The Comorbidity of HIV-Associated Neurocognitive Disorders and Alzheimer’s Disease: A Foreseeable Medical Challenge in Post-HAART Era View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2009-06

AUTHORS

Jiqing Xu, Tsuneya Ikezu

ABSTRACT

Although the introduction of highly active antiretroviral therapy (HAART) has led to a strong reduction of HIV-associated dementia (HAD) incidence, the prevalence of minor HIV-1-associated neurocognitive disorder (HAND) is rising among AIDS patients. HAART medication has shifted neuropathology from a subacute encephalitic condition to a subtle neurodegenerative process involving synaptic and dendritic degeneration, particularly of hippocampal neurons that are spared prior to HAART medication. Considerable neuroinflammation coupled with mononuclear phagocyte activation is present in HAART-medicated brains, particularly in the hippocampus. Accumulating evidence suggests that the resultant elevated secretion of pro-inflammatory cytokines such as interferon-gamma, tumor necrosis factor-alpha, and interleukin-1beta can increase amyloid-beta peptide (Abeta) generation and reduce Abeta clearance. Recent advancements in Alzheimer's disease (AD) research identified Abeta biogenesis and clearance venues that are potentially influenced by HIV viral infection, providing new insights into beta-amyloidosis segregation in HIV patients. Our study suggests enhanced beta-amyloidosis in ART-treated HAD and HIV-associated encephalitis brains and suppression of Abeta clearance by viral infection of human primary macrophages. A growing awareness of potential convergent mechanisms leading to neurodegeneration shared by HIV and Abeta points to a significant chance of comorbidity of AD and HAND in senile HIV patients, which calls for a need of basic studies. More... »

PAGES

200-212

References to SciGraph publications

  • 2006-04. Synaptic scaling mediated by glial TNF-α in NATURE
  • 2006-06. Neurobiology of Multiple Insults: HIV-1-Associated Brain Disorders in Those Who Use Illicit Drugs in JOURNAL OF NEUROIMMUNE PHARMACOLOGY
  • 2006-06. Neuroimmunity and the Blood–Brain Barrier: Molecular Regulation of Leukocyte Transmigration and Viral Entry into the Nervous System with a Focus on NeuroAIDS in JOURNAL OF NEUROIMMUNE PHARMACOLOGY
  • 2004-03. Brain aging in acquired immunodeficiency syndrome: Increased ubiquitin-protein conjugate is correlated with decreased synaptic protein but not amyloid plaque accumulation in JOURNAL OF NEUROVIROLOGY
  • 2004-06. Ethyl-eicosapentaenoic acid ingestion prevents corticosterone-mediated memory impairment induced by central administration of interleukin-1β in rats in MOLECULAR PSYCHIATRY
  • 2005-04. Fulminant inflammatory leukoencephalopathy associated with HAART-induced immune restoration in AIDS-related progressive multifocal leukoencephalopathy in ACTA NEUROPATHOLOGICA
  • 2005-01. The neuropathogenesis of AIDS in NATURE REVIEWS IMMUNOLOGY
  • 2005-12. Inhibition of dynamin-dependent endocytosis increases shedding of the amyloid precursor protein ectodomain and reduces generation of amyloid β protein in BMC CELL BIOLOGY
  • 2007-08-12. Clearance of amyloid-β by circulating lipoprotein receptors in NATURE MEDICINE
  • 2001-04. Pathways to neuronal injury and apoptosis in HIV-associated dementia in NATURE
  • 2005-08. HIV-1 infection and AIDS: consequences for the central nervous system in CELL DEATH & DIFFERENTIATION
  • 2006-10. RAGE, LRP-1, and amyloid-beta protein in Alzheimer’s disease in ACTA NEUROPATHOLOGICA
  • 1995-04. Activation of microglial cells by β-amyloid protein and interferon-γ in NATURE
  • 2006-06. Accelerated Tau deposition in the brains of individuals infected with human immunodeficiency virus-1 before and after the advent of highly active anti-retroviral therapy in ACTA NEUROPATHOLOGICA
  • 2008-03. The role of exosomes in the processing of proteins associated with neurodegenerative diseases in EUROPEAN BIOPHYSICS JOURNAL
  • 2004-09. Immune restoration inflammatory syndromes: Apparently paradoxical clinical events after the initiation of HAART in CURRENT HIV/AIDS REPORTS
  • 1995-10. GM1 ganglioside–bound amyloid β–protein (Aβ): A possible form of preamyloid in Alzheimer's disease in NATURE MEDICINE
  • 1999-04. Effect of HIV-1 gp41 peptides on secretion of β-amyloid precursor protein in human astroglial cell line, T98G in JOURNAL OF MOLECULAR NEUROSCIENCE
  • 2005-08. The synaptic Aβ hypothesis of Alzheimer disease in NATURE NEUROSCIENCE
  • 2005-11-01. Central nervous system immune reconstitution disease in acquired immunodeficiency syndrome patients receiving highly active antiretroviral treatment. in JOURNAL OF NEUROVIROLOGY
  • 2005-03. The shifting patterns of HIV encephalitis neuropathology in NEUROTOXICITY RESEARCH
  • 2000-12. Uptake of HIV-1 Tat protein mediated by low-density lipoprotein receptor-related protein disrupts the neuronal metabolic balance of the receptor ligands in NATURE MEDICINE
  • 2006-05. Tat peptides inhibit neprilysin in JOURNAL OF NEUROVIROLOGY
  • 2001-07. Symptomatic gastrointestinal amyloidosis in an HIV-infected patient in THE AMERICAN JOURNAL OF GASTROENTEROLOGY
  • 2003-05. Immune restoration inflammatory syndromes: The dark side of successful antiretroviral treatment in CURRENT INFECTIOUS DISEASE REPORTS
  • 2006-03. Protecting the Synapse: Evidence for a Rational Strategy to Treat HIV-1 Associated Neurologic Disease in JOURNAL OF NEUROIMMUNE PHARMACOLOGY
  • 2005-12. Inflammatory cytokine levels correlate with amyloid load in transgenic mouse models of Alzheimer's disease in JOURNAL OF NEUROINFLAMMATION
  • 2000-07. Clearance of amyloid β-peptide from brain: transport or metabolism? in NATURE MEDICINE
  • 2005-08. Interleukin-1 and neuronal injury in NATURE REVIEWS IMMUNOLOGY
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1007/s11481-008-9136-0

    DOI

    http://dx.doi.org/10.1007/s11481-008-9136-0

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1021367268

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/19016329


    Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
    Incoming Citations Browse incoming citations for this publication using opencitations.net

    JSON-LD is the canonical representation for SciGraph data.

    TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

    [
      {
        "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
        "about": [
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1109", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Neurosciences", 
            "type": "DefinedTerm"
          }, 
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Medical and Health Sciences", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "AIDS Dementia Complex", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Alzheimer Disease", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Amyloid beta-Peptides", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Antiretroviral Therapy, Highly Active", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Brain", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Cognition Disorders", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Comorbidity", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "HIV Infections", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Humans", 
            "type": "DefinedTerm"
          }
        ], 
        "author": [
          {
            "affiliation": {
              "alternateName": "University of Nebraska Medical Center", 
              "id": "https://www.grid.ac/institutes/grid.266813.8", 
              "name": [
                "Department of Pharmacology and Experimental Neuroscience, Center for Neurovirology and Neurodegenerative Disorders, University of Nebraska Medical Center, 68198-5880, Omaha, NE, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Xu", 
            "givenName": "Jiqing", 
            "id": "sg:person.0631130657.10", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0631130657.10"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "University of Nebraska Medical Center", 
              "id": "https://www.grid.ac/institutes/grid.266813.8", 
              "name": [
                "Department of Pharmacology and Experimental Neuroscience, Center for Neurovirology and Neurodegenerative Disorders, University of Nebraska Medical Center, 68198-5880, Omaha, NE, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Ikezu", 
            "givenName": "Tsuneya", 
            "id": "sg:person.0625160427.93", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0625160427.93"
            ], 
            "type": "Person"
          }
        ], 
        "citation": [
          {
            "id": "https://doi.org/10.1073/pnas.0503839103", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1000361610"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature04671", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1000381986", 
              "https://doi.org/10.1038/nature04671"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature04671", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1000381986", 
              "https://doi.org/10.1038/nature04671"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature04671", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1000381986", 
              "https://doi.org/10.1038/nature04671"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s11481-006-9018-2", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1000628562", 
              "https://doi.org/10.1007/s11481-006-9018-2"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s11481-006-9018-2", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1000628562", 
              "https://doi.org/10.1007/s11481-006-9018-2"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nri1664", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1001096453", 
              "https://doi.org/10.1038/nri1664"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nri1664", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1001096453", 
              "https://doi.org/10.1038/nri1664"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nri1664", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1001096453", 
              "https://doi.org/10.1038/nri1664"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1523/jneurosci.1418-07.2007", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1001217304"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1006/brbi.1995.1012", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1001292030"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/j.1600-0854.2006.00503.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1001856613"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nri1527", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1001952502", 
              "https://doi.org/10.1038/nri1527"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nri1527", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1001952502", 
              "https://doi.org/10.1038/nri1527"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/jnr.1095", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1002422895"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/00042560-199512050-00004", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1002553477"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/00042560-199512050-00004", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1002553477"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.0507995103", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1002919789"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/j.1471-4159.2007.05128.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1002979618"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1523/jneurosci.0616-08.2008", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1003145749"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/01.cco.0000239886.13537.ed", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1003180227"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/01.cco.0000239886.13537.ed", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1003180227"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s11908-003-0083-x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1003570092", 
              "https://doi.org/10.1007/s11908-003-0083-x"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1182/blood.v98.8.2339", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1003924148"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00249-007-0246-z", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1004893273", 
              "https://doi.org/10.1007/s00249-007-0246-z"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00249-007-0246-z", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1004893273", 
              "https://doi.org/10.1007/s00249-007-0246-z"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1080/13550280600760677", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1004929179", 
              "https://doi.org/10.1080/13550280600760677"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1046/j.1471-4159.2000.740457.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1005570589"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1006/nbdi.2002.0515", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1005894247"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/(sici)1098-2396(200002)35:2<151::aid-syn8>3.0.co;2-p", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1006035707"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/00005072-199810000-00001", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1006262499"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/0014-2999(90)90099-r", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1006307267"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/0014-2999(90)90099-r", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1006307267"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nm1635", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1006313139", 
              "https://doi.org/10.1038/nm1635"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/sj.mp.4001462", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1006805948", 
              "https://doi.org/10.1038/sj.mp.4001462"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/sj.mp.4001462", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1006805948", 
              "https://doi.org/10.1038/sj.mp.4001462"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1136/jnnp.65.1.29", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1007015092"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/jnen/62.5.429", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1007232919"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0166-4328(01)00232-7", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1007669141"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/00005072-199911000-00005", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1007902932"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1590/s1413-86702007000400012", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1008204858"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1006/exnr.2000.7393", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1008831992"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.0307981100", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1009108282"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.virusres.2005.04.009", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1009527561"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.virusres.2005.04.009", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1009527561"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1523/jneurosci.0849-05.2005", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1010168402"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/glia.20710", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1010316311"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nm1095-1062", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1011262193", 
              "https://doi.org/10.1038/nm1095-1062"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/00002030-200205030-00008", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1011551434"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/00002030-200205030-00008", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1011551434"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.tvjl.2003.10.016", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1013943230"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1074/jbc.271.43.26482", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1014463652"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s11904-004-0018-7", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1014653661", 
              "https://doi.org/10.1007/s11904-004-0018-7"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/hipo.10135", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1015175792"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/01.qai.0000021701.48448.20", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1015189921"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/01.qai.0000021701.48448.20", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1015189921"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nn0805-977", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1015265989", 
              "https://doi.org/10.1038/nn0805-977"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nn0805-977", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1015265989", 
              "https://doi.org/10.1038/nn0805-977"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nn0805-977", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1015265989", 
              "https://doi.org/10.1038/nn0805-977"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.jneuroim.2004.08.042", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1016238068"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s11481-005-9006-y", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1017104416", 
              "https://doi.org/10.1007/s11481-005-9006-y"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s11481-005-9006-y", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1017104416", 
              "https://doi.org/10.1007/s11481-005-9006-y"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/glia.20080", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1017729745"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1006/abbi.2001.2304", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1017793594"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0002-9440(10)64463-x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1017801326"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/35073667", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1018601522", 
              "https://doi.org/10.1038/35073667"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/35073667", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1018601522", 
              "https://doi.org/10.1038/35073667"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.bbrc.2005.06.208", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1018934994"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.neurobiolaging.2004.07.002", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1019121715"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1038/sj.bjp.0704382", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1019875481"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/glia.10178", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1020626213"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/1471-2121-6-30", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1020767769", 
              "https://doi.org/10.1186/1471-2121-6-30"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1074/jbc.271.25.15002", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1021079986"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1074/jbc.m203518200", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1021136446"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.chom.2007.06.011", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1021774190"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/00042560-199510050-00004", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1021860464"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/00042560-199510050-00004", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1021860464"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/glia.20451", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1021875953"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1006/nbdi.2000.0321", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1021953243"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1046/j.1471-4159.2001.00113.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1022121701"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/01.aids.0000161770.06158.5c", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1022183452"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/01.aids.0000161770.06158.5c", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1022183452"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/1742-2094-2-9", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1022385552", 
              "https://doi.org/10.1186/1742-2094-2-9"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/j.1471-4159.2007.05127.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1022400808"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s11481-006-9017-3", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1022938277", 
              "https://doi.org/10.1007/s11481-006-9017-3"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/j.1463-1326.2005.00546.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1023681870"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/00002030-200101260-00013", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1024271710"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/00002030-200101260-00013", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1024271710"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.bbamem.2007.01.009", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1024868519"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1026133541", 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00401-006-0037-0", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1026777635", 
              "https://doi.org/10.1007/s00401-006-0037-0"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00401-006-0037-0", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1026777635", 
              "https://doi.org/10.1007/s00401-006-0037-0"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0092-8674(00)80984-8", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1026953147"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/00002030-200401001-00011", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1027195372"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/00002030-200401001-00011", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1027195372"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/j.1750-3639.2008.00132.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1027424485"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/00002030-200501280-00004", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1027651333"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/00002030-200501280-00004", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1027651333"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/bf03033819", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1027731607", 
              "https://doi.org/10.1007/bf03033819"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/bf03033819", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1027731607", 
              "https://doi.org/10.1007/bf03033819"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0022-510x(99)00253-1", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1027776269"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/ana.410420108", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1027830311"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1258/095646207780749691", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1027978693"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1258/095646207780749691", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1027978693"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.neurobiolaging.2007.11.013", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1028001598"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1172/jci31450", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1028559047"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1074/jbc.m302530200", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1029719757"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/qad.0b013e3282f56b40", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1029914602"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/qad.0b013e3282f56b40", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1029914602"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/00000441-200612000-00012", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1030016605"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/00000441-200612000-00012", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1030016605"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/82199", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1030025933", 
              "https://doi.org/10.1038/82199"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1080/13506120701456293", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1030111228"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.2353/ajpath.2008.070620", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1030380032"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.0230450100", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1030968331"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1046/j.1471-4159.1995.65041431.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1031326546"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1113/expphysiol.2005.030734", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1031876059"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1113/expphysiol.2005.030734", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1031876059"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1172/jci10498", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1031916105"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.cell.2007.10.014", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1032702430"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0006-291x(03)01270-1", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1034843616"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0006-291x(03)01270-1", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1034843616"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/77397", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1034890692", 
              "https://doi.org/10.1038/77397"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/77397", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1034890692", 
              "https://doi.org/10.1038/77397"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/j.1532-5415.2005.53360.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1035059975"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/j.1532-5415.2005.53360.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1035059975"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0079-6123(07)63020-9", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1035676506"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/374647a0", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1036018613", 
              "https://doi.org/10.1038/374647a0"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1083/jcb.200505082", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1036273182"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1083/jcb.200505082", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1036273182"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/j.1471-4159.2006.04165.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1036471656"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.4049/jimmunol.181.6.3877", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1036609313"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00401-005-0983-y", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1037359300", 
              "https://doi.org/10.1007/s00401-005-0983-y"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0896-6273(01)00475-5", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1037507194"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1074/jbc.m301938200", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1037807523"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.jneuroim.2005.07.009", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1038742746"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.jneuroim.2005.07.009", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1038742746"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.mcn.2005.12.003", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1039037169"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1083/jcb.200705042", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1039297621"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/jnen/64.6.529", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1040133543"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.neurobiolaging.2006.11.004", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1040521787"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.bbadis.2006.12.001", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1040550107"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/1097-4547(20010301)63:5<410::aid-jnr1036>3.0.co;2-b", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1040835038"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1111/j.1572-0241.2001.03969.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1041676387", 
              "https://doi.org/10.1111/j.1572-0241.2001.03969.x"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1371/journal.pmed.0040262", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1042719073"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0169-328x(98)00164-8", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1043105527"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1080/13550280490279816", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1043179894", 
              "https://doi.org/10.1080/13550280490279816"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1074/jbc.m402034200", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1043396252"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0072-9752(07)85004-4", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1044278445"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/j.1471-4159.2004.02895.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1044648138"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/bf02736928", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1044738711", 
              "https://doi.org/10.1007/bf02736928"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/bf02736928", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1044738711", 
              "https://doi.org/10.1007/bf02736928"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0140-6736(05)62505-6", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1045005118"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/0165-6147(92)90047-a", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1045982607"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/0165-6147(92)90047-a", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1045982607"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/0197-4580(96)00115-7", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1047343069"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/j.1365-2362.2006.01657.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1047395182"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1172/jci32356", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1047777318"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00401-006-0115-3", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1047793597", 
              "https://doi.org/10.1007/s00401-006-0115-3"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00401-006-0115-3", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1047793597", 
              "https://doi.org/10.1007/s00401-006-0115-3"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0896-6273(03)00787-6", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1047810561"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.0803526105", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1048079513"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0304-3940(98)00549-7", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1048227654"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.ceb.2004.06.003", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1048336107"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.molimm.2004.06.020", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1049073101"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/j.1471-4159.2007.05197.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1049791758"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.86.19.7611", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1049930546"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/jnr.20680", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1049950494"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/jnr.20680", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1049950494"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0006-8993(99)02445-2", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1050541653"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1126/science.1059946", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1051196367"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.2353/ajpath.2007.060378", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1051514225"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/sj.cdd.4401623", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1051717697", 
              "https://doi.org/10.1038/sj.cdd.4401623"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/sj.cdd.4401623", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1051717697", 
              "https://doi.org/10.1038/sj.cdd.4401623"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0197-0186(01)00041-9", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1052329061"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1126/science.1072994", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1052597019"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/00001756-200412030-00025", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1052614071"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/00001756-200412030-00025", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1052614071"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/j.1471-4159.2007.04594.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1053536699"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1055/s-2006-956759", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1057470148"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1080/13550280500511741", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1058383227", 
              "https://doi.org/10.1080/13550280500511741"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1080/13550280500511741", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1058383227", 
              "https://doi.org/10.1080/13550280500511741"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1089/apc.2006.0153", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1059228625"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1089/apc.2007.0093", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1059228823"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/01.jnen.0000178444.33972.e0", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1060330606"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1126/science.1067859", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1062445759"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1126/science.1566067", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1062491586"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1126/science.2148832", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1062524153"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1126/science.286.5448.2352", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1062567722"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1126/science.287.5453.602", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1062568160"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1126/science.3016903", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1062582881"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1212/01.wnl.0000183293.95787.b7", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1064347574"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1212/01.wnl.0000183293.95787.b7", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1064347574"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1212/01.wnl.0000183293.95787.b7", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1064347574"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1212/wnl.42.9.1736", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1064371018"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.2174/138161206776055877", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1069165781"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.2174/156720507780362254", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1069188740"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1074697774", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1523/jneurosci.20-18-06811.2000", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1074700561"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1152/physrev.2001.81.2.741", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1074791168"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1074950057", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1523/jneurosci.23-05-01605.2003", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1075249766"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1077641008", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1079842403", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1083206064", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1523/jneurosci.18-08-02974.1998", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1083236479"
            ], 
            "type": "CreativeWork"
          }
        ], 
        "datePublished": "2009-06", 
        "datePublishedReg": "2009-06-01", 
        "description": "Although the introduction of highly active antiretroviral therapy (HAART) has led to a strong reduction of HIV-associated dementia (HAD) incidence, the prevalence of minor HIV-1-associated neurocognitive disorder (HAND) is rising among AIDS patients. HAART medication has shifted neuropathology from a subacute encephalitic condition to a subtle neurodegenerative process involving synaptic and dendritic degeneration, particularly of hippocampal neurons that are spared prior to HAART medication. Considerable neuroinflammation coupled with mononuclear phagocyte activation is present in HAART-medicated brains, particularly in the hippocampus. Accumulating evidence suggests that the resultant elevated secretion of pro-inflammatory cytokines such as interferon-gamma, tumor necrosis factor-alpha, and interleukin-1beta can increase amyloid-beta peptide (Abeta) generation and reduce Abeta clearance. Recent advancements in Alzheimer's disease (AD) research identified Abeta biogenesis and clearance venues that are potentially influenced by HIV viral infection, providing new insights into beta-amyloidosis segregation in HIV patients. Our study suggests enhanced beta-amyloidosis in ART-treated HAD and HIV-associated encephalitis brains and suppression of Abeta clearance by viral infection of human primary macrophages. A growing awareness of potential convergent mechanisms leading to neurodegeneration shared by HIV and Abeta points to a significant chance of comorbidity of AD and HAND in senile HIV patients, which calls for a need of basic studies.", 
        "genre": "research_article", 
        "id": "sg:pub.10.1007/s11481-008-9136-0", 
        "inLanguage": [
          "en"
        ], 
        "isAccessibleForFree": true, 
        "isFundedItemOf": [
          {
            "id": "sg:grant.2550845", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.2437437", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.2438398", 
            "type": "MonetaryGrant"
          }
        ], 
        "isPartOf": [
          {
            "id": "sg:journal.1035881", 
            "issn": [
              "1557-1890", 
              "1557-1904"
            ], 
            "name": "Journal of Neuroimmune Pharmacology", 
            "type": "Periodical"
          }, 
          {
            "issueNumber": "2", 
            "type": "PublicationIssue"
          }, 
          {
            "type": "PublicationVolume", 
            "volumeNumber": "4"
          }
        ], 
        "name": "The Comorbidity of HIV-Associated Neurocognitive Disorders and Alzheimer\u2019s Disease: A Foreseeable Medical Challenge in Post-HAART Era", 
        "pagination": "200-212", 
        "productId": [
          {
            "name": "readcube_id", 
            "type": "PropertyValue", 
            "value": [
              "65cdb5ff15e8e14083c84d6ad771cf6d92f7798490039cc0c44697e72e9385b0"
            ]
          }, 
          {
            "name": "pubmed_id", 
            "type": "PropertyValue", 
            "value": [
              "19016329"
            ]
          }, 
          {
            "name": "nlm_unique_id", 
            "type": "PropertyValue", 
            "value": [
              "101256586"
            ]
          }, 
          {
            "name": "doi", 
            "type": "PropertyValue", 
            "value": [
              "10.1007/s11481-008-9136-0"
            ]
          }, 
          {
            "name": "dimensions_id", 
            "type": "PropertyValue", 
            "value": [
              "pub.1021367268"
            ]
          }
        ], 
        "sameAs": [
          "https://doi.org/10.1007/s11481-008-9136-0", 
          "https://app.dimensions.ai/details/publication/pub.1021367268"
        ], 
        "sdDataset": "articles", 
        "sdDatePublished": "2019-04-10T23:26", 
        "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
        "sdPublisher": {
          "name": "Springer Nature - SN SciGraph project", 
          "type": "Organization"
        }, 
        "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8693_00000521.jsonl", 
        "type": "ScholarlyArticle", 
        "url": "http://link.springer.com/10.1007%2Fs11481-008-9136-0"
      }
    ]
     

    Download the RDF metadata as:  json-ld nt turtle xml License info

    HOW TO GET THIS DATA PROGRAMMATICALLY:

    JSON-LD is a popular format for linked data which is fully compatible with JSON.

    curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s11481-008-9136-0'

    N-Triples is a line-based linked data format ideal for batch operations.

    curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s11481-008-9136-0'

    Turtle is a human-readable linked data format.

    curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s11481-008-9136-0'

    RDF/XML is a standard XML format for linked data.

    curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s11481-008-9136-0'


     

    This table displays all metadata directly associated to this object as RDF triples.

    630 TRIPLES      21 PREDICATES      201 URIs      30 LITERALS      18 BLANK NODES

    Subject Predicate Object
    1 sg:pub.10.1007/s11481-008-9136-0 schema:about N2d76496eb1d44dd69366938b2ed13051
    2 N33e258bb6d194cef8b48ec0190196af4
    3 N35e725c9f7cf442898bde2eeace5badb
    4 N49a50d33027849868188525ee927edf2
    5 N4e0b56608f434fef908b5934db79f733
    6 N70997439b444471c8786a2e9b50da9e0
    7 N729b4b4a914745388a6f4c9faf63e417
    8 N7ad2ec2eaad9456c8146bc8cb7b90c0e
    9 Nafaf0a9a91c24e608c1404c7fc653c74
    10 anzsrc-for:11
    11 anzsrc-for:1109
    12 schema:author Nea977239e76641b8938a6ddfd4495a9a
    13 schema:citation sg:pub.10.1007/bf02736928
    14 sg:pub.10.1007/bf03033819
    15 sg:pub.10.1007/s00249-007-0246-z
    16 sg:pub.10.1007/s00401-005-0983-y
    17 sg:pub.10.1007/s00401-006-0037-0
    18 sg:pub.10.1007/s00401-006-0115-3
    19 sg:pub.10.1007/s11481-005-9006-y
    20 sg:pub.10.1007/s11481-006-9017-3
    21 sg:pub.10.1007/s11481-006-9018-2
    22 sg:pub.10.1007/s11904-004-0018-7
    23 sg:pub.10.1007/s11908-003-0083-x
    24 sg:pub.10.1038/35073667
    25 sg:pub.10.1038/374647a0
    26 sg:pub.10.1038/77397
    27 sg:pub.10.1038/82199
    28 sg:pub.10.1038/nature04671
    29 sg:pub.10.1038/nm1095-1062
    30 sg:pub.10.1038/nm1635
    31 sg:pub.10.1038/nn0805-977
    32 sg:pub.10.1038/nri1527
    33 sg:pub.10.1038/nri1664
    34 sg:pub.10.1038/sj.cdd.4401623
    35 sg:pub.10.1038/sj.mp.4001462
    36 sg:pub.10.1080/13550280490279816
    37 sg:pub.10.1080/13550280500511741
    38 sg:pub.10.1080/13550280600760677
    39 sg:pub.10.1111/j.1572-0241.2001.03969.x
    40 sg:pub.10.1186/1471-2121-6-30
    41 sg:pub.10.1186/1742-2094-2-9
    42 https://app.dimensions.ai/details/publication/pub.1026133541
    43 https://app.dimensions.ai/details/publication/pub.1074697774
    44 https://app.dimensions.ai/details/publication/pub.1074950057
    45 https://app.dimensions.ai/details/publication/pub.1077641008
    46 https://app.dimensions.ai/details/publication/pub.1079842403
    47 https://app.dimensions.ai/details/publication/pub.1083206064
    48 https://doi.org/10.1002/(sici)1098-2396(200002)35:2<151::aid-syn8>3.0.co;2-p
    49 https://doi.org/10.1002/1097-4547(20010301)63:5<410::aid-jnr1036>3.0.co;2-b
    50 https://doi.org/10.1002/ana.410420108
    51 https://doi.org/10.1002/glia.10178
    52 https://doi.org/10.1002/glia.20080
    53 https://doi.org/10.1002/glia.20451
    54 https://doi.org/10.1002/glia.20710
    55 https://doi.org/10.1002/hipo.10135
    56 https://doi.org/10.1002/jnr.1095
    57 https://doi.org/10.1002/jnr.20680
    58 https://doi.org/10.1006/abbi.2001.2304
    59 https://doi.org/10.1006/brbi.1995.1012
    60 https://doi.org/10.1006/exnr.2000.7393
    61 https://doi.org/10.1006/nbdi.2000.0321
    62 https://doi.org/10.1006/nbdi.2002.0515
    63 https://doi.org/10.1016/0014-2999(90)90099-r
    64 https://doi.org/10.1016/0165-6147(92)90047-a
    65 https://doi.org/10.1016/0197-4580(96)00115-7
    66 https://doi.org/10.1016/j.bbadis.2006.12.001
    67 https://doi.org/10.1016/j.bbamem.2007.01.009
    68 https://doi.org/10.1016/j.bbrc.2005.06.208
    69 https://doi.org/10.1016/j.ceb.2004.06.003
    70 https://doi.org/10.1016/j.cell.2007.10.014
    71 https://doi.org/10.1016/j.chom.2007.06.011
    72 https://doi.org/10.1016/j.jneuroim.2004.08.042
    73 https://doi.org/10.1016/j.jneuroim.2005.07.009
    74 https://doi.org/10.1016/j.mcn.2005.12.003
    75 https://doi.org/10.1016/j.molimm.2004.06.020
    76 https://doi.org/10.1016/j.neurobiolaging.2004.07.002
    77 https://doi.org/10.1016/j.neurobiolaging.2006.11.004
    78 https://doi.org/10.1016/j.neurobiolaging.2007.11.013
    79 https://doi.org/10.1016/j.tvjl.2003.10.016
    80 https://doi.org/10.1016/j.virusres.2005.04.009
    81 https://doi.org/10.1016/s0002-9440(10)64463-x
    82 https://doi.org/10.1016/s0006-291x(03)01270-1
    83 https://doi.org/10.1016/s0006-8993(99)02445-2
    84 https://doi.org/10.1016/s0022-510x(99)00253-1
    85 https://doi.org/10.1016/s0072-9752(07)85004-4
    86 https://doi.org/10.1016/s0079-6123(07)63020-9
    87 https://doi.org/10.1016/s0092-8674(00)80984-8
    88 https://doi.org/10.1016/s0140-6736(05)62505-6
    89 https://doi.org/10.1016/s0166-4328(01)00232-7
    90 https://doi.org/10.1016/s0169-328x(98)00164-8
    91 https://doi.org/10.1016/s0197-0186(01)00041-9
    92 https://doi.org/10.1016/s0304-3940(98)00549-7
    93 https://doi.org/10.1016/s0896-6273(01)00475-5
    94 https://doi.org/10.1016/s0896-6273(03)00787-6
    95 https://doi.org/10.1038/sj.bjp.0704382
    96 https://doi.org/10.1046/j.1471-4159.1995.65041431.x
    97 https://doi.org/10.1046/j.1471-4159.2000.740457.x
    98 https://doi.org/10.1046/j.1471-4159.2001.00113.x
    99 https://doi.org/10.1055/s-2006-956759
    100 https://doi.org/10.1073/pnas.0230450100
    101 https://doi.org/10.1073/pnas.0307981100
    102 https://doi.org/10.1073/pnas.0503839103
    103 https://doi.org/10.1073/pnas.0507995103
    104 https://doi.org/10.1073/pnas.0803526105
    105 https://doi.org/10.1073/pnas.86.19.7611
    106 https://doi.org/10.1074/jbc.271.25.15002
    107 https://doi.org/10.1074/jbc.271.43.26482
    108 https://doi.org/10.1074/jbc.m203518200
    109 https://doi.org/10.1074/jbc.m301938200
    110 https://doi.org/10.1074/jbc.m302530200
    111 https://doi.org/10.1074/jbc.m402034200
    112 https://doi.org/10.1080/13506120701456293
    113 https://doi.org/10.1083/jcb.200505082
    114 https://doi.org/10.1083/jcb.200705042
    115 https://doi.org/10.1089/apc.2006.0153
    116 https://doi.org/10.1089/apc.2007.0093
    117 https://doi.org/10.1093/jnen/62.5.429
    118 https://doi.org/10.1093/jnen/64.6.529
    119 https://doi.org/10.1097/00000441-200612000-00012
    120 https://doi.org/10.1097/00001756-200412030-00025
    121 https://doi.org/10.1097/00002030-200101260-00013
    122 https://doi.org/10.1097/00002030-200205030-00008
    123 https://doi.org/10.1097/00002030-200401001-00011
    124 https://doi.org/10.1097/00002030-200501280-00004
    125 https://doi.org/10.1097/00005072-199810000-00001
    126 https://doi.org/10.1097/00005072-199911000-00005
    127 https://doi.org/10.1097/00042560-199510050-00004
    128 https://doi.org/10.1097/00042560-199512050-00004
    129 https://doi.org/10.1097/01.aids.0000161770.06158.5c
    130 https://doi.org/10.1097/01.cco.0000239886.13537.ed
    131 https://doi.org/10.1097/01.jnen.0000178444.33972.e0
    132 https://doi.org/10.1097/01.qai.0000021701.48448.20
    133 https://doi.org/10.1097/qad.0b013e3282f56b40
    134 https://doi.org/10.1111/j.1365-2362.2006.01657.x
    135 https://doi.org/10.1111/j.1463-1326.2005.00546.x
    136 https://doi.org/10.1111/j.1471-4159.2004.02895.x
    137 https://doi.org/10.1111/j.1471-4159.2006.04165.x
    138 https://doi.org/10.1111/j.1471-4159.2007.04594.x
    139 https://doi.org/10.1111/j.1471-4159.2007.05127.x
    140 https://doi.org/10.1111/j.1471-4159.2007.05128.x
    141 https://doi.org/10.1111/j.1471-4159.2007.05197.x
    142 https://doi.org/10.1111/j.1532-5415.2005.53360.x
    143 https://doi.org/10.1111/j.1600-0854.2006.00503.x
    144 https://doi.org/10.1111/j.1750-3639.2008.00132.x
    145 https://doi.org/10.1113/expphysiol.2005.030734
    146 https://doi.org/10.1126/science.1059946
    147 https://doi.org/10.1126/science.1067859
    148 https://doi.org/10.1126/science.1072994
    149 https://doi.org/10.1126/science.1566067
    150 https://doi.org/10.1126/science.2148832
    151 https://doi.org/10.1126/science.286.5448.2352
    152 https://doi.org/10.1126/science.287.5453.602
    153 https://doi.org/10.1126/science.3016903
    154 https://doi.org/10.1136/jnnp.65.1.29
    155 https://doi.org/10.1152/physrev.2001.81.2.741
    156 https://doi.org/10.1172/jci10498
    157 https://doi.org/10.1172/jci31450
    158 https://doi.org/10.1172/jci32356
    159 https://doi.org/10.1182/blood.v98.8.2339
    160 https://doi.org/10.1212/01.wnl.0000183293.95787.b7
    161 https://doi.org/10.1212/wnl.42.9.1736
    162 https://doi.org/10.1258/095646207780749691
    163 https://doi.org/10.1371/journal.pmed.0040262
    164 https://doi.org/10.1523/jneurosci.0616-08.2008
    165 https://doi.org/10.1523/jneurosci.0849-05.2005
    166 https://doi.org/10.1523/jneurosci.1418-07.2007
    167 https://doi.org/10.1523/jneurosci.18-08-02974.1998
    168 https://doi.org/10.1523/jneurosci.20-18-06811.2000
    169 https://doi.org/10.1523/jneurosci.23-05-01605.2003
    170 https://doi.org/10.1590/s1413-86702007000400012
    171 https://doi.org/10.2174/138161206776055877
    172 https://doi.org/10.2174/156720507780362254
    173 https://doi.org/10.2353/ajpath.2007.060378
    174 https://doi.org/10.2353/ajpath.2008.070620
    175 https://doi.org/10.4049/jimmunol.181.6.3877
    176 schema:datePublished 2009-06
    177 schema:datePublishedReg 2009-06-01
    178 schema:description Although the introduction of highly active antiretroviral therapy (HAART) has led to a strong reduction of HIV-associated dementia (HAD) incidence, the prevalence of minor HIV-1-associated neurocognitive disorder (HAND) is rising among AIDS patients. HAART medication has shifted neuropathology from a subacute encephalitic condition to a subtle neurodegenerative process involving synaptic and dendritic degeneration, particularly of hippocampal neurons that are spared prior to HAART medication. Considerable neuroinflammation coupled with mononuclear phagocyte activation is present in HAART-medicated brains, particularly in the hippocampus. Accumulating evidence suggests that the resultant elevated secretion of pro-inflammatory cytokines such as interferon-gamma, tumor necrosis factor-alpha, and interleukin-1beta can increase amyloid-beta peptide (Abeta) generation and reduce Abeta clearance. Recent advancements in Alzheimer's disease (AD) research identified Abeta biogenesis and clearance venues that are potentially influenced by HIV viral infection, providing new insights into beta-amyloidosis segregation in HIV patients. Our study suggests enhanced beta-amyloidosis in ART-treated HAD and HIV-associated encephalitis brains and suppression of Abeta clearance by viral infection of human primary macrophages. A growing awareness of potential convergent mechanisms leading to neurodegeneration shared by HIV and Abeta points to a significant chance of comorbidity of AD and HAND in senile HIV patients, which calls for a need of basic studies.
    179 schema:genre research_article
    180 schema:inLanguage en
    181 schema:isAccessibleForFree true
    182 schema:isPartOf N226393374fff40958057adff5fce0080
    183 Na77d444d8dcf4154aea59bed6e8f1db6
    184 sg:journal.1035881
    185 schema:name The Comorbidity of HIV-Associated Neurocognitive Disorders and Alzheimer’s Disease: A Foreseeable Medical Challenge in Post-HAART Era
    186 schema:pagination 200-212
    187 schema:productId N0916c612d4f04d809231f26dddd8f80f
    188 N5b380007fb5747ae9942975f8577faae
    189 N85a2a476dda24eeca6ab97f834b61a74
    190 N94c1f2c599574cffae64eedf16a3cca2
    191 Nd06bbc8fa11742de9a99b4ac3c99946b
    192 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021367268
    193 https://doi.org/10.1007/s11481-008-9136-0
    194 schema:sdDatePublished 2019-04-10T23:26
    195 schema:sdLicense https://scigraph.springernature.com/explorer/license/
    196 schema:sdPublisher N15e97d84a28f413c9d2712fc44ec2ab8
    197 schema:url http://link.springer.com/10.1007%2Fs11481-008-9136-0
    198 sgo:license sg:explorer/license/
    199 sgo:sdDataset articles
    200 rdf:type schema:ScholarlyArticle
    201 N0916c612d4f04d809231f26dddd8f80f schema:name dimensions_id
    202 schema:value pub.1021367268
    203 rdf:type schema:PropertyValue
    204 N15e97d84a28f413c9d2712fc44ec2ab8 schema:name Springer Nature - SN SciGraph project
    205 rdf:type schema:Organization
    206 N226393374fff40958057adff5fce0080 schema:volumeNumber 4
    207 rdf:type schema:PublicationVolume
    208 N2d76496eb1d44dd69366938b2ed13051 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    209 schema:name Antiretroviral Therapy, Highly Active
    210 rdf:type schema:DefinedTerm
    211 N33e258bb6d194cef8b48ec0190196af4 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    212 schema:name Alzheimer Disease
    213 rdf:type schema:DefinedTerm
    214 N35e725c9f7cf442898bde2eeace5badb schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    215 schema:name Comorbidity
    216 rdf:type schema:DefinedTerm
    217 N48f72f7801a94f9485334875be2b18cf rdf:first sg:person.0625160427.93
    218 rdf:rest rdf:nil
    219 N49a50d33027849868188525ee927edf2 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    220 schema:name Cognition Disorders
    221 rdf:type schema:DefinedTerm
    222 N4e0b56608f434fef908b5934db79f733 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    223 schema:name Humans
    224 rdf:type schema:DefinedTerm
    225 N5b380007fb5747ae9942975f8577faae schema:name readcube_id
    226 schema:value 65cdb5ff15e8e14083c84d6ad771cf6d92f7798490039cc0c44697e72e9385b0
    227 rdf:type schema:PropertyValue
    228 N70997439b444471c8786a2e9b50da9e0 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    229 schema:name HIV Infections
    230 rdf:type schema:DefinedTerm
    231 N729b4b4a914745388a6f4c9faf63e417 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    232 schema:name Brain
    233 rdf:type schema:DefinedTerm
    234 N7ad2ec2eaad9456c8146bc8cb7b90c0e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    235 schema:name AIDS Dementia Complex
    236 rdf:type schema:DefinedTerm
    237 N85a2a476dda24eeca6ab97f834b61a74 schema:name nlm_unique_id
    238 schema:value 101256586
    239 rdf:type schema:PropertyValue
    240 N94c1f2c599574cffae64eedf16a3cca2 schema:name doi
    241 schema:value 10.1007/s11481-008-9136-0
    242 rdf:type schema:PropertyValue
    243 Na77d444d8dcf4154aea59bed6e8f1db6 schema:issueNumber 2
    244 rdf:type schema:PublicationIssue
    245 Nafaf0a9a91c24e608c1404c7fc653c74 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    246 schema:name Amyloid beta-Peptides
    247 rdf:type schema:DefinedTerm
    248 Nd06bbc8fa11742de9a99b4ac3c99946b schema:name pubmed_id
    249 schema:value 19016329
    250 rdf:type schema:PropertyValue
    251 Nea977239e76641b8938a6ddfd4495a9a rdf:first sg:person.0631130657.10
    252 rdf:rest N48f72f7801a94f9485334875be2b18cf
    253 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
    254 schema:name Medical and Health Sciences
    255 rdf:type schema:DefinedTerm
    256 anzsrc-for:1109 schema:inDefinedTermSet anzsrc-for:
    257 schema:name Neurosciences
    258 rdf:type schema:DefinedTerm
    259 sg:grant.2437437 http://pending.schema.org/fundedItem sg:pub.10.1007/s11481-008-9136-0
    260 rdf:type schema:MonetaryGrant
    261 sg:grant.2438398 http://pending.schema.org/fundedItem sg:pub.10.1007/s11481-008-9136-0
    262 rdf:type schema:MonetaryGrant
    263 sg:grant.2550845 http://pending.schema.org/fundedItem sg:pub.10.1007/s11481-008-9136-0
    264 rdf:type schema:MonetaryGrant
    265 sg:journal.1035881 schema:issn 1557-1890
    266 1557-1904
    267 schema:name Journal of Neuroimmune Pharmacology
    268 rdf:type schema:Periodical
    269 sg:person.0625160427.93 schema:affiliation https://www.grid.ac/institutes/grid.266813.8
    270 schema:familyName Ikezu
    271 schema:givenName Tsuneya
    272 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0625160427.93
    273 rdf:type schema:Person
    274 sg:person.0631130657.10 schema:affiliation https://www.grid.ac/institutes/grid.266813.8
    275 schema:familyName Xu
    276 schema:givenName Jiqing
    277 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0631130657.10
    278 rdf:type schema:Person
    279 sg:pub.10.1007/bf02736928 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044738711
    280 https://doi.org/10.1007/bf02736928
    281 rdf:type schema:CreativeWork
    282 sg:pub.10.1007/bf03033819 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027731607
    283 https://doi.org/10.1007/bf03033819
    284 rdf:type schema:CreativeWork
    285 sg:pub.10.1007/s00249-007-0246-z schema:sameAs https://app.dimensions.ai/details/publication/pub.1004893273
    286 https://doi.org/10.1007/s00249-007-0246-z
    287 rdf:type schema:CreativeWork
    288 sg:pub.10.1007/s00401-005-0983-y schema:sameAs https://app.dimensions.ai/details/publication/pub.1037359300
    289 https://doi.org/10.1007/s00401-005-0983-y
    290 rdf:type schema:CreativeWork
    291 sg:pub.10.1007/s00401-006-0037-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026777635
    292 https://doi.org/10.1007/s00401-006-0037-0
    293 rdf:type schema:CreativeWork
    294 sg:pub.10.1007/s00401-006-0115-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047793597
    295 https://doi.org/10.1007/s00401-006-0115-3
    296 rdf:type schema:CreativeWork
    297 sg:pub.10.1007/s11481-005-9006-y schema:sameAs https://app.dimensions.ai/details/publication/pub.1017104416
    298 https://doi.org/10.1007/s11481-005-9006-y
    299 rdf:type schema:CreativeWork
    300 sg:pub.10.1007/s11481-006-9017-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022938277
    301 https://doi.org/10.1007/s11481-006-9017-3
    302 rdf:type schema:CreativeWork
    303 sg:pub.10.1007/s11481-006-9018-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000628562
    304 https://doi.org/10.1007/s11481-006-9018-2
    305 rdf:type schema:CreativeWork
    306 sg:pub.10.1007/s11904-004-0018-7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014653661
    307 https://doi.org/10.1007/s11904-004-0018-7
    308 rdf:type schema:CreativeWork
    309 sg:pub.10.1007/s11908-003-0083-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1003570092
    310 https://doi.org/10.1007/s11908-003-0083-x
    311 rdf:type schema:CreativeWork
    312 sg:pub.10.1038/35073667 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018601522
    313 https://doi.org/10.1038/35073667
    314 rdf:type schema:CreativeWork
    315 sg:pub.10.1038/374647a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036018613
    316 https://doi.org/10.1038/374647a0
    317 rdf:type schema:CreativeWork
    318 sg:pub.10.1038/77397 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034890692
    319 https://doi.org/10.1038/77397
    320 rdf:type schema:CreativeWork
    321 sg:pub.10.1038/82199 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030025933
    322 https://doi.org/10.1038/82199
    323 rdf:type schema:CreativeWork
    324 sg:pub.10.1038/nature04671 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000381986
    325 https://doi.org/10.1038/nature04671
    326 rdf:type schema:CreativeWork
    327 sg:pub.10.1038/nm1095-1062 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011262193
    328 https://doi.org/10.1038/nm1095-1062
    329 rdf:type schema:CreativeWork
    330 sg:pub.10.1038/nm1635 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006313139
    331 https://doi.org/10.1038/nm1635
    332 rdf:type schema:CreativeWork
    333 sg:pub.10.1038/nn0805-977 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015265989
    334 https://doi.org/10.1038/nn0805-977
    335 rdf:type schema:CreativeWork
    336 sg:pub.10.1038/nri1527 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001952502
    337 https://doi.org/10.1038/nri1527
    338 rdf:type schema:CreativeWork
    339 sg:pub.10.1038/nri1664 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001096453
    340 https://doi.org/10.1038/nri1664
    341 rdf:type schema:CreativeWork
    342 sg:pub.10.1038/sj.cdd.4401623 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051717697
    343 https://doi.org/10.1038/sj.cdd.4401623
    344 rdf:type schema:CreativeWork
    345 sg:pub.10.1038/sj.mp.4001462 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006805948
    346 https://doi.org/10.1038/sj.mp.4001462
    347 rdf:type schema:CreativeWork
    348 sg:pub.10.1080/13550280490279816 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043179894
    349 https://doi.org/10.1080/13550280490279816
    350 rdf:type schema:CreativeWork
    351 sg:pub.10.1080/13550280500511741 schema:sameAs https://app.dimensions.ai/details/publication/pub.1058383227
    352 https://doi.org/10.1080/13550280500511741
    353 rdf:type schema:CreativeWork
    354 sg:pub.10.1080/13550280600760677 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004929179
    355 https://doi.org/10.1080/13550280600760677
    356 rdf:type schema:CreativeWork
    357 sg:pub.10.1111/j.1572-0241.2001.03969.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1041676387
    358 https://doi.org/10.1111/j.1572-0241.2001.03969.x
    359 rdf:type schema:CreativeWork
    360 sg:pub.10.1186/1471-2121-6-30 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020767769
    361 https://doi.org/10.1186/1471-2121-6-30
    362 rdf:type schema:CreativeWork
    363 sg:pub.10.1186/1742-2094-2-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022385552
    364 https://doi.org/10.1186/1742-2094-2-9
    365 rdf:type schema:CreativeWork
    366 https://app.dimensions.ai/details/publication/pub.1026133541 schema:CreativeWork
    367 https://app.dimensions.ai/details/publication/pub.1074697774 schema:CreativeWork
    368 https://app.dimensions.ai/details/publication/pub.1074950057 schema:CreativeWork
    369 https://app.dimensions.ai/details/publication/pub.1077641008 schema:CreativeWork
    370 https://app.dimensions.ai/details/publication/pub.1079842403 schema:CreativeWork
    371 https://app.dimensions.ai/details/publication/pub.1083206064 schema:CreativeWork
    372 https://doi.org/10.1002/(sici)1098-2396(200002)35:2<151::aid-syn8>3.0.co;2-p schema:sameAs https://app.dimensions.ai/details/publication/pub.1006035707
    373 rdf:type schema:CreativeWork
    374 https://doi.org/10.1002/1097-4547(20010301)63:5<410::aid-jnr1036>3.0.co;2-b schema:sameAs https://app.dimensions.ai/details/publication/pub.1040835038
    375 rdf:type schema:CreativeWork
    376 https://doi.org/10.1002/ana.410420108 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027830311
    377 rdf:type schema:CreativeWork
    378 https://doi.org/10.1002/glia.10178 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020626213
    379 rdf:type schema:CreativeWork
    380 https://doi.org/10.1002/glia.20080 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017729745
    381 rdf:type schema:CreativeWork
    382 https://doi.org/10.1002/glia.20451 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021875953
    383 rdf:type schema:CreativeWork
    384 https://doi.org/10.1002/glia.20710 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010316311
    385 rdf:type schema:CreativeWork
    386 https://doi.org/10.1002/hipo.10135 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015175792
    387 rdf:type schema:CreativeWork
    388 https://doi.org/10.1002/jnr.1095 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002422895
    389 rdf:type schema:CreativeWork
    390 https://doi.org/10.1002/jnr.20680 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049950494
    391 rdf:type schema:CreativeWork
    392 https://doi.org/10.1006/abbi.2001.2304 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017793594
    393 rdf:type schema:CreativeWork
    394 https://doi.org/10.1006/brbi.1995.1012 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001292030
    395 rdf:type schema:CreativeWork
    396 https://doi.org/10.1006/exnr.2000.7393 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008831992
    397 rdf:type schema:CreativeWork
    398 https://doi.org/10.1006/nbdi.2000.0321 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021953243
    399 rdf:type schema:CreativeWork
    400 https://doi.org/10.1006/nbdi.2002.0515 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005894247
    401 rdf:type schema:CreativeWork
    402 https://doi.org/10.1016/0014-2999(90)90099-r schema:sameAs https://app.dimensions.ai/details/publication/pub.1006307267
    403 rdf:type schema:CreativeWork
    404 https://doi.org/10.1016/0165-6147(92)90047-a schema:sameAs https://app.dimensions.ai/details/publication/pub.1045982607
    405 rdf:type schema:CreativeWork
    406 https://doi.org/10.1016/0197-4580(96)00115-7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047343069
    407 rdf:type schema:CreativeWork
    408 https://doi.org/10.1016/j.bbadis.2006.12.001 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040550107
    409 rdf:type schema:CreativeWork
    410 https://doi.org/10.1016/j.bbamem.2007.01.009 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024868519
    411 rdf:type schema:CreativeWork
    412 https://doi.org/10.1016/j.bbrc.2005.06.208 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018934994
    413 rdf:type schema:CreativeWork
    414 https://doi.org/10.1016/j.ceb.2004.06.003 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048336107
    415 rdf:type schema:CreativeWork
    416 https://doi.org/10.1016/j.cell.2007.10.014 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032702430
    417 rdf:type schema:CreativeWork
    418 https://doi.org/10.1016/j.chom.2007.06.011 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021774190
    419 rdf:type schema:CreativeWork
    420 https://doi.org/10.1016/j.jneuroim.2004.08.042 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016238068
    421 rdf:type schema:CreativeWork
    422 https://doi.org/10.1016/j.jneuroim.2005.07.009 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038742746
    423 rdf:type schema:CreativeWork
    424 https://doi.org/10.1016/j.mcn.2005.12.003 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039037169
    425 rdf:type schema:CreativeWork
    426 https://doi.org/10.1016/j.molimm.2004.06.020 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049073101
    427 rdf:type schema:CreativeWork
    428 https://doi.org/10.1016/j.neurobiolaging.2004.07.002 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019121715
    429 rdf:type schema:CreativeWork
    430 https://doi.org/10.1016/j.neurobiolaging.2006.11.004 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040521787
    431 rdf:type schema:CreativeWork
    432 https://doi.org/10.1016/j.neurobiolaging.2007.11.013 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028001598
    433 rdf:type schema:CreativeWork
    434 https://doi.org/10.1016/j.tvjl.2003.10.016 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013943230
    435 rdf:type schema:CreativeWork
    436 https://doi.org/10.1016/j.virusres.2005.04.009 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009527561
    437 rdf:type schema:CreativeWork
    438 https://doi.org/10.1016/s0002-9440(10)64463-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1017801326
    439 rdf:type schema:CreativeWork
    440 https://doi.org/10.1016/s0006-291x(03)01270-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034843616
    441 rdf:type schema:CreativeWork
    442 https://doi.org/10.1016/s0006-8993(99)02445-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050541653
    443 rdf:type schema:CreativeWork
    444 https://doi.org/10.1016/s0022-510x(99)00253-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027776269
    445 rdf:type schema:CreativeWork
    446 https://doi.org/10.1016/s0072-9752(07)85004-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044278445
    447 rdf:type schema:CreativeWork
    448 https://doi.org/10.1016/s0079-6123(07)63020-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035676506
    449 rdf:type schema:CreativeWork
    450 https://doi.org/10.1016/s0092-8674(00)80984-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026953147
    451 rdf:type schema:CreativeWork
    452 https://doi.org/10.1016/s0140-6736(05)62505-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045005118
    453 rdf:type schema:CreativeWork
    454 https://doi.org/10.1016/s0166-4328(01)00232-7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007669141
    455 rdf:type schema:CreativeWork
    456 https://doi.org/10.1016/s0169-328x(98)00164-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043105527
    457 rdf:type schema:CreativeWork
    458 https://doi.org/10.1016/s0197-0186(01)00041-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052329061
    459 rdf:type schema:CreativeWork
    460 https://doi.org/10.1016/s0304-3940(98)00549-7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048227654
    461 rdf:type schema:CreativeWork
    462 https://doi.org/10.1016/s0896-6273(01)00475-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037507194
    463 rdf:type schema:CreativeWork
    464 https://doi.org/10.1016/s0896-6273(03)00787-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047810561
    465 rdf:type schema:CreativeWork
    466 https://doi.org/10.1038/sj.bjp.0704382 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019875481
    467 rdf:type schema:CreativeWork
    468 https://doi.org/10.1046/j.1471-4159.1995.65041431.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1031326546
    469 rdf:type schema:CreativeWork
    470 https://doi.org/10.1046/j.1471-4159.2000.740457.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1005570589
    471 rdf:type schema:CreativeWork
    472 https://doi.org/10.1046/j.1471-4159.2001.00113.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1022121701
    473 rdf:type schema:CreativeWork
    474 https://doi.org/10.1055/s-2006-956759 schema:sameAs https://app.dimensions.ai/details/publication/pub.1057470148
    475 rdf:type schema:CreativeWork
    476 https://doi.org/10.1073/pnas.0230450100 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030968331
    477 rdf:type schema:CreativeWork
    478 https://doi.org/10.1073/pnas.0307981100 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009108282
    479 rdf:type schema:CreativeWork
    480 https://doi.org/10.1073/pnas.0503839103 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000361610
    481 rdf:type schema:CreativeWork
    482 https://doi.org/10.1073/pnas.0507995103 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002919789
    483 rdf:type schema:CreativeWork
    484 https://doi.org/10.1073/pnas.0803526105 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048079513
    485 rdf:type schema:CreativeWork
    486 https://doi.org/10.1073/pnas.86.19.7611 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049930546
    487 rdf:type schema:CreativeWork
    488 https://doi.org/10.1074/jbc.271.25.15002 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021079986
    489 rdf:type schema:CreativeWork
    490 https://doi.org/10.1074/jbc.271.43.26482 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014463652
    491 rdf:type schema:CreativeWork
    492 https://doi.org/10.1074/jbc.m203518200 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021136446
    493 rdf:type schema:CreativeWork
    494 https://doi.org/10.1074/jbc.m301938200 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037807523
    495 rdf:type schema:CreativeWork
    496 https://doi.org/10.1074/jbc.m302530200 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029719757
    497 rdf:type schema:CreativeWork
    498 https://doi.org/10.1074/jbc.m402034200 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043396252
    499 rdf:type schema:CreativeWork
    500 https://doi.org/10.1080/13506120701456293 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030111228
    501 rdf:type schema:CreativeWork
    502 https://doi.org/10.1083/jcb.200505082 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036273182
    503 rdf:type schema:CreativeWork
    504 https://doi.org/10.1083/jcb.200705042 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039297621
    505 rdf:type schema:CreativeWork
    506 https://doi.org/10.1089/apc.2006.0153 schema:sameAs https://app.dimensions.ai/details/publication/pub.1059228625
    507 rdf:type schema:CreativeWork
    508 https://doi.org/10.1089/apc.2007.0093 schema:sameAs https://app.dimensions.ai/details/publication/pub.1059228823
    509 rdf:type schema:CreativeWork
    510 https://doi.org/10.1093/jnen/62.5.429 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007232919
    511 rdf:type schema:CreativeWork
    512 https://doi.org/10.1093/jnen/64.6.529 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040133543
    513 rdf:type schema:CreativeWork
    514 https://doi.org/10.1097/00000441-200612000-00012 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030016605
    515 rdf:type schema:CreativeWork
    516 https://doi.org/10.1097/00001756-200412030-00025 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052614071
    517 rdf:type schema:CreativeWork
    518 https://doi.org/10.1097/00002030-200101260-00013 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024271710
    519 rdf:type schema:CreativeWork
    520 https://doi.org/10.1097/00002030-200205030-00008 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011551434
    521 rdf:type schema:CreativeWork
    522 https://doi.org/10.1097/00002030-200401001-00011 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027195372
    523 rdf:type schema:CreativeWork
    524 https://doi.org/10.1097/00002030-200501280-00004 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027651333
    525 rdf:type schema:CreativeWork
    526 https://doi.org/10.1097/00005072-199810000-00001 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006262499
    527 rdf:type schema:CreativeWork
    528 https://doi.org/10.1097/00005072-199911000-00005 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007902932
    529 rdf:type schema:CreativeWork
    530 https://doi.org/10.1097/00042560-199510050-00004 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021860464
    531 rdf:type schema:CreativeWork
    532 https://doi.org/10.1097/00042560-199512050-00004 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002553477
    533 rdf:type schema:CreativeWork
    534 https://doi.org/10.1097/01.aids.0000161770.06158.5c schema:sameAs https://app.dimensions.ai/details/publication/pub.1022183452
    535 rdf:type schema:CreativeWork
    536 https://doi.org/10.1097/01.cco.0000239886.13537.ed schema:sameAs https://app.dimensions.ai/details/publication/pub.1003180227
    537 rdf:type schema:CreativeWork
    538 https://doi.org/10.1097/01.jnen.0000178444.33972.e0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1060330606
    539 rdf:type schema:CreativeWork
    540 https://doi.org/10.1097/01.qai.0000021701.48448.20 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015189921
    541 rdf:type schema:CreativeWork
    542 https://doi.org/10.1097/qad.0b013e3282f56b40 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029914602
    543 rdf:type schema:CreativeWork
    544 https://doi.org/10.1111/j.1365-2362.2006.01657.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1047395182
    545 rdf:type schema:CreativeWork
    546 https://doi.org/10.1111/j.1463-1326.2005.00546.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1023681870
    547 rdf:type schema:CreativeWork
    548 https://doi.org/10.1111/j.1471-4159.2004.02895.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1044648138
    549 rdf:type schema:CreativeWork
    550 https://doi.org/10.1111/j.1471-4159.2006.04165.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1036471656
    551 rdf:type schema:CreativeWork
    552 https://doi.org/10.1111/j.1471-4159.2007.04594.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1053536699
    553 rdf:type schema:CreativeWork
    554 https://doi.org/10.1111/j.1471-4159.2007.05127.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1022400808
    555 rdf:type schema:CreativeWork
    556 https://doi.org/10.1111/j.1471-4159.2007.05128.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1002979618
    557 rdf:type schema:CreativeWork
    558 https://doi.org/10.1111/j.1471-4159.2007.05197.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1049791758
    559 rdf:type schema:CreativeWork
    560 https://doi.org/10.1111/j.1532-5415.2005.53360.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1035059975
    561 rdf:type schema:CreativeWork
    562 https://doi.org/10.1111/j.1600-0854.2006.00503.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1001856613
    563 rdf:type schema:CreativeWork
    564 https://doi.org/10.1111/j.1750-3639.2008.00132.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1027424485
    565 rdf:type schema:CreativeWork
    566 https://doi.org/10.1113/expphysiol.2005.030734 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031876059
    567 rdf:type schema:CreativeWork
    568 https://doi.org/10.1126/science.1059946 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051196367
    569 rdf:type schema:CreativeWork
    570 https://doi.org/10.1126/science.1067859 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062445759
    571 rdf:type schema:CreativeWork
    572 https://doi.org/10.1126/science.1072994 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052597019
    573 rdf:type schema:CreativeWork
    574 https://doi.org/10.1126/science.1566067 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062491586
    575 rdf:type schema:CreativeWork
    576 https://doi.org/10.1126/science.2148832 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062524153
    577 rdf:type schema:CreativeWork
    578 https://doi.org/10.1126/science.286.5448.2352 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062567722
    579 rdf:type schema:CreativeWork
    580 https://doi.org/10.1126/science.287.5453.602 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062568160
    581 rdf:type schema:CreativeWork
    582 https://doi.org/10.1126/science.3016903 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062582881
    583 rdf:type schema:CreativeWork
    584 https://doi.org/10.1136/jnnp.65.1.29 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007015092
    585 rdf:type schema:CreativeWork
    586 https://doi.org/10.1152/physrev.2001.81.2.741 schema:sameAs https://app.dimensions.ai/details/publication/pub.1074791168
    587 rdf:type schema:CreativeWork
    588 https://doi.org/10.1172/jci10498 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031916105
    589 rdf:type schema:CreativeWork
    590 https://doi.org/10.1172/jci31450 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028559047
    591 rdf:type schema:CreativeWork
    592 https://doi.org/10.1172/jci32356 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047777318
    593 rdf:type schema:CreativeWork
    594 https://doi.org/10.1182/blood.v98.8.2339 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003924148
    595 rdf:type schema:CreativeWork
    596 https://doi.org/10.1212/01.wnl.0000183293.95787.b7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1064347574
    597 rdf:type schema:CreativeWork
    598 https://doi.org/10.1212/wnl.42.9.1736 schema:sameAs https://app.dimensions.ai/details/publication/pub.1064371018
    599 rdf:type schema:CreativeWork
    600 https://doi.org/10.1258/095646207780749691 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027978693
    601 rdf:type schema:CreativeWork
    602 https://doi.org/10.1371/journal.pmed.0040262 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042719073
    603 rdf:type schema:CreativeWork
    604 https://doi.org/10.1523/jneurosci.0616-08.2008 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003145749
    605 rdf:type schema:CreativeWork
    606 https://doi.org/10.1523/jneurosci.0849-05.2005 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010168402
    607 rdf:type schema:CreativeWork
    608 https://doi.org/10.1523/jneurosci.1418-07.2007 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001217304
    609 rdf:type schema:CreativeWork
    610 https://doi.org/10.1523/jneurosci.18-08-02974.1998 schema:sameAs https://app.dimensions.ai/details/publication/pub.1083236479
    611 rdf:type schema:CreativeWork
    612 https://doi.org/10.1523/jneurosci.20-18-06811.2000 schema:sameAs https://app.dimensions.ai/details/publication/pub.1074700561
    613 rdf:type schema:CreativeWork
    614 https://doi.org/10.1523/jneurosci.23-05-01605.2003 schema:sameAs https://app.dimensions.ai/details/publication/pub.1075249766
    615 rdf:type schema:CreativeWork
    616 https://doi.org/10.1590/s1413-86702007000400012 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008204858
    617 rdf:type schema:CreativeWork
    618 https://doi.org/10.2174/138161206776055877 schema:sameAs https://app.dimensions.ai/details/publication/pub.1069165781
    619 rdf:type schema:CreativeWork
    620 https://doi.org/10.2174/156720507780362254 schema:sameAs https://app.dimensions.ai/details/publication/pub.1069188740
    621 rdf:type schema:CreativeWork
    622 https://doi.org/10.2353/ajpath.2007.060378 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051514225
    623 rdf:type schema:CreativeWork
    624 https://doi.org/10.2353/ajpath.2008.070620 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030380032
    625 rdf:type schema:CreativeWork
    626 https://doi.org/10.4049/jimmunol.181.6.3877 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036609313
    627 rdf:type schema:CreativeWork
    628 https://www.grid.ac/institutes/grid.266813.8 schema:alternateName University of Nebraska Medical Center
    629 schema:name Department of Pharmacology and Experimental Neuroscience, Center for Neurovirology and Neurodegenerative Disorders, University of Nebraska Medical Center, 68198-5880, Omaha, NE, USA
    630 rdf:type schema:Organization
     




    Preview window. Press ESC to close (or click here)


    ...