Ontology type: schema:ScholarlyArticle Open Access: True
2008-12
AUTHORSKeng-Thye Woo, Choong-Meng Chan, Hui-Lin Choong, Han-Kim Tan, Marjorie Foo, Evan J. C. Lee, Chorh-Chuan Tan, Grace S. L. Lee, Seng-Hoe Tan, A. Vathsala, Cheng-Hong Lim, Gilbert S. C. Chiang, Stephanie Fook-Chong, Zhao Yi, H. B. Tan, Kok-Seng Wong
ABSTRACTBackground/aims Several studies have reported varying results of the influence of ACE gene on ACEI/ARB therapy. The efficacy of high dose ARB and its influence on ACE gene have not been explored. This is a 6 year randomised trial in IgA nephritis comparing high dose ARB (Losartan 200 mg/day) with normal dose ARB (Losartan 100 mg/day), normal dose ACEI (20 mg/day) and low dose ACEI (10 mg/day). Results Patients on high dose ARB had significantly lower proteinuria, 1.0 +/- 0.8 gm/day compared to 1.7 +/- 1.0 g/day in the other groups (P = 0.0005). The loss in eGFR was 0.7 ml min(-1)year(-1) for high dose ARB compared to 3.2-3.5 ml min(-1)year(-1) for the other three groups (P = 0.0005). There were more patients on high dose ARB with improvement in eGFR compared to other three groups (P < 0.001). Comparing patients with the three ACE genotypes DD, ID and II, all three groups responded well to therapy with decrease in proteinuria (P < 0.002). Only those on low dose ACEI (10 mg/day) with the I allele had increased in ESRF (P = 0.037). Conclusion High dose ARB is more efficacious in reducing proteinuria and preserving renal function when compared with normal dose ARB and ACEI, and also obviates the genomic influence of ACE gene polymorphism on renal survival. More... »
PAGES83-91
http://scigraph.springernature.com/pub.10.1007/s11568-009-9030-8
DOIhttp://dx.doi.org/10.1007/s11568-009-9030-8
DIMENSIONShttps://app.dimensions.ai/details/publication/pub.1046282671
PUBMEDhttps://www.ncbi.nlm.nih.gov/pubmed/19319668
JSON-LD is the canonical representation for SciGraph data.
TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT
[
{
"@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json",
"about": [
{
"id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1103",
"inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/",
"name": "Clinical Sciences",
"type": "DefinedTerm"
},
{
"id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11",
"inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/",
"name": "Medical and Health Sciences",
"type": "DefinedTerm"
}
],
"author": [
{
"affiliation": {
"alternateName": "Singapore General Hospital",
"id": "https://www.grid.ac/institutes/grid.163555.1",
"name": [
"Department of Renal Medicine, Singapore General Hospital, Outram Road, 169608, Singapore, Singapore"
],
"type": "Organization"
},
"familyName": "Woo",
"givenName": "Keng-Thye",
"id": "sg:person.0764260264.09",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0764260264.09"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Singapore General Hospital",
"id": "https://www.grid.ac/institutes/grid.163555.1",
"name": [
"Department of Renal Medicine, Singapore General Hospital, Outram Road, 169608, Singapore, Singapore"
],
"type": "Organization"
},
"familyName": "Chan",
"givenName": "Choong-Meng",
"id": "sg:person.0717665773.17",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0717665773.17"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Singapore General Hospital",
"id": "https://www.grid.ac/institutes/grid.163555.1",
"name": [
"Department of Renal Medicine, Singapore General Hospital, Outram Road, 169608, Singapore, Singapore"
],
"type": "Organization"
},
"familyName": "Choong",
"givenName": "Hui-Lin",
"id": "sg:person.01356177477.23",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01356177477.23"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Singapore General Hospital",
"id": "https://www.grid.ac/institutes/grid.163555.1",
"name": [
"Department of Renal Medicine, Singapore General Hospital, Outram Road, 169608, Singapore, Singapore"
],
"type": "Organization"
},
"familyName": "Tan",
"givenName": "Han-Kim",
"id": "sg:person.011534100427.37",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011534100427.37"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Singapore General Hospital",
"id": "https://www.grid.ac/institutes/grid.163555.1",
"name": [
"Department of Renal Medicine, Singapore General Hospital, Outram Road, 169608, Singapore, Singapore"
],
"type": "Organization"
},
"familyName": "Foo",
"givenName": "Marjorie",
"id": "sg:person.0612740071.13",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0612740071.13"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "National University Hospital",
"id": "https://www.grid.ac/institutes/grid.412106.0",
"name": [
"Division of Nephrology, National University Hospital, Singapore, Singapore"
],
"type": "Organization"
},
"familyName": "Lee",
"givenName": "Evan J. C.",
"id": "sg:person.011244440534.55",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011244440534.55"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "National University Hospital",
"id": "https://www.grid.ac/institutes/grid.412106.0",
"name": [
"Division of Nephrology, National University Hospital, Singapore, Singapore"
],
"type": "Organization"
},
"familyName": "Tan",
"givenName": "Chorh-Chuan",
"id": "sg:person.01105362327.17",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01105362327.17"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Gleneagles Hospital",
"id": "https://www.grid.ac/institutes/grid.415572.0",
"name": [
"Gleneagles Medical Centre, Penag, Singapore"
],
"type": "Organization"
},
"familyName": "Lee",
"givenName": "Grace S. L.",
"id": "sg:person.013376353104.95",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013376353104.95"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Tan Tock Seng Hospital",
"id": "https://www.grid.ac/institutes/grid.240988.f",
"name": [
"Department of Renal Medicine, Tan Tock Seng Hospital, Singapore, Singapore"
],
"type": "Organization"
},
"familyName": "Tan",
"givenName": "Seng-Hoe",
"id": "sg:person.01034702351.00",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01034702351.00"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Singapore General Hospital",
"id": "https://www.grid.ac/institutes/grid.163555.1",
"name": [
"Department of Renal Medicine, Singapore General Hospital, Outram Road, 169608, Singapore, Singapore"
],
"type": "Organization"
},
"familyName": "Vathsala",
"givenName": "A.",
"id": "sg:person.0645715736.54",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0645715736.54"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Singapore General Hospital",
"id": "https://www.grid.ac/institutes/grid.163555.1",
"name": [
"Department of Renal Medicine, Singapore General Hospital, Outram Road, 169608, Singapore, Singapore"
],
"type": "Organization"
},
"familyName": "Lim",
"givenName": "Cheng-Hong",
"id": "sg:person.0634360342.92",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0634360342.92"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Singapore General Hospital",
"id": "https://www.grid.ac/institutes/grid.163555.1",
"name": [
"Department of Renal Medicine, Singapore General Hospital, Outram Road, 169608, Singapore, Singapore"
],
"type": "Organization"
},
"familyName": "Chiang",
"givenName": "Gilbert S. C.",
"id": "sg:person.0612433227.30",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0612433227.30"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Singapore General Hospital",
"id": "https://www.grid.ac/institutes/grid.163555.1",
"name": [
"Department of Clinical Research, Singapore General Hospital, Outram Road, 169608, Singapore, Singapore"
],
"type": "Organization"
},
"familyName": "Fook-Chong",
"givenName": "Stephanie",
"id": "sg:person.0732007260.00",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0732007260.00"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Singapore General Hospital",
"id": "https://www.grid.ac/institutes/grid.163555.1",
"name": [
"Department of Clinical Research, Singapore General Hospital, Outram Road, 169608, Singapore, Singapore"
],
"type": "Organization"
},
"familyName": "Yi",
"givenName": "Zhao",
"id": "sg:person.0726661627.34",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0726661627.34"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Singapore General Hospital",
"id": "https://www.grid.ac/institutes/grid.163555.1",
"name": [
"Department of Renal Medicine, Singapore General Hospital, Outram Road, 169608, Singapore, Singapore"
],
"type": "Organization"
},
"familyName": "Tan",
"givenName": "H. B.",
"id": "sg:person.015317363027.64",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015317363027.64"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Singapore General Hospital",
"id": "https://www.grid.ac/institutes/grid.163555.1",
"name": [
"Department of Renal Medicine, Singapore General Hospital, Outram Road, 169608, Singapore, Singapore"
],
"type": "Organization"
},
"familyName": "Wong",
"givenName": "Kok-Seng",
"id": "sg:person.01005322164.24",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01005322164.24"
],
"type": "Person"
}
],
"citation": [
{
"id": "sg:pub.10.1046/j.1523-1755.2002.00410.x",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1006318168",
"https://doi.org/10.1046/j.1523-1755.2002.00410.x"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/s1062-1458(03)00161-2",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1009148169"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/s1062-1458(03)00161-2",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1009148169"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1097/hjh.0b013e328277596e",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1012963183"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1097/hjh.0b013e328277596e",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1012963183"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1159/000097367",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1014390518"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/j.diabres.2005.09.015",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1020728961"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/j.diabres.2005.09.015",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1020728961"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/s0272-6386(00)70261-7",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1028307634"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/s0140-6736(95)91088-3",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1028777678"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/s0140-6736(95)91088-3",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1028777678"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1053/j.ajkd.2005.08.034",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1033223391"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/s0140-6736(03)12229-5",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1035451935"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1046/j.1440-1797.1998.d01-30.x",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1036376072"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1007/s00125-005-1726-2",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1041223657",
"https://doi.org/10.1007/s00125-005-1726-2"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1007/s00125-005-1726-2",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1041223657",
"https://doi.org/10.1007/s00125-005-1726-2"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1007/s00125-005-1726-2",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1041223657",
"https://doi.org/10.1007/s00125-005-1726-2"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1046/j.1523-1755.2000.00432.x",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1045051652",
"https://doi.org/10.1046/j.1523-1755.2000.00432.x"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/j.semnephrol.2004.01.003",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1046018954"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/ki.1996.81",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1049151858",
"https://doi.org/10.1038/ki.1996.81"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.2337/diacare.27.4.874",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1051118987"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1111/j.1523-1755.2005.00511.x",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1053471411",
"https://doi.org/10.1111/j.1523-1755.2005.00511.x"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1111/j.1523-1755.2005.00511.x",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1053471411"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.3904/kjim.2000.15.1.13",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1071556506"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.5414/cnp68209",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1072833289"
],
"type": "CreativeWork"
},
{
"id": "https://app.dimensions.ai/details/publication/pub.1077011346",
"type": "CreativeWork"
},
{
"id": "https://app.dimensions.ai/details/publication/pub.1077658349",
"type": "CreativeWork"
}
],
"datePublished": "2008-12",
"datePublishedReg": "2008-12-01",
"description": "Background/aims Several studies have reported varying results of the influence of ACE gene on ACEI/ARB therapy. The efficacy of high dose ARB and its influence on ACE gene have not been explored. This is a 6 year randomised trial in IgA nephritis comparing high dose ARB (Losartan 200 mg/day) with normal dose ARB (Losartan 100 mg/day), normal dose ACEI (20 mg/day) and low dose ACEI (10 mg/day). Results Patients on high dose ARB had significantly lower proteinuria, 1.0 +/- 0.8 gm/day compared to 1.7 +/- 1.0 g/day in the other groups (P = 0.0005). The loss in eGFR was 0.7 ml min(-1)year(-1) for high dose ARB compared to 3.2-3.5 ml min(-1)year(-1) for the other three groups (P = 0.0005). There were more patients on high dose ARB with improvement in eGFR compared to other three groups (P < 0.001). Comparing patients with the three ACE genotypes DD, ID and II, all three groups responded well to therapy with decrease in proteinuria (P < 0.002). Only those on low dose ACEI (10 mg/day) with the I allele had increased in ESRF (P = 0.037). Conclusion High dose ARB is more efficacious in reducing proteinuria and preserving renal function when compared with normal dose ARB and ACEI, and also obviates the genomic influence of ACE gene polymorphism on renal survival.",
"genre": "research_article",
"id": "sg:pub.10.1007/s11568-009-9030-8",
"inLanguage": [
"en"
],
"isAccessibleForFree": true,
"isPartOf": [
{
"id": "sg:journal.1038392",
"issn": [
"1877-6558",
"1877-6566"
],
"name": "The HUGO Journal",
"type": "Periodical"
},
{
"issueNumber": "3-4",
"type": "PublicationIssue"
},
{
"type": "PublicationVolume",
"volumeNumber": "2"
}
],
"name": "High dose Losartan and ACE gene polymorphism in IgA nephritis",
"pagination": "83-91",
"productId": [
{
"name": "readcube_id",
"type": "PropertyValue",
"value": [
"dc77f18701d34847bbee1b845e4d704da1da0a46c97fe317692b4ff9c246bf98"
]
},
{
"name": "pubmed_id",
"type": "PropertyValue",
"value": [
"19319668"
]
},
{
"name": "nlm_unique_id",
"type": "PropertyValue",
"value": [
"101300020"
]
},
{
"name": "doi",
"type": "PropertyValue",
"value": [
"10.1007/s11568-009-9030-8"
]
},
{
"name": "dimensions_id",
"type": "PropertyValue",
"value": [
"pub.1046282671"
]
}
],
"sameAs": [
"https://doi.org/10.1007/s11568-009-9030-8",
"https://app.dimensions.ai/details/publication/pub.1046282671"
],
"sdDataset": "articles",
"sdDatePublished": "2019-04-10T18:23",
"sdLicense": "https://scigraph.springernature.com/explorer/license/",
"sdPublisher": {
"name": "Springer Nature - SN SciGraph project",
"type": "Organization"
},
"sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8675_00000524.jsonl",
"type": "ScholarlyArticle",
"url": "http://link.springer.com/10.1007%2Fs11568-009-9030-8"
}
]Download the RDF metadata as: json-ld nt turtle xml License info
JSON-LD is a popular format for linked data which is fully compatible with JSON.
curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s11568-009-9030-8'
N-Triples is a line-based linked data format ideal for batch operations.
curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s11568-009-9030-8'
Turtle is a human-readable linked data format.
curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s11568-009-9030-8'
RDF/XML is a standard XML format for linked data.
curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s11568-009-9030-8'
This table displays all metadata directly associated to this object as RDF triples.
250 TRIPLES
21 PREDICATES
50 URIs
21 LITERALS
9 BLANK NODES