Interplay between autophagy and apoptosis in pancreatic tumors in response to gemcitabine View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2014-06

AUTHORS

Daniela Laura Papademetrio, Victoria Cavaliere, Tania Simunovich, Susana Costantino, María Dolores Campos, Tomás Lombardo, Claudio Marcelo Fader Kaiser, Élida Álvarez

ABSTRACT

Pancreatic cancer is an aggressive disease. Its incidence has increased over the last two decades. It is currently the fourth cause of death among cancers in the western world. Unfortunately, systemic chemotherapy still relies on just a few drugs which until now have produced unsatisfactory results. Gemcitabine (2'-2'-difluorodeoxycytidine) is currently the standard chemotherapy treatment at all stages of pancreatic adenocarcinoma. Survival benefit and clinical impact however remain moderate due to a high degree of intrinsic and acquired resistance. Autophagy plays an important role in cell death decision but can also protect cells from various apoptotic stimuli. We investigated the function of autophagy in pancreatic carcinoma cells, which are frequently insensitive to standard chemotherapeutic agents. Here, we demonstrate that autophagy is one of the mechanisms responsible for the refractory response of pancreatic tumors to gemcitabine. We present evidence in vitro and in vivo that proves autophagy plays a protective role in pancreatic ductal carcinoma cells, preventing them from entering the apoptotic pathway after stimulus with gemcitabine, thus contributing to treatment resistance. A better understanding of the role in the process may help in the discovery of new strategies to overcome tumor drug resistance in this aggressive disease. More... »

PAGES

123-134

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s11523-013-0278-5

DOI

http://dx.doi.org/10.1007/s11523-013-0278-5

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1044693061

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/23588416


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