Axonal fusion via conduit-based delivery of hydrophilic polymers View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2015-12

AUTHORS

Kevin W. Sexton, Charles L. Rodriguez-Feo, Richard B. Boyer, Gabriel A. Del Corral, David C. Riley, Alonda C. Pollins, Nancy L. Cardwell, R. Bruce Shack, Lillian B. Nanney, Wesley P. Thayer

ABSTRACT

BACKGROUND: Hydrophilic polymers have been shown to improve physiologic recovery following repair of transected nerves with microsutures. Our study was designed to combine hydrophilic polymer therapy with nerve tubes (NT) to enhance polymer delivery to the site of nerve injury. METHODS: Using a rat sciatic nerve injury model, a single transection injury was repaired in an end-to-end fashion with NT + polyethylene glycol (PEG) to NT alone. Compound action potentials (CAPs) were recorded before nerve transection and after repair. Behavioral testing was performed for 5 weeks. RESULTS: PEG therapy restored CAPS in all, but one, animals, while no CAPS were recorded in animals not receiving PEG. Behavioral nerve function was measured using the standardized functional assessment technique and foot fault asymmetry scores (FF). FF scores were improved for the PEG therapy groups on postoperative days 7, 14, and 21. However, after expected eventual axonal outgrowth, the benefit was less noticeable at days 28 and 35. Immunohistochemistry of the distal axon segments showed an increase number of sensory and motor axons in the NT + PEG group as compared to NT alone. CONCLUSION: These data suggest that PEG delivery via a conduit may provide a simple, effective way to fuse severed axons and regain early nerve function. For proximal nerve injuries in large animals, recovery of axonal continuity could dramatically improve outcomes, even if fusion only occurs in a small percentage of axons. More... »

PAGES

688-694

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s11552-015-9780-9

DOI

http://dx.doi.org/10.1007/s11552-015-9780-9

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1053260615

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/26568724


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1109", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Neurosciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Vanderbilt University Medical Center", 
          "id": "https://www.grid.ac/institutes/grid.412807.8", 
          "name": [
            "Department of Plastic Surgery, Vanderbilt University Medical Center, 1161 21st Avenue South S2221, Medical Center North, 37232, Nashville, TN, USA", 
            "Department of General Surgery, Vanderbilt University Medical Center, 1161 21st Avenue South, 37232, Nashville, TN, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Sexton", 
        "givenName": "Kevin W.", 
        "id": "sg:person.0720111324.99", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0720111324.99"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Vanderbilt University", 
          "id": "https://www.grid.ac/institutes/grid.152326.1", 
          "name": [
            "Vanderbilt University School of Medicine, 215 Light Hall, 37232, Nashville, TN, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Rodriguez-Feo", 
        "givenName": "Charles L.", 
        "id": "sg:person.01143246476.22", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01143246476.22"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Vanderbilt University", 
          "id": "https://www.grid.ac/institutes/grid.152326.1", 
          "name": [
            "Vanderbilt University School of Medicine, 215 Light Hall, 37232, Nashville, TN, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Boyer", 
        "givenName": "Richard B.", 
        "id": "sg:person.01257475076.53", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01257475076.53"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Vanderbilt University Medical Center", 
          "id": "https://www.grid.ac/institutes/grid.412807.8", 
          "name": [
            "Department of Plastic Surgery, Vanderbilt University Medical Center, 1161 21st Avenue South S2221, Medical Center North, 37232, Nashville, TN, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Del Corral", 
        "givenName": "Gabriel A.", 
        "id": "sg:person.0776672357.42", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0776672357.42"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Vanderbilt University Medical Center", 
          "id": "https://www.grid.ac/institutes/grid.412807.8", 
          "name": [
            "Department of Plastic Surgery, Vanderbilt University Medical Center, 1161 21st Avenue South S2221, Medical Center North, 37232, Nashville, TN, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Riley", 
        "givenName": "David C.", 
        "id": "sg:person.01122256163.18", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01122256163.18"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Vanderbilt University Medical Center", 
          "id": "https://www.grid.ac/institutes/grid.412807.8", 
          "name": [
            "Department of Plastic Surgery, Vanderbilt University Medical Center, 1161 21st Avenue South S2221, Medical Center North, 37232, Nashville, TN, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Pollins", 
        "givenName": "Alonda C.", 
        "id": "sg:person.0745400361.10", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0745400361.10"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Vanderbilt University Medical Center", 
          "id": "https://www.grid.ac/institutes/grid.412807.8", 
          "name": [
            "Department of Plastic Surgery, Vanderbilt University Medical Center, 1161 21st Avenue South S2221, Medical Center North, 37232, Nashville, TN, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Cardwell", 
        "givenName": "Nancy L.", 
        "id": "sg:person.0730557157.66", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0730557157.66"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Vanderbilt University Medical Center", 
          "id": "https://www.grid.ac/institutes/grid.412807.8", 
          "name": [
            "Department of Plastic Surgery, Vanderbilt University Medical Center, 1161 21st Avenue South S2221, Medical Center North, 37232, Nashville, TN, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Shack", 
        "givenName": "R. Bruce", 
        "id": "sg:person.01104022773.55", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01104022773.55"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Vanderbilt University Medical Center", 
          "id": "https://www.grid.ac/institutes/grid.412807.8", 
          "name": [
            "Department of Plastic Surgery, Vanderbilt University Medical Center, 1161 21st Avenue South S2221, Medical Center North, 37232, Nashville, TN, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Nanney", 
        "givenName": "Lillian B.", 
        "id": "sg:person.01161234157.68", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01161234157.68"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Vanderbilt University Medical Center", 
          "id": "https://www.grid.ac/institutes/grid.412807.8", 
          "name": [
            "Department of Plastic Surgery, Vanderbilt University Medical Center, 1161 21st Avenue South S2221, Medical Center North, 37232, Nashville, TN, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Thayer", 
        "givenName": "Wesley P.", 
        "id": "sg:person.01227347357.76", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01227347357.76"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1016/0006-8993(83)90373-6", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000540176"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0006-8993(83)90373-6", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000540176"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1006/exnr.1998.6955", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004073167"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/mus.21652", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006362562"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/mus.21652", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006362562"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1053/jhsu.2000.jhsu025a0104", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006390463"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1053/jhsu.2000.jhsu025a0104", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006390463"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nprot.2010.128", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1007192322", 
          "https://doi.org/10.1038/nprot.2010.128"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf00453481", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1008998009", 
          "https://doi.org/10.1007/bf00453481"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf00453481", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1008998009", 
          "https://doi.org/10.1007/bf00453481"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf01105896", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012016327", 
          "https://doi.org/10.1007/bf01105896"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf01105896", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012016327", 
          "https://doi.org/10.1007/bf01105896"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.jss.2012.03.049", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014429335"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/jnr.23023", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017079553"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1227/01.neu.0000134388.86603.11", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018864167"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.jneumeth.2008.01.022", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020487903"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.jhsa.2007.07.015", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021744683"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1006/exnr.2000.7600", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022547545"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1152/jn.01051.2009", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023013022"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0267-6605(92)90100-8", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1026697753"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/dvdy.22606", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036555025"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/micr.20799", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037123835"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/micr.20799", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037123835"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.neubiorev.2007.10.001", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038623256"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0020-1383(97)00086-7", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041939986"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/j.1875-9114.1986.tb03459.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041973882"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.jneumeth.2008.06.019", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1043505768"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0006-8993(88)90145-x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046062968"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0006-8993(88)90145-x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046062968"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.brainres.2004.08.040", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046640361"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1177/35.8.3110266", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1049529224"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1177/35.8.3110266", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1049529224"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.clinph.2008.03.018", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051857458"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1089/neu.2006.23.227", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1059300412"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1682/jrrd.1992.04.0001", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1068243940"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1523/jneurosci.19-07-02442.1999", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1074268103"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1074597944", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1523/jneurosci.15-05-04109.1995", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1082492597"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1083313132", 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2015-12", 
    "datePublishedReg": "2015-12-01", 
    "description": "BACKGROUND: Hydrophilic polymers have been shown to improve physiologic recovery following repair of transected nerves with microsutures. Our study was designed to combine hydrophilic polymer therapy with nerve tubes (NT) to enhance polymer delivery to the site of nerve injury.\nMETHODS: Using a rat sciatic nerve injury model, a single transection injury was repaired in an end-to-end fashion with NT\u2009+\u2009polyethylene glycol (PEG) to NT alone. Compound action potentials (CAPs) were recorded before nerve transection and after repair. Behavioral testing was performed for 5\u00a0weeks.\nRESULTS: PEG therapy restored CAPS in all, but one, animals, while no CAPS were recorded in animals not receiving PEG. Behavioral nerve function was measured using the standardized functional assessment technique and foot fault asymmetry scores (FF). FF scores were improved for the PEG therapy groups on postoperative days 7, 14, and 21. However, after expected eventual axonal outgrowth, the benefit was less noticeable at days 28 and 35. Immunohistochemistry of the distal axon segments showed an increase number of sensory and motor axons in the NT\u2009+\u2009PEG group as compared to NT alone.\nCONCLUSION: These data suggest that PEG delivery via a conduit may provide a simple, effective way to fuse severed axons and regain early nerve function. For proximal nerve injuries in large animals, recovery of axonal continuity could dramatically improve outcomes, even if fusion only occurs in a small percentage of axons.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1007/s11552-015-9780-9", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": true, 
    "isFundedItemOf": [
      {
        "id": "sg:grant.2705135", 
        "type": "MonetaryGrant"
      }
    ], 
    "isPartOf": [
      {
        "id": "sg:journal.1036379", 
        "issn": [
          "1558-9447", 
          "1558-9455"
        ], 
        "name": "HAND", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "4", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "10"
      }
    ], 
    "name": "Axonal fusion via conduit-based delivery of hydrophilic polymers", 
    "pagination": "688-694", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "fdb10aad0f4c669122db398bc6a7007e427bd9adb877226d3345c3946094f360"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "26568724"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "101264149"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1007/s11552-015-9780-9"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1053260615"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1007/s11552-015-9780-9", 
      "https://app.dimensions.ai/details/publication/pub.1053260615"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-10T21:40", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8687_00000524.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "http://link.springer.com/10.1007%2Fs11552-015-9780-9"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s11552-015-9780-9'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s11552-015-9780-9'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s11552-015-9780-9'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s11552-015-9780-9'


 

This table displays all metadata directly associated to this object as RDF triples.

232 TRIPLES      21 PREDICATES      60 URIs      21 LITERALS      9 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1007/s11552-015-9780-9 schema:about anzsrc-for:11
2 anzsrc-for:1109
3 schema:author N1a52675622d246e9bd68993b7789b976
4 schema:citation sg:pub.10.1007/bf00453481
5 sg:pub.10.1007/bf01105896
6 sg:pub.10.1038/nprot.2010.128
7 https://app.dimensions.ai/details/publication/pub.1074597944
8 https://app.dimensions.ai/details/publication/pub.1083313132
9 https://doi.org/10.1002/dvdy.22606
10 https://doi.org/10.1002/j.1875-9114.1986.tb03459.x
11 https://doi.org/10.1002/jnr.23023
12 https://doi.org/10.1002/micr.20799
13 https://doi.org/10.1002/mus.21652
14 https://doi.org/10.1006/exnr.1998.6955
15 https://doi.org/10.1006/exnr.2000.7600
16 https://doi.org/10.1016/0006-8993(83)90373-6
17 https://doi.org/10.1016/0006-8993(88)90145-x
18 https://doi.org/10.1016/0267-6605(92)90100-8
19 https://doi.org/10.1016/j.brainres.2004.08.040
20 https://doi.org/10.1016/j.clinph.2008.03.018
21 https://doi.org/10.1016/j.jhsa.2007.07.015
22 https://doi.org/10.1016/j.jneumeth.2008.01.022
23 https://doi.org/10.1016/j.jneumeth.2008.06.019
24 https://doi.org/10.1016/j.jss.2012.03.049
25 https://doi.org/10.1016/j.neubiorev.2007.10.001
26 https://doi.org/10.1016/s0020-1383(97)00086-7
27 https://doi.org/10.1053/jhsu.2000.jhsu025a0104
28 https://doi.org/10.1089/neu.2006.23.227
29 https://doi.org/10.1152/jn.01051.2009
30 https://doi.org/10.1177/35.8.3110266
31 https://doi.org/10.1227/01.neu.0000134388.86603.11
32 https://doi.org/10.1523/jneurosci.15-05-04109.1995
33 https://doi.org/10.1523/jneurosci.19-07-02442.1999
34 https://doi.org/10.1682/jrrd.1992.04.0001
35 schema:datePublished 2015-12
36 schema:datePublishedReg 2015-12-01
37 schema:description BACKGROUND: Hydrophilic polymers have been shown to improve physiologic recovery following repair of transected nerves with microsutures. Our study was designed to combine hydrophilic polymer therapy with nerve tubes (NT) to enhance polymer delivery to the site of nerve injury. METHODS: Using a rat sciatic nerve injury model, a single transection injury was repaired in an end-to-end fashion with NT + polyethylene glycol (PEG) to NT alone. Compound action potentials (CAPs) were recorded before nerve transection and after repair. Behavioral testing was performed for 5 weeks. RESULTS: PEG therapy restored CAPS in all, but one, animals, while no CAPS were recorded in animals not receiving PEG. Behavioral nerve function was measured using the standardized functional assessment technique and foot fault asymmetry scores (FF). FF scores were improved for the PEG therapy groups on postoperative days 7, 14, and 21. However, after expected eventual axonal outgrowth, the benefit was less noticeable at days 28 and 35. Immunohistochemistry of the distal axon segments showed an increase number of sensory and motor axons in the NT + PEG group as compared to NT alone. CONCLUSION: These data suggest that PEG delivery via a conduit may provide a simple, effective way to fuse severed axons and regain early nerve function. For proximal nerve injuries in large animals, recovery of axonal continuity could dramatically improve outcomes, even if fusion only occurs in a small percentage of axons.
38 schema:genre research_article
39 schema:inLanguage en
40 schema:isAccessibleForFree true
41 schema:isPartOf Nc92deee81b3b4b46ad2a63329a07d9e0
42 Ndc2d9ae4d25341eab26b480999a711f7
43 sg:journal.1036379
44 schema:name Axonal fusion via conduit-based delivery of hydrophilic polymers
45 schema:pagination 688-694
46 schema:productId N295f29d45e224b1694ab6baaff544336
47 N2bc3a66870fa4df9a310e7d749405aea
48 N4215ec5b5b4d4376b1a7cc897d4dfab6
49 Nc92fbc6b5d7c4d58a8bf84d8122b700a
50 Nc97e70d462eb49edb5e299074ab9709e
51 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053260615
52 https://doi.org/10.1007/s11552-015-9780-9
53 schema:sdDatePublished 2019-04-10T21:40
54 schema:sdLicense https://scigraph.springernature.com/explorer/license/
55 schema:sdPublisher N680e84a166524dc08f798d1146e9d9f6
56 schema:url http://link.springer.com/10.1007%2Fs11552-015-9780-9
57 sgo:license sg:explorer/license/
58 sgo:sdDataset articles
59 rdf:type schema:ScholarlyArticle
60 N0cf011de926e4a1ba8037f14d3b942f8 rdf:first sg:person.01227347357.76
61 rdf:rest rdf:nil
62 N1a52675622d246e9bd68993b7789b976 rdf:first sg:person.0720111324.99
63 rdf:rest N9d94d67ba3b94444803433d14f6bd7f7
64 N295f29d45e224b1694ab6baaff544336 schema:name readcube_id
65 schema:value fdb10aad0f4c669122db398bc6a7007e427bd9adb877226d3345c3946094f360
66 rdf:type schema:PropertyValue
67 N2bc3a66870fa4df9a310e7d749405aea schema:name nlm_unique_id
68 schema:value 101264149
69 rdf:type schema:PropertyValue
70 N4215ec5b5b4d4376b1a7cc897d4dfab6 schema:name pubmed_id
71 schema:value 26568724
72 rdf:type schema:PropertyValue
73 N45d34d7fc80a4e1ab1155d288cdb2501 rdf:first sg:person.01104022773.55
74 rdf:rest N912d10c1bed248878767031a8609bcad
75 N680e84a166524dc08f798d1146e9d9f6 schema:name Springer Nature - SN SciGraph project
76 rdf:type schema:Organization
77 N6dac0289d9b14091830db87ba7d78aa1 rdf:first sg:person.01257475076.53
78 rdf:rest Nd448a4c1adaa410b9a1811d822711722
79 N912d10c1bed248878767031a8609bcad rdf:first sg:person.01161234157.68
80 rdf:rest N0cf011de926e4a1ba8037f14d3b942f8
81 N9d94d67ba3b94444803433d14f6bd7f7 rdf:first sg:person.01143246476.22
82 rdf:rest N6dac0289d9b14091830db87ba7d78aa1
83 N9e348ea519ef44999c60f7130887a8d0 rdf:first sg:person.0745400361.10
84 rdf:rest Na5503ab184604bc2b0eb886799ea53c1
85 Na5503ab184604bc2b0eb886799ea53c1 rdf:first sg:person.0730557157.66
86 rdf:rest N45d34d7fc80a4e1ab1155d288cdb2501
87 Nc92deee81b3b4b46ad2a63329a07d9e0 schema:issueNumber 4
88 rdf:type schema:PublicationIssue
89 Nc92fbc6b5d7c4d58a8bf84d8122b700a schema:name doi
90 schema:value 10.1007/s11552-015-9780-9
91 rdf:type schema:PropertyValue
92 Nc97e70d462eb49edb5e299074ab9709e schema:name dimensions_id
93 schema:value pub.1053260615
94 rdf:type schema:PropertyValue
95 Nd448a4c1adaa410b9a1811d822711722 rdf:first sg:person.0776672357.42
96 rdf:rest Nde8e0b04bcfb482a806c6ea2de59a200
97 Ndc2d9ae4d25341eab26b480999a711f7 schema:volumeNumber 10
98 rdf:type schema:PublicationVolume
99 Nde8e0b04bcfb482a806c6ea2de59a200 rdf:first sg:person.01122256163.18
100 rdf:rest N9e348ea519ef44999c60f7130887a8d0
101 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
102 schema:name Medical and Health Sciences
103 rdf:type schema:DefinedTerm
104 anzsrc-for:1109 schema:inDefinedTermSet anzsrc-for:
105 schema:name Neurosciences
106 rdf:type schema:DefinedTerm
107 sg:grant.2705135 http://pending.schema.org/fundedItem sg:pub.10.1007/s11552-015-9780-9
108 rdf:type schema:MonetaryGrant
109 sg:journal.1036379 schema:issn 1558-9447
110 1558-9455
111 schema:name HAND
112 rdf:type schema:Periodical
113 sg:person.01104022773.55 schema:affiliation https://www.grid.ac/institutes/grid.412807.8
114 schema:familyName Shack
115 schema:givenName R. Bruce
116 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01104022773.55
117 rdf:type schema:Person
118 sg:person.01122256163.18 schema:affiliation https://www.grid.ac/institutes/grid.412807.8
119 schema:familyName Riley
120 schema:givenName David C.
121 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01122256163.18
122 rdf:type schema:Person
123 sg:person.01143246476.22 schema:affiliation https://www.grid.ac/institutes/grid.152326.1
124 schema:familyName Rodriguez-Feo
125 schema:givenName Charles L.
126 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01143246476.22
127 rdf:type schema:Person
128 sg:person.01161234157.68 schema:affiliation https://www.grid.ac/institutes/grid.412807.8
129 schema:familyName Nanney
130 schema:givenName Lillian B.
131 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01161234157.68
132 rdf:type schema:Person
133 sg:person.01227347357.76 schema:affiliation https://www.grid.ac/institutes/grid.412807.8
134 schema:familyName Thayer
135 schema:givenName Wesley P.
136 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01227347357.76
137 rdf:type schema:Person
138 sg:person.01257475076.53 schema:affiliation https://www.grid.ac/institutes/grid.152326.1
139 schema:familyName Boyer
140 schema:givenName Richard B.
141 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01257475076.53
142 rdf:type schema:Person
143 sg:person.0720111324.99 schema:affiliation https://www.grid.ac/institutes/grid.412807.8
144 schema:familyName Sexton
145 schema:givenName Kevin W.
146 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0720111324.99
147 rdf:type schema:Person
148 sg:person.0730557157.66 schema:affiliation https://www.grid.ac/institutes/grid.412807.8
149 schema:familyName Cardwell
150 schema:givenName Nancy L.
151 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0730557157.66
152 rdf:type schema:Person
153 sg:person.0745400361.10 schema:affiliation https://www.grid.ac/institutes/grid.412807.8
154 schema:familyName Pollins
155 schema:givenName Alonda C.
156 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0745400361.10
157 rdf:type schema:Person
158 sg:person.0776672357.42 schema:affiliation https://www.grid.ac/institutes/grid.412807.8
159 schema:familyName Del Corral
160 schema:givenName Gabriel A.
161 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0776672357.42
162 rdf:type schema:Person
163 sg:pub.10.1007/bf00453481 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008998009
164 https://doi.org/10.1007/bf00453481
165 rdf:type schema:CreativeWork
166 sg:pub.10.1007/bf01105896 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012016327
167 https://doi.org/10.1007/bf01105896
168 rdf:type schema:CreativeWork
169 sg:pub.10.1038/nprot.2010.128 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007192322
170 https://doi.org/10.1038/nprot.2010.128
171 rdf:type schema:CreativeWork
172 https://app.dimensions.ai/details/publication/pub.1074597944 schema:CreativeWork
173 https://app.dimensions.ai/details/publication/pub.1083313132 schema:CreativeWork
174 https://doi.org/10.1002/dvdy.22606 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036555025
175 rdf:type schema:CreativeWork
176 https://doi.org/10.1002/j.1875-9114.1986.tb03459.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1041973882
177 rdf:type schema:CreativeWork
178 https://doi.org/10.1002/jnr.23023 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017079553
179 rdf:type schema:CreativeWork
180 https://doi.org/10.1002/micr.20799 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037123835
181 rdf:type schema:CreativeWork
182 https://doi.org/10.1002/mus.21652 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006362562
183 rdf:type schema:CreativeWork
184 https://doi.org/10.1006/exnr.1998.6955 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004073167
185 rdf:type schema:CreativeWork
186 https://doi.org/10.1006/exnr.2000.7600 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022547545
187 rdf:type schema:CreativeWork
188 https://doi.org/10.1016/0006-8993(83)90373-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000540176
189 rdf:type schema:CreativeWork
190 https://doi.org/10.1016/0006-8993(88)90145-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1046062968
191 rdf:type schema:CreativeWork
192 https://doi.org/10.1016/0267-6605(92)90100-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026697753
193 rdf:type schema:CreativeWork
194 https://doi.org/10.1016/j.brainres.2004.08.040 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046640361
195 rdf:type schema:CreativeWork
196 https://doi.org/10.1016/j.clinph.2008.03.018 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051857458
197 rdf:type schema:CreativeWork
198 https://doi.org/10.1016/j.jhsa.2007.07.015 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021744683
199 rdf:type schema:CreativeWork
200 https://doi.org/10.1016/j.jneumeth.2008.01.022 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020487903
201 rdf:type schema:CreativeWork
202 https://doi.org/10.1016/j.jneumeth.2008.06.019 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043505768
203 rdf:type schema:CreativeWork
204 https://doi.org/10.1016/j.jss.2012.03.049 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014429335
205 rdf:type schema:CreativeWork
206 https://doi.org/10.1016/j.neubiorev.2007.10.001 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038623256
207 rdf:type schema:CreativeWork
208 https://doi.org/10.1016/s0020-1383(97)00086-7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041939986
209 rdf:type schema:CreativeWork
210 https://doi.org/10.1053/jhsu.2000.jhsu025a0104 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006390463
211 rdf:type schema:CreativeWork
212 https://doi.org/10.1089/neu.2006.23.227 schema:sameAs https://app.dimensions.ai/details/publication/pub.1059300412
213 rdf:type schema:CreativeWork
214 https://doi.org/10.1152/jn.01051.2009 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023013022
215 rdf:type schema:CreativeWork
216 https://doi.org/10.1177/35.8.3110266 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049529224
217 rdf:type schema:CreativeWork
218 https://doi.org/10.1227/01.neu.0000134388.86603.11 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018864167
219 rdf:type schema:CreativeWork
220 https://doi.org/10.1523/jneurosci.15-05-04109.1995 schema:sameAs https://app.dimensions.ai/details/publication/pub.1082492597
221 rdf:type schema:CreativeWork
222 https://doi.org/10.1523/jneurosci.19-07-02442.1999 schema:sameAs https://app.dimensions.ai/details/publication/pub.1074268103
223 rdf:type schema:CreativeWork
224 https://doi.org/10.1682/jrrd.1992.04.0001 schema:sameAs https://app.dimensions.ai/details/publication/pub.1068243940
225 rdf:type schema:CreativeWork
226 https://www.grid.ac/institutes/grid.152326.1 schema:alternateName Vanderbilt University
227 schema:name Vanderbilt University School of Medicine, 215 Light Hall, 37232, Nashville, TN, USA
228 rdf:type schema:Organization
229 https://www.grid.ac/institutes/grid.412807.8 schema:alternateName Vanderbilt University Medical Center
230 schema:name Department of General Surgery, Vanderbilt University Medical Center, 1161 21st Avenue South, 37232, Nashville, TN, USA
231 Department of Plastic Surgery, Vanderbilt University Medical Center, 1161 21st Avenue South S2221, Medical Center North, 37232, Nashville, TN, USA
232 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...