Fetal MRI as a complement to US in the evaluation of cleft lip and palate View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2011-04-19

AUTHORS

L. Manganaro, A. Tomei, F. Fierro, M. Di Maurizio, P. Sollazzo, M. E. Sergi, V. Vinci, S. Bernardo, D. Irimia, P. Cascone, M. Marini

ABSTRACT

PurposeThe aim of our study was to investigate the role of fetal magnetic resonance imaging (MRI) as a complement to ultrasound (US) in the evaluation of cleft lip and palate (CLP), whether isolated or in association with syndromic conditions.Materials and methodsWe enrolled 24 pregnant women (27 fetuses) (mean gestational age 23.7 weeks) with a level-two US diagnosis of cleft lip (CL) or CLP with or without associated central nervous system (CNS) or facial-bone anomalies. All individuals underwent a fetal MRI examination to study the facial skeleton, CNS and fetal body. For each fetus, the main anatomical facial landmarks and biometric parameters [anteroposterior diameter (APD), biparietal diameter (BPD), inferior facial angle (IFA), frontomaxillary angle (FMA), bi-orbital diameter (BOD), intraorbital diameter (IOD)] were measured.ResultsTwenty-five of 27 fetuses had a US diagnosis of CL or CLP. MRI confirmed the diagnosis in 16/25 fetuses and added information about the extent of the cleft and the degree of involvement of the anterior and posterior palate in 8/25 fetuses. MRI ruled out the diagnosis in 1/25 fetuses and identified an alteration of the parameters IFA, FMA and IOD in 6/24 fetuses.ConclusionsIn the study of CLP fetal, MRI is able to define the degree of involvement of the posterior palate and the lateral extent of the cleft with higher diagnostic accuracy than US. Furthermore, MRI provides a complete study of the fetal head and biometric development of the facial bones, thus enabling early detection of potential syndromic conditions. More... »

PAGES

1134-1148

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s11547-011-0683-8

DOI

http://dx.doi.org/10.1007/s11547-011-0683-8

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1043635438

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/21509548


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33 ConclusionsIn
34 FMA
35 IFA
36 IOD
37 MRI examinations
38 MethodsWe
39 ResultsTwenty-five
40 US diagnosis
41 accuracy
42 aim
43 alterations
44 anatomical facial landmarks
45 anomalies
46 association
47 biometric development
48 biometric parameters
49 body
50 bone
51 central nervous system
52 cleft
53 cleft lip
54 complement
55 complete study
56 conditions
57 degree
58 degree of involvement
59 detection
60 development
61 diagnosis
62 diagnostic accuracy
63 early detection
64 evaluation
65 examination
66 extent
67 facial bones
68 facial landmarks
69 facial skeleton
70 facial-bone anomalies
71 fetal
72 fetal MRI examinations
73 fetal body
74 fetal head
75 fetal magnetic resonance imaging
76 fetuses
77 head
78 high diagnostic accuracy
79 imaging
80 individuals
81 information
82 involvement
83 landmarks
84 lateral extent
85 level-two US diagnosis
86 lip
87 magnetic resonance imaging
88 main anatomical facial landmarks
89 materials
90 nervous system
91 palate
92 parameters
93 parameters IFA
94 posterior palate
95 potential syndromic conditions
96 pregnant women
97 resonance imaging
98 role
99 skeleton
100 study
101 syndromic conditions
102 system
103 uses
104 women
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