Extracellular Vesicles: Intercellular Mediators in Alcohol-Induced Pathologies. View Full Text


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Article Info

DATE

2019-04-06

AUTHORS

Mohammad A Rahman, Benjamin J Patters, Sunitha Kodidela, Santosh Kumar

ABSTRACT

Though alcoholic liver injury plays the primary role in direct alcohol-related morbidity, alcohol consumption is also interlinked with many other diseases in extra-hepatic tissues/organs. The mechanism of alcoholic tissue injury is well documented, however the mechanisms that affect extra-hepatic tissues have not yet been well defined. Extracellular vesicles (EVs) such as exosomes and microvesicles, have been identified as key components of alcohol-induced extra-hepatic effects. We have reviewed the recent findings on the potential impact of alcohol-modified EVs/exosomes production and their downstream effects on extra-hepatic tissues. In this review, we discuss the available information on the cross-talk between hepatocytes and immune cells via EV/exosomal cargos (miRNA, mRNA, protein, etc.) in alcoholic liver diseases. We also discuss the effects of alcohol exposure on the contents of EVs/exosomes derived from various extra-hepatic tissues and their associated pathological consequences on recipient cells. Finally, we speculate on other potential EV/exosomal agents that may mediate alcohol-induced tissue damage. Graphical Abstract Alcohol can alter contents of extracellular vesicles (EVs) (e.g. exosomes) such as miRNAs, protein, cytokines, etc. in hepatic and extra-hepatic cells. The transfer of these alcohol modified EVs to nearby or distant cells can play vital role in inflammatory pathways in alcohol induced pathogenesis/comorbidities. More... »

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  • Identifiers

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    http://scigraph.springernature.com/pub.10.1007/s11481-019-09848-z

    DOI

    http://dx.doi.org/10.1007/s11481-019-09848-z

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    https://app.dimensions.ai/details/publication/pub.1113283616

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/30955131


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