Magnetic resonance-guided focused ultrasound for the treatment of painful bone metastases: role of apparent diffusion coefficient (ADC) and dynamic contrast ... View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2016-12

AUTHORS

Michele Anzidei, Alessandro Napoli, Beatrice Sacconi, Fabrizio Boni, Vincenzo Noce, Michele Di Martino, Luca Saba, Carlo Catalano

ABSTRACT

PURPOSE: To assess the correlation between functional MRI, including ADC values obtained from DWI and DCE, and clinical outcome in patients with bone metastases treated with MRgFUS. METHODS AND MATERIALS: Twenty-three patients with symptomatic bone metastases underwent MRgFUS treatment (ExAblate 2100 system InSightec) for pain palliation. All patients underwent clinical and imaging follow-up examinations at 1, 3 and 6 months after treatment. Visual Analog Scale (VAS) score was used to evaluate treatment efficacy in terms of pain palliation while ADC maps obtained by DWI sequences, and DCE data were used for quantitative assessment of treatment response at imaging. Spearman Correlation Coefficient Test was calculated to assess the correlation between VAS, ADC and DCE data. RESULTS: All treatments were performed successfully without adverse events. On the basis of VAS score, 16 (69.6 %) patients were classified as complete clinical responders, 6 (26.1 %) as partial responders and only one (4.3 %) was classified as a non-responder. The mean VAS score decreased from 7.09 ± 1.8 at baseline to 2.65 ± 1.36 at 1 month, 1.04 ± 1.91 at 3 months and 1.09 ± 1.99 at 6 months (p < 0.001). Baseline mean ADC value of treated lesions was 1.05 ± 0.15 mm2/s, increasing along follow-up period (1.57 ± 0.27 mm2/s 1st month; 1.49 ± 0.3 mm2/s 3rd month; 1.45 ± 0.32 mm2/s 6th month, p < 0.001). Non perfused volume (NPV) was 46.4 at 1 month, 45.2 at 3 months and 43.8 at 6 months. Spearman Coefficient demonstrated a statistically significant negative correlation between VAS and ADC values (ρ = -0.684; p = 0.03), but no significant correlation between VAS and NPV (ρ = 0.02216, p = 0.9305). Among other DCE data, Ktrans significantly changed in complete responders (3 months Ktrans = 2.14/min; -ΔKt = 52.65 % p < 0.01) and was not significantly different in partial responders (3 months Ktrans 0.042/min; ΔKt = 11.39 % p > 0.01). CONCLUSION: In patients with painful bone metastases treated with MRgFUS, ADC and Ktrans variation observed in the ablated lesions correlate with VAS values and may play a role as objective imaging marker of treatment response. More... »

PAGES

905-915

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s11547-016-0675-9

DOI

http://dx.doi.org/10.1007/s11547-016-0675-9

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1049988985

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/27567615


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1103", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Clinical Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Adult", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Aged", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Aged, 80 and over", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Bone Neoplasms", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Contrast Media", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Diffusion Magnetic Resonance Imaging", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Female", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "High-Intensity Focused Ultrasound Ablation", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Life Expectancy", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Magnetic Resonance Imaging", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Magnetic Resonance Imaging, Interventional", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Male", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Middle Aged", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Pain Management", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Prospective Studies", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Surgery, Computer-Assisted", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Treatment Outcome", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Sapienza University of Rome", 
          "id": "https://www.grid.ac/institutes/grid.7841.a", 
          "name": [
            "Department of Radiological, Oncological and Anatomopathological Sciences, Radiology, \u201cSapienza\u201d University of Rome, Viale Regina Elena 324, 00161, Rome, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Anzidei", 
        "givenName": "Michele", 
        "id": "sg:person.0735362216.50", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0735362216.50"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Sapienza University of Rome", 
          "id": "https://www.grid.ac/institutes/grid.7841.a", 
          "name": [
            "Department of Radiological, Oncological and Anatomopathological Sciences, Radiology, \u201cSapienza\u201d University of Rome, Viale Regina Elena 324, 00161, Rome, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Napoli", 
        "givenName": "Alessandro", 
        "id": "sg:person.01351075172.34", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01351075172.34"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Italian Institute of Technology", 
          "id": "https://www.grid.ac/institutes/grid.25786.3e", 
          "name": [
            "Department of Radiological, Oncological and Anatomopathological Sciences, Radiology, \u201cSapienza\u201d University of Rome, Viale Regina Elena 324, 00161, Rome, Italy", 
            "Center for Life Nano Science@Sapienza, Istituto Italiano di Tecnologia, Viale Regina Elena 291, Rome, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Sacconi", 
        "givenName": "Beatrice", 
        "id": "sg:person.01001510455.25", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01001510455.25"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Sapienza University of Rome", 
          "id": "https://www.grid.ac/institutes/grid.7841.a", 
          "name": [
            "Department of Radiological, Oncological and Anatomopathological Sciences, Radiology, \u201cSapienza\u201d University of Rome, Viale Regina Elena 324, 00161, Rome, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Boni", 
        "givenName": "Fabrizio", 
        "id": "sg:person.0657547501.54", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0657547501.54"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Sapienza University of Rome", 
          "id": "https://www.grid.ac/institutes/grid.7841.a", 
          "name": [
            "Department of Radiological, Oncological and Anatomopathological Sciences, Radiology, \u201cSapienza\u201d University of Rome, Viale Regina Elena 324, 00161, Rome, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Noce", 
        "givenName": "Vincenzo", 
        "id": "sg:person.01304656564.08", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01304656564.08"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Sapienza University of Rome", 
          "id": "https://www.grid.ac/institutes/grid.7841.a", 
          "name": [
            "Department of Radiological, Oncological and Anatomopathological Sciences, Radiology, \u201cSapienza\u201d University of Rome, Viale Regina Elena 324, 00161, Rome, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Di Martino", 
        "givenName": "Michele", 
        "id": "sg:person.01277660452.20", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01277660452.20"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Department of Radiology, Azienda Ospedaliero Universitaria (A.O.U.), di Cagliari, Polo di Monserrato, Cagliari, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Saba", 
        "givenName": "Luca", 
        "id": "sg:person.01332126323.54", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01332126323.54"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Sapienza University of Rome", 
          "id": "https://www.grid.ac/institutes/grid.7841.a", 
          "name": [
            "Department of Radiological, Oncological and Anatomopathological Sciences, Radiology, \u201cSapienza\u201d University of Rome, Viale Regina Elena 324, 00161, Rome, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Catalano", 
        "givenName": "Carlo", 
        "id": "sg:person.01250755056.04", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01250755056.04"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1148/rg.336125162", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002205265"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/rct.0000000000000281", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004011063"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/rct.0000000000000281", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004011063"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/rct.0000000000000281", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004011063"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/pros.23196", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004850642"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00520-011-1144-6", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006527808", 
          "https://doi.org/10.1007/s00520-011-1144-6"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1593/neo.03343", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1007220686"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.bjc.6603515", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1008061600", 
          "https://doi.org/10.1038/sj.bjc.6603515"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.bjc.6603515", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1008061600", 
          "https://doi.org/10.1038/sj.bjc.6603515"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1245/s10434-008-0011-2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1008093770", 
          "https://doi.org/10.1245/s10434-008-0011-2"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s1166-7087(08)74574-3", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1008643020"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.bjc.6605546", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012133557", 
          "https://doi.org/10.1038/sj.bjc.6605546"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0140-6736(02)09520-x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012279775"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0360-3016(03)00208-6", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014801696"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0360-3016(03)00208-6", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014801696"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/mrm.22415", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018247605"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.acra.2014.05.021", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018480750"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1155/2013/740195", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020392716"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0301-5629(01)00454-9", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025871478"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1371/journal.pone.0091779", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1026077034"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/jnci/dju082", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028476617"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.mri.2006.09.006", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030785348"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3109/0284186x.2015.1027411", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032879003"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1158/1078-0432.ccr-09-2932", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033187130"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1148/radiol.13120873", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1034927157"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/jmri.20864", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035043730"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/01.rct.0000171913.74086.1b", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035345088"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/01.rct.0000171913.74086.1b", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035345088"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/01.rct.0000171913.74086.1b", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035345088"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s12032-011-9842-y", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035378336", 
          "https://doi.org/10.1007/s12032-011-9842-y"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/rli.0b013e318285bbab", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036782808"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/rli.0b013e318285bbab", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036782808"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/jmri.22786", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037427011"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/rct.0b013e318230d905", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038613084"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/rct.0b013e318230d905", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038613084"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/jmri.24784", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039917515"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3109/07357909909032842", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1040194930"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1102/1470-7330.2011.9034", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041050307"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.ejrad.2010.03.011", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041441251"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1038/sj.neo.7900009", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041890930"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00520-011-1356-9", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042600757", 
          "https://doi.org/10.1007/s00520-011-1356-9"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.ijsu.2016.06.018", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1043686032"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.clon.2011.03.010", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1043792002"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1148/radiol.10092469", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1044414762"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.4103/0972-3919.119545", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047923662"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.4103/0972-3919.119545", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047923662"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.mric.2015.08.006", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048892507"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00330-013-2792-3", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1049854576", 
          "https://doi.org/10.1007/s00330-013-2792-3"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1136/bcr.11.2009.2457", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1062765673"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1136/bcr.11.2009.2457", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1062765673"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1200/jco.2003.05.069", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1064203595"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1259/bjr.20120174", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1064565027"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1082904521", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1083347306", 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2016-12", 
    "datePublishedReg": "2016-12-01", 
    "description": "PURPOSE: To assess the correlation between functional MRI, including ADC values obtained from DWI and DCE, and clinical outcome in patients with bone metastases treated with MRgFUS.\nMETHODS AND MATERIALS: Twenty-three patients with symptomatic bone metastases underwent MRgFUS treatment (ExAblate 2100 system InSightec) for pain palliation. All patients underwent clinical and imaging follow-up examinations at 1, 3 and 6\u00a0months after treatment. Visual Analog Scale (VAS) score was used to evaluate treatment efficacy in terms of pain palliation while ADC maps obtained by DWI sequences, and DCE data were used for quantitative assessment of treatment response at imaging. Spearman Correlation Coefficient Test was calculated to assess the correlation between VAS, ADC and DCE data.\nRESULTS: All treatments were performed successfully without adverse events. On the basis of VAS score, 16 (69.6\u00a0%) patients were classified as complete clinical responders, 6 (26.1\u00a0%) as partial responders and only one (4.3\u00a0%) was classified as a non-responder. The mean VAS score decreased from 7.09\u00a0\u00b1\u00a01.8 at baseline to 2.65\u00a0\u00b1\u00a01.36 at 1\u00a0month, 1.04\u00a0\u00b1\u00a01.91 at 3\u00a0months and 1.09\u00a0\u00b1\u00a01.99 at 6\u00a0months (p\u00a0<\u00a00.001). Baseline mean ADC value of treated lesions was 1.05\u00a0\u00b1\u00a00.15\u00a0mm2/s, increasing along follow-up period (1.57\u00a0\u00b1\u00a00.27\u00a0mm2/s 1st month; 1.49\u00a0\u00b1\u00a00.3\u00a0mm2/s 3rd month; 1.45\u00a0\u00b1\u00a00.32\u00a0mm2/s 6th month, p\u00a0<\u00a00.001). Non perfused volume (NPV) was 46.4 at 1\u00a0month, 45.2 at 3\u00a0months and 43.8 at 6\u00a0months. Spearman Coefficient demonstrated a statistically significant negative correlation between VAS and ADC values (\u03c1\u00a0=\u00a0-0.684; p\u00a0=\u00a00.03), but no significant correlation between VAS and NPV (\u03c1\u00a0=\u00a00.02216, p\u00a0=\u00a00.9305). Among other DCE data, Ktrans significantly changed in complete responders (3\u00a0months Ktrans\u00a0=\u00a02.14/min; -\u0394Kt\u00a0=\u00a052.65\u00a0% p\u00a0<\u00a00.01) and was not significantly different in partial responders (3\u00a0months Ktrans 0.042/min; \u0394Kt\u00a0=\u00a011.39\u00a0% p\u00a0>\u00a00.01).\nCONCLUSION: In patients with painful bone metastases treated with MRgFUS, ADC and Ktrans variation observed in the ablated lesions correlate with VAS values and may play a role as objective imaging marker of treatment response.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1007/s11547-016-0675-9", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": false, 
    "isPartOf": [
      {
        "id": "sg:journal.1357346", 
        "issn": [
          "0026-4962", 
          "1826-6983"
        ], 
        "name": "La radiologia medica", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "12", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "121"
      }
    ], 
    "name": "Magnetic resonance-guided focused ultrasound for the treatment of painful bone metastases: role of apparent diffusion coefficient (ADC) and dynamic contrast enhanced (DCE) MRI in the assessment of clinical outcome", 
    "pagination": "905-915", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "ee2180736116ec1a13f993e15f839b7cb2779b6bb800d3cfd23cbf38fb5d87ac"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "27567615"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "0177625"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1007/s11547-016-0675-9"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1049988985"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1007/s11547-016-0675-9", 
      "https://app.dimensions.ai/details/publication/pub.1049988985"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-11T12:44", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000363_0000000363/records_70068_00000002.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://link.springer.com/10.1007%2Fs11547-016-0675-9"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s11547-016-0675-9'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s11547-016-0675-9'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s11547-016-0675-9'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s11547-016-0675-9'


 

This table displays all metadata directly associated to this object as RDF triples.

333 TRIPLES      21 PREDICATES      91 URIs      39 LITERALS      27 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1007/s11547-016-0675-9 schema:about N045465b0922d41ba966de24916534720
2 N0d44fcd1fcbd4768a371cf91574c8309
3 N11fdb2545613453c82cff8bb12aa53b2
4 N1a2ea06dce3f43f5a1f1c2050ec8d2b5
5 N1c31b364c9434d00a1abad542e84cfdf
6 N34fdccfa73f840058d07f5e44c7a8abf
7 N3f3bd9b177474978b1117e60e0dca7bd
8 N4004d9495d964874929c29dfc97fef0c
9 N4aceca77d7cd4ac28c940d2fae1a1042
10 N599f222edd944340b73f6a0bbc6a1ad5
11 N5aa0b0e6a9e24427b50de1b05f0753ae
12 N5edd7ac5ec44473e9a0ac3824750fa5b
13 N68c488421ea54bf6bed0d2e2b37cc911
14 N9e7d77c4de8e46e58d685e6475d4e850
15 Na3d56c80491041848eeaa47b0ae7ee3a
16 Nb65dd211c51f4d728dbf620d5e2b7161
17 Ncf6f3264fe5a4e68a47ef14d2bbf92a2
18 Ned04022875574317b64b8df0a9d98c2b
19 anzsrc-for:11
20 anzsrc-for:1103
21 schema:author Na554fdcd94eb4a96991da8455b96742b
22 schema:citation sg:pub.10.1007/s00330-013-2792-3
23 sg:pub.10.1007/s00520-011-1144-6
24 sg:pub.10.1007/s00520-011-1356-9
25 sg:pub.10.1007/s12032-011-9842-y
26 sg:pub.10.1038/sj.bjc.6603515
27 sg:pub.10.1038/sj.bjc.6605546
28 sg:pub.10.1245/s10434-008-0011-2
29 https://app.dimensions.ai/details/publication/pub.1082904521
30 https://app.dimensions.ai/details/publication/pub.1083347306
31 https://doi.org/10.1002/jmri.20864
32 https://doi.org/10.1002/jmri.22786
33 https://doi.org/10.1002/jmri.24784
34 https://doi.org/10.1002/mrm.22415
35 https://doi.org/10.1002/pros.23196
36 https://doi.org/10.1016/j.acra.2014.05.021
37 https://doi.org/10.1016/j.clon.2011.03.010
38 https://doi.org/10.1016/j.ejrad.2010.03.011
39 https://doi.org/10.1016/j.ijsu.2016.06.018
40 https://doi.org/10.1016/j.mri.2006.09.006
41 https://doi.org/10.1016/j.mric.2015.08.006
42 https://doi.org/10.1016/s0140-6736(02)09520-x
43 https://doi.org/10.1016/s0301-5629(01)00454-9
44 https://doi.org/10.1016/s0360-3016(03)00208-6
45 https://doi.org/10.1016/s1166-7087(08)74574-3
46 https://doi.org/10.1038/sj.neo.7900009
47 https://doi.org/10.1093/jnci/dju082
48 https://doi.org/10.1097/01.rct.0000171913.74086.1b
49 https://doi.org/10.1097/rct.0000000000000281
50 https://doi.org/10.1097/rct.0b013e318230d905
51 https://doi.org/10.1097/rli.0b013e318285bbab
52 https://doi.org/10.1102/1470-7330.2011.9034
53 https://doi.org/10.1136/bcr.11.2009.2457
54 https://doi.org/10.1148/radiol.10092469
55 https://doi.org/10.1148/radiol.13120873
56 https://doi.org/10.1148/rg.336125162
57 https://doi.org/10.1155/2013/740195
58 https://doi.org/10.1158/1078-0432.ccr-09-2932
59 https://doi.org/10.1200/jco.2003.05.069
60 https://doi.org/10.1259/bjr.20120174
61 https://doi.org/10.1371/journal.pone.0091779
62 https://doi.org/10.1593/neo.03343
63 https://doi.org/10.3109/0284186x.2015.1027411
64 https://doi.org/10.3109/07357909909032842
65 https://doi.org/10.4103/0972-3919.119545
66 schema:datePublished 2016-12
67 schema:datePublishedReg 2016-12-01
68 schema:description PURPOSE: To assess the correlation between functional MRI, including ADC values obtained from DWI and DCE, and clinical outcome in patients with bone metastases treated with MRgFUS. METHODS AND MATERIALS: Twenty-three patients with symptomatic bone metastases underwent MRgFUS treatment (ExAblate 2100 system InSightec) for pain palliation. All patients underwent clinical and imaging follow-up examinations at 1, 3 and 6 months after treatment. Visual Analog Scale (VAS) score was used to evaluate treatment efficacy in terms of pain palliation while ADC maps obtained by DWI sequences, and DCE data were used for quantitative assessment of treatment response at imaging. Spearman Correlation Coefficient Test was calculated to assess the correlation between VAS, ADC and DCE data. RESULTS: All treatments were performed successfully without adverse events. On the basis of VAS score, 16 (69.6 %) patients were classified as complete clinical responders, 6 (26.1 %) as partial responders and only one (4.3 %) was classified as a non-responder. The mean VAS score decreased from 7.09 ± 1.8 at baseline to 2.65 ± 1.36 at 1 month, 1.04 ± 1.91 at 3 months and 1.09 ± 1.99 at 6 months (p < 0.001). Baseline mean ADC value of treated lesions was 1.05 ± 0.15 mm2/s, increasing along follow-up period (1.57 ± 0.27 mm2/s 1st month; 1.49 ± 0.3 mm2/s 3rd month; 1.45 ± 0.32 mm2/s 6th month, p < 0.001). Non perfused volume (NPV) was 46.4 at 1 month, 45.2 at 3 months and 43.8 at 6 months. Spearman Coefficient demonstrated a statistically significant negative correlation between VAS and ADC values (ρ = -0.684; p = 0.03), but no significant correlation between VAS and NPV (ρ = 0.02216, p = 0.9305). Among other DCE data, Ktrans significantly changed in complete responders (3 months Ktrans = 2.14/min; -ΔKt = 52.65 % p < 0.01) and was not significantly different in partial responders (3 months Ktrans 0.042/min; ΔKt = 11.39 % p > 0.01). CONCLUSION: In patients with painful bone metastases treated with MRgFUS, ADC and Ktrans variation observed in the ablated lesions correlate with VAS values and may play a role as objective imaging marker of treatment response.
69 schema:genre research_article
70 schema:inLanguage en
71 schema:isAccessibleForFree false
72 schema:isPartOf N53cdcb2ec0534cc28c76670ea14235e9
73 N7ca8f02240264b9ab3b1603480767fdd
74 sg:journal.1357346
75 schema:name Magnetic resonance-guided focused ultrasound for the treatment of painful bone metastases: role of apparent diffusion coefficient (ADC) and dynamic contrast enhanced (DCE) MRI in the assessment of clinical outcome
76 schema:pagination 905-915
77 schema:productId N3965517d94314b538e903511058cb152
78 N9796f060c3994089953b39d7f29565f2
79 N9c4308a258344acdb3259a3659aad0a7
80 Ne480f1edb3694998ae56f5861fdda862
81 Nff122e80f56b4637837d67fc2f0acb4d
82 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049988985
83 https://doi.org/10.1007/s11547-016-0675-9
84 schema:sdDatePublished 2019-04-11T12:44
85 schema:sdLicense https://scigraph.springernature.com/explorer/license/
86 schema:sdPublisher N3ece7c2ca97941b6a704771b1334459d
87 schema:url https://link.springer.com/10.1007%2Fs11547-016-0675-9
88 sgo:license sg:explorer/license/
89 sgo:sdDataset articles
90 rdf:type schema:ScholarlyArticle
91 N045465b0922d41ba966de24916534720 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
92 schema:name Humans
93 rdf:type schema:DefinedTerm
94 N0d44fcd1fcbd4768a371cf91574c8309 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
95 schema:name Middle Aged
96 rdf:type schema:DefinedTerm
97 N113a2af757d440ba8c3a516498f18d03 rdf:first sg:person.01304656564.08
98 rdf:rest N4a62358bd9d14f219403faaa35b32dc8
99 N11fdb2545613453c82cff8bb12aa53b2 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
100 schema:name Adult
101 rdf:type schema:DefinedTerm
102 N1a2ea06dce3f43f5a1f1c2050ec8d2b5 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
103 schema:name Female
104 rdf:type schema:DefinedTerm
105 N1c31b364c9434d00a1abad542e84cfdf schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
106 schema:name Life Expectancy
107 rdf:type schema:DefinedTerm
108 N34fdccfa73f840058d07f5e44c7a8abf schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
109 schema:name Aged
110 rdf:type schema:DefinedTerm
111 N3965517d94314b538e903511058cb152 schema:name pubmed_id
112 schema:value 27567615
113 rdf:type schema:PropertyValue
114 N3ece7c2ca97941b6a704771b1334459d schema:name Springer Nature - SN SciGraph project
115 rdf:type schema:Organization
116 N3f3bd9b177474978b1117e60e0dca7bd schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
117 schema:name Male
118 rdf:type schema:DefinedTerm
119 N4004d9495d964874929c29dfc97fef0c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
120 schema:name Contrast Media
121 rdf:type schema:DefinedTerm
122 N4a62358bd9d14f219403faaa35b32dc8 rdf:first sg:person.01277660452.20
123 rdf:rest N79119c29364a4ed28ac28a6fba9f89e7
124 N4aceca77d7cd4ac28c940d2fae1a1042 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
125 schema:name Bone Neoplasms
126 rdf:type schema:DefinedTerm
127 N53cdcb2ec0534cc28c76670ea14235e9 schema:issueNumber 12
128 rdf:type schema:PublicationIssue
129 N599f222edd944340b73f6a0bbc6a1ad5 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
130 schema:name Diffusion Magnetic Resonance Imaging
131 rdf:type schema:DefinedTerm
132 N5aa0b0e6a9e24427b50de1b05f0753ae schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
133 schema:name Surgery, Computer-Assisted
134 rdf:type schema:DefinedTerm
135 N5edd7ac5ec44473e9a0ac3824750fa5b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
136 schema:name Magnetic Resonance Imaging, Interventional
137 rdf:type schema:DefinedTerm
138 N62244fcd430e42c9b125e5f49c0d6cae rdf:first sg:person.01001510455.25
139 rdf:rest N7e865f57f9e24a2e86762f8bc8e97202
140 N68bb886aba894e8a9929c649fcb868de rdf:first sg:person.01351075172.34
141 rdf:rest N62244fcd430e42c9b125e5f49c0d6cae
142 N68c488421ea54bf6bed0d2e2b37cc911 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
143 schema:name Aged, 80 and over
144 rdf:type schema:DefinedTerm
145 N6f1e1b19fe9948d897d27c8905a02c66 schema:name Department of Radiology, Azienda Ospedaliero Universitaria (A.O.U.), di Cagliari, Polo di Monserrato, Cagliari, Italy
146 rdf:type schema:Organization
147 N79119c29364a4ed28ac28a6fba9f89e7 rdf:first sg:person.01332126323.54
148 rdf:rest Nb832ac3fa3d948aa8de4a40fc2ea5822
149 N7ca8f02240264b9ab3b1603480767fdd schema:volumeNumber 121
150 rdf:type schema:PublicationVolume
151 N7e865f57f9e24a2e86762f8bc8e97202 rdf:first sg:person.0657547501.54
152 rdf:rest N113a2af757d440ba8c3a516498f18d03
153 N9796f060c3994089953b39d7f29565f2 schema:name nlm_unique_id
154 schema:value 0177625
155 rdf:type schema:PropertyValue
156 N9c4308a258344acdb3259a3659aad0a7 schema:name doi
157 schema:value 10.1007/s11547-016-0675-9
158 rdf:type schema:PropertyValue
159 N9e7d77c4de8e46e58d685e6475d4e850 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
160 schema:name High-Intensity Focused Ultrasound Ablation
161 rdf:type schema:DefinedTerm
162 Na3d56c80491041848eeaa47b0ae7ee3a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
163 schema:name Magnetic Resonance Imaging
164 rdf:type schema:DefinedTerm
165 Na554fdcd94eb4a96991da8455b96742b rdf:first sg:person.0735362216.50
166 rdf:rest N68bb886aba894e8a9929c649fcb868de
167 Nb65dd211c51f4d728dbf620d5e2b7161 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
168 schema:name Treatment Outcome
169 rdf:type schema:DefinedTerm
170 Nb832ac3fa3d948aa8de4a40fc2ea5822 rdf:first sg:person.01250755056.04
171 rdf:rest rdf:nil
172 Ncf6f3264fe5a4e68a47ef14d2bbf92a2 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
173 schema:name Prospective Studies
174 rdf:type schema:DefinedTerm
175 Ne480f1edb3694998ae56f5861fdda862 schema:name dimensions_id
176 schema:value pub.1049988985
177 rdf:type schema:PropertyValue
178 Ned04022875574317b64b8df0a9d98c2b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
179 schema:name Pain Management
180 rdf:type schema:DefinedTerm
181 Nff122e80f56b4637837d67fc2f0acb4d schema:name readcube_id
182 schema:value ee2180736116ec1a13f993e15f839b7cb2779b6bb800d3cfd23cbf38fb5d87ac
183 rdf:type schema:PropertyValue
184 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
185 schema:name Medical and Health Sciences
186 rdf:type schema:DefinedTerm
187 anzsrc-for:1103 schema:inDefinedTermSet anzsrc-for:
188 schema:name Clinical Sciences
189 rdf:type schema:DefinedTerm
190 sg:journal.1357346 schema:issn 0026-4962
191 1826-6983
192 schema:name La radiologia medica
193 rdf:type schema:Periodical
194 sg:person.01001510455.25 schema:affiliation https://www.grid.ac/institutes/grid.25786.3e
195 schema:familyName Sacconi
196 schema:givenName Beatrice
197 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01001510455.25
198 rdf:type schema:Person
199 sg:person.01250755056.04 schema:affiliation https://www.grid.ac/institutes/grid.7841.a
200 schema:familyName Catalano
201 schema:givenName Carlo
202 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01250755056.04
203 rdf:type schema:Person
204 sg:person.01277660452.20 schema:affiliation https://www.grid.ac/institutes/grid.7841.a
205 schema:familyName Di Martino
206 schema:givenName Michele
207 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01277660452.20
208 rdf:type schema:Person
209 sg:person.01304656564.08 schema:affiliation https://www.grid.ac/institutes/grid.7841.a
210 schema:familyName Noce
211 schema:givenName Vincenzo
212 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01304656564.08
213 rdf:type schema:Person
214 sg:person.01332126323.54 schema:affiliation N6f1e1b19fe9948d897d27c8905a02c66
215 schema:familyName Saba
216 schema:givenName Luca
217 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01332126323.54
218 rdf:type schema:Person
219 sg:person.01351075172.34 schema:affiliation https://www.grid.ac/institutes/grid.7841.a
220 schema:familyName Napoli
221 schema:givenName Alessandro
222 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01351075172.34
223 rdf:type schema:Person
224 sg:person.0657547501.54 schema:affiliation https://www.grid.ac/institutes/grid.7841.a
225 schema:familyName Boni
226 schema:givenName Fabrizio
227 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0657547501.54
228 rdf:type schema:Person
229 sg:person.0735362216.50 schema:affiliation https://www.grid.ac/institutes/grid.7841.a
230 schema:familyName Anzidei
231 schema:givenName Michele
232 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0735362216.50
233 rdf:type schema:Person
234 sg:pub.10.1007/s00330-013-2792-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049854576
235 https://doi.org/10.1007/s00330-013-2792-3
236 rdf:type schema:CreativeWork
237 sg:pub.10.1007/s00520-011-1144-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006527808
238 https://doi.org/10.1007/s00520-011-1144-6
239 rdf:type schema:CreativeWork
240 sg:pub.10.1007/s00520-011-1356-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042600757
241 https://doi.org/10.1007/s00520-011-1356-9
242 rdf:type schema:CreativeWork
243 sg:pub.10.1007/s12032-011-9842-y schema:sameAs https://app.dimensions.ai/details/publication/pub.1035378336
244 https://doi.org/10.1007/s12032-011-9842-y
245 rdf:type schema:CreativeWork
246 sg:pub.10.1038/sj.bjc.6603515 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008061600
247 https://doi.org/10.1038/sj.bjc.6603515
248 rdf:type schema:CreativeWork
249 sg:pub.10.1038/sj.bjc.6605546 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012133557
250 https://doi.org/10.1038/sj.bjc.6605546
251 rdf:type schema:CreativeWork
252 sg:pub.10.1245/s10434-008-0011-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008093770
253 https://doi.org/10.1245/s10434-008-0011-2
254 rdf:type schema:CreativeWork
255 https://app.dimensions.ai/details/publication/pub.1082904521 schema:CreativeWork
256 https://app.dimensions.ai/details/publication/pub.1083347306 schema:CreativeWork
257 https://doi.org/10.1002/jmri.20864 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035043730
258 rdf:type schema:CreativeWork
259 https://doi.org/10.1002/jmri.22786 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037427011
260 rdf:type schema:CreativeWork
261 https://doi.org/10.1002/jmri.24784 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039917515
262 rdf:type schema:CreativeWork
263 https://doi.org/10.1002/mrm.22415 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018247605
264 rdf:type schema:CreativeWork
265 https://doi.org/10.1002/pros.23196 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004850642
266 rdf:type schema:CreativeWork
267 https://doi.org/10.1016/j.acra.2014.05.021 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018480750
268 rdf:type schema:CreativeWork
269 https://doi.org/10.1016/j.clon.2011.03.010 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043792002
270 rdf:type schema:CreativeWork
271 https://doi.org/10.1016/j.ejrad.2010.03.011 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041441251
272 rdf:type schema:CreativeWork
273 https://doi.org/10.1016/j.ijsu.2016.06.018 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043686032
274 rdf:type schema:CreativeWork
275 https://doi.org/10.1016/j.mri.2006.09.006 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030785348
276 rdf:type schema:CreativeWork
277 https://doi.org/10.1016/j.mric.2015.08.006 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048892507
278 rdf:type schema:CreativeWork
279 https://doi.org/10.1016/s0140-6736(02)09520-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1012279775
280 rdf:type schema:CreativeWork
281 https://doi.org/10.1016/s0301-5629(01)00454-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025871478
282 rdf:type schema:CreativeWork
283 https://doi.org/10.1016/s0360-3016(03)00208-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014801696
284 rdf:type schema:CreativeWork
285 https://doi.org/10.1016/s1166-7087(08)74574-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008643020
286 rdf:type schema:CreativeWork
287 https://doi.org/10.1038/sj.neo.7900009 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041890930
288 rdf:type schema:CreativeWork
289 https://doi.org/10.1093/jnci/dju082 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028476617
290 rdf:type schema:CreativeWork
291 https://doi.org/10.1097/01.rct.0000171913.74086.1b schema:sameAs https://app.dimensions.ai/details/publication/pub.1035345088
292 rdf:type schema:CreativeWork
293 https://doi.org/10.1097/rct.0000000000000281 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004011063
294 rdf:type schema:CreativeWork
295 https://doi.org/10.1097/rct.0b013e318230d905 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038613084
296 rdf:type schema:CreativeWork
297 https://doi.org/10.1097/rli.0b013e318285bbab schema:sameAs https://app.dimensions.ai/details/publication/pub.1036782808
298 rdf:type schema:CreativeWork
299 https://doi.org/10.1102/1470-7330.2011.9034 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041050307
300 rdf:type schema:CreativeWork
301 https://doi.org/10.1136/bcr.11.2009.2457 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062765673
302 rdf:type schema:CreativeWork
303 https://doi.org/10.1148/radiol.10092469 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044414762
304 rdf:type schema:CreativeWork
305 https://doi.org/10.1148/radiol.13120873 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034927157
306 rdf:type schema:CreativeWork
307 https://doi.org/10.1148/rg.336125162 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002205265
308 rdf:type schema:CreativeWork
309 https://doi.org/10.1155/2013/740195 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020392716
310 rdf:type schema:CreativeWork
311 https://doi.org/10.1158/1078-0432.ccr-09-2932 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033187130
312 rdf:type schema:CreativeWork
313 https://doi.org/10.1200/jco.2003.05.069 schema:sameAs https://app.dimensions.ai/details/publication/pub.1064203595
314 rdf:type schema:CreativeWork
315 https://doi.org/10.1259/bjr.20120174 schema:sameAs https://app.dimensions.ai/details/publication/pub.1064565027
316 rdf:type schema:CreativeWork
317 https://doi.org/10.1371/journal.pone.0091779 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026077034
318 rdf:type schema:CreativeWork
319 https://doi.org/10.1593/neo.03343 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007220686
320 rdf:type schema:CreativeWork
321 https://doi.org/10.3109/0284186x.2015.1027411 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032879003
322 rdf:type schema:CreativeWork
323 https://doi.org/10.3109/07357909909032842 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040194930
324 rdf:type schema:CreativeWork
325 https://doi.org/10.4103/0972-3919.119545 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047923662
326 rdf:type schema:CreativeWork
327 https://www.grid.ac/institutes/grid.25786.3e schema:alternateName Italian Institute of Technology
328 schema:name Center for Life Nano Science@Sapienza, Istituto Italiano di Tecnologia, Viale Regina Elena 291, Rome, Italy
329 Department of Radiological, Oncological and Anatomopathological Sciences, Radiology, “Sapienza” University of Rome, Viale Regina Elena 324, 00161, Rome, Italy
330 rdf:type schema:Organization
331 https://www.grid.ac/institutes/grid.7841.a schema:alternateName Sapienza University of Rome
332 schema:name Department of Radiological, Oncological and Anatomopathological Sciences, Radiology, “Sapienza” University of Rome, Viale Regina Elena 324, 00161, Rome, Italy
333 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...