Tumours of the atlas and axis: a 37-year experience with diagnosis and management View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2011-11-17

AUTHORS

A. F. Mavrogenis, G. Guerra, M. Romantini, C. Romagnoli, R. Casadei, P. Ruggieri

ABSTRACT

PurposeThis paper presents a single institution’s longterm experience regarding the incidence and management of tumours of the atlas and axis and discusses clinical and imaging findings and treatment options.Materials and methodsWe searched the registry of the Istituto Ortopedico Rizzoli for patients admitted and treated for tumours of the upper cervical spine. We identified 62 patients over 37 years, from July 1973 to October 2010. There were 39 male and 23 female patients, with a mean age of 39.5 (range 5–77) years. For each patient, we collected data on clinical presentation, imaging and treatment. Mean follow-up was 10 years.ResultsBenign bone tumours were diagnosed in 24 (39%) and malignant tumours in 38 (61%) patients. The most common tumours were bone metastases, followed by osteoid osteomas and chordomas. The atlas was involved in six and the axis in 52 patients; in four patients, both the atlas and axis were involved. The most common clinical presentation was pain, torticollis, dysphagia and neurological deficits. Surgical treatment was performed in 35 patients and conservative treatment, including intralesional methylprednisolone injections and halo-vest immobilisation with or without radiation therapy, chemotherapy or embolisation, in the remaining patients. One patient with osteoblastoma of the atlas had local recurrence. All patients with metastatic bone disease had local recurrence; four of the eight patients with plasmacytoma progressed to multiple myeloma within 1–4 years. All patients with chordomas had two to four local recurrences. Patients with osteosarcomas and chondrosarcoma died owing to local and distant disease progression.ConclusionsBone tumours of the cervical spine are rare. However, they should be kept in mind when examining patients with neck pain or neurological symptoms at the extremities. In most cases, only intralesional surgery can be administered. Combined radiation therapy and chemotherapy is indicated for certain tumour histologies. More... »

PAGES

616-635

References to SciGraph publications

  • 2009-11-18. Odontoid metastasis: a potential lethal complication in JOURNAL OF ORTHOPAEDICS AND TRAUMATOLOGY
  • 1981-09. Fibromyxoma of the femoral neck in JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
  • 1992-07. CT-guided percutaneous biopsy of the cervical spine: a series of 12 cases in NEURORADIOLOGY
  • 2010-10-08. CT-guided corticosteroid injection for solitary eosinophilic granuloma of the spine in SKELETAL RADIOLOGY
  • 2008-04-10. Craniovertebral junction neoplasms in the pediatric population in CHILD'S NERVOUS SYSTEM
  • 1995-09. Spinal cord compression by eosinophilic granuloma of the cervical spine. Case report and review of the literature in NEUROSURGICAL REVIEW
  • 1995-06. Surgical management of haemangioendothelioma of the spine in EUROPEAN SPINE JOURNAL
  • 2006-05-01. Osteoma in the upper cervical spine with spinal cord compression in EUROPEAN SPINE JOURNAL
  • 1991-02. Fibromyxoma of bone in SKELETAL RADIOLOGY
  • 2002-11-21. Vertebral chondroblastoma in SKELETAL RADIOLOGY
  • 2008-04-04. Anatomy and biomechanics of normal craniovertebral junction (a) and biomechanics of stabilization (b) in CHILD'S NERVOUS SYSTEM
  • 1994-01. Total en bloc spondylectomy and circumspinal decompression for solitary spinal metastasis in SPINAL CORD
  • 2007-10-25. Benign osteoblastoma of the odontoid process of the axis with secondary aneurysmal bone cyst component: a case report in NEUROSURGICAL REVIEW
  • 2001-02. Surgical treatment of giant cell tumours of the thoracic and lumbar spine: report of nine patients in EUROPEAN SPINE JOURNAL
  • 2000-01. Myxoma of the humerus: an exceptional site of origin in SKELETAL RADIOLOGY
  • 2006-05-17. Bone tumors at the cranio-cervical junction. Surgical management and results from a series of 41 cases in ACTA NEUROCHIRURGICA
  • 1999-05. Aneurysmal bone cysts of the spine in ARCHIVES OF ORTHOPAEDIC AND TRAUMA SURGERY
  • 1985-01. Spinal osteoblastoma in children and adolescents in CHILD'S NERVOUS SYSTEM
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1007/s11547-011-0753-y

    DOI

    http://dx.doi.org/10.1007/s11547-011-0753-y

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1037744146

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/22095422


    Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
    Incoming Citations Browse incoming citations for this publication using opencitations.net

    JSON-LD is the canonical representation for SciGraph data.

    TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

    [
      {
        "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
        "about": [
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Medical and Health Sciences", 
            "type": "DefinedTerm"
          }, 
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1103", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Clinical Sciences", 
            "type": "DefinedTerm"
          }, 
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1112", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Oncology and Carcinogenesis", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Adolescent", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Adult", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Aged", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Axis, Cervical Vertebra", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Cervical Atlas", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Child", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Child, Preschool", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Diagnosis, Differential", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Disease Progression", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Female", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Humans", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Italy", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Magnetic Resonance Imaging", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Male", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Middle Aged", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Spinal Neoplasms", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Tomography, X-Ray Computed", 
            "type": "DefinedTerm"
          }
        ], 
        "author": [
          {
            "affiliation": {
              "alternateName": "Orthopaedic Oncology Service, Department of Orthopaedics, Istituto Ortopedico Rizzoli, University of Bologna, Via Di Barbiano 1/10, 40136, Bologna, Italy", 
              "id": "http://www.grid.ac/institutes/None", 
              "name": [
                "Orthopaedic Oncology Service, Department of Orthopaedics, Istituto Ortopedico Rizzoli, University of Bologna, Via Di Barbiano 1/10, 40136, Bologna, Italy"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Mavrogenis", 
            "givenName": "A. F.", 
            "id": "sg:person.01366422124.48", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01366422124.48"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Orthopaedic Oncology Service, Department of Orthopaedics, Istituto Ortopedico Rizzoli, University of Bologna, Via Di Barbiano 1/10, 40136, Bologna, Italy", 
              "id": "http://www.grid.ac/institutes/None", 
              "name": [
                "Orthopaedic Oncology Service, Department of Orthopaedics, Istituto Ortopedico Rizzoli, University of Bologna, Via Di Barbiano 1/10, 40136, Bologna, Italy"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Guerra", 
            "givenName": "G.", 
            "id": "sg:person.01056372431.26", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01056372431.26"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Orthopaedic Oncology Service, Department of Orthopaedics, Istituto Ortopedico Rizzoli, University of Bologna, Via Di Barbiano 1/10, 40136, Bologna, Italy", 
              "id": "http://www.grid.ac/institutes/None", 
              "name": [
                "Orthopaedic Oncology Service, Department of Orthopaedics, Istituto Ortopedico Rizzoli, University of Bologna, Via Di Barbiano 1/10, 40136, Bologna, Italy"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Romantini", 
            "givenName": "M.", 
            "id": "sg:person.0624431707.14", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0624431707.14"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Orthopaedic Oncology Service, Department of Orthopaedics, Istituto Ortopedico Rizzoli, University of Bologna, Via Di Barbiano 1/10, 40136, Bologna, Italy", 
              "id": "http://www.grid.ac/institutes/None", 
              "name": [
                "Orthopaedic Oncology Service, Department of Orthopaedics, Istituto Ortopedico Rizzoli, University of Bologna, Via Di Barbiano 1/10, 40136, Bologna, Italy"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Romagnoli", 
            "givenName": "C.", 
            "id": "sg:person.01301722607.21", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01301722607.21"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Orthopaedic Oncology Service, Department of Orthopaedics, Istituto Ortopedico Rizzoli, University of Bologna, Via Di Barbiano 1/10, 40136, Bologna, Italy", 
              "id": "http://www.grid.ac/institutes/None", 
              "name": [
                "Orthopaedic Oncology Service, Department of Orthopaedics, Istituto Ortopedico Rizzoli, University of Bologna, Via Di Barbiano 1/10, 40136, Bologna, Italy"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Casadei", 
            "givenName": "R.", 
            "id": "sg:person.010347170674.75", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010347170674.75"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Orthopaedic Oncology Service, Department of Orthopaedics, Istituto Ortopedico Rizzoli, University of Bologna, Via Di Barbiano 1/10, 40136, Bologna, Italy", 
              "id": "http://www.grid.ac/institutes/None", 
              "name": [
                "Orthopaedic Oncology Service, Department of Orthopaedics, Istituto Ortopedico Rizzoli, University of Bologna, Via Di Barbiano 1/10, 40136, Bologna, Italy"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Ruggieri", 
            "givenName": "P.", 
            "id": "sg:person.01267530665.46", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01267530665.46"
            ], 
            "type": "Person"
          }
        ], 
        "citation": [
          {
            "id": "sg:pub.10.1007/s00256-010-1045-7", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1044361404", 
              "https://doi.org/10.1007/s00256-010-1045-7"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00586-006-0107-y", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1047455115", 
              "https://doi.org/10.1007/s00586-006-0107-y"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/bf00298244", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1038082102", 
              "https://doi.org/10.1007/bf00298244"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00256-002-0599-4", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1004924893", 
              "https://doi.org/10.1007/s00256-002-0599-4"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00701-006-0789-2", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1007401320", 
              "https://doi.org/10.1007/s00701-006-0789-2"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00381-008-0606-8", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1000275018", 
              "https://doi.org/10.1007/s00381-008-0606-8"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/bf00383729", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1012296973", 
              "https://doi.org/10.1007/bf00383729"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s005860000206", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1005327747", 
              "https://doi.org/10.1007/s005860000206"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/bf00413312", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1013463793", 
              "https://doi.org/10.1007/bf00413312"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s10143-007-0113-5", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1028964209", 
              "https://doi.org/10.1007/s10143-007-0113-5"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/sc.1994.7", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1033059902", 
              "https://doi.org/10.1038/sc.1994.7"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s004020050381", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1039380579", 
              "https://doi.org/10.1007/s004020050381"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/bf00706727", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1040706864", 
              "https://doi.org/10.1007/bf00706727"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00381-008-0598-4", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1015083856", 
              "https://doi.org/10.1007/s00381-008-0598-4"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s002560050011", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1024170306", 
              "https://doi.org/10.1007/s002560050011"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s10195-009-0073-3", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1050001110", 
              "https://doi.org/10.1007/s10195-009-0073-3"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/bf00588205", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1017917950", 
              "https://doi.org/10.1007/bf00588205"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/bf00193818", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1022060471", 
              "https://doi.org/10.1007/bf00193818"
            ], 
            "type": "CreativeWork"
          }
        ], 
        "datePublished": "2011-11-17", 
        "datePublishedReg": "2011-11-17", 
        "description": "PurposeThis paper presents a single institution\u2019s longterm experience regarding the incidence and management of tumours of the atlas and axis and discusses clinical and imaging findings and treatment options.Materials and methodsWe searched the registry of the Istituto Ortopedico Rizzoli for patients admitted and treated for tumours of the upper cervical spine. We identified 62 patients over 37 years, from July 1973 to October 2010. There were 39 male and 23 female patients, with a mean age of 39.5 (range 5\u201377) years. For each patient, we collected data on clinical presentation, imaging and treatment. Mean follow-up was 10 years.ResultsBenign bone tumours were diagnosed in 24 (39%) and malignant tumours in 38 (61%) patients. The most common tumours were bone metastases, followed by osteoid osteomas and chordomas. The atlas was involved in six and the axis in 52 patients; in four patients, both the atlas and axis were involved. The most common clinical presentation was pain, torticollis, dysphagia and neurological deficits. Surgical treatment was performed in 35 patients and conservative treatment, including intralesional methylprednisolone injections and halo-vest immobilisation with or without radiation therapy, chemotherapy or embolisation, in the remaining patients. One patient with osteoblastoma of the atlas had local recurrence. All patients with metastatic bone disease had local recurrence; four of the eight patients with plasmacytoma progressed to multiple myeloma within 1\u20134 years. All patients with chordomas had two to four local recurrences. Patients with osteosarcomas and chondrosarcoma died owing to local and distant disease progression.ConclusionsBone tumours of the cervical spine are rare. However, they should be kept in mind when examining patients with neck pain or neurological symptoms at the extremities. In most cases, only intralesional surgery can be administered. Combined radiation therapy and chemotherapy is indicated for certain tumour histologies.", 
        "genre": "article", 
        "id": "sg:pub.10.1007/s11547-011-0753-y", 
        "isAccessibleForFree": false, 
        "isPartOf": [
          {
            "id": "sg:journal.1371234", 
            "issn": [
              "0026-4962", 
              "1826-6983"
            ], 
            "name": "La radiologia medica", 
            "publisher": "Springer Nature", 
            "type": "Periodical"
          }, 
          {
            "issueNumber": "4", 
            "type": "PublicationIssue"
          }, 
          {
            "type": "PublicationVolume", 
            "volumeNumber": "117"
          }
        ], 
        "keywords": [
          "local recurrence", 
          "clinical presentation", 
          "cervical spine", 
          "radiation therapy", 
          "intralesional methylprednisolone injection", 
          "halo vest immobilisation", 
          "distant disease progression", 
          "common clinical presentation", 
          "metastatic bone disease", 
          "Istituto Ortopedico Rizzoli", 
          "combined radiation therapy", 
          "management of tumors", 
          "upper cervical spine", 
          "longterm experience", 
          "methylprednisolone injection", 
          "neck pain", 
          "neurological deficits", 
          "conservative treatment", 
          "bone metastases", 
          "surgical treatment", 
          "intralesional surgery", 
          "female patients", 
          "neurological symptoms", 
          "tumor histology", 
          "treatment options", 
          "mean age", 
          "multiple myeloma", 
          "common tumors", 
          "osteoid osteoma", 
          "bone tumors", 
          "disease progression", 
          "malignant tumors", 
          "bone disease", 
          "patients", 
          "tumors", 
          "recurrence", 
          "pain", 
          "chemotherapy", 
          "therapy", 
          "chordoma", 
          "treatment", 
          "spine", 
          "presentation", 
          "years", 
          "most cases", 
          "dysphagia", 
          "embolisation", 
          "atlas", 
          "torticollis", 
          "myeloma", 
          "surgery", 
          "osteoblastoma", 
          "osteoma", 
          "registry", 
          "metastasis", 
          "osteosarcoma", 
          "plasmacytoma", 
          "chondrosarcoma", 
          "symptoms", 
          "histology", 
          "incidence", 
          "MethodsWe", 
          "disease", 
          "extremities", 
          "diagnosis", 
          "progression", 
          "Rizzoli", 
          "age", 
          "management", 
          "injection", 
          "deficits", 
          "imaging", 
          "axis", 
          "experience", 
          "options", 
          "PurposeThis paper", 
          "findings", 
          "cases", 
          "immobilisation", 
          "data", 
          "mind", 
          "materials", 
          "discusses", 
          "paper"
        ], 
        "name": "Tumours of the atlas and axis: a 37-year experience with diagnosis and management", 
        "pagination": "616-635", 
        "productId": [
          {
            "name": "dimensions_id", 
            "type": "PropertyValue", 
            "value": [
              "pub.1037744146"
            ]
          }, 
          {
            "name": "doi", 
            "type": "PropertyValue", 
            "value": [
              "10.1007/s11547-011-0753-y"
            ]
          }, 
          {
            "name": "pubmed_id", 
            "type": "PropertyValue", 
            "value": [
              "22095422"
            ]
          }
        ], 
        "sameAs": [
          "https://doi.org/10.1007/s11547-011-0753-y", 
          "https://app.dimensions.ai/details/publication/pub.1037744146"
        ], 
        "sdDataset": "articles", 
        "sdDatePublished": "2022-12-01T06:28", 
        "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
        "sdPublisher": {
          "name": "Springer Nature - SN SciGraph project", 
          "type": "Organization"
        }, 
        "sdSource": "s3://com-springernature-scigraph/baseset/20221201/entities/gbq_results/article/article_526.jsonl", 
        "type": "ScholarlyArticle", 
        "url": "https://doi.org/10.1007/s11547-011-0753-y"
      }
    ]
     

    Download the RDF metadata as:  json-ld nt turtle xml License info

    HOW TO GET THIS DATA PROGRAMMATICALLY:

    JSON-LD is a popular format for linked data which is fully compatible with JSON.

    curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s11547-011-0753-y'

    N-Triples is a line-based linked data format ideal for batch operations.

    curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s11547-011-0753-y'

    Turtle is a human-readable linked data format.

    curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s11547-011-0753-y'

    RDF/XML is a standard XML format for linked data.

    curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s11547-011-0753-y'


     

    This table displays all metadata directly associated to this object as RDF triples.

    324 TRIPLES      21 PREDICATES      145 URIs      118 LITERALS      24 BLANK NODES

    Subject Predicate Object
    1 sg:pub.10.1007/s11547-011-0753-y schema:about N16fda1d17ac6476cbcce16dbbcf2a5df
    2 N1cb1bf6b7419449ba43656b51047afea
    3 N2c04a78eee6d4cc49c8ce8908b589990
    4 N32fb3a0a8b104dd689b3486f17a26dd0
    5 N3897f6f112004578841e54a3cdbcc991
    6 N4254b71c177040bf938c6f933fcab825
    7 N68ea931acf91485ea986dc5e90bce037
    8 N71fce11d5d99436fa414c34bb7a097c2
    9 N7af7bb4b071d4d00b9e16ec26bbb4694
    10 N926ffde21bc1486886100a4e9f8f1d18
    11 N9764e2c08f8947d087ff3684364e90a0
    12 Nb4ad18731b804f43b84a94793540c643
    13 Nb9626aaa28e2451382b6afc430baba9e
    14 Nc69f39d6449c4469abd20963223fe254
    15 Nd32943fc3de14731be1b0a6db5682674
    16 Ne4e27d1b6b3e417ab811b3934a1eaca2
    17 Ned9916b1573e426d8988b68fbda1ef88
    18 anzsrc-for:11
    19 anzsrc-for:1103
    20 anzsrc-for:1112
    21 schema:author N0efd1aaf16e8413b8f2b619892efb367
    22 schema:citation sg:pub.10.1007/bf00193818
    23 sg:pub.10.1007/bf00298244
    24 sg:pub.10.1007/bf00383729
    25 sg:pub.10.1007/bf00413312
    26 sg:pub.10.1007/bf00588205
    27 sg:pub.10.1007/bf00706727
    28 sg:pub.10.1007/s00256-002-0599-4
    29 sg:pub.10.1007/s00256-010-1045-7
    30 sg:pub.10.1007/s002560050011
    31 sg:pub.10.1007/s00381-008-0598-4
    32 sg:pub.10.1007/s00381-008-0606-8
    33 sg:pub.10.1007/s004020050381
    34 sg:pub.10.1007/s00586-006-0107-y
    35 sg:pub.10.1007/s005860000206
    36 sg:pub.10.1007/s00701-006-0789-2
    37 sg:pub.10.1007/s10143-007-0113-5
    38 sg:pub.10.1007/s10195-009-0073-3
    39 sg:pub.10.1038/sc.1994.7
    40 schema:datePublished 2011-11-17
    41 schema:datePublishedReg 2011-11-17
    42 schema:description PurposeThis paper presents a single institution’s longterm experience regarding the incidence and management of tumours of the atlas and axis and discusses clinical and imaging findings and treatment options.Materials and methodsWe searched the registry of the Istituto Ortopedico Rizzoli for patients admitted and treated for tumours of the upper cervical spine. We identified 62 patients over 37 years, from July 1973 to October 2010. There were 39 male and 23 female patients, with a mean age of 39.5 (range 5–77) years. For each patient, we collected data on clinical presentation, imaging and treatment. Mean follow-up was 10 years.ResultsBenign bone tumours were diagnosed in 24 (39%) and malignant tumours in 38 (61%) patients. The most common tumours were bone metastases, followed by osteoid osteomas and chordomas. The atlas was involved in six and the axis in 52 patients; in four patients, both the atlas and axis were involved. The most common clinical presentation was pain, torticollis, dysphagia and neurological deficits. Surgical treatment was performed in 35 patients and conservative treatment, including intralesional methylprednisolone injections and halo-vest immobilisation with or without radiation therapy, chemotherapy or embolisation, in the remaining patients. One patient with osteoblastoma of the atlas had local recurrence. All patients with metastatic bone disease had local recurrence; four of the eight patients with plasmacytoma progressed to multiple myeloma within 1–4 years. All patients with chordomas had two to four local recurrences. Patients with osteosarcomas and chondrosarcoma died owing to local and distant disease progression.ConclusionsBone tumours of the cervical spine are rare. However, they should be kept in mind when examining patients with neck pain or neurological symptoms at the extremities. In most cases, only intralesional surgery can be administered. Combined radiation therapy and chemotherapy is indicated for certain tumour histologies.
    43 schema:genre article
    44 schema:isAccessibleForFree false
    45 schema:isPartOf N8977d3ea9fb8454d95fd1ff99c8f2809
    46 Nb8ac9edce0494cb199391a6eaed4ff49
    47 sg:journal.1371234
    48 schema:keywords Istituto Ortopedico Rizzoli
    49 MethodsWe
    50 PurposeThis paper
    51 Rizzoli
    52 age
    53 atlas
    54 axis
    55 bone disease
    56 bone metastases
    57 bone tumors
    58 cases
    59 cervical spine
    60 chemotherapy
    61 chondrosarcoma
    62 chordoma
    63 clinical presentation
    64 combined radiation therapy
    65 common clinical presentation
    66 common tumors
    67 conservative treatment
    68 data
    69 deficits
    70 diagnosis
    71 discusses
    72 disease
    73 disease progression
    74 distant disease progression
    75 dysphagia
    76 embolisation
    77 experience
    78 extremities
    79 female patients
    80 findings
    81 halo vest immobilisation
    82 histology
    83 imaging
    84 immobilisation
    85 incidence
    86 injection
    87 intralesional methylprednisolone injection
    88 intralesional surgery
    89 local recurrence
    90 longterm experience
    91 malignant tumors
    92 management
    93 management of tumors
    94 materials
    95 mean age
    96 metastasis
    97 metastatic bone disease
    98 methylprednisolone injection
    99 mind
    100 most cases
    101 multiple myeloma
    102 myeloma
    103 neck pain
    104 neurological deficits
    105 neurological symptoms
    106 options
    107 osteoblastoma
    108 osteoid osteoma
    109 osteoma
    110 osteosarcoma
    111 pain
    112 paper
    113 patients
    114 plasmacytoma
    115 presentation
    116 progression
    117 radiation therapy
    118 recurrence
    119 registry
    120 spine
    121 surgery
    122 surgical treatment
    123 symptoms
    124 therapy
    125 torticollis
    126 treatment
    127 treatment options
    128 tumor histology
    129 tumors
    130 upper cervical spine
    131 years
    132 schema:name Tumours of the atlas and axis: a 37-year experience with diagnosis and management
    133 schema:pagination 616-635
    134 schema:productId N0546d10fcc5f4c3f9f749084e3c59f7c
    135 N18445580dbf64136a69ade5fd6ac07cc
    136 N96cb30ba05ff45bc93c7a76ae3c97169
    137 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037744146
    138 https://doi.org/10.1007/s11547-011-0753-y
    139 schema:sdDatePublished 2022-12-01T06:28
    140 schema:sdLicense https://scigraph.springernature.com/explorer/license/
    141 schema:sdPublisher Nf3d00cb4c1f84285bee78d9077033d20
    142 schema:url https://doi.org/10.1007/s11547-011-0753-y
    143 sgo:license sg:explorer/license/
    144 sgo:sdDataset articles
    145 rdf:type schema:ScholarlyArticle
    146 N0546d10fcc5f4c3f9f749084e3c59f7c schema:name doi
    147 schema:value 10.1007/s11547-011-0753-y
    148 rdf:type schema:PropertyValue
    149 N0efd1aaf16e8413b8f2b619892efb367 rdf:first sg:person.01366422124.48
    150 rdf:rest N277555d7a5824408b3888476a3ec673e
    151 N16fda1d17ac6476cbcce16dbbcf2a5df schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    152 schema:name Female
    153 rdf:type schema:DefinedTerm
    154 N18445580dbf64136a69ade5fd6ac07cc schema:name dimensions_id
    155 schema:value pub.1037744146
    156 rdf:type schema:PropertyValue
    157 N1cb1bf6b7419449ba43656b51047afea schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    158 schema:name Humans
    159 rdf:type schema:DefinedTerm
    160 N277555d7a5824408b3888476a3ec673e rdf:first sg:person.01056372431.26
    161 rdf:rest Nd0c1bb8484df4fd0bcbe101e350d6be4
    162 N2c04a78eee6d4cc49c8ce8908b589990 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    163 schema:name Child
    164 rdf:type schema:DefinedTerm
    165 N32fb3a0a8b104dd689b3486f17a26dd0 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    166 schema:name Adolescent
    167 rdf:type schema:DefinedTerm
    168 N34342d50844b4a0193475fd34404e45d rdf:first sg:person.010347170674.75
    169 rdf:rest N4a257e892a7945ceaea81bb7f6663861
    170 N3897f6f112004578841e54a3cdbcc991 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    171 schema:name Disease Progression
    172 rdf:type schema:DefinedTerm
    173 N4254b71c177040bf938c6f933fcab825 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    174 schema:name Italy
    175 rdf:type schema:DefinedTerm
    176 N4a257e892a7945ceaea81bb7f6663861 rdf:first sg:person.01267530665.46
    177 rdf:rest rdf:nil
    178 N606a9b17d5864ae0a21e7c126ec21f81 rdf:first sg:person.01301722607.21
    179 rdf:rest N34342d50844b4a0193475fd34404e45d
    180 N68ea931acf91485ea986dc5e90bce037 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    181 schema:name Male
    182 rdf:type schema:DefinedTerm
    183 N71fce11d5d99436fa414c34bb7a097c2 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    184 schema:name Cervical Atlas
    185 rdf:type schema:DefinedTerm
    186 N7af7bb4b071d4d00b9e16ec26bbb4694 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    187 schema:name Adult
    188 rdf:type schema:DefinedTerm
    189 N8977d3ea9fb8454d95fd1ff99c8f2809 schema:volumeNumber 117
    190 rdf:type schema:PublicationVolume
    191 N926ffde21bc1486886100a4e9f8f1d18 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    192 schema:name Child, Preschool
    193 rdf:type schema:DefinedTerm
    194 N96cb30ba05ff45bc93c7a76ae3c97169 schema:name pubmed_id
    195 schema:value 22095422
    196 rdf:type schema:PropertyValue
    197 N9764e2c08f8947d087ff3684364e90a0 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    198 schema:name Middle Aged
    199 rdf:type schema:DefinedTerm
    200 Nb4ad18731b804f43b84a94793540c643 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    201 schema:name Spinal Neoplasms
    202 rdf:type schema:DefinedTerm
    203 Nb8ac9edce0494cb199391a6eaed4ff49 schema:issueNumber 4
    204 rdf:type schema:PublicationIssue
    205 Nb9626aaa28e2451382b6afc430baba9e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    206 schema:name Axis, Cervical Vertebra
    207 rdf:type schema:DefinedTerm
    208 Nc69f39d6449c4469abd20963223fe254 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    209 schema:name Tomography, X-Ray Computed
    210 rdf:type schema:DefinedTerm
    211 Nd0c1bb8484df4fd0bcbe101e350d6be4 rdf:first sg:person.0624431707.14
    212 rdf:rest N606a9b17d5864ae0a21e7c126ec21f81
    213 Nd32943fc3de14731be1b0a6db5682674 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    214 schema:name Diagnosis, Differential
    215 rdf:type schema:DefinedTerm
    216 Ne4e27d1b6b3e417ab811b3934a1eaca2 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    217 schema:name Magnetic Resonance Imaging
    218 rdf:type schema:DefinedTerm
    219 Ned9916b1573e426d8988b68fbda1ef88 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    220 schema:name Aged
    221 rdf:type schema:DefinedTerm
    222 Nf3d00cb4c1f84285bee78d9077033d20 schema:name Springer Nature - SN SciGraph project
    223 rdf:type schema:Organization
    224 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
    225 schema:name Medical and Health Sciences
    226 rdf:type schema:DefinedTerm
    227 anzsrc-for:1103 schema:inDefinedTermSet anzsrc-for:
    228 schema:name Clinical Sciences
    229 rdf:type schema:DefinedTerm
    230 anzsrc-for:1112 schema:inDefinedTermSet anzsrc-for:
    231 schema:name Oncology and Carcinogenesis
    232 rdf:type schema:DefinedTerm
    233 sg:journal.1371234 schema:issn 0026-4962
    234 1826-6983
    235 schema:name La radiologia medica
    236 schema:publisher Springer Nature
    237 rdf:type schema:Periodical
    238 sg:person.010347170674.75 schema:affiliation grid-institutes:None
    239 schema:familyName Casadei
    240 schema:givenName R.
    241 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010347170674.75
    242 rdf:type schema:Person
    243 sg:person.01056372431.26 schema:affiliation grid-institutes:None
    244 schema:familyName Guerra
    245 schema:givenName G.
    246 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01056372431.26
    247 rdf:type schema:Person
    248 sg:person.01267530665.46 schema:affiliation grid-institutes:None
    249 schema:familyName Ruggieri
    250 schema:givenName P.
    251 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01267530665.46
    252 rdf:type schema:Person
    253 sg:person.01301722607.21 schema:affiliation grid-institutes:None
    254 schema:familyName Romagnoli
    255 schema:givenName C.
    256 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01301722607.21
    257 rdf:type schema:Person
    258 sg:person.01366422124.48 schema:affiliation grid-institutes:None
    259 schema:familyName Mavrogenis
    260 schema:givenName A. F.
    261 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01366422124.48
    262 rdf:type schema:Person
    263 sg:person.0624431707.14 schema:affiliation grid-institutes:None
    264 schema:familyName Romantini
    265 schema:givenName M.
    266 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0624431707.14
    267 rdf:type schema:Person
    268 sg:pub.10.1007/bf00193818 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022060471
    269 https://doi.org/10.1007/bf00193818
    270 rdf:type schema:CreativeWork
    271 sg:pub.10.1007/bf00298244 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038082102
    272 https://doi.org/10.1007/bf00298244
    273 rdf:type schema:CreativeWork
    274 sg:pub.10.1007/bf00383729 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012296973
    275 https://doi.org/10.1007/bf00383729
    276 rdf:type schema:CreativeWork
    277 sg:pub.10.1007/bf00413312 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013463793
    278 https://doi.org/10.1007/bf00413312
    279 rdf:type schema:CreativeWork
    280 sg:pub.10.1007/bf00588205 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017917950
    281 https://doi.org/10.1007/bf00588205
    282 rdf:type schema:CreativeWork
    283 sg:pub.10.1007/bf00706727 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040706864
    284 https://doi.org/10.1007/bf00706727
    285 rdf:type schema:CreativeWork
    286 sg:pub.10.1007/s00256-002-0599-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004924893
    287 https://doi.org/10.1007/s00256-002-0599-4
    288 rdf:type schema:CreativeWork
    289 sg:pub.10.1007/s00256-010-1045-7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044361404
    290 https://doi.org/10.1007/s00256-010-1045-7
    291 rdf:type schema:CreativeWork
    292 sg:pub.10.1007/s002560050011 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024170306
    293 https://doi.org/10.1007/s002560050011
    294 rdf:type schema:CreativeWork
    295 sg:pub.10.1007/s00381-008-0598-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015083856
    296 https://doi.org/10.1007/s00381-008-0598-4
    297 rdf:type schema:CreativeWork
    298 sg:pub.10.1007/s00381-008-0606-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000275018
    299 https://doi.org/10.1007/s00381-008-0606-8
    300 rdf:type schema:CreativeWork
    301 sg:pub.10.1007/s004020050381 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039380579
    302 https://doi.org/10.1007/s004020050381
    303 rdf:type schema:CreativeWork
    304 sg:pub.10.1007/s00586-006-0107-y schema:sameAs https://app.dimensions.ai/details/publication/pub.1047455115
    305 https://doi.org/10.1007/s00586-006-0107-y
    306 rdf:type schema:CreativeWork
    307 sg:pub.10.1007/s005860000206 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005327747
    308 https://doi.org/10.1007/s005860000206
    309 rdf:type schema:CreativeWork
    310 sg:pub.10.1007/s00701-006-0789-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007401320
    311 https://doi.org/10.1007/s00701-006-0789-2
    312 rdf:type schema:CreativeWork
    313 sg:pub.10.1007/s10143-007-0113-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028964209
    314 https://doi.org/10.1007/s10143-007-0113-5
    315 rdf:type schema:CreativeWork
    316 sg:pub.10.1007/s10195-009-0073-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050001110
    317 https://doi.org/10.1007/s10195-009-0073-3
    318 rdf:type schema:CreativeWork
    319 sg:pub.10.1038/sc.1994.7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033059902
    320 https://doi.org/10.1038/sc.1994.7
    321 rdf:type schema:CreativeWork
    322 grid-institutes:None schema:alternateName Orthopaedic Oncology Service, Department of Orthopaedics, Istituto Ortopedico Rizzoli, University of Bologna, Via Di Barbiano 1/10, 40136, Bologna, Italy
    323 schema:name Orthopaedic Oncology Service, Department of Orthopaedics, Istituto Ortopedico Rizzoli, University of Bologna, Via Di Barbiano 1/10, 40136, Bologna, Italy
    324 rdf:type schema:Organization
     




    Preview window. Press ESC to close (or click here)


    ...