Dynamics of Influenza Virus and Human Host Interactions During Infection and Replication Cycle View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2013-06

AUTHORS

Alex Madrahimov, Tomáš Helikar, Bryan Kowal, Guoqing Lu, Jim Rogers

ABSTRACT

The replication and life cycle of the influenza virus is governed by an intricate network of intracellular regulatory events during infection, including interactions with an even more complex system of biochemical interactions of the host cell. Computational modeling and systems biology have been successfully employed to further the understanding of various biological systems, however, computational studies of the complexity of intracellular interactions during influenza infection is lacking. In this work, we present the first large-scale dynamical model of the infection and replication cycle of influenza, as well as some of its interactions with the host's signaling machinery. Specifically, we focus on and visualize the dynamics of the internalization and endocytosis of the virus, replication and translation of its genomic components, as well as the assembly of progeny virions. Simulations and analyses of the models dynamics qualitatively reproduced numerous biological phenomena discovered in the laboratory. Finally, comparisons of the dynamics of existing and proposed drugs, our results suggest that a drug targeting PB1:PA would be more efficient than existing Amantadin/Rimantaine or Zanamivir/Oseltamivir. More... »

PAGES

988-1011

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s11538-012-9777-2

DOI

http://dx.doi.org/10.1007/s11538-012-9777-2

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1010928745

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/23081726


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1108", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical Microbiology", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Computer Simulation", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Host-Pathogen Interactions", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Influenza A virus", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Influenza, Human", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "MAP Kinase Signaling System", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mathematical Concepts", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Models, Biological", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Phosphatidylinositol 3-Kinases", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Protein Kinase C", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Systems Biology", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Virus Replication", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "University of Nebraska at Omaha", 
          "id": "https://www.grid.ac/institutes/grid.266815.e", 
          "name": [
            "Department of Biology, University of Nebraska at Omaha, 68182, Omaha, NE, USA", 
            "Department of Mathematics, University of Nebraska at Omaha, 68182, Omaha, NE, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Madrahimov", 
        "givenName": "Alex", 
        "id": "sg:person.0715651465.90", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0715651465.90"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Nebraska at Omaha", 
          "id": "https://www.grid.ac/institutes/grid.266815.e", 
          "name": [
            "Department of Mathematics, University of Nebraska at Omaha, 68182, Omaha, NE, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Helikar", 
        "givenName": "Tom\u00e1\u0161", 
        "id": "sg:person.01210600565.65", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01210600565.65"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Nebraska at Omaha", 
          "id": "https://www.grid.ac/institutes/grid.266815.e", 
          "name": [
            "College of Information Technology, University of Nebraska at Omaha, 68182, Omaha, NE, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Kowal", 
        "givenName": "Bryan", 
        "id": "sg:person.01256713765.36", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01256713765.36"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Nebraska at Omaha", 
          "id": "https://www.grid.ac/institutes/grid.266815.e", 
          "name": [
            "Department of Biology, University of Nebraska at Omaha, 68182, Omaha, NE, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Lu", 
        "givenName": "Guoqing", 
        "id": "sg:person.0736107606.01", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0736107606.01"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Nebraska Medical Center", 
          "id": "https://www.grid.ac/institutes/grid.266813.8", 
          "name": [
            "Department of Mathematics, University of Nebraska at Omaha, 68182, Omaha, NE, USA", 
            "Department of Pathology and Microbiology, University of Nebraska Medical Center, 68198-5900, Omaha, NE, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Rogers", 
        "givenName": "Jim", 
        "id": "sg:person.01146326465.48", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01146326465.48"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1016/j.jtbi.2006.12.015", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001797329"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.2217/fvl.11.63", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001879910"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.1075090", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001953109"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1462-5822.2005.00678.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002052489"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1462-5822.2005.00678.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002052489"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/nar/gkh192", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002563729"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1128/jvi.77.1.460-469.2003", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002835370"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1371/journal.ppat.1001099", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003045779"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/35060098", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003144645", 
          "https://doi.org/10.1038/35060098"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/35060098", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003144645", 
          "https://doi.org/10.1038/35060098"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/bioinformatics/btp617", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004150196"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/978-1-60761-800-3_14", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004589016", 
          "https://doi.org/10.1007/978-1-60761-800-3_14"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.coviro.2011.08.002", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005729682"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.jtbi.2005.01.023", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1008162511"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ng881", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010954918", 
          "https://doi.org/10.1038/ng881"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ng881", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010954918", 
          "https://doi.org/10.1038/ng881"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.1089769", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1013406614"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0960-9822(01)00330-x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1013522517"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nrg2102", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1013630449", 
          "https://doi.org/10.1038/nrg2102"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.jtbi.2004.08.001", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014493085"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.virol.2010.12.003", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014505491"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1371/journal.pcbi.1000912", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015000430"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.1108876", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015079672"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.chom.2010.05.008", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015706813"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/bit.20096", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015997441"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1371/journal.pcbi.1002074", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1016980765"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.febslet.2007.10.025", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017835406"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/scisignal.2000008", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018816787"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1348-0421.2002.tb02682.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019140057"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1128/jvi.02082-06", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021011940"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/1752-0509-6-96", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021096684", 
          "https://doi.org/10.1186/1752-0509-6-96"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nrd2175", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021213320", 
          "https://doi.org/10.1038/nrd2175"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nrd2175", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021213320", 
          "https://doi.org/10.1038/nrd2175"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0092-8674(92)90452-i", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021447532"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0092-8674(81)90208-7", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022306378"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.molcel.2011.08.002", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022716404"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0968-0004(94)90133-3", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023116659"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.2133841100", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023151304"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nm.2612", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024636004", 
          "https://doi.org/10.1038/nm.2612"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1074/jbc.r110.117531", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024862949"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/infdis/jis338", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025530322"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s1359-6446(05)03735-9", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025785306"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.cell.2009.12.018", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027257663"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1371/journal.pcbi.1002121", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029026039"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1177/1947601911407323", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029141735"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1177/1947601911407323", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029141735"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/nar/24.22.4456", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030476514"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.jmb.2003.09.049", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031122384"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.antiviral.2007.12.010", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031674702"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1128/jvi.00724-07", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032570789"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature08699", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032984965", 
          "https://doi.org/10.1038/nature08699"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature08699", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032984965", 
          "https://doi.org/10.1038/nature08699"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0960-9822(03)00083-6", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033047185"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00430-010-0176-8", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033116253", 
          "https://doi.org/10.1007/s00430-010-0176-8"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.298.5594.824", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033238539"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/1752-0509-3-35", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033681695", 
          "https://doi.org/10.1186/1752-0509-3-35"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0140-6736(99)11433-8", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033874618"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1371/journal.pcbi.0030163", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1034464810"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.virusres.2006.09.013", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035120754"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/bioinformatics/bts036", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036251835"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/1752-0509-3-58", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037902586", 
          "https://doi.org/10.1186/1752-0509-3-58"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.biologicals.2009.02.012", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037972928"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ni.2078", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038313747", 
          "https://doi.org/10.1038/ni.2078"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s10265-011-0418-x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038352559", 
          "https://doi.org/10.1007/s10265-011-0418-x"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.coviro.2011.09.002", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038417219"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/rmv.512", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1040660695"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1371/journal.pone.0007517", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042868961"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1128/jvi.76.3.1391-1399.2002", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1043916461"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1371/journal.pone.0046417", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045343616"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1462-5822.2006.00713.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046898293"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1462-5822.2006.00713.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046898293"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.0705088105", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1049279196"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.cell.2005.08.020", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1049638413"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.cell.2005.08.020", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1049638413"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.1069492", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050549261"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.mehy.2005.11.017", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050595981"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/emboj/17.1.288", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052897069"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1021/bi902202q", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052982050"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1021/bi902202q", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052982050"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1049/ip-syb:20050079", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1056860261"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1089/vim.2010.0125", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1059327064"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1099/0022-1317-81-11-2697", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1060361450"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1109/tnn.2009.2039802", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1061717665"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.1160617", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1062458433"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.2174/092986707779313444", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1069160865"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.4149/av_2010_03_155", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1072260860"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1077028651", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1079949417", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1082375723", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1082957606", 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2013-06", 
    "datePublishedReg": "2013-06-01", 
    "description": "The replication and life cycle of the influenza virus is governed by an intricate network of intracellular regulatory events during infection, including interactions with an even more complex system of biochemical interactions of the host cell. Computational modeling and systems biology have been successfully employed to further the understanding of various biological systems, however, computational studies of the complexity of intracellular interactions during influenza infection is lacking. In this work, we present the first large-scale dynamical model of the infection and replication cycle of influenza, as well as some of its interactions with the host's signaling machinery. Specifically, we focus on and visualize the dynamics of the internalization and endocytosis of the virus, replication and translation of its genomic components, as well as the assembly of progeny virions. Simulations and analyses of the models dynamics qualitatively reproduced numerous biological phenomena discovered in the laboratory. Finally, comparisons of the dynamics of existing and proposed drugs, our results suggest that a drug targeting PB1:PA would be more efficient than existing Amantadin/Rimantaine or Zanamivir/Oseltamivir.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1007/s11538-012-9777-2", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": false, 
    "isPartOf": [
      {
        "id": "sg:journal.1018370", 
        "issn": [
          "0092-8240", 
          "1522-9602"
        ], 
        "name": "Bulletin of Mathematical Biology", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "6", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "75"
      }
    ], 
    "name": "Dynamics of Influenza Virus and Human Host Interactions During Infection and Replication Cycle", 
    "pagination": "988-1011", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "341161acdfdacaed90f7968435f796c0a9e4ac315c67296c0472c36bd69c5b47"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "23081726"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "0401404"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1007/s11538-012-9777-2"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1010928745"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1007/s11538-012-9777-2", 
      "https://app.dimensions.ai/details/publication/pub.1010928745"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-10T19:12", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8678_00000530.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "http://link.springer.com/10.1007%2Fs11538-012-9777-2"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s11538-012-9777-2'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s11538-012-9777-2'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s11538-012-9777-2'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s11538-012-9777-2'


 

This table displays all metadata directly associated to this object as RDF triples.

403 TRIPLES      21 PREDICATES      122 URIs      33 LITERALS      21 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1007/s11538-012-9777-2 schema:about N0ea30e40d5ed4e9b9a3bfd463839828e
2 N1cdc1df95bea46f4ad56ce96bca6e67d
3 N23605826f4234fa7ba9cd357003c5b5e
4 N2cb24db3d3324fb3b4683859c7de5e12
5 N3c0dfefc97404dc8a76487a62118bf0b
6 N734220ac9fc34bdbb7a19d01ec49c575
7 N861bba351cc049e99f4cb76b5c5c1a7c
8 N8bbe3995900c4951b36911ac47453161
9 Nc414b2c2555d494eac776b6f2a5ec689
10 Nc962e42266e9431a8c7594d52013e374
11 Nef610557efec478e95b9c57e58e5895a
12 Nfd1bf631d9c54153b49b50f14a686fcc
13 anzsrc-for:11
14 anzsrc-for:1108
15 schema:author Na07802f012d04d5d87c9a5580280dceb
16 schema:citation sg:pub.10.1007/978-1-60761-800-3_14
17 sg:pub.10.1007/s00430-010-0176-8
18 sg:pub.10.1007/s10265-011-0418-x
19 sg:pub.10.1038/35060098
20 sg:pub.10.1038/nature08699
21 sg:pub.10.1038/ng881
22 sg:pub.10.1038/ni.2078
23 sg:pub.10.1038/nm.2612
24 sg:pub.10.1038/nrd2175
25 sg:pub.10.1038/nrg2102
26 sg:pub.10.1186/1752-0509-3-35
27 sg:pub.10.1186/1752-0509-3-58
28 sg:pub.10.1186/1752-0509-6-96
29 https://app.dimensions.ai/details/publication/pub.1077028651
30 https://app.dimensions.ai/details/publication/pub.1079949417
31 https://app.dimensions.ai/details/publication/pub.1082375723
32 https://app.dimensions.ai/details/publication/pub.1082957606
33 https://doi.org/10.1002/bit.20096
34 https://doi.org/10.1002/rmv.512
35 https://doi.org/10.1016/0092-8674(81)90208-7
36 https://doi.org/10.1016/0092-8674(92)90452-i
37 https://doi.org/10.1016/0968-0004(94)90133-3
38 https://doi.org/10.1016/j.antiviral.2007.12.010
39 https://doi.org/10.1016/j.biologicals.2009.02.012
40 https://doi.org/10.1016/j.cell.2005.08.020
41 https://doi.org/10.1016/j.cell.2009.12.018
42 https://doi.org/10.1016/j.chom.2010.05.008
43 https://doi.org/10.1016/j.coviro.2011.08.002
44 https://doi.org/10.1016/j.coviro.2011.09.002
45 https://doi.org/10.1016/j.febslet.2007.10.025
46 https://doi.org/10.1016/j.jmb.2003.09.049
47 https://doi.org/10.1016/j.jtbi.2004.08.001
48 https://doi.org/10.1016/j.jtbi.2005.01.023
49 https://doi.org/10.1016/j.jtbi.2006.12.015
50 https://doi.org/10.1016/j.mehy.2005.11.017
51 https://doi.org/10.1016/j.molcel.2011.08.002
52 https://doi.org/10.1016/j.virol.2010.12.003
53 https://doi.org/10.1016/j.virusres.2006.09.013
54 https://doi.org/10.1016/s0140-6736(99)11433-8
55 https://doi.org/10.1016/s0960-9822(01)00330-x
56 https://doi.org/10.1016/s0960-9822(03)00083-6
57 https://doi.org/10.1016/s1359-6446(05)03735-9
58 https://doi.org/10.1021/bi902202q
59 https://doi.org/10.1049/ip-syb:20050079
60 https://doi.org/10.1073/pnas.0705088105
61 https://doi.org/10.1073/pnas.2133841100
62 https://doi.org/10.1074/jbc.r110.117531
63 https://doi.org/10.1089/vim.2010.0125
64 https://doi.org/10.1093/bioinformatics/btp617
65 https://doi.org/10.1093/bioinformatics/bts036
66 https://doi.org/10.1093/emboj/17.1.288
67 https://doi.org/10.1093/infdis/jis338
68 https://doi.org/10.1093/nar/24.22.4456
69 https://doi.org/10.1093/nar/gkh192
70 https://doi.org/10.1099/0022-1317-81-11-2697
71 https://doi.org/10.1109/tnn.2009.2039802
72 https://doi.org/10.1111/j.1348-0421.2002.tb02682.x
73 https://doi.org/10.1111/j.1462-5822.2005.00678.x
74 https://doi.org/10.1111/j.1462-5822.2006.00713.x
75 https://doi.org/10.1126/science.1069492
76 https://doi.org/10.1126/science.1075090
77 https://doi.org/10.1126/science.1089769
78 https://doi.org/10.1126/science.1108876
79 https://doi.org/10.1126/science.1160617
80 https://doi.org/10.1126/science.298.5594.824
81 https://doi.org/10.1126/scisignal.2000008
82 https://doi.org/10.1128/jvi.00724-07
83 https://doi.org/10.1128/jvi.02082-06
84 https://doi.org/10.1128/jvi.76.3.1391-1399.2002
85 https://doi.org/10.1128/jvi.77.1.460-469.2003
86 https://doi.org/10.1177/1947601911407323
87 https://doi.org/10.1371/journal.pcbi.0030163
88 https://doi.org/10.1371/journal.pcbi.1000912
89 https://doi.org/10.1371/journal.pcbi.1002074
90 https://doi.org/10.1371/journal.pcbi.1002121
91 https://doi.org/10.1371/journal.pone.0007517
92 https://doi.org/10.1371/journal.pone.0046417
93 https://doi.org/10.1371/journal.ppat.1001099
94 https://doi.org/10.2174/092986707779313444
95 https://doi.org/10.2217/fvl.11.63
96 https://doi.org/10.4149/av_2010_03_155
97 schema:datePublished 2013-06
98 schema:datePublishedReg 2013-06-01
99 schema:description The replication and life cycle of the influenza virus is governed by an intricate network of intracellular regulatory events during infection, including interactions with an even more complex system of biochemical interactions of the host cell. Computational modeling and systems biology have been successfully employed to further the understanding of various biological systems, however, computational studies of the complexity of intracellular interactions during influenza infection is lacking. In this work, we present the first large-scale dynamical model of the infection and replication cycle of influenza, as well as some of its interactions with the host's signaling machinery. Specifically, we focus on and visualize the dynamics of the internalization and endocytosis of the virus, replication and translation of its genomic components, as well as the assembly of progeny virions. Simulations and analyses of the models dynamics qualitatively reproduced numerous biological phenomena discovered in the laboratory. Finally, comparisons of the dynamics of existing and proposed drugs, our results suggest that a drug targeting PB1:PA would be more efficient than existing Amantadin/Rimantaine or Zanamivir/Oseltamivir.
100 schema:genre research_article
101 schema:inLanguage en
102 schema:isAccessibleForFree false
103 schema:isPartOf N611d90901e504b80aa19d89147339e82
104 N88187483030c45f8903fc66aab0a7da3
105 sg:journal.1018370
106 schema:name Dynamics of Influenza Virus and Human Host Interactions During Infection and Replication Cycle
107 schema:pagination 988-1011
108 schema:productId N1858fb7736924c6b81c6133c4e03c8bd
109 N48e1f6b2868e48a79d5bd8b60b42a637
110 Nc4a7370151a0413c94ead673c925cbe7
111 Nccf12ac97a634ae7961f517e0753638f
112 Ne172dd5ffcc94e01aca60b0f9e7500b6
113 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010928745
114 https://doi.org/10.1007/s11538-012-9777-2
115 schema:sdDatePublished 2019-04-10T19:12
116 schema:sdLicense https://scigraph.springernature.com/explorer/license/
117 schema:sdPublisher Nafd6deedcc744a179510539201f9920c
118 schema:url http://link.springer.com/10.1007%2Fs11538-012-9777-2
119 sgo:license sg:explorer/license/
120 sgo:sdDataset articles
121 rdf:type schema:ScholarlyArticle
122 N0ea30e40d5ed4e9b9a3bfd463839828e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
123 schema:name Models, Biological
124 rdf:type schema:DefinedTerm
125 N1858fb7736924c6b81c6133c4e03c8bd schema:name readcube_id
126 schema:value 341161acdfdacaed90f7968435f796c0a9e4ac315c67296c0472c36bd69c5b47
127 rdf:type schema:PropertyValue
128 N1cdc1df95bea46f4ad56ce96bca6e67d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
129 schema:name Protein Kinase C
130 rdf:type schema:DefinedTerm
131 N23605826f4234fa7ba9cd357003c5b5e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
132 schema:name Host-Pathogen Interactions
133 rdf:type schema:DefinedTerm
134 N2cb24db3d3324fb3b4683859c7de5e12 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
135 schema:name Humans
136 rdf:type schema:DefinedTerm
137 N3c0dfefc97404dc8a76487a62118bf0b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
138 schema:name MAP Kinase Signaling System
139 rdf:type schema:DefinedTerm
140 N48e1f6b2868e48a79d5bd8b60b42a637 schema:name nlm_unique_id
141 schema:value 0401404
142 rdf:type schema:PropertyValue
143 N5154093bab1c452c908634af7bcd82ae rdf:first sg:person.01146326465.48
144 rdf:rest rdf:nil
145 N5fc484af37b348d08f865d3df6dbce8b rdf:first sg:person.0736107606.01
146 rdf:rest N5154093bab1c452c908634af7bcd82ae
147 N611d90901e504b80aa19d89147339e82 schema:volumeNumber 75
148 rdf:type schema:PublicationVolume
149 N734220ac9fc34bdbb7a19d01ec49c575 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
150 schema:name Computer Simulation
151 rdf:type schema:DefinedTerm
152 N861bba351cc049e99f4cb76b5c5c1a7c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
153 schema:name Virus Replication
154 rdf:type schema:DefinedTerm
155 N88187483030c45f8903fc66aab0a7da3 schema:issueNumber 6
156 rdf:type schema:PublicationIssue
157 N8bbe3995900c4951b36911ac47453161 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
158 schema:name Mathematical Concepts
159 rdf:type schema:DefinedTerm
160 Na07802f012d04d5d87c9a5580280dceb rdf:first sg:person.0715651465.90
161 rdf:rest Nb1a4c154eadd445d9ef16af5a54df722
162 Na6e5150372e04eb7815cac0106decc8e rdf:first sg:person.01256713765.36
163 rdf:rest N5fc484af37b348d08f865d3df6dbce8b
164 Nafd6deedcc744a179510539201f9920c schema:name Springer Nature - SN SciGraph project
165 rdf:type schema:Organization
166 Nb1a4c154eadd445d9ef16af5a54df722 rdf:first sg:person.01210600565.65
167 rdf:rest Na6e5150372e04eb7815cac0106decc8e
168 Nc414b2c2555d494eac776b6f2a5ec689 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
169 schema:name Influenza, Human
170 rdf:type schema:DefinedTerm
171 Nc4a7370151a0413c94ead673c925cbe7 schema:name dimensions_id
172 schema:value pub.1010928745
173 rdf:type schema:PropertyValue
174 Nc962e42266e9431a8c7594d52013e374 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
175 schema:name Systems Biology
176 rdf:type schema:DefinedTerm
177 Nccf12ac97a634ae7961f517e0753638f schema:name pubmed_id
178 schema:value 23081726
179 rdf:type schema:PropertyValue
180 Ne172dd5ffcc94e01aca60b0f9e7500b6 schema:name doi
181 schema:value 10.1007/s11538-012-9777-2
182 rdf:type schema:PropertyValue
183 Nef610557efec478e95b9c57e58e5895a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
184 schema:name Influenza A virus
185 rdf:type schema:DefinedTerm
186 Nfd1bf631d9c54153b49b50f14a686fcc schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
187 schema:name Phosphatidylinositol 3-Kinases
188 rdf:type schema:DefinedTerm
189 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
190 schema:name Medical and Health Sciences
191 rdf:type schema:DefinedTerm
192 anzsrc-for:1108 schema:inDefinedTermSet anzsrc-for:
193 schema:name Medical Microbiology
194 rdf:type schema:DefinedTerm
195 sg:journal.1018370 schema:issn 0092-8240
196 1522-9602
197 schema:name Bulletin of Mathematical Biology
198 rdf:type schema:Periodical
199 sg:person.01146326465.48 schema:affiliation https://www.grid.ac/institutes/grid.266813.8
200 schema:familyName Rogers
201 schema:givenName Jim
202 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01146326465.48
203 rdf:type schema:Person
204 sg:person.01210600565.65 schema:affiliation https://www.grid.ac/institutes/grid.266815.e
205 schema:familyName Helikar
206 schema:givenName Tomáš
207 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01210600565.65
208 rdf:type schema:Person
209 sg:person.01256713765.36 schema:affiliation https://www.grid.ac/institutes/grid.266815.e
210 schema:familyName Kowal
211 schema:givenName Bryan
212 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01256713765.36
213 rdf:type schema:Person
214 sg:person.0715651465.90 schema:affiliation https://www.grid.ac/institutes/grid.266815.e
215 schema:familyName Madrahimov
216 schema:givenName Alex
217 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0715651465.90
218 rdf:type schema:Person
219 sg:person.0736107606.01 schema:affiliation https://www.grid.ac/institutes/grid.266815.e
220 schema:familyName Lu
221 schema:givenName Guoqing
222 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0736107606.01
223 rdf:type schema:Person
224 sg:pub.10.1007/978-1-60761-800-3_14 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004589016
225 https://doi.org/10.1007/978-1-60761-800-3_14
226 rdf:type schema:CreativeWork
227 sg:pub.10.1007/s00430-010-0176-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033116253
228 https://doi.org/10.1007/s00430-010-0176-8
229 rdf:type schema:CreativeWork
230 sg:pub.10.1007/s10265-011-0418-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1038352559
231 https://doi.org/10.1007/s10265-011-0418-x
232 rdf:type schema:CreativeWork
233 sg:pub.10.1038/35060098 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003144645
234 https://doi.org/10.1038/35060098
235 rdf:type schema:CreativeWork
236 sg:pub.10.1038/nature08699 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032984965
237 https://doi.org/10.1038/nature08699
238 rdf:type schema:CreativeWork
239 sg:pub.10.1038/ng881 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010954918
240 https://doi.org/10.1038/ng881
241 rdf:type schema:CreativeWork
242 sg:pub.10.1038/ni.2078 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038313747
243 https://doi.org/10.1038/ni.2078
244 rdf:type schema:CreativeWork
245 sg:pub.10.1038/nm.2612 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024636004
246 https://doi.org/10.1038/nm.2612
247 rdf:type schema:CreativeWork
248 sg:pub.10.1038/nrd2175 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021213320
249 https://doi.org/10.1038/nrd2175
250 rdf:type schema:CreativeWork
251 sg:pub.10.1038/nrg2102 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013630449
252 https://doi.org/10.1038/nrg2102
253 rdf:type schema:CreativeWork
254 sg:pub.10.1186/1752-0509-3-35 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033681695
255 https://doi.org/10.1186/1752-0509-3-35
256 rdf:type schema:CreativeWork
257 sg:pub.10.1186/1752-0509-3-58 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037902586
258 https://doi.org/10.1186/1752-0509-3-58
259 rdf:type schema:CreativeWork
260 sg:pub.10.1186/1752-0509-6-96 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021096684
261 https://doi.org/10.1186/1752-0509-6-96
262 rdf:type schema:CreativeWork
263 https://app.dimensions.ai/details/publication/pub.1077028651 schema:CreativeWork
264 https://app.dimensions.ai/details/publication/pub.1079949417 schema:CreativeWork
265 https://app.dimensions.ai/details/publication/pub.1082375723 schema:CreativeWork
266 https://app.dimensions.ai/details/publication/pub.1082957606 schema:CreativeWork
267 https://doi.org/10.1002/bit.20096 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015997441
268 rdf:type schema:CreativeWork
269 https://doi.org/10.1002/rmv.512 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040660695
270 rdf:type schema:CreativeWork
271 https://doi.org/10.1016/0092-8674(81)90208-7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022306378
272 rdf:type schema:CreativeWork
273 https://doi.org/10.1016/0092-8674(92)90452-i schema:sameAs https://app.dimensions.ai/details/publication/pub.1021447532
274 rdf:type schema:CreativeWork
275 https://doi.org/10.1016/0968-0004(94)90133-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023116659
276 rdf:type schema:CreativeWork
277 https://doi.org/10.1016/j.antiviral.2007.12.010 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031674702
278 rdf:type schema:CreativeWork
279 https://doi.org/10.1016/j.biologicals.2009.02.012 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037972928
280 rdf:type schema:CreativeWork
281 https://doi.org/10.1016/j.cell.2005.08.020 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049638413
282 rdf:type schema:CreativeWork
283 https://doi.org/10.1016/j.cell.2009.12.018 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027257663
284 rdf:type schema:CreativeWork
285 https://doi.org/10.1016/j.chom.2010.05.008 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015706813
286 rdf:type schema:CreativeWork
287 https://doi.org/10.1016/j.coviro.2011.08.002 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005729682
288 rdf:type schema:CreativeWork
289 https://doi.org/10.1016/j.coviro.2011.09.002 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038417219
290 rdf:type schema:CreativeWork
291 https://doi.org/10.1016/j.febslet.2007.10.025 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017835406
292 rdf:type schema:CreativeWork
293 https://doi.org/10.1016/j.jmb.2003.09.049 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031122384
294 rdf:type schema:CreativeWork
295 https://doi.org/10.1016/j.jtbi.2004.08.001 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014493085
296 rdf:type schema:CreativeWork
297 https://doi.org/10.1016/j.jtbi.2005.01.023 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008162511
298 rdf:type schema:CreativeWork
299 https://doi.org/10.1016/j.jtbi.2006.12.015 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001797329
300 rdf:type schema:CreativeWork
301 https://doi.org/10.1016/j.mehy.2005.11.017 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050595981
302 rdf:type schema:CreativeWork
303 https://doi.org/10.1016/j.molcel.2011.08.002 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022716404
304 rdf:type schema:CreativeWork
305 https://doi.org/10.1016/j.virol.2010.12.003 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014505491
306 rdf:type schema:CreativeWork
307 https://doi.org/10.1016/j.virusres.2006.09.013 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035120754
308 rdf:type schema:CreativeWork
309 https://doi.org/10.1016/s0140-6736(99)11433-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033874618
310 rdf:type schema:CreativeWork
311 https://doi.org/10.1016/s0960-9822(01)00330-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1013522517
312 rdf:type schema:CreativeWork
313 https://doi.org/10.1016/s0960-9822(03)00083-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033047185
314 rdf:type schema:CreativeWork
315 https://doi.org/10.1016/s1359-6446(05)03735-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025785306
316 rdf:type schema:CreativeWork
317 https://doi.org/10.1021/bi902202q schema:sameAs https://app.dimensions.ai/details/publication/pub.1052982050
318 rdf:type schema:CreativeWork
319 https://doi.org/10.1049/ip-syb:20050079 schema:sameAs https://app.dimensions.ai/details/publication/pub.1056860261
320 rdf:type schema:CreativeWork
321 https://doi.org/10.1073/pnas.0705088105 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049279196
322 rdf:type schema:CreativeWork
323 https://doi.org/10.1073/pnas.2133841100 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023151304
324 rdf:type schema:CreativeWork
325 https://doi.org/10.1074/jbc.r110.117531 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024862949
326 rdf:type schema:CreativeWork
327 https://doi.org/10.1089/vim.2010.0125 schema:sameAs https://app.dimensions.ai/details/publication/pub.1059327064
328 rdf:type schema:CreativeWork
329 https://doi.org/10.1093/bioinformatics/btp617 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004150196
330 rdf:type schema:CreativeWork
331 https://doi.org/10.1093/bioinformatics/bts036 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036251835
332 rdf:type schema:CreativeWork
333 https://doi.org/10.1093/emboj/17.1.288 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052897069
334 rdf:type schema:CreativeWork
335 https://doi.org/10.1093/infdis/jis338 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025530322
336 rdf:type schema:CreativeWork
337 https://doi.org/10.1093/nar/24.22.4456 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030476514
338 rdf:type schema:CreativeWork
339 https://doi.org/10.1093/nar/gkh192 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002563729
340 rdf:type schema:CreativeWork
341 https://doi.org/10.1099/0022-1317-81-11-2697 schema:sameAs https://app.dimensions.ai/details/publication/pub.1060361450
342 rdf:type schema:CreativeWork
343 https://doi.org/10.1109/tnn.2009.2039802 schema:sameAs https://app.dimensions.ai/details/publication/pub.1061717665
344 rdf:type schema:CreativeWork
345 https://doi.org/10.1111/j.1348-0421.2002.tb02682.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1019140057
346 rdf:type schema:CreativeWork
347 https://doi.org/10.1111/j.1462-5822.2005.00678.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1002052489
348 rdf:type schema:CreativeWork
349 https://doi.org/10.1111/j.1462-5822.2006.00713.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1046898293
350 rdf:type schema:CreativeWork
351 https://doi.org/10.1126/science.1069492 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050549261
352 rdf:type schema:CreativeWork
353 https://doi.org/10.1126/science.1075090 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001953109
354 rdf:type schema:CreativeWork
355 https://doi.org/10.1126/science.1089769 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013406614
356 rdf:type schema:CreativeWork
357 https://doi.org/10.1126/science.1108876 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015079672
358 rdf:type schema:CreativeWork
359 https://doi.org/10.1126/science.1160617 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062458433
360 rdf:type schema:CreativeWork
361 https://doi.org/10.1126/science.298.5594.824 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033238539
362 rdf:type schema:CreativeWork
363 https://doi.org/10.1126/scisignal.2000008 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018816787
364 rdf:type schema:CreativeWork
365 https://doi.org/10.1128/jvi.00724-07 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032570789
366 rdf:type schema:CreativeWork
367 https://doi.org/10.1128/jvi.02082-06 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021011940
368 rdf:type schema:CreativeWork
369 https://doi.org/10.1128/jvi.76.3.1391-1399.2002 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043916461
370 rdf:type schema:CreativeWork
371 https://doi.org/10.1128/jvi.77.1.460-469.2003 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002835370
372 rdf:type schema:CreativeWork
373 https://doi.org/10.1177/1947601911407323 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029141735
374 rdf:type schema:CreativeWork
375 https://doi.org/10.1371/journal.pcbi.0030163 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034464810
376 rdf:type schema:CreativeWork
377 https://doi.org/10.1371/journal.pcbi.1000912 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015000430
378 rdf:type schema:CreativeWork
379 https://doi.org/10.1371/journal.pcbi.1002074 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016980765
380 rdf:type schema:CreativeWork
381 https://doi.org/10.1371/journal.pcbi.1002121 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029026039
382 rdf:type schema:CreativeWork
383 https://doi.org/10.1371/journal.pone.0007517 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042868961
384 rdf:type schema:CreativeWork
385 https://doi.org/10.1371/journal.pone.0046417 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045343616
386 rdf:type schema:CreativeWork
387 https://doi.org/10.1371/journal.ppat.1001099 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003045779
388 rdf:type schema:CreativeWork
389 https://doi.org/10.2174/092986707779313444 schema:sameAs https://app.dimensions.ai/details/publication/pub.1069160865
390 rdf:type schema:CreativeWork
391 https://doi.org/10.2217/fvl.11.63 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001879910
392 rdf:type schema:CreativeWork
393 https://doi.org/10.4149/av_2010_03_155 schema:sameAs https://app.dimensions.ai/details/publication/pub.1072260860
394 rdf:type schema:CreativeWork
395 https://www.grid.ac/institutes/grid.266813.8 schema:alternateName University of Nebraska Medical Center
396 schema:name Department of Mathematics, University of Nebraska at Omaha, 68182, Omaha, NE, USA
397 Department of Pathology and Microbiology, University of Nebraska Medical Center, 68198-5900, Omaha, NE, USA
398 rdf:type schema:Organization
399 https://www.grid.ac/institutes/grid.266815.e schema:alternateName University of Nebraska at Omaha
400 schema:name College of Information Technology, University of Nebraska at Omaha, 68182, Omaha, NE, USA
401 Department of Biology, University of Nebraska at Omaha, 68182, Omaha, NE, USA
402 Department of Mathematics, University of Nebraska at Omaha, 68182, Omaha, NE, USA
403 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...