Modeling Intercellular Interactions in Early Mycobacterium Infection View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2006-05-20

AUTHORS

Christina Warrender, Stephanie Forrest, Frederick Koster

ABSTRACT

Infection with Mycobacterium tuberculosis (Mtb) is characterized by localized, roughly spherical lesions within which the pathogen interacts with host cells. Containment of the infection or progression of disease depends on the behavior of individual cells, which, in turn, depends on the local molecular environment and on contact with neighboring cells. Modeling can help us understand the nonlinear interactions that drive the overall dynamics in this system. Early events in infection are particularly important, as are spatial effects and inherently stochastic processes. We describe a model of early Mycobacterium infection using the CyCells simulator, which was designed to capture these effects. We relate CyCells simulations of the model to several experimental observations of individual components of the response to Mtb. More... »

PAGES

2233-2261

References to SciGraph publications

  • 2003-11. Regulation of macrophage activation in CELLULAR AND MOLECULAR LIFE SCIENCES
  • 2001-03. Visualizing the generation of memory CD4 T cells in the whole body in NATURE
  • 2001-10. How can immunology contribute to the control of tuberculosis? in NATURE REVIEWS IMMUNOLOGY
  • 2004-11. Homeostasis of peripheral immune effectors in BULLETIN OF MATHEMATICAL BIOLOGY
  • 2000-12-01. Latent Mycobacterium tuberculosis–persistence, patience, and winning by waiting in NATURE MEDICINE
  • 1999-05. Th1/Th2 differentiation and cross-regulation in BULLETIN OF MATHEMATICAL BIOLOGY
  • 2003-11. Tuberculosis: a problem with persistence in NATURE REVIEWS MICROBIOLOGY
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1007/s11538-006-9103-y

    DOI

    http://dx.doi.org/10.1007/s11538-006-9103-y

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1024400280

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/17086496


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    197 grid-institutes:grid.266832.b schema:alternateName Department of Computer Science, University of New Mexico, P.O. Box 5800 MS 1423, 87185-1423, Albuquerque, NM, USA
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    200 grid-institutes:grid.280401.f schema:alternateName Lovelace Respiratory Research Institute, 2425 Ridgecrest Drive SE, 87108 5127, Albuquerque, NM, USA
    201 schema:name Lovelace Respiratory Research Institute, 2425 Ridgecrest Drive SE, 87108 5127, Albuquerque, NM, USA
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