Efficacy of N-Acetylserotonin and Melatonin in the EAE Model of Multiple Sclerosis View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2016-12

AUTHORS

Jie Wen, Prasanth S. Ariyannur, Rachel Ribeiro, Mikiei Tanaka, John R. Moffett, Batool F. Kirmani, Aryan M.A. Namboodiri, Yumin Zhang

ABSTRACT

Melatonin and N-acetylserotonin (NAS) are tryptophan metabolites that have potent anti-oxidant, anti-inflammatory and neuroprotective properties in several animal models of neurological injury and disease including multiple sclerosis (MS). The therapeutic effect of NAS has not been reported previously in experimental autoimmune encephalomyelitis (EAE), a commonly used animal model of MS. Using a MOG-peptide induced EAE mouse model we examined the effects of melatonin and NAS on clinical score, inflammatory markers, free radical generation, and sparing of axons, oligodendrocytes and myelin. We found that NAS and melatonin reduced clinical scores when administered prior to or after symptom onset. This effect was more pronounced when melatonin and NAS were administrated prior to symptom onset whereby the appearance of motor symptoms was significantly delayed. Activated microglia and CD4+ T-cells were increased in the white matter of untreated EAE mice, with a return to near control levels after melatonin or NAS treatment. The expression of the NADPH oxidase component p67phox and inducible nitric oxide synthase (iNOS) was increased in the EAE mice as compared with controls, and both drug treated groups had significant reductions in their expression. Melatonin and NAS treatment significantly reduced the loss of mature oligodendrocytes, demyelination and axonal injury. Both compounds also significantly attenuated iNOS induction and reactive oxygen species (ROS) generation in lipopolysaccharide-activated microglia in culture. Our results show for the first time the therapeutic effects of NAS and confirm previous reports on the effectiveness of melatonin in the EAE model of MS. More... »

PAGES

763-773

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s11481-016-9702-9

DOI

http://dx.doi.org/10.1007/s11481-016-9702-9

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1046906636

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/27562847


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1109", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Neurosciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Animals", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cells, Cultured", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Disease Models, Animal", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Encephalomyelitis, Autoimmune, Experimental", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Female", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Melatonin", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mice", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mice, Inbred C57BL", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Multiple Sclerosis", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Serotonin", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Treatment Outcome", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Uniformed Services University of the Health Sciences", 
          "id": "https://www.grid.ac/institutes/grid.265436.0", 
          "name": [
            "Department of Anatomy, Physiology and Genetics, Neuroscience Program, Bldg. C, Uniformed Services University of the Health Sciences, 20814, Bethesda, MD, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Wen", 
        "givenName": "Jie", 
        "id": "sg:person.01323242623.29", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01323242623.29"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Amrita Institute of Medical Sciences and Research Centre", 
          "id": "https://www.grid.ac/institutes/grid.427788.6", 
          "name": [
            "Molecular Diagnostics Div., Department of Medical Oncology, Amrita Institute of Medical Sciences, Amrita University, Kochi, India"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Ariyannur", 
        "givenName": "Prasanth S.", 
        "id": "sg:person.0742455503.65", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0742455503.65"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Uniformed Services University of the Health Sciences", 
          "id": "https://www.grid.ac/institutes/grid.265436.0", 
          "name": [
            "Department of Anatomy, Physiology and Genetics, Neuroscience Program, Bldg. C, Uniformed Services University of the Health Sciences, 20814, Bethesda, MD, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Ribeiro", 
        "givenName": "Rachel", 
        "id": "sg:person.01013154737.87", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01013154737.87"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Uniformed Services University of the Health Sciences", 
          "id": "https://www.grid.ac/institutes/grid.265436.0", 
          "name": [
            "Department of Anatomy, Physiology and Genetics, Neuroscience Program, Bldg. C, Uniformed Services University of the Health Sciences, 20814, Bethesda, MD, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Tanaka", 
        "givenName": "Mikiei", 
        "id": "sg:person.0600141763.21", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0600141763.21"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Uniformed Services University of the Health Sciences", 
          "id": "https://www.grid.ac/institutes/grid.265436.0", 
          "name": [
            "Department of Anatomy, Physiology and Genetics, Neuroscience Program, Bldg. C, Uniformed Services University of the Health Sciences, 20814, Bethesda, MD, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Moffett", 
        "givenName": "John R.", 
        "id": "sg:person.01371610543.10", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01371610543.10"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Scott & White Memorial Hospital", 
          "id": "https://www.grid.ac/institutes/grid.240736.4", 
          "name": [
            "Epilepsy Center, Department of Neurology, Scott and White Hospital, Texas A&M University, Temple, TX, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Kirmani", 
        "givenName": "Batool F.", 
        "id": "sg:person.0765025046.63", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0765025046.63"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Uniformed Services University of the Health Sciences", 
          "id": "https://www.grid.ac/institutes/grid.265436.0", 
          "name": [
            "Department of Anatomy, Physiology and Genetics, Neuroscience Program, Bldg. C, Uniformed Services University of the Health Sciences, 20814, Bethesda, MD, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Namboodiri", 
        "givenName": "Aryan M.A.", 
        "id": "sg:person.0600374503.50", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0600374503.50"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Uniformed Services University of the Health Sciences", 
          "id": "https://www.grid.ac/institutes/grid.265436.0", 
          "name": [
            "Department of Anatomy, Physiology and Genetics, Neuroscience Program, Bldg. C, Uniformed Services University of the Health Sciences, 20814, Bethesda, MD, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Zhang", 
        "givenName": "Yumin", 
        "id": "sg:person.01316240001.66", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01316240001.66"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1523/jneurosci.1948-13.2014", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003018158"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1021/acs.jpcb.5b04920", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006725454"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0165-5728(02)00176-5", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1008004175"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.micinf.2009.04.003", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012830261"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00221-014-3946-5", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014863540", 
          "https://doi.org/10.1007/s00221-014-3946-5"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.0912531107", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1016571855"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/s12974-014-0204-5", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018878417", 
          "https://doi.org/10.1186/s12974-014-0204-5"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/s12974-014-0204-5", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018878417", 
          "https://doi.org/10.1186/s12974-014-0204-5"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.mcn.2011.06.006", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020537357"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3390/ijms140917680", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023334868"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0014-2999(01)01369-3", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024719111"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.ajpath.2012.03.044", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1026394460"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.neuroscience.2011.04.007", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027650862"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.bbi.2015.06.021", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029606011"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.cell.2015.08.025", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031601290"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.cell.2015.08.025", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031601290"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/jnr.10408", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1034031338"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1096/fj.04-3228fje", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036129643"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.autrev.2009.11.010", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1040046801"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1517/13543784.2012.681045", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1040334279"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3390/ijms14048638", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1040565090"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.tox.2010.04.008", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1040573672"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1385/endo:27:2:189", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041873765", 
          "https://doi.org/10.1385/endo:27:2:189"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1371/journal.pone.0130715", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1043299999"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.neuint.2015.10.008", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1043806703"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.intimp.2015.12.020", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045113498"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1742-4658.2012.08487.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045274288"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1084/jem.178.2.643", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045981472"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.0502552102", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046935235"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.0502552102", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046935235"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.2174/157015910792246155", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048274223"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.tips.2012.09.006", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048378922"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.expneurol.2011.05.014", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1049313349"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/bs.apha.2016.01.005", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050006166"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/jpi.12203", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050498139"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.msard.2014.12.001", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050765883"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.4103/2319-4170.125885", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051709893"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.2174/1568026023394335", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1069192858"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.2174/1568026023394425", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1069192863"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.4137/ijtr.s4282", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1072253473"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.4137/ijtr.s4282", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1072253473"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.4161/sgtp.27952", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1072310916"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1076596146", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.4142/jvs.2001.2.2.85", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1076596146"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.4142/jvs.2001.2.2.85", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1076596146"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.4142/jvs.2001.2.2.85", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1076596146"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1076629180", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1076842785", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1077383464", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1079763315", 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2016-12", 
    "datePublishedReg": "2016-12-01", 
    "description": "Melatonin and N-acetylserotonin (NAS) are tryptophan metabolites that have potent anti-oxidant, anti-inflammatory and neuroprotective properties in several animal models of neurological injury and disease including multiple sclerosis (MS). The therapeutic effect of NAS has not been reported previously in experimental autoimmune encephalomyelitis (EAE), a commonly used animal model of MS. Using a MOG-peptide induced EAE mouse model we examined the effects of melatonin and NAS on clinical score, inflammatory markers, free radical generation, and sparing of axons, oligodendrocytes and myelin. We found that NAS and melatonin reduced clinical scores when administered prior to or after symptom onset. This effect was more pronounced when melatonin and NAS were administrated prior to symptom onset whereby the appearance of motor symptoms was significantly delayed. Activated microglia and CD4+ T-cells were increased in the white matter of untreated EAE mice, with a return to near control levels after melatonin or NAS treatment. The expression of the NADPH oxidase component p67phox and inducible nitric oxide synthase (iNOS) was increased in the EAE mice as compared with controls, and both drug treated groups had significant reductions in their expression. Melatonin and NAS treatment significantly reduced the loss of mature oligodendrocytes, demyelination and axonal injury. Both compounds also significantly attenuated iNOS induction and reactive oxygen species (ROS) generation in lipopolysaccharide-activated microglia in culture. Our results show for the first time the therapeutic effects of NAS and confirm previous reports on the effectiveness of melatonin in the EAE model of MS.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1007/s11481-016-9702-9", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": false, 
    "isFundedItemOf": [
      {
        "id": "sg:grant.3492708", 
        "type": "MonetaryGrant"
      }
    ], 
    "isPartOf": [
      {
        "id": "sg:journal.1035881", 
        "issn": [
          "1557-1890", 
          "1557-1904"
        ], 
        "name": "Journal of Neuroimmune Pharmacology", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "4", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "11"
      }
    ], 
    "name": "Efficacy of N-Acetylserotonin and Melatonin in the EAE Model of Multiple Sclerosis", 
    "pagination": "763-773", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "df720acbde9e72747aedaeb219b91ace10d5457b63ad385126021b180d910d07"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "27562847"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "101256586"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1007/s11481-016-9702-9"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1046906636"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1007/s11481-016-9702-9", 
      "https://app.dimensions.ai/details/publication/pub.1046906636"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-11T12:42", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000363_0000000363/records_70058_00000002.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://link.springer.com/10.1007%2Fs11481-016-9702-9"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s11481-016-9702-9'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s11481-016-9702-9'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s11481-016-9702-9'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s11481-016-9702-9'


 

This table displays all metadata directly associated to this object as RDF triples.

300 TRIPLES      21 PREDICATES      84 URIs      32 LITERALS      20 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1007/s11481-016-9702-9 schema:about N024db8089b5742b5a2746123aed5b019
2 N09046e62af38441eb41c978b32b5a9e7
3 N0f0b0813da2d4e2685799c73ad812163
4 N1620dec4072a4f7081275a4429cc9ce8
5 N20467e66b58d4075beee8fc656e3b189
6 N248d178cf2cd486e886d55e095ed65f0
7 N2816b85d97c640199074d14b990d4b27
8 N531276f10c6f46d6a883554c8a62f529
9 N777f8db3ac364cd5848edaf38b1b7096
10 N77b8f20636e24b6f83277da81a40e14c
11 N9475fc0333f64a838a23efc429377de1
12 anzsrc-for:11
13 anzsrc-for:1109
14 schema:author Na9eb3d4a2c5442d7b009eb56dd9d4c8a
15 schema:citation sg:pub.10.1007/s00221-014-3946-5
16 sg:pub.10.1186/s12974-014-0204-5
17 sg:pub.10.1385/endo:27:2:189
18 https://app.dimensions.ai/details/publication/pub.1076596146
19 https://app.dimensions.ai/details/publication/pub.1076629180
20 https://app.dimensions.ai/details/publication/pub.1076842785
21 https://app.dimensions.ai/details/publication/pub.1077383464
22 https://app.dimensions.ai/details/publication/pub.1079763315
23 https://doi.org/10.1002/jnr.10408
24 https://doi.org/10.1016/bs.apha.2016.01.005
25 https://doi.org/10.1016/j.ajpath.2012.03.044
26 https://doi.org/10.1016/j.autrev.2009.11.010
27 https://doi.org/10.1016/j.bbi.2015.06.021
28 https://doi.org/10.1016/j.cell.2015.08.025
29 https://doi.org/10.1016/j.expneurol.2011.05.014
30 https://doi.org/10.1016/j.intimp.2015.12.020
31 https://doi.org/10.1016/j.mcn.2011.06.006
32 https://doi.org/10.1016/j.micinf.2009.04.003
33 https://doi.org/10.1016/j.msard.2014.12.001
34 https://doi.org/10.1016/j.neuint.2015.10.008
35 https://doi.org/10.1016/j.neuroscience.2011.04.007
36 https://doi.org/10.1016/j.tips.2012.09.006
37 https://doi.org/10.1016/j.tox.2010.04.008
38 https://doi.org/10.1016/s0014-2999(01)01369-3
39 https://doi.org/10.1016/s0165-5728(02)00176-5
40 https://doi.org/10.1021/acs.jpcb.5b04920
41 https://doi.org/10.1073/pnas.0502552102
42 https://doi.org/10.1073/pnas.0912531107
43 https://doi.org/10.1084/jem.178.2.643
44 https://doi.org/10.1096/fj.04-3228fje
45 https://doi.org/10.1111/j.1742-4658.2012.08487.x
46 https://doi.org/10.1111/jpi.12203
47 https://doi.org/10.1371/journal.pone.0130715
48 https://doi.org/10.1517/13543784.2012.681045
49 https://doi.org/10.1523/jneurosci.1948-13.2014
50 https://doi.org/10.2174/1568026023394335
51 https://doi.org/10.2174/1568026023394425
52 https://doi.org/10.2174/157015910792246155
53 https://doi.org/10.3390/ijms14048638
54 https://doi.org/10.3390/ijms140917680
55 https://doi.org/10.4103/2319-4170.125885
56 https://doi.org/10.4137/ijtr.s4282
57 https://doi.org/10.4142/jvs.2001.2.2.85
58 https://doi.org/10.4161/sgtp.27952
59 schema:datePublished 2016-12
60 schema:datePublishedReg 2016-12-01
61 schema:description Melatonin and N-acetylserotonin (NAS) are tryptophan metabolites that have potent anti-oxidant, anti-inflammatory and neuroprotective properties in several animal models of neurological injury and disease including multiple sclerosis (MS). The therapeutic effect of NAS has not been reported previously in experimental autoimmune encephalomyelitis (EAE), a commonly used animal model of MS. Using a MOG-peptide induced EAE mouse model we examined the effects of melatonin and NAS on clinical score, inflammatory markers, free radical generation, and sparing of axons, oligodendrocytes and myelin. We found that NAS and melatonin reduced clinical scores when administered prior to or after symptom onset. This effect was more pronounced when melatonin and NAS were administrated prior to symptom onset whereby the appearance of motor symptoms was significantly delayed. Activated microglia and CD4<sup>+</sup> T-cells were increased in the white matter of untreated EAE mice, with a return to near control levels after melatonin or NAS treatment. The expression of the NADPH oxidase component p67phox and inducible nitric oxide synthase (iNOS) was increased in the EAE mice as compared with controls, and both drug treated groups had significant reductions in their expression. Melatonin and NAS treatment significantly reduced the loss of mature oligodendrocytes, demyelination and axonal injury. Both compounds also significantly attenuated iNOS induction and reactive oxygen species (ROS) generation in lipopolysaccharide-activated microglia in culture. Our results show for the first time the therapeutic effects of NAS and confirm previous reports on the effectiveness of melatonin in the EAE model of MS.
62 schema:genre research_article
63 schema:inLanguage en
64 schema:isAccessibleForFree false
65 schema:isPartOf N324bfd69d4e343cf87af539f5d941fd9
66 Nff3d6bc559b94839a744270f2632a100
67 sg:journal.1035881
68 schema:name Efficacy of N-Acetylserotonin and Melatonin in the EAE Model of Multiple Sclerosis
69 schema:pagination 763-773
70 schema:productId N075863984518448ea1ddb56a249e1847
71 N39d7a7bbec0a4095b833ba06d93153c7
72 N58455d3a3af44969b9d5a5e01d6608b6
73 Ne98d74c0a9ba45f1a16085faf198f1ce
74 Nf5759abd03994549ad689719884575c9
75 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046906636
76 https://doi.org/10.1007/s11481-016-9702-9
77 schema:sdDatePublished 2019-04-11T12:42
78 schema:sdLicense https://scigraph.springernature.com/explorer/license/
79 schema:sdPublisher N975c081e189f477d80aa8e70dfc561b0
80 schema:url https://link.springer.com/10.1007%2Fs11481-016-9702-9
81 sgo:license sg:explorer/license/
82 sgo:sdDataset articles
83 rdf:type schema:ScholarlyArticle
84 N024db8089b5742b5a2746123aed5b019 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
85 schema:name Melatonin
86 rdf:type schema:DefinedTerm
87 N039b00acc5864aa49a8e9e5bc6b42d51 rdf:first sg:person.01371610543.10
88 rdf:rest N4549e4f3868c4cdd9008e412c73abe7f
89 N075863984518448ea1ddb56a249e1847 schema:name doi
90 schema:value 10.1007/s11481-016-9702-9
91 rdf:type schema:PropertyValue
92 N09046e62af38441eb41c978b32b5a9e7 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
93 schema:name Female
94 rdf:type schema:DefinedTerm
95 N0f0b0813da2d4e2685799c73ad812163 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
96 schema:name Cells, Cultured
97 rdf:type schema:DefinedTerm
98 N1620dec4072a4f7081275a4429cc9ce8 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
99 schema:name Multiple Sclerosis
100 rdf:type schema:DefinedTerm
101 N1a0fb0ab12e14b899a2ac53266f7dcf0 rdf:first sg:person.0600374503.50
102 rdf:rest N4b5818edff534fbab4445b76d1f1f24e
103 N20467e66b58d4075beee8fc656e3b189 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
104 schema:name Encephalomyelitis, Autoimmune, Experimental
105 rdf:type schema:DefinedTerm
106 N248d178cf2cd486e886d55e095ed65f0 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
107 schema:name Disease Models, Animal
108 rdf:type schema:DefinedTerm
109 N2816b85d97c640199074d14b990d4b27 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
110 schema:name Treatment Outcome
111 rdf:type schema:DefinedTerm
112 N324bfd69d4e343cf87af539f5d941fd9 schema:volumeNumber 11
113 rdf:type schema:PublicationVolume
114 N39d7a7bbec0a4095b833ba06d93153c7 schema:name dimensions_id
115 schema:value pub.1046906636
116 rdf:type schema:PropertyValue
117 N4549e4f3868c4cdd9008e412c73abe7f rdf:first sg:person.0765025046.63
118 rdf:rest N1a0fb0ab12e14b899a2ac53266f7dcf0
119 N4b5818edff534fbab4445b76d1f1f24e rdf:first sg:person.01316240001.66
120 rdf:rest rdf:nil
121 N4d2fc633a52c418486c86d3f997007cc rdf:first sg:person.01013154737.87
122 rdf:rest N6e15528d9f974c3fa51937b643c0306a
123 N531276f10c6f46d6a883554c8a62f529 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
124 schema:name Animals
125 rdf:type schema:DefinedTerm
126 N54e6367986ae41098fc088197ea51183 rdf:first sg:person.0742455503.65
127 rdf:rest N4d2fc633a52c418486c86d3f997007cc
128 N58455d3a3af44969b9d5a5e01d6608b6 schema:name readcube_id
129 schema:value df720acbde9e72747aedaeb219b91ace10d5457b63ad385126021b180d910d07
130 rdf:type schema:PropertyValue
131 N6e15528d9f974c3fa51937b643c0306a rdf:first sg:person.0600141763.21
132 rdf:rest N039b00acc5864aa49a8e9e5bc6b42d51
133 N777f8db3ac364cd5848edaf38b1b7096 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
134 schema:name Serotonin
135 rdf:type schema:DefinedTerm
136 N77b8f20636e24b6f83277da81a40e14c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
137 schema:name Mice
138 rdf:type schema:DefinedTerm
139 N9475fc0333f64a838a23efc429377de1 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
140 schema:name Mice, Inbred C57BL
141 rdf:type schema:DefinedTerm
142 N975c081e189f477d80aa8e70dfc561b0 schema:name Springer Nature - SN SciGraph project
143 rdf:type schema:Organization
144 Na9eb3d4a2c5442d7b009eb56dd9d4c8a rdf:first sg:person.01323242623.29
145 rdf:rest N54e6367986ae41098fc088197ea51183
146 Ne98d74c0a9ba45f1a16085faf198f1ce schema:name pubmed_id
147 schema:value 27562847
148 rdf:type schema:PropertyValue
149 Nf5759abd03994549ad689719884575c9 schema:name nlm_unique_id
150 schema:value 101256586
151 rdf:type schema:PropertyValue
152 Nff3d6bc559b94839a744270f2632a100 schema:issueNumber 4
153 rdf:type schema:PublicationIssue
154 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
155 schema:name Medical and Health Sciences
156 rdf:type schema:DefinedTerm
157 anzsrc-for:1109 schema:inDefinedTermSet anzsrc-for:
158 schema:name Neurosciences
159 rdf:type schema:DefinedTerm
160 sg:grant.3492708 http://pending.schema.org/fundedItem sg:pub.10.1007/s11481-016-9702-9
161 rdf:type schema:MonetaryGrant
162 sg:journal.1035881 schema:issn 1557-1890
163 1557-1904
164 schema:name Journal of Neuroimmune Pharmacology
165 rdf:type schema:Periodical
166 sg:person.01013154737.87 schema:affiliation https://www.grid.ac/institutes/grid.265436.0
167 schema:familyName Ribeiro
168 schema:givenName Rachel
169 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01013154737.87
170 rdf:type schema:Person
171 sg:person.01316240001.66 schema:affiliation https://www.grid.ac/institutes/grid.265436.0
172 schema:familyName Zhang
173 schema:givenName Yumin
174 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01316240001.66
175 rdf:type schema:Person
176 sg:person.01323242623.29 schema:affiliation https://www.grid.ac/institutes/grid.265436.0
177 schema:familyName Wen
178 schema:givenName Jie
179 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01323242623.29
180 rdf:type schema:Person
181 sg:person.01371610543.10 schema:affiliation https://www.grid.ac/institutes/grid.265436.0
182 schema:familyName Moffett
183 schema:givenName John R.
184 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01371610543.10
185 rdf:type schema:Person
186 sg:person.0600141763.21 schema:affiliation https://www.grid.ac/institutes/grid.265436.0
187 schema:familyName Tanaka
188 schema:givenName Mikiei
189 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0600141763.21
190 rdf:type schema:Person
191 sg:person.0600374503.50 schema:affiliation https://www.grid.ac/institutes/grid.265436.0
192 schema:familyName Namboodiri
193 schema:givenName Aryan M.A.
194 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0600374503.50
195 rdf:type schema:Person
196 sg:person.0742455503.65 schema:affiliation https://www.grid.ac/institutes/grid.427788.6
197 schema:familyName Ariyannur
198 schema:givenName Prasanth S.
199 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0742455503.65
200 rdf:type schema:Person
201 sg:person.0765025046.63 schema:affiliation https://www.grid.ac/institutes/grid.240736.4
202 schema:familyName Kirmani
203 schema:givenName Batool F.
204 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0765025046.63
205 rdf:type schema:Person
206 sg:pub.10.1007/s00221-014-3946-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014863540
207 https://doi.org/10.1007/s00221-014-3946-5
208 rdf:type schema:CreativeWork
209 sg:pub.10.1186/s12974-014-0204-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018878417
210 https://doi.org/10.1186/s12974-014-0204-5
211 rdf:type schema:CreativeWork
212 sg:pub.10.1385/endo:27:2:189 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041873765
213 https://doi.org/10.1385/endo:27:2:189
214 rdf:type schema:CreativeWork
215 https://app.dimensions.ai/details/publication/pub.1076596146 schema:CreativeWork
216 https://app.dimensions.ai/details/publication/pub.1076629180 schema:CreativeWork
217 https://app.dimensions.ai/details/publication/pub.1076842785 schema:CreativeWork
218 https://app.dimensions.ai/details/publication/pub.1077383464 schema:CreativeWork
219 https://app.dimensions.ai/details/publication/pub.1079763315 schema:CreativeWork
220 https://doi.org/10.1002/jnr.10408 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034031338
221 rdf:type schema:CreativeWork
222 https://doi.org/10.1016/bs.apha.2016.01.005 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050006166
223 rdf:type schema:CreativeWork
224 https://doi.org/10.1016/j.ajpath.2012.03.044 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026394460
225 rdf:type schema:CreativeWork
226 https://doi.org/10.1016/j.autrev.2009.11.010 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040046801
227 rdf:type schema:CreativeWork
228 https://doi.org/10.1016/j.bbi.2015.06.021 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029606011
229 rdf:type schema:CreativeWork
230 https://doi.org/10.1016/j.cell.2015.08.025 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031601290
231 rdf:type schema:CreativeWork
232 https://doi.org/10.1016/j.expneurol.2011.05.014 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049313349
233 rdf:type schema:CreativeWork
234 https://doi.org/10.1016/j.intimp.2015.12.020 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045113498
235 rdf:type schema:CreativeWork
236 https://doi.org/10.1016/j.mcn.2011.06.006 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020537357
237 rdf:type schema:CreativeWork
238 https://doi.org/10.1016/j.micinf.2009.04.003 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012830261
239 rdf:type schema:CreativeWork
240 https://doi.org/10.1016/j.msard.2014.12.001 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050765883
241 rdf:type schema:CreativeWork
242 https://doi.org/10.1016/j.neuint.2015.10.008 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043806703
243 rdf:type schema:CreativeWork
244 https://doi.org/10.1016/j.neuroscience.2011.04.007 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027650862
245 rdf:type schema:CreativeWork
246 https://doi.org/10.1016/j.tips.2012.09.006 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048378922
247 rdf:type schema:CreativeWork
248 https://doi.org/10.1016/j.tox.2010.04.008 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040573672
249 rdf:type schema:CreativeWork
250 https://doi.org/10.1016/s0014-2999(01)01369-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024719111
251 rdf:type schema:CreativeWork
252 https://doi.org/10.1016/s0165-5728(02)00176-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008004175
253 rdf:type schema:CreativeWork
254 https://doi.org/10.1021/acs.jpcb.5b04920 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006725454
255 rdf:type schema:CreativeWork
256 https://doi.org/10.1073/pnas.0502552102 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046935235
257 rdf:type schema:CreativeWork
258 https://doi.org/10.1073/pnas.0912531107 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016571855
259 rdf:type schema:CreativeWork
260 https://doi.org/10.1084/jem.178.2.643 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045981472
261 rdf:type schema:CreativeWork
262 https://doi.org/10.1096/fj.04-3228fje schema:sameAs https://app.dimensions.ai/details/publication/pub.1036129643
263 rdf:type schema:CreativeWork
264 https://doi.org/10.1111/j.1742-4658.2012.08487.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1045274288
265 rdf:type schema:CreativeWork
266 https://doi.org/10.1111/jpi.12203 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050498139
267 rdf:type schema:CreativeWork
268 https://doi.org/10.1371/journal.pone.0130715 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043299999
269 rdf:type schema:CreativeWork
270 https://doi.org/10.1517/13543784.2012.681045 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040334279
271 rdf:type schema:CreativeWork
272 https://doi.org/10.1523/jneurosci.1948-13.2014 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003018158
273 rdf:type schema:CreativeWork
274 https://doi.org/10.2174/1568026023394335 schema:sameAs https://app.dimensions.ai/details/publication/pub.1069192858
275 rdf:type schema:CreativeWork
276 https://doi.org/10.2174/1568026023394425 schema:sameAs https://app.dimensions.ai/details/publication/pub.1069192863
277 rdf:type schema:CreativeWork
278 https://doi.org/10.2174/157015910792246155 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048274223
279 rdf:type schema:CreativeWork
280 https://doi.org/10.3390/ijms14048638 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040565090
281 rdf:type schema:CreativeWork
282 https://doi.org/10.3390/ijms140917680 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023334868
283 rdf:type schema:CreativeWork
284 https://doi.org/10.4103/2319-4170.125885 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051709893
285 rdf:type schema:CreativeWork
286 https://doi.org/10.4137/ijtr.s4282 schema:sameAs https://app.dimensions.ai/details/publication/pub.1072253473
287 rdf:type schema:CreativeWork
288 https://doi.org/10.4142/jvs.2001.2.2.85 schema:sameAs https://app.dimensions.ai/details/publication/pub.1076596146
289 rdf:type schema:CreativeWork
290 https://doi.org/10.4161/sgtp.27952 schema:sameAs https://app.dimensions.ai/details/publication/pub.1072310916
291 rdf:type schema:CreativeWork
292 https://www.grid.ac/institutes/grid.240736.4 schema:alternateName Scott & White Memorial Hospital
293 schema:name Epilepsy Center, Department of Neurology, Scott and White Hospital, Texas A&M University, Temple, TX, USA
294 rdf:type schema:Organization
295 https://www.grid.ac/institutes/grid.265436.0 schema:alternateName Uniformed Services University of the Health Sciences
296 schema:name Department of Anatomy, Physiology and Genetics, Neuroscience Program, Bldg. C, Uniformed Services University of the Health Sciences, 20814, Bethesda, MD, USA
297 rdf:type schema:Organization
298 https://www.grid.ac/institutes/grid.427788.6 schema:alternateName Amrita Institute of Medical Sciences and Research Centre
299 schema:name Molecular Diagnostics Div., Department of Medical Oncology, Amrita Institute of Medical Sciences, Amrita University, Kochi, India
300 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...