Combinatorial assessments of brain tissue metabolomics and histopathology in rodent models of human immunodeficiency virus infection View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2013-12

AUTHORS

Adrian A. Epstein, Prabagaran Narayanasamy, Prasanta K. Dash, Robin High, Sai Praneeth R. Bathena, Santhi Gorantla, Larisa Y. Poluektova, Yazen Alnouti, Howard E. Gendelman, Michael D. Boska

ABSTRACT

Metabolites are biomarkers for a broad range of central nervous system disorders serving as molecular drivers and byproducts of disease pathobiology. However, despite their importance, routine measures of brain tissue metabolomics are not readily available based on the requirements of rapid tissue preservation. They require preservation by microwave irradiation, rapid freezing or other methods designed to reduce post mortem metabolism. Our research on human immunodeficiency virus type one (HIV-1) infection has highlighted immediate needs to better link histology to neural metabolites. To this end, we investigated such needs in well-studied rodent models. First, the dynamics of brain metabolism during ex vivo tissue preparation was shown by proton magnetic resonance spectroscopy in normal mice. Second, tissue preservation methodologies were assessed using liquid chromatography tandem mass spectrometry and immunohistology to measure metabolites and neural antigens. Third, these methods were applied to two animal models. In the first, immunodeficient mice reconstituted with human peripheral blood lymphocytes then acutely infected with HIV-1. In the second, NOD scid IL2 receptor gamma chain knockout mice were humanized with CD34+ human hematopoietic stem cells and chronically infected with HIV-1. Replicate infected animals were treated with nanoformulated antiretroviral therapy (nanoART). Results from chronic infection showed that microgliosis was associated with increased myoinostitol, choline, phosphocholine concentrations and with decreased creatine concentrations. These changes were partially reversed with nanoART. Metabolite responses were contingent on the animal model. Taken together, these studies integrate brain metabolomics with histopathology towards uncovering putative biomarkers for neuroAIDS. More... »

PAGES

1224-1238

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s11481-013-9461-9

DOI

http://dx.doi.org/10.1007/s11481-013-9461-9

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1041845481

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/23702663


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1109", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Neurosciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "AIDS Dementia Complex", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Animals", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Brain", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Chromatography, Liquid", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cryopreservation", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Disease Models, Animal", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "HIV Infections", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Magnetic Resonance Spectroscopy", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Metabolomics", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mice", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mice, Inbred NOD", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mice, Knockout", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mice, SCID", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Microwaves", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Tandem Mass Spectrometry", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Tissue Fixation", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "University of Nebraska Medical Center", 
          "id": "https://www.grid.ac/institutes/grid.266813.8", 
          "name": [
            "Department of Pharmacology and Experimental Neuroscience, College of Medicine, University of Nebraska Medical Center, 68198, Omaha, NE, USA", 
            "Department of Radiology, College of Medicine, University of Nebraska Medical Center, 68198, Omaha, NE, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Epstein", 
        "givenName": "Adrian A.", 
        "id": "sg:person.0743307135.12", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0743307135.12"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Nebraska Medical Center", 
          "id": "https://www.grid.ac/institutes/grid.266813.8", 
          "name": [
            "Department of Pharmacology and Experimental Neuroscience, College of Medicine, University of Nebraska Medical Center, 68198, Omaha, NE, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Narayanasamy", 
        "givenName": "Prabagaran", 
        "id": "sg:person.0577270623.83", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0577270623.83"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Nebraska Medical Center", 
          "id": "https://www.grid.ac/institutes/grid.266813.8", 
          "name": [
            "Department of Pharmacology and Experimental Neuroscience, College of Medicine, University of Nebraska Medical Center, 68198, Omaha, NE, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Dash", 
        "givenName": "Prasanta K.", 
        "id": "sg:person.014224720137.37", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014224720137.37"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Nebraska Medical Center", 
          "id": "https://www.grid.ac/institutes/grid.266813.8", 
          "name": [
            "Department of Biostatistics, College of Public Health, University of Nebraska Medical Center, 68198, Omaha, NE, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "High", 
        "givenName": "Robin", 
        "id": "sg:person.01246513575.79", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01246513575.79"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Nebraska Medical Center", 
          "id": "https://www.grid.ac/institutes/grid.266813.8", 
          "name": [
            "Department of Pharmaceutical Sciences, College of Pharmacy, University of Nebraska Medical Center, 68198, Omaha, NE, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Bathena", 
        "givenName": "Sai Praneeth R.", 
        "id": "sg:person.0733362241.37", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0733362241.37"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Nebraska Medical Center", 
          "id": "https://www.grid.ac/institutes/grid.266813.8", 
          "name": [
            "Department of Pharmacology and Experimental Neuroscience, College of Medicine, University of Nebraska Medical Center, 68198, Omaha, NE, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Gorantla", 
        "givenName": "Santhi", 
        "id": "sg:person.01326542635.31", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01326542635.31"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Nebraska Medical Center", 
          "id": "https://www.grid.ac/institutes/grid.266813.8", 
          "name": [
            "Department of Pharmacology and Experimental Neuroscience, College of Medicine, University of Nebraska Medical Center, 68198, Omaha, NE, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Poluektova", 
        "givenName": "Larisa Y.", 
        "id": "sg:person.015532126607.07", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015532126607.07"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Nebraska Medical Center", 
          "id": "https://www.grid.ac/institutes/grid.266813.8", 
          "name": [
            "Department of Pharmaceutical Sciences, College of Pharmacy, University of Nebraska Medical Center, 68198, Omaha, NE, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Alnouti", 
        "givenName": "Yazen", 
        "id": "sg:person.0621261030.30", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0621261030.30"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Nebraska Medical Center", 
          "id": "https://www.grid.ac/institutes/grid.266813.8", 
          "name": [
            "Department of Pharmacology and Experimental Neuroscience, College of Medicine, University of Nebraska Medical Center, 68198, Omaha, NE, USA", 
            "Department of Pharmacology and Experimental Neuroscience, Nebraska Medical Center, 985880, 68198-5880, Omaha, NE, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Gendelman", 
        "givenName": "Howard E.", 
        "id": "sg:person.01235657370.48", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01235657370.48"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Nebraska Medical Center", 
          "id": "https://www.grid.ac/institutes/grid.266813.8", 
          "name": [
            "Department of Radiology, College of Medicine, University of Nebraska Medical Center, 68198, Omaha, NE, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Boska", 
        "givenName": "Michael D.", 
        "id": "sg:person.01033077163.61", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01033077163.61"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "sg:pub.10.1007/s13365-012-0114-1", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001544018", 
          "https://doi.org/10.1007/s13365-012-0114-1"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s13365-012-0114-1", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001544018", 
          "https://doi.org/10.1007/s13365-012-0114-1"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1172/jci34138", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002523501"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.2147/ijn.s27830", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003448338"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.jneuroim.2008.10.013", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005326809"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/mrm.20073", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1007115702"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/nbm.895", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010997233"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/1559-0275-9-3", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1011022600", 
          "https://doi.org/10.1186/1559-0275-9-3"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.bbi.2011.09.011", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1011191597"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1074/jbc.m111.309849", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014362437"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1006/jmre.1999.1895", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014501690"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.jchromb.2012.01.035", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017214316"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/qad.0b013e328357f5ad", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017378011"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/qad.0b013e328357f5ad", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017378011"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/qad.0b013e328357f5ad", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017378011"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s13365-011-0030-9", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018832915", 
          "https://doi.org/10.1007/s13365-011-0030-9"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1365-2249.2009.03933.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019172125"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1365-2249.2009.03933.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019172125"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0165-0270(95)00119-0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019605423"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1006/jmra.1994.1008", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020014290"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/nbm.1145", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020624084"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/1471-2377-11-148", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020663393", 
          "https://doi.org/10.1186/1471-2377-11-148"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nchembio.767", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021422491", 
          "https://doi.org/10.1038/nchembio.767"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/cid/cir524", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024315691"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.tins.2011.12.006", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025810521"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1371/journal.pone.0043152", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027892448"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s11481-009-9174-2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028027903", 
          "https://doi.org/10.1007/s11481-009-9174-2"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s11481-009-9174-2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028027903", 
          "https://doi.org/10.1007/s11481-009-9174-2"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s11481-009-9174-2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028027903", 
          "https://doi.org/10.1007/s11481-009-9174-2"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1006/meth.1998.0613", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028488203"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1006/meth.1998.0613", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028488203"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/infdis/jis326", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031856100"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1371/journal.pone.0038853", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031949737"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/1099-1492(200005)13:3<129::aid-nbm619>3.0.co;2-v", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032265127"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.jneuroim.2010.08.014", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033849874"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/mrm.22821", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1034866653"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/npp.2012.40", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035074695", 
          "https://doi.org/10.1038/npp.2012.40"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00018-012-1071-9", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035612593", 
          "https://doi.org/10.1007/s00018-012-1071-9"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1021/pr070220c", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035909781"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0003-2697(82)90621-2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037199636"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/mrm.10445", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037330761"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s11481-010-9225-8", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1040117506", 
          "https://doi.org/10.1007/s11481-010-9225-8"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s11481-010-9225-8", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1040117506", 
          "https://doi.org/10.1007/s11481-010-9225-8"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1471-4159.2009.05967.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1040310147"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.2353/ajpath.2008.080045", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1040682509"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.neuron.2009.09.042", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1040720018"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.2353/ajpath.2010.100536", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1044955820"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.jneumeth.2011.07.014", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045150834"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.jneuroim.2007.08.004", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045299997"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/infdis/jis395", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046264041"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3791/2460", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047362823"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1371/journal.pone.0042878", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048676918"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1084/jem.167.4.1428", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048751928"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/mrm.20184", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050553468"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1523/jneurosci.5473-10.2011", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050836975"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.taap.2011.05.015", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052408483"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1021/pr1010263", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1056292396"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1086/515693", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1058790081"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.1209200", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1062464935"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1212/wnl.0b013e3181ab2b3b", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1064354428"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1212/wnl.0b013e3181ab2b3b", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1064354428"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1212/wnl.0b013e3181ab2b3b", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1064354428"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.2174/1570162043485095", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1069197440"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1083045613", 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2013-12", 
    "datePublishedReg": "2013-12-01", 
    "description": "Metabolites are biomarkers for a broad range of central nervous system disorders serving as molecular drivers and byproducts of disease pathobiology. However, despite their importance, routine measures of brain tissue metabolomics are not readily available based on the requirements of rapid tissue preservation. They require preservation by microwave irradiation, rapid freezing or other methods designed to reduce post mortem metabolism. Our research on human immunodeficiency virus type one (HIV-1) infection has highlighted immediate needs to better link histology to neural metabolites. To this end, we investigated such needs in well-studied rodent models. First, the dynamics of brain metabolism during ex vivo tissue preparation was shown by proton magnetic resonance spectroscopy in normal mice. Second, tissue preservation methodologies were assessed using liquid chromatography tandem mass spectrometry and immunohistology to measure metabolites and neural antigens. Third, these methods were applied to two animal models. In the first, immunodeficient mice reconstituted with human peripheral blood lymphocytes then acutely infected with HIV-1. In the second, NOD scid IL2 receptor gamma chain knockout mice were humanized with CD34+ human hematopoietic stem cells and chronically infected with HIV-1. Replicate infected animals were treated with nanoformulated antiretroviral therapy (nanoART). Results from chronic infection showed that microgliosis was associated with increased myoinostitol, choline, phosphocholine concentrations and with decreased creatine concentrations. These changes were partially reversed with nanoART. Metabolite responses were contingent on the animal model. Taken together, these studies integrate brain metabolomics with histopathology towards uncovering putative biomarkers for neuroAIDS. ", 
    "genre": "research_article", 
    "id": "sg:pub.10.1007/s11481-013-9461-9", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": true, 
    "isFundedItemOf": [
      {
        "id": "sg:grant.2636159", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.2437365", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.2437192", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.2558463", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.2449062", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.2558029", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.2439392", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.2589589", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.2435940", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.2558462", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.2435941", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.2437437", 
        "type": "MonetaryGrant"
      }
    ], 
    "isPartOf": [
      {
        "id": "sg:journal.1035881", 
        "issn": [
          "1557-1890", 
          "1557-1904"
        ], 
        "name": "Journal of Neuroimmune Pharmacology", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "5", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "8"
      }
    ], 
    "name": "Combinatorial assessments of brain tissue metabolomics and histopathology in rodent models of human immunodeficiency virus infection", 
    "pagination": "1224-1238", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "c7551e16f43c30e41987f615868b16b8bcee5ea9455e0e18ca3fb19d1d0b2bdc"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "23702663"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "101256586"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1007/s11481-013-9461-9"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1041845481"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1007/s11481-013-9461-9", 
      "https://app.dimensions.ai/details/publication/pub.1041845481"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-11T13:06", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000367_0000000367/records_88218_00000000.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://link.springer.com/10.1007%2Fs11481-013-9461-9"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s11481-013-9461-9'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s11481-013-9461-9'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s11481-013-9461-9'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s11481-013-9461-9'


 

This table displays all metadata directly associated to this object as RDF triples.

398 TRIPLES      21 PREDICATES      100 URIs      38 LITERALS      26 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1007/s11481-013-9461-9 schema:about N01857b64eb02437496a22af112873a11
2 N026edd260dc74965bbd42fc65aac9e5c
3 N1b85f0a59791426990ec2a5481a1d794
4 N25737c01bac5439e8dd7632e5a1ea7a9
5 N2e21cc2669c14912a3770df3bdc83d89
6 N423c5a5924f343c99a6eef363afc4bee
7 N469fac5c95db4423af2a934d292b58af
8 N6e42850486fd471098f81b3ba2f938e2
9 N8ba8de217359456b8744acd6205d9166
10 N94e76e5a2f2d4e099396af22c9473f44
11 N9edb8d28caf2485384fc90a80ba73628
12 Nbe3671f8c8834628a6430a8feeeb5bc3
13 Nc5723dbbd33143118224924c89c83097
14 Nde5199516d4c4a97ae6bb69a9fdc38b9
15 Nf465402549fb4153aadc2607d440965c
16 Nf8c9b2ed5db14eedba86591bf8e51da4
17 Nfb98c5c5f6454e4e8f806cc29212329f
18 anzsrc-for:11
19 anzsrc-for:1109
20 schema:author N187ce60022a8464b9e281895a32c8b3a
21 schema:citation sg:pub.10.1007/s00018-012-1071-9
22 sg:pub.10.1007/s11481-009-9174-2
23 sg:pub.10.1007/s11481-010-9225-8
24 sg:pub.10.1007/s13365-011-0030-9
25 sg:pub.10.1007/s13365-012-0114-1
26 sg:pub.10.1038/nchembio.767
27 sg:pub.10.1038/npp.2012.40
28 sg:pub.10.1186/1471-2377-11-148
29 sg:pub.10.1186/1559-0275-9-3
30 https://app.dimensions.ai/details/publication/pub.1083045613
31 https://doi.org/10.1002/1099-1492(200005)13:3<129::aid-nbm619>3.0.co;2-v
32 https://doi.org/10.1002/mrm.10445
33 https://doi.org/10.1002/mrm.20073
34 https://doi.org/10.1002/mrm.20184
35 https://doi.org/10.1002/mrm.22821
36 https://doi.org/10.1002/nbm.1145
37 https://doi.org/10.1002/nbm.895
38 https://doi.org/10.1006/jmra.1994.1008
39 https://doi.org/10.1006/jmre.1999.1895
40 https://doi.org/10.1006/meth.1998.0613
41 https://doi.org/10.1016/0003-2697(82)90621-2
42 https://doi.org/10.1016/0165-0270(95)00119-0
43 https://doi.org/10.1016/j.bbi.2011.09.011
44 https://doi.org/10.1016/j.jchromb.2012.01.035
45 https://doi.org/10.1016/j.jneumeth.2011.07.014
46 https://doi.org/10.1016/j.jneuroim.2007.08.004
47 https://doi.org/10.1016/j.jneuroim.2008.10.013
48 https://doi.org/10.1016/j.jneuroim.2010.08.014
49 https://doi.org/10.1016/j.neuron.2009.09.042
50 https://doi.org/10.1016/j.taap.2011.05.015
51 https://doi.org/10.1016/j.tins.2011.12.006
52 https://doi.org/10.1021/pr070220c
53 https://doi.org/10.1021/pr1010263
54 https://doi.org/10.1074/jbc.m111.309849
55 https://doi.org/10.1084/jem.167.4.1428
56 https://doi.org/10.1086/515693
57 https://doi.org/10.1093/cid/cir524
58 https://doi.org/10.1093/infdis/jis326
59 https://doi.org/10.1093/infdis/jis395
60 https://doi.org/10.1097/qad.0b013e328357f5ad
61 https://doi.org/10.1111/j.1365-2249.2009.03933.x
62 https://doi.org/10.1111/j.1471-4159.2009.05967.x
63 https://doi.org/10.1126/science.1209200
64 https://doi.org/10.1172/jci34138
65 https://doi.org/10.1212/wnl.0b013e3181ab2b3b
66 https://doi.org/10.1371/journal.pone.0038853
67 https://doi.org/10.1371/journal.pone.0042878
68 https://doi.org/10.1371/journal.pone.0043152
69 https://doi.org/10.1523/jneurosci.5473-10.2011
70 https://doi.org/10.2147/ijn.s27830
71 https://doi.org/10.2174/1570162043485095
72 https://doi.org/10.2353/ajpath.2008.080045
73 https://doi.org/10.2353/ajpath.2010.100536
74 https://doi.org/10.3791/2460
75 schema:datePublished 2013-12
76 schema:datePublishedReg 2013-12-01
77 schema:description Metabolites are biomarkers for a broad range of central nervous system disorders serving as molecular drivers and byproducts of disease pathobiology. However, despite their importance, routine measures of brain tissue metabolomics are not readily available based on the requirements of rapid tissue preservation. They require preservation by microwave irradiation, rapid freezing or other methods designed to reduce post mortem metabolism. Our research on human immunodeficiency virus type one (HIV-1) infection has highlighted immediate needs to better link histology to neural metabolites. To this end, we investigated such needs in well-studied rodent models. First, the dynamics of brain metabolism during ex vivo tissue preparation was shown by proton magnetic resonance spectroscopy in normal mice. Second, tissue preservation methodologies were assessed using liquid chromatography tandem mass spectrometry and immunohistology to measure metabolites and neural antigens. Third, these methods were applied to two animal models. In the first, immunodeficient mice reconstituted with human peripheral blood lymphocytes then acutely infected with HIV-1. In the second, NOD scid IL2 receptor gamma chain knockout mice were humanized with CD34+ human hematopoietic stem cells and chronically infected with HIV-1. Replicate infected animals were treated with nanoformulated antiretroviral therapy (nanoART). Results from chronic infection showed that microgliosis was associated with increased myoinostitol, choline, phosphocholine concentrations and with decreased creatine concentrations. These changes were partially reversed with nanoART. Metabolite responses were contingent on the animal model. Taken together, these studies integrate brain metabolomics with histopathology towards uncovering putative biomarkers for neuroAIDS.
78 schema:genre research_article
79 schema:inLanguage en
80 schema:isAccessibleForFree true
81 schema:isPartOf Ncc1bac845f6e449b956ac53ef391ed15
82 Ncc85ec99786545c29ac10549371786ae
83 sg:journal.1035881
84 schema:name Combinatorial assessments of brain tissue metabolomics and histopathology in rodent models of human immunodeficiency virus infection
85 schema:pagination 1224-1238
86 schema:productId N07e0207e9c3948e682bdc906109691f5
87 N19501ed295ef4e6f9fcb400bed4618f2
88 N46d82e5a6f4d407e81f3dff67b2d50db
89 Na0c5d498b48c4223bec555915486bd69
90 Nb3ff77ce105a4b97bcbf77b92e441b22
91 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041845481
92 https://doi.org/10.1007/s11481-013-9461-9
93 schema:sdDatePublished 2019-04-11T13:06
94 schema:sdLicense https://scigraph.springernature.com/explorer/license/
95 schema:sdPublisher Nf0d2101e02b44e559067f582ce89db5e
96 schema:url https://link.springer.com/10.1007%2Fs11481-013-9461-9
97 sgo:license sg:explorer/license/
98 sgo:sdDataset articles
99 rdf:type schema:ScholarlyArticle
100 N01857b64eb02437496a22af112873a11 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
101 schema:name Brain
102 rdf:type schema:DefinedTerm
103 N026edd260dc74965bbd42fc65aac9e5c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
104 schema:name Magnetic Resonance Spectroscopy
105 rdf:type schema:DefinedTerm
106 N07e0207e9c3948e682bdc906109691f5 schema:name dimensions_id
107 schema:value pub.1041845481
108 rdf:type schema:PropertyValue
109 N081d8ae08e2b4bd5955e310aabcd0047 rdf:first sg:person.015532126607.07
110 rdf:rest Nc243a9a3ed5247f4b69f796986773ce2
111 N187ce60022a8464b9e281895a32c8b3a rdf:first sg:person.0743307135.12
112 rdf:rest Nd59ffa592f554eaa94c6cd766aa87d45
113 N19501ed295ef4e6f9fcb400bed4618f2 schema:name readcube_id
114 schema:value c7551e16f43c30e41987f615868b16b8bcee5ea9455e0e18ca3fb19d1d0b2bdc
115 rdf:type schema:PropertyValue
116 N1b85f0a59791426990ec2a5481a1d794 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
117 schema:name Chromatography, Liquid
118 rdf:type schema:DefinedTerm
119 N20b314f124e5465096530c2cdc0eb0f5 rdf:first sg:person.01235657370.48
120 rdf:rest N9c610ccc92604420928fa85b747627bf
121 N25737c01bac5439e8dd7632e5a1ea7a9 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
122 schema:name AIDS Dementia Complex
123 rdf:type schema:DefinedTerm
124 N263340650d2a4474a66ff9120206fcb5 rdf:first sg:person.01246513575.79
125 rdf:rest Nb5b627ad82784c1c883163c8e9471f88
126 N2e21cc2669c14912a3770df3bdc83d89 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
127 schema:name Microwaves
128 rdf:type schema:DefinedTerm
129 N423c5a5924f343c99a6eef363afc4bee schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
130 schema:name Disease Models, Animal
131 rdf:type schema:DefinedTerm
132 N469fac5c95db4423af2a934d292b58af schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
133 schema:name Mice, SCID
134 rdf:type schema:DefinedTerm
135 N46d82e5a6f4d407e81f3dff67b2d50db schema:name pubmed_id
136 schema:value 23702663
137 rdf:type schema:PropertyValue
138 N6e42850486fd471098f81b3ba2f938e2 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
139 schema:name Tissue Fixation
140 rdf:type schema:DefinedTerm
141 N8ba8de217359456b8744acd6205d9166 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
142 schema:name Mice, Inbred NOD
143 rdf:type schema:DefinedTerm
144 N94e76e5a2f2d4e099396af22c9473f44 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
145 schema:name Mice, Knockout
146 rdf:type schema:DefinedTerm
147 N9c610ccc92604420928fa85b747627bf rdf:first sg:person.01033077163.61
148 rdf:rest rdf:nil
149 N9edb8d28caf2485384fc90a80ba73628 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
150 schema:name Animals
151 rdf:type schema:DefinedTerm
152 Na0c5d498b48c4223bec555915486bd69 schema:name nlm_unique_id
153 schema:value 101256586
154 rdf:type schema:PropertyValue
155 Nacd88d1905524d598f50ce9745edd2eb rdf:first sg:person.014224720137.37
156 rdf:rest N263340650d2a4474a66ff9120206fcb5
157 Nb02a7d1170b44bcd99972d69604a809e rdf:first sg:person.01326542635.31
158 rdf:rest N081d8ae08e2b4bd5955e310aabcd0047
159 Nb3ff77ce105a4b97bcbf77b92e441b22 schema:name doi
160 schema:value 10.1007/s11481-013-9461-9
161 rdf:type schema:PropertyValue
162 Nb5b627ad82784c1c883163c8e9471f88 rdf:first sg:person.0733362241.37
163 rdf:rest Nb02a7d1170b44bcd99972d69604a809e
164 Nbe3671f8c8834628a6430a8feeeb5bc3 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
165 schema:name Tandem Mass Spectrometry
166 rdf:type schema:DefinedTerm
167 Nc243a9a3ed5247f4b69f796986773ce2 rdf:first sg:person.0621261030.30
168 rdf:rest N20b314f124e5465096530c2cdc0eb0f5
169 Nc5723dbbd33143118224924c89c83097 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
170 schema:name HIV Infections
171 rdf:type schema:DefinedTerm
172 Ncc1bac845f6e449b956ac53ef391ed15 schema:issueNumber 5
173 rdf:type schema:PublicationIssue
174 Ncc85ec99786545c29ac10549371786ae schema:volumeNumber 8
175 rdf:type schema:PublicationVolume
176 Nd59ffa592f554eaa94c6cd766aa87d45 rdf:first sg:person.0577270623.83
177 rdf:rest Nacd88d1905524d598f50ce9745edd2eb
178 Nde5199516d4c4a97ae6bb69a9fdc38b9 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
179 schema:name Humans
180 rdf:type schema:DefinedTerm
181 Nf0d2101e02b44e559067f582ce89db5e schema:name Springer Nature - SN SciGraph project
182 rdf:type schema:Organization
183 Nf465402549fb4153aadc2607d440965c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
184 schema:name Metabolomics
185 rdf:type schema:DefinedTerm
186 Nf8c9b2ed5db14eedba86591bf8e51da4 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
187 schema:name Cryopreservation
188 rdf:type schema:DefinedTerm
189 Nfb98c5c5f6454e4e8f806cc29212329f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
190 schema:name Mice
191 rdf:type schema:DefinedTerm
192 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
193 schema:name Medical and Health Sciences
194 rdf:type schema:DefinedTerm
195 anzsrc-for:1109 schema:inDefinedTermSet anzsrc-for:
196 schema:name Neurosciences
197 rdf:type schema:DefinedTerm
198 sg:grant.2435940 http://pending.schema.org/fundedItem sg:pub.10.1007/s11481-013-9461-9
199 rdf:type schema:MonetaryGrant
200 sg:grant.2435941 http://pending.schema.org/fundedItem sg:pub.10.1007/s11481-013-9461-9
201 rdf:type schema:MonetaryGrant
202 sg:grant.2437192 http://pending.schema.org/fundedItem sg:pub.10.1007/s11481-013-9461-9
203 rdf:type schema:MonetaryGrant
204 sg:grant.2437365 http://pending.schema.org/fundedItem sg:pub.10.1007/s11481-013-9461-9
205 rdf:type schema:MonetaryGrant
206 sg:grant.2437437 http://pending.schema.org/fundedItem sg:pub.10.1007/s11481-013-9461-9
207 rdf:type schema:MonetaryGrant
208 sg:grant.2439392 http://pending.schema.org/fundedItem sg:pub.10.1007/s11481-013-9461-9
209 rdf:type schema:MonetaryGrant
210 sg:grant.2449062 http://pending.schema.org/fundedItem sg:pub.10.1007/s11481-013-9461-9
211 rdf:type schema:MonetaryGrant
212 sg:grant.2558029 http://pending.schema.org/fundedItem sg:pub.10.1007/s11481-013-9461-9
213 rdf:type schema:MonetaryGrant
214 sg:grant.2558462 http://pending.schema.org/fundedItem sg:pub.10.1007/s11481-013-9461-9
215 rdf:type schema:MonetaryGrant
216 sg:grant.2558463 http://pending.schema.org/fundedItem sg:pub.10.1007/s11481-013-9461-9
217 rdf:type schema:MonetaryGrant
218 sg:grant.2589589 http://pending.schema.org/fundedItem sg:pub.10.1007/s11481-013-9461-9
219 rdf:type schema:MonetaryGrant
220 sg:grant.2636159 http://pending.schema.org/fundedItem sg:pub.10.1007/s11481-013-9461-9
221 rdf:type schema:MonetaryGrant
222 sg:journal.1035881 schema:issn 1557-1890
223 1557-1904
224 schema:name Journal of Neuroimmune Pharmacology
225 rdf:type schema:Periodical
226 sg:person.01033077163.61 schema:affiliation https://www.grid.ac/institutes/grid.266813.8
227 schema:familyName Boska
228 schema:givenName Michael D.
229 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01033077163.61
230 rdf:type schema:Person
231 sg:person.01235657370.48 schema:affiliation https://www.grid.ac/institutes/grid.266813.8
232 schema:familyName Gendelman
233 schema:givenName Howard E.
234 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01235657370.48
235 rdf:type schema:Person
236 sg:person.01246513575.79 schema:affiliation https://www.grid.ac/institutes/grid.266813.8
237 schema:familyName High
238 schema:givenName Robin
239 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01246513575.79
240 rdf:type schema:Person
241 sg:person.01326542635.31 schema:affiliation https://www.grid.ac/institutes/grid.266813.8
242 schema:familyName Gorantla
243 schema:givenName Santhi
244 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01326542635.31
245 rdf:type schema:Person
246 sg:person.014224720137.37 schema:affiliation https://www.grid.ac/institutes/grid.266813.8
247 schema:familyName Dash
248 schema:givenName Prasanta K.
249 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014224720137.37
250 rdf:type schema:Person
251 sg:person.015532126607.07 schema:affiliation https://www.grid.ac/institutes/grid.266813.8
252 schema:familyName Poluektova
253 schema:givenName Larisa Y.
254 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015532126607.07
255 rdf:type schema:Person
256 sg:person.0577270623.83 schema:affiliation https://www.grid.ac/institutes/grid.266813.8
257 schema:familyName Narayanasamy
258 schema:givenName Prabagaran
259 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0577270623.83
260 rdf:type schema:Person
261 sg:person.0621261030.30 schema:affiliation https://www.grid.ac/institutes/grid.266813.8
262 schema:familyName Alnouti
263 schema:givenName Yazen
264 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0621261030.30
265 rdf:type schema:Person
266 sg:person.0733362241.37 schema:affiliation https://www.grid.ac/institutes/grid.266813.8
267 schema:familyName Bathena
268 schema:givenName Sai Praneeth R.
269 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0733362241.37
270 rdf:type schema:Person
271 sg:person.0743307135.12 schema:affiliation https://www.grid.ac/institutes/grid.266813.8
272 schema:familyName Epstein
273 schema:givenName Adrian A.
274 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0743307135.12
275 rdf:type schema:Person
276 sg:pub.10.1007/s00018-012-1071-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035612593
277 https://doi.org/10.1007/s00018-012-1071-9
278 rdf:type schema:CreativeWork
279 sg:pub.10.1007/s11481-009-9174-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028027903
280 https://doi.org/10.1007/s11481-009-9174-2
281 rdf:type schema:CreativeWork
282 sg:pub.10.1007/s11481-010-9225-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040117506
283 https://doi.org/10.1007/s11481-010-9225-8
284 rdf:type schema:CreativeWork
285 sg:pub.10.1007/s13365-011-0030-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018832915
286 https://doi.org/10.1007/s13365-011-0030-9
287 rdf:type schema:CreativeWork
288 sg:pub.10.1007/s13365-012-0114-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001544018
289 https://doi.org/10.1007/s13365-012-0114-1
290 rdf:type schema:CreativeWork
291 sg:pub.10.1038/nchembio.767 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021422491
292 https://doi.org/10.1038/nchembio.767
293 rdf:type schema:CreativeWork
294 sg:pub.10.1038/npp.2012.40 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035074695
295 https://doi.org/10.1038/npp.2012.40
296 rdf:type schema:CreativeWork
297 sg:pub.10.1186/1471-2377-11-148 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020663393
298 https://doi.org/10.1186/1471-2377-11-148
299 rdf:type schema:CreativeWork
300 sg:pub.10.1186/1559-0275-9-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011022600
301 https://doi.org/10.1186/1559-0275-9-3
302 rdf:type schema:CreativeWork
303 https://app.dimensions.ai/details/publication/pub.1083045613 schema:CreativeWork
304 https://doi.org/10.1002/1099-1492(200005)13:3<129::aid-nbm619>3.0.co;2-v schema:sameAs https://app.dimensions.ai/details/publication/pub.1032265127
305 rdf:type schema:CreativeWork
306 https://doi.org/10.1002/mrm.10445 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037330761
307 rdf:type schema:CreativeWork
308 https://doi.org/10.1002/mrm.20073 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007115702
309 rdf:type schema:CreativeWork
310 https://doi.org/10.1002/mrm.20184 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050553468
311 rdf:type schema:CreativeWork
312 https://doi.org/10.1002/mrm.22821 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034866653
313 rdf:type schema:CreativeWork
314 https://doi.org/10.1002/nbm.1145 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020624084
315 rdf:type schema:CreativeWork
316 https://doi.org/10.1002/nbm.895 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010997233
317 rdf:type schema:CreativeWork
318 https://doi.org/10.1006/jmra.1994.1008 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020014290
319 rdf:type schema:CreativeWork
320 https://doi.org/10.1006/jmre.1999.1895 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014501690
321 rdf:type schema:CreativeWork
322 https://doi.org/10.1006/meth.1998.0613 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028488203
323 rdf:type schema:CreativeWork
324 https://doi.org/10.1016/0003-2697(82)90621-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037199636
325 rdf:type schema:CreativeWork
326 https://doi.org/10.1016/0165-0270(95)00119-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019605423
327 rdf:type schema:CreativeWork
328 https://doi.org/10.1016/j.bbi.2011.09.011 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011191597
329 rdf:type schema:CreativeWork
330 https://doi.org/10.1016/j.jchromb.2012.01.035 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017214316
331 rdf:type schema:CreativeWork
332 https://doi.org/10.1016/j.jneumeth.2011.07.014 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045150834
333 rdf:type schema:CreativeWork
334 https://doi.org/10.1016/j.jneuroim.2007.08.004 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045299997
335 rdf:type schema:CreativeWork
336 https://doi.org/10.1016/j.jneuroim.2008.10.013 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005326809
337 rdf:type schema:CreativeWork
338 https://doi.org/10.1016/j.jneuroim.2010.08.014 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033849874
339 rdf:type schema:CreativeWork
340 https://doi.org/10.1016/j.neuron.2009.09.042 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040720018
341 rdf:type schema:CreativeWork
342 https://doi.org/10.1016/j.taap.2011.05.015 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052408483
343 rdf:type schema:CreativeWork
344 https://doi.org/10.1016/j.tins.2011.12.006 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025810521
345 rdf:type schema:CreativeWork
346 https://doi.org/10.1021/pr070220c schema:sameAs https://app.dimensions.ai/details/publication/pub.1035909781
347 rdf:type schema:CreativeWork
348 https://doi.org/10.1021/pr1010263 schema:sameAs https://app.dimensions.ai/details/publication/pub.1056292396
349 rdf:type schema:CreativeWork
350 https://doi.org/10.1074/jbc.m111.309849 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014362437
351 rdf:type schema:CreativeWork
352 https://doi.org/10.1084/jem.167.4.1428 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048751928
353 rdf:type schema:CreativeWork
354 https://doi.org/10.1086/515693 schema:sameAs https://app.dimensions.ai/details/publication/pub.1058790081
355 rdf:type schema:CreativeWork
356 https://doi.org/10.1093/cid/cir524 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024315691
357 rdf:type schema:CreativeWork
358 https://doi.org/10.1093/infdis/jis326 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031856100
359 rdf:type schema:CreativeWork
360 https://doi.org/10.1093/infdis/jis395 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046264041
361 rdf:type schema:CreativeWork
362 https://doi.org/10.1097/qad.0b013e328357f5ad schema:sameAs https://app.dimensions.ai/details/publication/pub.1017378011
363 rdf:type schema:CreativeWork
364 https://doi.org/10.1111/j.1365-2249.2009.03933.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1019172125
365 rdf:type schema:CreativeWork
366 https://doi.org/10.1111/j.1471-4159.2009.05967.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1040310147
367 rdf:type schema:CreativeWork
368 https://doi.org/10.1126/science.1209200 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062464935
369 rdf:type schema:CreativeWork
370 https://doi.org/10.1172/jci34138 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002523501
371 rdf:type schema:CreativeWork
372 https://doi.org/10.1212/wnl.0b013e3181ab2b3b schema:sameAs https://app.dimensions.ai/details/publication/pub.1064354428
373 rdf:type schema:CreativeWork
374 https://doi.org/10.1371/journal.pone.0038853 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031949737
375 rdf:type schema:CreativeWork
376 https://doi.org/10.1371/journal.pone.0042878 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048676918
377 rdf:type schema:CreativeWork
378 https://doi.org/10.1371/journal.pone.0043152 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027892448
379 rdf:type schema:CreativeWork
380 https://doi.org/10.1523/jneurosci.5473-10.2011 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050836975
381 rdf:type schema:CreativeWork
382 https://doi.org/10.2147/ijn.s27830 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003448338
383 rdf:type schema:CreativeWork
384 https://doi.org/10.2174/1570162043485095 schema:sameAs https://app.dimensions.ai/details/publication/pub.1069197440
385 rdf:type schema:CreativeWork
386 https://doi.org/10.2353/ajpath.2008.080045 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040682509
387 rdf:type schema:CreativeWork
388 https://doi.org/10.2353/ajpath.2010.100536 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044955820
389 rdf:type schema:CreativeWork
390 https://doi.org/10.3791/2460 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047362823
391 rdf:type schema:CreativeWork
392 https://www.grid.ac/institutes/grid.266813.8 schema:alternateName University of Nebraska Medical Center
393 schema:name Department of Biostatistics, College of Public Health, University of Nebraska Medical Center, 68198, Omaha, NE, USA
394 Department of Pharmaceutical Sciences, College of Pharmacy, University of Nebraska Medical Center, 68198, Omaha, NE, USA
395 Department of Pharmacology and Experimental Neuroscience, College of Medicine, University of Nebraska Medical Center, 68198, Omaha, NE, USA
396 Department of Pharmacology and Experimental Neuroscience, Nebraska Medical Center, 985880, 68198-5880, Omaha, NE, USA
397 Department of Radiology, College of Medicine, University of Nebraska Medical Center, 68198, Omaha, NE, USA
398 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...