. Pathology of the hereditary colorectal carcinoma in FAMILIAL CANCER
  • 2006-07. BEAMing: single-molecule PCR on microparticles in water-in-oil emulsions in NATURE METHODS
  • 1987-05. Prevalence of ras gene mutations in human colorectal cancers in NATURE
  • 1991-04. Mutational hot spot in the p53 gene in human hepatocellular carcinomas in NATURE
  • 2007-09. Evaluation of epidermal growth factor receptor mutation status in serum DNA as a predictor of response to gefitinib (IRESSA) in BRITISH JOURNAL OF CANCER
  • 2008-09. Cell-free DNA resuscitated for tumor testing in NATURE MEDICINE
  • 2005-02. PIK3CA gene is frequently mutated in breast carcinomas and hepatocellular carcinomas in ONCOGENE
  • 2005-09. 249ser TP53 mutation in plasma DNA, hepatitis B viral infection, and risk of hepatocellular carcinoma in ONCOGENE
  • 2008-09. Circulating mutant DNA to assess tumor dynamics in NATURE MEDICINE
  • 2009-04. The cancer genome in NATURE
  • 2010-04. Detection of PIK3CA mutations in circulating free DNA in patients with breast cancer in BREAST CANCER RESEARCH AND TREATMENT
  • 2004-07. Molecular Detection of APC, K-ras, and p53 Mutations in the Serum of Colorectal Cancer Patients as Circulating Biomarkers in WORLD JOURNAL OF SURGERY
  • 2009-12. Complex landscapes of somatic rearrangement in human breast cancer genomes in NATURE
  • 2007-04. TP53 mutations and hepatocellular carcinoma: insights into the etiology and pathogenesis of liver cancer in ONCOGENE
  • 2009-11. Detection of BRAF mutations in the tumour and serum of patients enrolled in the AZD6244 (ARRY-142886) advanced melanoma phase II study in BRITISH JOURNAL OF CANCER
  • 2006-02. BEAMing up for detection and quantification of rare sequence variants in NATURE METHODS
  • 2009-10-08. Mutational evolution in a lobular breast tumour profiled at single nucleotide resolution in NATURE
  • 2009-03. Transcriptome sequencing to detect gene fusions in cancer in NATURE
  • 2011-01. Large genomic rearrangements of the BRCA1 and BRCA2 genes: review of the literature and report of a novel BRCA1 mutation in BREAST CANCER RESEARCH AND TREATMENT
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1007/s11568-011-9149-2

    DOI

    http://dx.doi.org/10.1007/s11568-011-9149-2

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1010897549

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/22132062


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