Preliminary experience with MRA in evaluating the degree of carotid stenosis and plaque morphology using high-resolution sequences after gadofosveset trisodium ... View Full Text


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Article Info

DATE

2010-06

AUTHORS

Michele Anzidei, A. Napoli, D. Geiger, B. Cavallo Marincola, C. Zini, F. Zaccagna, P. Di Paolo, C. Catalano, R. Passariello

ABSTRACT

PURPOSE: The authors performed a preliminary study with blood-pool contrast-enhanced magnetic resonance angiography (MRA) in evaluating the degree of carotid artery stenosis and plaque morphology, comparing the diagnostic performance of first-pass (FP) and steady-state (SS) acquisitions with 64-slice computed tomography angiography (CTA) and using digital subtraction angiography (DSA) as the reference standard. MATERIALS AND METHODS: Twenty patients with >or=50% carotid artery stenosis at Doppler sonography underwent blood-pool contrast-enhanced MRA, CTA and DSA. Two independent radiologists evaluated MRA and CTA examinations to assess the degree of stenosis and characterise plaque morphology. Accuracy, sensitivity, specificity, positive predictive value (PPV) and negative predictive value (NPV) were calculated for FP, SS and CTA. The McNemar and Wilcoxon tests were used to determine significant differences (p<0.05) between the diagnostic performance of the three modalities. RESULTS: Forty carotid bifurcations were studied. For stenosis grading, accuracy, sensitivity, specificity, PPV and NPV were 90%, 89%, 90%, 89% and 90%, respectively, at FP; 95%, 95%, 95%, 95% and 95%, respectively, at SS; and 97.5%, 95%, 100%, 100% and 95%, respectively, at CTA. SS and CTA were superior to FP for evaluating the degree of stenosis (p<0.05). For evaluating plaque morphology, accuracy, sensitivity, specificity, PPV and NPV were 87.5%, 89%, 86%, 85% and 90%, respectively, at FP; 97.5%, 100%, 95%, 95% and 100%, respectively, at SS; and 100%, 100%, 100%, 100% and 100%, respectively, at CTA. There were no significant differences between FP, SS and CTA for plaque assessment (p>0.05). CONCLUSIONS: Blood-pool contrast-enhanced MRA with SS sequences allow improved diagnostic evaluation of the degree of carotid stenosis and plaque morphology compared with FP and is substantially equal to CTA and DSA. More... »

PAGES

634-647

References to SciGraph publications

  • 2006-02. Initial imaging recommendations for Vasovist angiography in EUROPEAN RADIOLOGY
  • 2005-12. MRA of the carotid arteries in EUROPEAN RADIOLOGY
  • 2004-08. MR angiography with MultiHance for imaging the supra-aortic vessels in EUROPEAN RADIOLOGY
  • 2006-02. Vasovist-enhanced MR angiography in EUROPEAN RADIOLOGY
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1007/s11547-010-0535-y

    DOI

    http://dx.doi.org/10.1007/s11547-010-0535-y

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1017078640

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/20177976


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